UniProtKB - P70587 (LRRC7_RAT)
Protein
Leucine-rich repeat-containing protein 7
Gene
Lrrc7
Organism
Rattus norvegicus (Rat)
Status
Functioni
Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression (By similarity).By similarity
GO - Molecular functioni
- protein C-terminus binding Source: RGD
GO - Biological processi
- cell-cell adhesion Source: GO_Central
- establishment or maintenance of epithelial cell apical/basal polarity Source: GO_Central
- positive regulation of neuron projection development Source: RGD
- receptor clustering Source: GO_Central
- receptor localization to synapse Source: GO_Central
- response to organic cyclic compound Source: RGD
Enzyme and pathway databases
Reactomei | R-RNO-438066, Unblocking of NMDA receptors, glutamate binding and activation R-RNO-5673001, RAF/MAP kinase cascade R-RNO-6798695, Neutrophil degranulation |
Names & Taxonomyi
Protein namesi | Recommended name: Leucine-rich repeat-containing protein 7Alternative name(s): Densin-180 Short name: Densin Protein LAP1 |
Gene namesi | Name:Lrrc7 Synonyms:Lap1 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 708527, Lrrc7 |
Subcellular locationi
Other locations
- Cytoplasm By similarity
- postsynaptic density By similarity
Plasma Membrane
- basolateral plasma membrane Source: GO_Central
- plasma membrane Source: RGD
Other locations
- axon initial segment Source: RGD
- cell junction Source: GO_Central
- cytoplasm Source: RGD
- dendritic spine Source: RGD
- filopodium Source: RGD
- neuron projection Source: RGD
- postsynaptic density Source: RGD
- synapse Source: RGD
Keywords - Cellular componenti
Cell junction, Cytoplasm, SynapsePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 1288 | S → D: Decrease in the level of phosphorylation. Strong decrease in the level of phosphorylation; when associated with D-1392. 1 Publication | 1 | |
Mutagenesisi | 1392 | S → D: Strong decrease in the level of phosphorylation; when associated with D-1288. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000188300 | 1 – 1490 | Leucine-rich repeat-containing protein 7Add BLAST | 1490 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 439 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 441 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 443 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 831 | PhosphothreonineBy similarity | 1 | ||
Modified residuei | 850 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 865 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 869 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 947 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 949 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1118 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 1149 | Omega-N-methylarginineBy similarity | 1 | ||
Modified residuei | 1233 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 1288 | Phosphoserine1 Publication | 1 | ||
Modified residuei | 1392 | PhosphoserineCombined sources1 Publication | 1 | ||
Isoform 4 (identifier: P70587-4) | |||||
Modified residuei | 1288 | PhosphoserineCurated | 1 |
Post-translational modificationi
O-glycosylated and phosphorylated.1 Publication
Keywords - PTMi
Glycoprotein, Methylation, PhosphoproteinProteomic databases
PaxDbi | P70587 |
PRIDEi | P70587 |
PTM databases
iPTMneti | P70587 |
PhosphoSitePlusi | P70587 |
SwissPalmi | P70587 |
Expressioni
Tissue specificityi
Brain-specific. Highly concentrated at synapses.1 Publication
Developmental stagei
Expression of isoform 2 is predominant at E18, but decreased during postnatal development paralleling increased expression of isoform 4 and isoform 5.1 Publication
Interactioni
Subunit structurei
Binary interactionsi
Hide detailsP70587
With | #Exp. | IntAct |
---|---|---|
Camk2a [P11275] | 2 | EBI-7798464,EBI-2640645 |
Cnksr2 [Q9Z1T4] | 3 | EBI-7798464,EBI-8548356 |
Dlg4 [P31016] | 5 | EBI-7798464,EBI-375655 |
Camk2a [P11798] from Mus musculus. | 2 | EBI-7798464,EBI-400384 |
GO - Molecular functioni
- protein C-terminus binding Source: RGD
Protein-protein interaction databases
BioGRIDi | 250730, 7 interactors |
CORUMi | P70587 |
IntActi | P70587, 9 interactors |
MINTi | P70587 |
STRINGi | 10116.ENSRNOP00000016453 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 23 – 44 | LRR 1Add BLAST | 22 | |
Repeati | 47 – 68 | LRR 2Add BLAST | 22 | |
Repeati | 70 – 91 | LRR 3Add BLAST | 22 | |
Repeati | 93 – 114 | LRR 4Add BLAST | 22 | |
Repeati | 116 – 137 | LRR 5Add BLAST | 22 | |
Repeati | 139 – 161 | LRR 6Add BLAST | 23 | |
Repeati | 162 – 183 | LRR 7Add BLAST | 22 | |
Repeati | 185 – 206 | LRR 8Add BLAST | 22 | |
Repeati | 208 – 229 | LRR 9Add BLAST | 22 | |
Repeati | 231 – 253 | LRR 10Add BLAST | 23 | |
Repeati | 254 – 275 | LRR 11Add BLAST | 22 | |
Repeati | 277 – 298 | LRR 12Add BLAST | 22 | |
Repeati | 300 – 321 | LRR 13Add BLAST | 22 | |
Repeati | 323 – 344 | LRR 14Add BLAST | 22 | |
Repeati | 346 – 367 | LRR 15Add BLAST | 22 | |
Repeati | 369 – 391 | LRR 16Add BLAST | 23 | |
Repeati | 392 – 413 | LRR 17Add BLAST | 22 | |
Domaini | 1398 – 1488 | PDZPROSITE-ProRule annotationAdd BLAST | 91 |
Sequence similaritiesi
Belongs to the LAP (LRR and PDZ) protein family.Curated
Keywords - Domaini
Leucine-rich repeat, RepeatPhylogenomic databases
eggNOGi | KOG0619, Eukaryota |
InParanoidi | P70587 |
OrthoDBi | 40683at2759 |
Family and domain databases
Gene3Di | 2.30.42.10, 1 hit 3.80.10.10, 4 hits |
InterProi | View protein in InterPro IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf IPR001478, PDZ IPR036034, PDZ_sf |
Pfami | View protein in Pfam PF13855, LRR_8, 3 hits PF00595, PDZ, 1 hit |
SMARTi | View protein in SMART SM00369, LRR_TYP, 11 hits SM00228, PDZ, 1 hit |
SUPFAMi | SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS51450, LRR, 15 hits PS50106, PDZ, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P70587-1) [UniParc]FASTAAdd to basket
Also known as: Variant A
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTTKRKLIGR LVPCRCFRGE EEIISVLDYS HCSLQQVPKE VFNFERTLEE
60 70 80 90 100
LYLDANQIEE LPKQLFNCQA LRKLSIPDND LSSLPTSIAS LVNLKELDIS
110 120 130 140 150
KNGVQEFPEN IKCCKCLTII EASVNPISKL PDGFTQLLNL TQLYLNDAFL
160 170 180 190 200
EFLPANFGRL VKLRILELRE NHLKTLPKSM HKLAQLERLD LGNNEFSELP
210 220 230 240 250
EVLDQIQNLR ELWMDNNALQ VLPGSIGKLK MLVYLDMSKN RIETVDMDIS
260 270 280 290 300
GCEALEDLLL SSNMLQQLPD SIGLLKKLTT LKVDDNQLTM LPNTIGNLSL
310 320 330 340 350
LEEFDCSCNE LESLPPTIGY LHSLRTLAVD ENFLPELPRE IGSCKNVTVM
360 370 380 390 400
SLRSNKLEFL PEEIGQMQRL RVLNLSDNRL KNLPFSFTKL KELAALWLSD
410 420 430 440 450
NQSKALIPLQ TEAHPETKQR VLTNYMFPQQ PRGDEDFQSD SDSFNPTLWE
460 470 480 490 500
EQRQQRMTVA FEFEDKKEDD ESAGKVKALS CQAPWDRGQR GITLQPARLS
510 520 530 540 550
GDCCTPWARC DQQIQDMPVP QSDPQLAWGC ISGLQQERSM CAPLPVAAQS
560 570 580 590 600
TTLPSLSGRQ VEINLKRYPT PYPEDLKNMV KSVQNLVGKP SHGVRVENAN
610 620 630 640 650
PTANTEQTVK EKFEHKWPVA PKEITVEDSF VHPANEMRIG ELHPSLAETP
660 670 680 690 700
LYPPKLVLLG KDKKESTDES EVDKTHCLNN SVSSGTYSDY SPSQASSASS
710 720 730 740 750
NTRVKVGSLQ PTTKDAVHNS LWGNRIAPPF PQPLDAKPLL TQREAVPPGN
760 770 780 790 800
LPQRPDRLPM SDAFPDNWTD GSHYDNTGFV SEEATGENAN NNPLLSSKAR
810 820 830 840 850
SVPAHGRRPL IRQERIVGVP LELEQSTHRH TPETEVPPSN PWQNWTRTPS
860 870 880 890 900
PFEDRTAFPS KLETTPTTSP LPERKDHMKE PTETPGPFSP GVPWEYHDPT
910 920 930 940 950
PNRSLGNVFS QIHCRPDSSK GVIAISKSTE RLSPLMKDIK SNKFKKSQSI
960 970 980 990 1000
DEIDVGTYKV YNIPLENYAS GSDHLGSHER PDKFLGPEHG MSSMSRSQSV
1010 1020 1030 1040 1050
PMLDDEMLMY GSSKGPPQQK ASMTKKVYQF DQSFNPQGAV EVKAEKRIPP
1060 1070 1080 1090 1100
PFAHNSEYVQ QPGKNIAKDL VSPRAYRGYP PMEQMFSFSQ PSVNEDAMVN
1110 1120 1130 1140 1150
AQFASQGPRA GFLRRADSLA SSTEMAMFRR VSEPHELPPG DRYGRAAYRG
1160 1170 1180 1190 1200
GLEGQSSVSM TDPQFLKRNG RYEDEHPSYQ EVKAQAGSFP AKNLTQRRPL
1210 1220 1230 1240 1250
SARSYSTESY GASQTRPVSA RPTMAALLEK IPSDYNLGNY GDKTSDNSDI
1260 1270 1280 1290 1300
KTRPTPVKGE ESCGKMPADW RQQLLRHIEA RRLDRTPSQQ SNILDNGQED
1310 1320 1330 1340 1350
VSPSGQWNPY PLGRRDVPPD TITKKAGSHI QTLMGSQSLQ HRSREQQPYE
1360 1370 1380 1390 1400
GNINKVTIQQ FQSPLPIQIP SSQATRGPQP GRCLIQTKGQ RSMDGYPEQF
1410 1420 1430 1440 1450
CVRIEKNPGL GFSISGGISG QGNPFKPSDK GIFVTRVQPD GPASNLLQPG
1460 1470 1480 1490
DKILQANGHS FVHMEHEKAV LLLKSFQNTV DLVIQRELTV
Isoform 2 (identifier: P70587-2) [UniParc]FASTAAdd to basket
Also known as: Variant D
The sequence of this isoform differs from the canonical sequence as follows:
1285-1285: R → RNAAYKHNTVNLGMLPYGGISAMHAGRSMTLNLQTKSKFDLQDLPLQK
Note: This is the only isoform to have a potential transmembrane domain.Curated
Show »Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF1M4K6 | F1M4K6_RAT | Leucine-rich repeat-containing prot... | Lrrc7 rCG_28757 | 1,495 | Annotation score: | ||
A0A0A0MXW8 | A0A0A0MXW8_RAT | Leucine-rich repeat-containing prot... | Lrrc7 | 447 | Annotation score: | ||
F1LMG7 | F1LMG7_RAT | Leucine-rich repeat-containing prot... | Lrrc7 | 495 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 722 | W → R AA sequence (PubMed:8824323).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_010798 | 1218 – 1241 | Missing in isoform 3. 1 PublicationAdd BLAST | 24 | |
Alternative sequenceiVSP_010799 | 1285 | R → RNAAYKHNTVNLGMLPYGGI SAMHAGRSMTLNLQTKSKFD LQDLPLQK in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_010800 | 1286 – 1325 | Missing in isoform 4. 1 PublicationAdd BLAST | 40 | |
Alternative sequenceiVSP_010801 | 1326 – 1399 | Missing in isoform 5. 1 PublicationAdd BLAST | 74 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U66707 mRNA Translation: AAC52881.1 AF266164 mRNA Translation: AAF76466.1 |
PIRi | T31434 |
RefSeqi | NP_476483.1, NM_057142.1 |
Genome annotation databases
GeneIDi | 117284 |
KEGGi | rno:117284 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U66707 mRNA Translation: AAC52881.1 AF266164 mRNA Translation: AAF76466.1 |
PIRi | T31434 |
RefSeqi | NP_476483.1, NM_057142.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 250730, 7 interactors |
CORUMi | P70587 |
IntActi | P70587, 9 interactors |
MINTi | P70587 |
STRINGi | 10116.ENSRNOP00000016453 |
PTM databases
iPTMneti | P70587 |
PhosphoSitePlusi | P70587 |
SwissPalmi | P70587 |
Proteomic databases
PaxDbi | P70587 |
PRIDEi | P70587 |
Genome annotation databases
GeneIDi | 117284 |
KEGGi | rno:117284 |
Organism-specific databases
CTDi | 57554 |
RGDi | 708527, Lrrc7 |
Phylogenomic databases
eggNOGi | KOG0619, Eukaryota |
InParanoidi | P70587 |
OrthoDBi | 40683at2759 |
Enzyme and pathway databases
Reactomei | R-RNO-438066, Unblocking of NMDA receptors, glutamate binding and activation R-RNO-5673001, RAF/MAP kinase cascade R-RNO-6798695, Neutrophil degranulation |
Miscellaneous databases
PROi | PR:P70587 |
Family and domain databases
Gene3Di | 2.30.42.10, 1 hit 3.80.10.10, 4 hits |
InterProi | View protein in InterPro IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf IPR001478, PDZ IPR036034, PDZ_sf |
Pfami | View protein in Pfam PF13855, LRR_8, 3 hits PF00595, PDZ, 1 hit |
SMARTi | View protein in SMART SM00369, LRR_TYP, 11 hits SM00228, PDZ, 1 hit |
SUPFAMi | SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS51450, LRR, 15 hits PS50106, PDZ, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LRRC7_RAT | |
Accessioni | P70587Primary (citable) accession number: P70587 Secondary accession number(s): Q9JI42 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2004 |
Last sequence update: | April 18, 2012 | |
Last modified: | December 2, 2020 | |
This is version 143 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families