UniProtKB - P70596 (MC4R_RAT)
Melanocortin receptor 4
Mc4r
Functioni
Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).
By similarityGO - Molecular functioni
- G protein-coupled receptor activity Source: GO_Central
- hormone binding Source: RGD
- melanocortin receptor activity Source: RGD
- melanocyte-stimulating hormone receptor activity Source: RGD
- neuropeptide binding Source: RGD
- peptide hormone binding Source: RGD
- ubiquitin protein ligase binding Source: RGD
GO - Biological processi
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: RGD
- diet induced thermogenesis Source: RGD
- energy reserve metabolic process Source: RGD
- feeding behavior Source: RGD
- insulin secretion Source: RGD
- negative regulation of feeding behavior Source: RGD
- positive regulation of bone resorption Source: RGD
- regulation of eating behavior Source: RGD
- regulation of feeding behavior Source: RGD
- regulation of grooming behavior Source: RGD
- regulation of metabolic process Source: RGD
- response to insulin Source: RGD
- response to melanocyte-stimulating hormone Source: RGD
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-RNO-375276, Peptide ligand-binding receptors |
Names & Taxonomyi
Protein namesi | Recommended name: Melanocortin receptor 4Short name: MC4-R |
Gene namesi | Name:Mc4r |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 3057, Mc4r |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein Sequence analysis
Nucleus
- nucleus Source: RGD
Plasma Membrane
- plasma membrane Source: RGD
Other locations
- cytoplasm Source: GO_Central
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 43 | ExtracellularSequence analysisAdd BLAST | 43 | |
Transmembranei | 44 – 69 | Helical; Name=1Sequence analysisAdd BLAST | 26 | |
Topological domaini | 70 – 81 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 82 – 106 | Helical; Name=2Sequence analysisAdd BLAST | 25 | |
Topological domaini | 107 – 123 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 124 – 145 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 146 – 165 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 166 – 186 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 187 – 191 | ExtracellularSequence analysis | 5 | |
Transmembranei | 192 – 215 | Helical; Name=5Sequence analysisAdd BLAST | 24 | |
Topological domaini | 216 – 248 | CytoplasmicSequence analysisAdd BLAST | 33 | |
Transmembranei | 249 – 271 | Helical; Name=6Sequence analysisAdd BLAST | 23 | |
Topological domaini | 272 – 280 | ExtracellularSequence analysis | 9 | |
Transmembranei | 281 – 304 | Helical; Name=7Sequence analysisAdd BLAST | 24 | |
Topological domaini | 305 – 332 | CytoplasmicSequence analysisAdd BLAST | 28 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069726 | 1 – 332 | Melanocortin receptor 4Add BLAST | 332 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 2 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 17 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 26 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 84 | InterchainPROSITE-ProRule annotation | ||
Lipidationi | 318 | S-palmitoyl cysteineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, Lipoprotein, PalmitateProteomic databases
PaxDbi | P70596 |
PTM databases
GlyGeni | P70596, 3 sites |
PhosphoSitePlusi | P70596 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSRNOG00000018692, Expressed in testis and 10 other tissues |
Genevisiblei | P70596, RN |
Interactioni
Subunit structurei
Interacts with ATRNL1 (By similarity). Homodimer; disulfide-linked, also forms higher order oligomers.
Interacts with MGRN1, but does not undergo MGRN1-mediated ubiquitination; this interaction competes with GNAS-binding and thus inhibits agonist-induced cAMP production.
Interacts with MRAP and MRAP2; these associated factors increase ligand-sensitivity and generation of cAMP (By similarity).
By similarityGO - Molecular functioni
- ubiquitin protein ligase binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000025223 |
Chemistry databases
BindingDBi | P70596 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01030000234510 |
HOGENOMi | CLU_009579_13_0_1 |
InParanoidi | P70596 |
OMAi | YCTCFMS |
OrthoDBi | 869396at2759 |
PhylomeDBi | P70596 |
TreeFami | TF332646 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000155, Mcort_rcpt_4 IPR001908, Melancort_rcpt IPR001671, Melcrt_ACTH_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00534, MCRFAMILY PR00535, MELNOCORTINR PR01062, MELNOCORTN4R |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MNSTHHHGMY TSLHLWNRSS HGLHGNASES LGKGHSDGGC YEQLFVSPEV
60 70 80 90 100
FVTLGVISLL ENILVIVAIA KNKNLHSPMY FFICSLAVAD MLVSVSNGSE
110 120 130 140 150
TIVITLLNST DTDAQSFTVN IDNVIDSVIC SSLLASICSL LSIAVDRYFT
160 170 180 190 200
IFYALQYHNI MTVRRVGIII SCIWAACTVS GVLFIIYSDS SAVIICLITM
210 220 230 240 250
FFTMLVLMAS LYVHMFLMAR LHIKRIAVLP GTGTIRQGAN MKGAITLTIL
260 270 280 290 300
IGVFVVCWAP FFLHLLFYIS CPQNPYCVCF MSHFNLYLIL IMCNAVIDPL
310 320 330
IYALRSQELR KTFKEIICFY PLGGICELPG RY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U67863 mRNA Translation: AAB36517.1 |
PIRi | B57055 |
RefSeqi | NP_037231.1, NM_013099.3 |
Genome annotation databases
Ensembli | ENSRNOT00000025223; ENSRNOP00000025223; ENSRNOG00000018692 |
GeneIDi | 25635 |
KEGGi | rno:25635 |
UCSCi | RGD:3057, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U67863 mRNA Translation: AAB36517.1 |
PIRi | B57055 |
RefSeqi | NP_037231.1, NM_013099.3 |
3D structure databases
SMRi | P70596 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000025223 |
Chemistry databases
BindingDBi | P70596 |
ChEMBLi | CHEMBL2700 |
GuidetoPHARMACOLOGYi | 285 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P70596, 3 sites |
PhosphoSitePlusi | P70596 |
Proteomic databases
PaxDbi | P70596 |
Protocols and materials databases
DNASUi | 25635 |
Genome annotation databases
Ensembli | ENSRNOT00000025223; ENSRNOP00000025223; ENSRNOG00000018692 |
GeneIDi | 25635 |
KEGGi | rno:25635 |
UCSCi | RGD:3057, rat |
Organism-specific databases
CTDi | 4160 |
RGDi | 3057, Mc4r |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01030000234510 |
HOGENOMi | CLU_009579_13_0_1 |
InParanoidi | P70596 |
OMAi | YCTCFMS |
OrthoDBi | 869396at2759 |
PhylomeDBi | P70596 |
TreeFami | TF332646 |
Enzyme and pathway databases
Reactomei | R-RNO-375276, Peptide ligand-binding receptors |
Miscellaneous databases
PROi | PR:P70596 |
Gene expression databases
Bgeei | ENSRNOG00000018692, Expressed in testis and 10 other tissues |
Genevisiblei | P70596, RN |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000155, Mcort_rcpt_4 IPR001908, Melancort_rcpt IPR001671, Melcrt_ACTH_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00534, MCRFAMILY PR00535, MELNOCORTINR PR01062, MELNOCORTN4R |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MC4R_RAT | |
Accessioni | P70596Primary (citable) accession number: P70596 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | February 1, 1997 | |
Last modified: | February 23, 2022 | |
This is version 142 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - SIMILARITY comments
Index of protein domains and families