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UniProtKB - P70581 (NUP58_RAT)

Entry version 147 (23 Feb 2022)
Sequence version 1 (01 Feb 1997)
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Protein

Nucleoporin p58/p45

Gene

Nup58

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-RNO-159227, Transport of the SLBP independent Mature mRNA
R-RNO-159230, Transport of the SLBP Dependant Mature mRNA
R-RNO-159231, Transport of Mature mRNA Derived from an Intronless Transcript
R-RNO-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript
R-RNO-170822, Regulation of Glucokinase by Glucokinase Regulatory Protein
R-RNO-191859, snRNP Assembly
R-RNO-3108214, SUMOylation of DNA damage response and repair proteins
R-RNO-3232142, SUMOylation of ubiquitinylation proteins
R-RNO-3301854, Nuclear Pore Complex (NPC) Disassembly
R-RNO-3371453, Regulation of HSF1-mediated heat shock response
R-RNO-4085377, SUMOylation of SUMOylation proteins
R-RNO-4551638, SUMOylation of chromatin organization proteins
R-RNO-4570464, SUMOylation of RNA binding proteins
R-RNO-4615885, SUMOylation of DNA replication proteins
R-RNO-5578749, Transcriptional regulation by small RNAs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nucleoporin p58/p45Curated
Alternative name(s):
58 kDa nucleoporinImported
Nucleoporin-like protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nup58Imported
Synonyms:Nupl1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Rat genome database

More...RGDi		631334, Nup58

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Membrane, Nuclear pore complex, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002048941 – 585Nucleoporin p58/p45Add BLAST585

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei317PhosphothreonineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

O-glycosylated.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P70581

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P70581

PRoteomics IDEntifications database

More...PRIDEi		P70581

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in liver.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSRNOG00000012644, Expressed in testis and 20 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P70581, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P70581, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the p62 complex, a complex composed of NUP62, NUP54, and isoform p58 and isoform p45 of NUP58. Isoform p58 interacts with NUTF2. Isoform p58 interacts with SRP1-alpha and Importin p97 proteins when they are together, but not with SRP1-alpha protein alone.

1 Publication

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		251446, 1 interactor

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P70581

STRING: functional protein association networks

More...STRINGi		10116.ENSRNOP00000017204

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1585
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P70581

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P70581

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati7 – 812
Repeati30 – 3122
Repeati42 – 4332
Repeati61 – 6242
Repeati66 – 6752
Repeati474 – 47562
Repeati478 – 47972
Repeati499 – 50082
Repeati505 – 50692
Repeati515 – 516102
Repeati517 – 518112
Repeati531 – 532122
Repeati554 – 555132
Repeati564 – 565142

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni7 – 56514 X 2 AA repeats of F-GAdd BLAST559
Regioni194 – 232DisorderedSequence analysisAdd BLAST39
Regioni563 – 585DisorderedSequence analysisAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili242 – 262Sequence analysisAdd BLAST21
Coiled coili300 – 367Sequence analysisAdd BLAST68

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi194 – 209Polar residuesSequence analysisAdd BLAST16
Compositional biasi210 – 230Basic and acidic residuesSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited.Curated

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NUP58 family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QRD8, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00730000111111

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_034851_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P70581

Identification of Orthologs from Complete Genome Data

More...OMAi		FTKSTKF

Database of Orthologous Groups

More...OrthoDBi		885529at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P70581

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR024882, Nucleoporin_p58/p45

The PANTHER Classification System

More...PANTHERi		PTHR13437, PTHR13437, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform p58 (identifier: P70581-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATGFSFGSG TLGSTTVAPG GTGTGSGFSF GASSTPSVGL NFGTLGSSAT 
        60         70         80         90        100
PASTSTSASG FGTGLFGSKP GTGFTLGGTS AGTTATTSAS TTGFSLGFSK 
       110        120        130        140        150
PAASATPFAL PVTSTTASGL TLSSALTSAP AASTGFTLNN LGATPATTTA 
       160        170        180        190        200
ASTGLSLGGA LAGLGGSLFQ SGNTATSGLG QNALSLSLGT ATPTSAASSE 
       210        220        230        240        250
GLGGIDFSTS SDKKSDKTGT RPEDSKALKD ENLPPVICQD VENLQKFVKE 
       260        270        280        290        300
QKQVQEEISR MSSKAMLKVQ EDIKALKQLL SLAASGLQRN TLNIDKLKLE 
       310        320        330        340        350
TAQELKNAEI ALRTQKTPPG LQHENTAPAD YFRVLVQQFE VQLQQYRQQI 
       360        370        380        390        400
EELENHLATQ ANNSHITPQD LSMAMQKIYQ TFVALAAQLQ SIHENVKVLK 
       410        420        430        440        450
EQYLSYRKMF LGDAGDVFEA RRTEAKKWQN APRVTTGPTP FSTMPNAAAV 
       460        470        480        490        500
AMAATLTQQQ QPATGPQPSL GVSFGTPFGS GIGTGLQSSG LGSSNLGGFG 
       510        520        530        540        550
TSSGFGCGTT GASTFGFGTT DKPSGSLSAG FGSSSTSGFN FSNPGITASA 
       560        570        580 
GLTFGVSNPA SAGFGTGGQL LQLKRPPAGN KRGKR
Length:585
Mass (Da):59,265
Last modified:February 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4D5F5C2744A75C3C
GO
Isoform p45 (identifier: P70581-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     224-245: Missing.
     531-535: FGSSS → LCASA
     536-585: Missing.

Show »
Length:513
Mass (Da):51,821
Checksum:iC70EC7465F5AAD0B
GO
Isoform p23 (identifier: P70581-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-260: Missing.
     328-337: PADYFRVLVQ → SPDDERLQVH
     466-468: PQP → DGW
     469-585: Missing.

Show »
Length:208
Mass (Da):23,325
Checksum:i372EE982D097DBCD
GO
Isoform H6 (identifier: P70581-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     466-471: PQPSLG → LNAFKL
     472-585: Missing.

Show »
Length:471
Mass (Da):48,579
Checksum:i689BE7709B203C17
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3ZVG3D3ZVG3_RAT
Nucleoporin p58/p45
Nup58 Nupl1
206Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0085821 – 260Missing in isoform p23. 1 PublicationAdd BLAST260
Alternative sequenceiVSP_008579224 – 245Missing in isoform p45. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_008576328 – 337PADYFRVLVQ → SPDDERLQVH in isoform p23. 1 Publication10
Alternative sequenceiVSP_008583466 – 471PQPSLG → LNAFKL in isoform H6. Curated6
Alternative sequenceiVSP_008577466 – 468PQP → DGW in isoform p23. 1 Publication3
Alternative sequenceiVSP_008578469 – 585Missing in isoform p23. 1 PublicationAdd BLAST117
Alternative sequenceiVSP_008584472 – 585Missing in isoform H6. CuratedAdd BLAST114
Alternative sequenceiVSP_008580531 – 535FGSSS → LCASA in isoform p45. 1 Publication5
Alternative sequenceiVSP_008581536 – 585Missing in isoform p45. 1 PublicationAdd BLAST50

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U63839 mRNA Translation: AAC52789.1
AH007036 mRNA Translation: AAC82539.1
AF000900 mRNA Translation: AAC82318.1
BC085690 mRNA Translation: AAH85690.1
AF000901 mRNA Translation: AAC82319.1

NCBI Reference Sequences

More...RefSeqi		NP_620791.1, NM_139091.2 [P70581-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSRNOT00000017204; ENSRNOP00000017204; ENSRNOG00000012644 [P70581-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		245922

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		rno:245922

UCSC genome browser

More...UCSCi		RGD:631334, rat [P70581-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63839 mRNA Translation: AAC52789.1
AH007036 mRNA Translation: AAC82539.1
AF000900 mRNA Translation: AAC82318.1
BC085690 mRNA Translation: AAH85690.1
AF000901 mRNA Translation: AAC82319.1
RefSeqiNP_620791.1, NM_139091.2 [P70581-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OSZX-ray2.85A/B/C/D327-415[»]
3T98X-ray2.50B327-415[»]
SMRiP70581
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi251446, 1 interactor
CORUMiP70581
STRINGi10116.ENSRNOP00000017204

Proteomic databases

jPOSTiP70581
PaxDbiP70581
PRIDEiP70581

Genome annotation databases

EnsembliENSRNOT00000017204; ENSRNOP00000017204; ENSRNOG00000012644 [P70581-1]
GeneIDi245922
KEGGirno:245922
UCSCiRGD:631334, rat [P70581-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9818
RGDi631334, Nup58

Phylogenomic databases

eggNOGiENOG502QRD8, Eukaryota
GeneTreeiENSGT00730000111111
HOGENOMiCLU_034851_1_0_1
InParanoidiP70581
OMAiFTKSTKF
OrthoDBi885529at2759
PhylomeDBiP70581

Enzyme and pathway databases

ReactomeiR-RNO-159227, Transport of the SLBP independent Mature mRNA
R-RNO-159230, Transport of the SLBP Dependant Mature mRNA
R-RNO-159231, Transport of Mature mRNA Derived from an Intronless Transcript
R-RNO-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript
R-RNO-170822, Regulation of Glucokinase by Glucokinase Regulatory Protein
R-RNO-191859, snRNP Assembly
R-RNO-3108214, SUMOylation of DNA damage response and repair proteins
R-RNO-3232142, SUMOylation of ubiquitinylation proteins
R-RNO-3301854, Nuclear Pore Complex (NPC) Disassembly
R-RNO-3371453, Regulation of HSF1-mediated heat shock response
R-RNO-4085377, SUMOylation of SUMOylation proteins
R-RNO-4551638, SUMOylation of chromatin organization proteins
R-RNO-4570464, SUMOylation of RNA binding proteins
R-RNO-4615885, SUMOylation of DNA replication proteins
R-RNO-5578749, Transcriptional regulation by small RNAs

Miscellaneous databases

EvolutionaryTraceiP70581

Protein Ontology

More...PROi		PR:P70581

Gene expression databases

BgeeiENSRNOG00000012644, Expressed in testis and 20 other tissues
ExpressionAtlasiP70581, baseline and differential
GenevisibleiP70581, RN

Family and domain databases

InterProiView protein in InterPro
IPR024882, Nucleoporin_p58/p45
PANTHERiPTHR13437, PTHR13437, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNUP58_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P70581
Secondary accession number(s): Q9JHE1, Q9QWK7, Q9Z2W7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: February 1, 1997
Last modified: February 23, 2022
This is version 147 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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