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Protein

Nuclear pore complex protein Nup54

Gene

Nup54

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane.1 Publication

GO - Molecular functioni

  • structural constituent of nuclear pore Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-RNO-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-RNO-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-RNO-191859 snRNP Assembly
R-RNO-3108214 SUMOylation of DNA damage response and repair proteins
R-RNO-3232142 SUMOylation of ubiquitinylation proteins
R-RNO-3301854 Nuclear Pore Complex (NPC) Disassembly
R-RNO-3371453 Regulation of HSF1-mediated heat shock response
R-RNO-4085377 SUMOylation of SUMOylation proteins
R-RNO-4551638 SUMOylation of chromatin organization proteins
R-RNO-4570464 SUMOylation of RNA binding proteins
R-RNO-4615885 SUMOylation of DNA replication proteins
R-RNO-5578749 Transcriptional regulation by small RNAs

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear pore complex protein Nup54
Alternative name(s):
54 kDa nucleoporin
Nucleoporin Nup54
Gene namesi
Name:Nup54
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi619926 Nup54

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002048761 – 510Nuclear pore complex protein Nup54Add BLAST510

Post-translational modificationi

O-glycosylated.

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP70582
PRIDEiP70582

Expressioni

Gene expression databases

BgeeiENSRNOG00000002247 Expressed in 10 organ(s), highest expression level in spleen
GenevisibleiP70582 RN

Interactioni

Subunit structurei

Component of the p62 complex, a complex composed of NUP62, NUP54, and the isoform p58 and isoform p45 of NUP58. Interacts with NUTF2.1 Publication

Protein-protein interaction databases

BioGridi248440, 2 interactors
CORUMiP70582
STRINGi10116.ENSRNOP00000003070

Structurei

Secondary structure

1510
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SMRiP70582
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati5 – 612
Repeati25 – 2622
Repeati28 – 2932
Repeati61 – 6242
Repeati63 – 6452
Repeati67 – 6862
Repeati87 – 8872
Repeati447 – 44882

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni5 – 4488 X 2 AA repeats of F-GAdd BLAST444

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi6 – 89Gly-richAdd BLAST84
Compositional biasi30 – 34Poly-Thr5
Compositional biasi93 – 100Poly-Gln8
Compositional biasi208 – 211Poly-Gln4

Domaini

Contains FG repeats.

Sequence similaritiesi

Belongs to the NUP54 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3091 Eukaryota
ENOG410XPU5 LUCA
GeneTreeiENSGT00390000013620
HOGENOMiHOG000046583
HOVERGENiHBG052698
InParanoidiP70582
KOiK14308
OMAiCRRKHLV
OrthoDBiEOG091G0BAH
PhylomeDBiP70582
TreeFamiTF320237

Family and domain databases

InterProiView protein in InterPro
IPR024864 Nup54/Nup57/Nup44
IPR025712 Nup54_alpha-helical_dom
PANTHERiPTHR13000 PTHR13000, 1 hit
PfamiView protein in Pfam
PF13874 Nup54, 1 hit

Sequencei

Sequence statusi: Complete.

P70582-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFNFGAPSG TSGTSTATAA PAGGFGGFGT TTTTAGSAFS FSAPTNTGST
60 70 80 90 100
GLLGGTQNKG FGFGTGFGTS TGTGTGLGTG LGTGLGFGGF NTQQQQQQQQ
110 120 130 140 150
TSLGGLFSQP AQAPAQSNQL INTASALSAP TLLGDERDAI LAKWNQLQAF
160 170 180 190 200
WGTGKGYFNN NIPPVEFTQE NPFCRFKAVG YSCMPNNKDE DGLVVLIFNK
210 220 230 240 250
KETDIRSQQQ QLVESLHKVL GGNQTLTVNV EGIKTLPDDQ TEVVIYIVER
260 270 280 290 300
SPNGTSRRVP ATTLYAHFEQ ANIKTQLQQL GVTLSMTRTE LSPAQIKQLL
310 320 330 340 350
QNPPAGVDPI IWEQAKVDNP DSEKLIPVPM VGFKELLRRL KVQDQMTKQH
360 370 380 390 400
QTRLDIISED ISELQKNQTT TMAKIAQYKR KLMDLSHRTL QVLIKQEIQR
410 420 430 440 450
KSGYAIQAEE EQLRVQLDTI QGELNAPTQF KGRLNELMSQ IRMQNHFGAV
460 470 480 490 500
KSEEKYYIDA DLLREIKQHL KQQQEGLSHL ISIIKDDLED IKLVEHGLNE
510
TIHSRGGVFS
Length:510
Mass (Da):55,745
Last modified:February 1, 1997 - v1
Checksum:i10454CFED967B910
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63840 mRNA Translation: AAC52790.1
BC078858 mRNA Translation: AAH78858.1
RefSeqiNP_059057.1, NM_017361.1
UniGeneiRn.11160

Genome annotation databases

EnsembliENSRNOT00000003070; ENSRNOP00000003070; ENSRNOG00000002247
GeneIDi53372
KEGGirno:53372
UCSCiRGD:619926 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63840 mRNA Translation: AAC52790.1
BC078858 mRNA Translation: AAH78858.1
RefSeqiNP_059057.1, NM_017361.1
UniGeneiRn.11160

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3T97X-ray2.80B346-407[»]
3T98X-ray2.50A/C445-494[»]
4J3HX-ray1.50A/B453-494[»]
SMRiP70582
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248440, 2 interactors
CORUMiP70582
STRINGi10116.ENSRNOP00000003070

Proteomic databases

PaxDbiP70582
PRIDEiP70582

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000003070; ENSRNOP00000003070; ENSRNOG00000002247
GeneIDi53372
KEGGirno:53372
UCSCiRGD:619926 rat

Organism-specific databases

CTDi53371
RGDi619926 Nup54

Phylogenomic databases

eggNOGiKOG3091 Eukaryota
ENOG410XPU5 LUCA
GeneTreeiENSGT00390000013620
HOGENOMiHOG000046583
HOVERGENiHBG052698
InParanoidiP70582
KOiK14308
OMAiCRRKHLV
OrthoDBiEOG091G0BAH
PhylomeDBiP70582
TreeFamiTF320237

Enzyme and pathway databases

ReactomeiR-RNO-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-RNO-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-RNO-191859 snRNP Assembly
R-RNO-3108214 SUMOylation of DNA damage response and repair proteins
R-RNO-3232142 SUMOylation of ubiquitinylation proteins
R-RNO-3301854 Nuclear Pore Complex (NPC) Disassembly
R-RNO-3371453 Regulation of HSF1-mediated heat shock response
R-RNO-4085377 SUMOylation of SUMOylation proteins
R-RNO-4551638 SUMOylation of chromatin organization proteins
R-RNO-4570464 SUMOylation of RNA binding proteins
R-RNO-4615885 SUMOylation of DNA replication proteins
R-RNO-5578749 Transcriptional regulation by small RNAs

Miscellaneous databases

PROiPR:P70582

Gene expression databases

BgeeiENSRNOG00000002247 Expressed in 10 organ(s), highest expression level in spleen
GenevisibleiP70582 RN

Family and domain databases

InterProiView protein in InterPro
IPR024864 Nup54/Nup57/Nup44
IPR025712 Nup54_alpha-helical_dom
PANTHERiPTHR13000 PTHR13000, 1 hit
PfamiView protein in Pfam
PF13874 Nup54, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNUP54_RAT
AccessioniPrimary (citable) accession number: P70582
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: February 1, 1997
Last modified: November 7, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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