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UniProtKB - P70587 (LRRC7_RAT)

Protein

Leucine-rich repeat-containing protein 7

Gene

Lrrc7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression (By similarity).By similarity

GO - Molecular functioni

  • protein C-terminus binding Source: RGD
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 7
Alternative name(s):
Densin-180
Short name:
Densin
Protein LAP1
Gene namesi
Name:Lrrc7
Synonyms:Lap1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi708527 Lrrc7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi1288S → D: Decrease in the level of phosphorylation. Strong decrease in the level of phosphorylation; when associated with D-1392. 1 Publication1
Mutagenesisi1392S → D: Strong decrease in the level of phosphorylation; when associated with D-1288. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001883001 – 1490Leucine-rich repeat-containing protein 7Add BLAST1490

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei439PhosphoserineCombined sources1
Modified residuei441PhosphoserineCombined sources1
Modified residuei443PhosphoserineCombined sources1
Modified residuei831PhosphothreonineBy similarity1
Modified residuei850PhosphoserineCombined sources1
Modified residuei865PhosphothreonineCombined sources1
Modified residuei869PhosphoserineBy similarity1
Modified residuei947PhosphoserineCombined sources1
Modified residuei949PhosphoserineCombined sources1
Modified residuei1118PhosphoserineBy similarity1
Modified residuei1149Omega-N-methylarginineBy similarity1
Modified residuei1233PhosphoserineBy similarity1
Modified residuei1288Phosphoserine1 Publication1
Modified residuei1392PhosphoserineCombined sources1 Publication1
Isoform 4 (identifier: P70587-4)
Modified residuei1288Phosphoserine1 Publication1

Post-translational modificationi

O-glycosylated and phosphorylated.1 Publication

Keywords - PTMi

Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

PaxDbiP70587
PRIDEiP70587

PTM databases

iPTMnetiP70587
PhosphoSitePlusiP70587
SwissPalmiP70587

Expressioni

Tissue specificityi

Brain-specific. Highly concentrated at synapses.1 Publication

Developmental stagei

Expression of isoform 2 is predominant at E18, but decreased during postnatal development paralleling increased expression of isoform 4 and isoform 5.1 Publication

Interactioni

Subunit structurei

Interacts with CNKSR2 and DLG4 (PubMed:12390249). Interacts with CTNND2/Catenin delta-2. Forms a complex with N-cadherin through CTNND2 (By similarity). Interacts with CAMK2A (PubMed:10827168).By similarity2 Publications

Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi250730, 6 interactors
CORUMiP70587
IntActiP70587, 9 interactors
MINTiP70587
STRINGi10116.ENSRNOP00000016453

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati23 – 44LRR 1Add BLAST22
Repeati47 – 68LRR 2Add BLAST22
Repeati70 – 91LRR 3Add BLAST22
Repeati93 – 114LRR 4Add BLAST22
Repeati116 – 137LRR 5Add BLAST22
Repeati139 – 161LRR 6Add BLAST23
Repeati162 – 183LRR 7Add BLAST22
Repeati185 – 206LRR 8Add BLAST22
Repeati208 – 229LRR 9Add BLAST22
Repeati231 – 253LRR 10Add BLAST23
Repeati254 – 275LRR 11Add BLAST22
Repeati277 – 298LRR 12Add BLAST22
Repeati300 – 321LRR 13Add BLAST22
Repeati323 – 344LRR 14Add BLAST22
Repeati346 – 367LRR 15Add BLAST22
Repeati369 – 391LRR 16Add BLAST23
Repeati392 – 413LRR 17Add BLAST22
Domaini1398 – 1488PDZPROSITE-ProRule annotationAdd BLAST91

Sequence similaritiesi

Belongs to the LAP (LRR and PDZ) protein family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410KCZ0 Eukaryota
COG4886 LUCA
HOGENOMiHOG000060229
HOVERGENiHBG052305
InParanoidiP70587

Family and domain databases

Gene3Di3.80.10.10, 4 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR001478 PDZ
IPR036034 PDZ_sf
PfamiView protein in Pfam
PF13855 LRR_8, 4 hits
PF00595 PDZ, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 11 hits
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 15 hits
PS50106 PDZ, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: P70587-1) [UniParc]FASTAAdd to basket
Also known as: Variant A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTTKRKLIGR LVPCRCFRGE EEIISVLDYS HCSLQQVPKE VFNFERTLEE 
        60         70         80         90        100
LYLDANQIEE LPKQLFNCQA LRKLSIPDND LSSLPTSIAS LVNLKELDIS 
       110        120        130        140        150
KNGVQEFPEN IKCCKCLTII EASVNPISKL PDGFTQLLNL TQLYLNDAFL 
       160        170        180        190        200
EFLPANFGRL VKLRILELRE NHLKTLPKSM HKLAQLERLD LGNNEFSELP 
       210        220        230        240        250
EVLDQIQNLR ELWMDNNALQ VLPGSIGKLK MLVYLDMSKN RIETVDMDIS 
       260        270        280        290        300
GCEALEDLLL SSNMLQQLPD SIGLLKKLTT LKVDDNQLTM LPNTIGNLSL 
       310        320        330        340        350
LEEFDCSCNE LESLPPTIGY LHSLRTLAVD ENFLPELPRE IGSCKNVTVM 
       360        370        380        390        400
SLRSNKLEFL PEEIGQMQRL RVLNLSDNRL KNLPFSFTKL KELAALWLSD 
       410        420        430        440        450
NQSKALIPLQ TEAHPETKQR VLTNYMFPQQ PRGDEDFQSD SDSFNPTLWE 
       460        470        480        490        500
EQRQQRMTVA FEFEDKKEDD ESAGKVKALS CQAPWDRGQR GITLQPARLS 
       510        520        530        540        550
GDCCTPWARC DQQIQDMPVP QSDPQLAWGC ISGLQQERSM CAPLPVAAQS 
       560        570        580        590        600
TTLPSLSGRQ VEINLKRYPT PYPEDLKNMV KSVQNLVGKP SHGVRVENAN 
       610        620        630        640        650
PTANTEQTVK EKFEHKWPVA PKEITVEDSF VHPANEMRIG ELHPSLAETP 
       660        670        680        690        700
LYPPKLVLLG KDKKESTDES EVDKTHCLNN SVSSGTYSDY SPSQASSASS 
       710        720        730        740        750
NTRVKVGSLQ PTTKDAVHNS LWGNRIAPPF PQPLDAKPLL TQREAVPPGN 
       760        770        780        790        800
LPQRPDRLPM SDAFPDNWTD GSHYDNTGFV SEEATGENAN NNPLLSSKAR 
       810        820        830        840        850
SVPAHGRRPL IRQERIVGVP LELEQSTHRH TPETEVPPSN PWQNWTRTPS 
       860        870        880        890        900
PFEDRTAFPS KLETTPTTSP LPERKDHMKE PTETPGPFSP GVPWEYHDPT 
       910        920        930        940        950
PNRSLGNVFS QIHCRPDSSK GVIAISKSTE RLSPLMKDIK SNKFKKSQSI 
       960        970        980        990       1000
DEIDVGTYKV YNIPLENYAS GSDHLGSHER PDKFLGPEHG MSSMSRSQSV 
      1010       1020       1030       1040       1050
PMLDDEMLMY GSSKGPPQQK ASMTKKVYQF DQSFNPQGAV EVKAEKRIPP 
      1060       1070       1080       1090       1100
PFAHNSEYVQ QPGKNIAKDL VSPRAYRGYP PMEQMFSFSQ PSVNEDAMVN 
      1110       1120       1130       1140       1150
AQFASQGPRA GFLRRADSLA SSTEMAMFRR VSEPHELPPG DRYGRAAYRG 
      1160       1170       1180       1190       1200
GLEGQSSVSM TDPQFLKRNG RYEDEHPSYQ EVKAQAGSFP AKNLTQRRPL 
      1210       1220       1230       1240       1250
SARSYSTESY GASQTRPVSA RPTMAALLEK IPSDYNLGNY GDKTSDNSDI 
      1260       1270       1280       1290       1300
KTRPTPVKGE ESCGKMPADW RQQLLRHIEA RRLDRTPSQQ SNILDNGQED 
      1310       1320       1330       1340       1350
VSPSGQWNPY PLGRRDVPPD TITKKAGSHI QTLMGSQSLQ HRSREQQPYE 
      1360       1370       1380       1390       1400
GNINKVTIQQ FQSPLPIQIP SSQATRGPQP GRCLIQTKGQ RSMDGYPEQF 
      1410       1420       1430       1440       1450
CVRIEKNPGL GFSISGGISG QGNPFKPSDK GIFVTRVQPD GPASNLLQPG 
      1460       1470       1480       1490
DKILQANGHS FVHMEHEKAV LLLKSFQNTV DLVIQRELTV
Length:1,490
Mass (Da):166,879
Last modified:April 18, 2012 - v2
Checksum:i30DC3E92EB44F2A5
GO
Isoform 2 (identifier: P70587-2) [UniParc]FASTAAdd to basket
Also known as: Variant D

The sequence of this isoform differs from the canonical sequence as follows:
     1285-1285: R → RNAAYKHNTVNLGMLPYGGISAMHAGRSMTLNLQTKSKFDLQDLPLQK

Note: This is the only isoform to have a potential transmembrane domain.
Show »
Length:1,537
Mass (Da):172,035
Checksum:i1710B4823C93F5FD
GO
Isoform 3 (identifier: P70587-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1218-1241: Missing.

Note: No experimental confirmation available.
Show »
Length:1,466
Mass (Da):164,316
Checksum:i80CF7AB619551849
GO
Isoform 4 (identifier: P70587-4) [UniParc]FASTAAdd to basket
Also known as: Variant B

The sequence of this isoform differs from the canonical sequence as follows:
     1286-1325: Missing.

Note: No experimental confirmation available.1 Publication
Show »
Length:1,450
Mass (Da):162,460
Checksum:i32B3A3C4CD5860D0
GO
Isoform 5 (identifier: P70587-5) [UniParc]FASTAAdd to basket
Also known as: Variant C

The sequence of this isoform differs from the canonical sequence as follows:
     1326-1399: Missing.

Note: No experimental confirmation available.
Show »
Length:1,416
Mass (Da):158,650
Checksum:i5CD541D2CCABD0C3
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1M4K6F1M4K6_RAT
Leucine-rich repeat-containing prot...
Lrrc7 rCG_28757
1,495Annotation score:
F1LMG7F1LMG7_RAT
Leucine-rich repeat-containing prot...
Lrrc7
495Annotation score:
A0A0A0MXW8A0A0A0MXW8_RAT
Leucine-rich repeat-containing prot...
Lrrc7
447Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti722W → R AA sequence (PubMed:8824323).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0107981218 – 1241Missing in isoform 3. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_0107991285R → RNAAYKHNTVNLGMLPYGGI SAMHAGRSMTLNLQTKSKFD LQDLPLQK in isoform 2. 1 Publication1
Alternative sequenceiVSP_0108001286 – 1325Missing in isoform 4. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_0108011326 – 1399Missing in isoform 5. 1 PublicationAdd BLAST74

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66707 mRNA Translation: AAC52881.1
AF266164 mRNA Translation: AAF76466.1
PIRiT31434
RefSeqiNP_476483.1, NM_057142.1
UniGeneiRn.89629

Genome annotation databases

GeneIDi117284
KEGGirno:117284

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66707 mRNA Translation: AAC52881.1
AF266164 mRNA Translation: AAF76466.1
PIRiT31434
RefSeqiNP_476483.1, NM_057142.1
UniGeneiRn.89629

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250730, 6 interactors
CORUMiP70587
IntActiP70587, 9 interactors
MINTiP70587
STRINGi10116.ENSRNOP00000016453

PTM databases

iPTMnetiP70587
PhosphoSitePlusiP70587
SwissPalmiP70587

Proteomic databases

PaxDbiP70587
PRIDEiP70587

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi117284
KEGGirno:117284

Organism-specific databases

CTDi57554
RGDi708527 Lrrc7

Phylogenomic databases

eggNOGiENOG410KCZ0 Eukaryota
COG4886 LUCA
HOGENOMiHOG000060229
HOVERGENiHBG052305
InParanoidiP70587

Miscellaneous databases

PROiPR:P70587

Family and domain databases

Gene3Di3.80.10.10, 4 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR001478 PDZ
IPR036034 PDZ_sf
PfamiView protein in Pfam
PF13855 LRR_8, 4 hits
PF00595 PDZ, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 11 hits
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 15 hits
PS50106 PDZ, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLRRC7_RAT
AccessioniPrimary (citable) accession number: P70587
Secondary accession number(s): Q9JI42
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: April 18, 2012
Last modified: September 12, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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