UniProtKB - P70566 (TMOD2_RAT)
Tropomodulin-2
Tmod2
Functioni
Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity).
By similarityGO - Molecular functioni
- actin binding Source: RGD
- tropomyosin binding Source: RGD
GO - Biological processi
- actin filament organization Source: GO_Central
- learning or memory Source: RGD
- muscle contraction Source: GO_Central
- myofibril assembly Source: GO_Central
- neuron-neuron synaptic transmission Source: RGD
- pointed-end actin filament capping Source: InterPro
- positive regulation of G protein-coupled receptor signaling pathway Source: RGD
Keywordsi
Molecular function | Actin-binding |
Enzyme and pathway databases
Reactomei | R-RNO-390522, Striated Muscle Contraction |
Names & Taxonomyi
Protein namesi | Recommended name: Tropomodulin-2Alternative name(s): Neuronal tropomodulin Short name: N-Tmod |
Gene namesi | Name:Tmod2 Synonyms:Ntmod |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 61948, Tmod2 |
Subcellular locationi
Cytoskeleton
- cytoskeleton By similarity
Cytoskeleton
- cytoskeleton Source: GO_Central
- striated muscle thin filament Source: GO_Central
Other locations
- growth cone Source: RGD
- myofibril Source: GO_Central
- neuron projection Source: RGD
- synapse Source: GOC
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000186133 | 1 – 351 | Tropomodulin-2Add BLAST | 351 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 25 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | P70566 |
PaxDbi | P70566 |
PRIDEi | P70566 |
2D gel databases
World-2DPAGEi | 0004:P70566 |
PTM databases
iPTMneti | P70566 |
PhosphoSitePlusi | P70566 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSRNOG00000010447, Expressed in brain and 21 other tissues |
Genevisiblei | P70566, RN |
Interactioni
Subunit structurei
Binds to the N-terminus of tropomyosin and to actin. Binds to TMBr3 as well as to other low molecular mass tropomyosins (TM5a or TM5), but not to high molecular mass tropomyosins (TM2 or TMBr1).
GO - Molecular functioni
- actin binding Source: RGD
- tropomyosin binding Source: RGD
Protein-protein interaction databases
BioGRIDi | 248623, 5 interactors |
IntActi | P70566, 3 interactors |
MINTi | P70566 |
STRINGi | 10116.ENSRNOP00000014124 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3735, Eukaryota |
GeneTreei | ENSGT00940000160631 |
HOGENOMi | CLU_031052_0_1_1 |
InParanoidi | P70566 |
OMAi | DCVPFTG |
OrthoDBi | 1025132at2759 |
PhylomeDBi | P70566 |
TreeFami | TF315841 |
Family and domain databases
Gene3Di | 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR032675, LRR_dom_sf IPR004934, TMOD IPR030130, TMOD2 |
PANTHERi | PTHR10901, PTHR10901, 1 hit PTHR10901:SF15, PTHR10901:SF15, 1 hit |
Pfami | View protein in Pfam PF03250, Tropomodulin, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MALPFQKGLE KYKNIDEDEL LGKLSEEELK QLENVLDDLD PESATLPAGF
60 70 80 90 100
RQKDQTQKAA TGPFDREHLL MYLEKEALEQ KDREDFVPFT GEKKGRVFIP
110 120 130 140 150
KEKPVETRKE EKVTLDPELE EALASASDTE LYDLAAVLGV HNLLNNPKFD
160 170 180 190 200
EETTNGQGRK GPVRNVVKGE KAKPVFEEPP NPTNVEASLQ QMKANDPSLQ
210 220 230 240 250
EVNLNNIKNI PIPTLKEFAK ALETNTHVRK FSLAATRSND PVALAFAEML
260 270 280 290 300
KVNKTLKSLN VESNFITGAG ILALVEALRE NDTLTEIKID NQRQQLGTAV
310 320 330 340 350
EMEIAQMLEE NSRILKFGYQ FTKQGPRTRV AAAITKNNDL VRKKRVEGDR
R
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A8I5ZMG0 | A0A8I5ZMG0_RAT | Tropomodulin-2 | Tmod2 | 351 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U59240 mRNA Translation: AAC52854.1 |
RefSeqi | NP_113801.1, NM_031613.1 XP_006243469.1, XM_006243407.3 XP_006243470.1, XM_006243408.3 XP_008764553.1, XM_008766331.2 XP_017451363.1, XM_017595874.1 |
Genome annotation databases
Ensembli | ENSRNOT00000014124; ENSRNOP00000014124; ENSRNOG00000010447 |
GeneIDi | 58814 |
KEGGi | rno:58814 |
UCSCi | RGD:61948, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U59240 mRNA Translation: AAC52854.1 |
RefSeqi | NP_113801.1, NM_031613.1 XP_006243469.1, XM_006243407.3 XP_006243470.1, XM_006243408.3 XP_008764553.1, XM_008766331.2 XP_017451363.1, XM_017595874.1 |
3D structure databases
AlphaFoldDBi | P70566 |
SMRi | P70566 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 248623, 5 interactors |
IntActi | P70566, 3 interactors |
MINTi | P70566 |
STRINGi | 10116.ENSRNOP00000014124 |
PTM databases
iPTMneti | P70566 |
PhosphoSitePlusi | P70566 |
2D gel databases
World-2DPAGEi | 0004:P70566 |
Proteomic databases
jPOSTi | P70566 |
PaxDbi | P70566 |
PRIDEi | P70566 |
Genome annotation databases
Ensembli | ENSRNOT00000014124; ENSRNOP00000014124; ENSRNOG00000010447 |
GeneIDi | 58814 |
KEGGi | rno:58814 |
UCSCi | RGD:61948, rat |
Organism-specific databases
CTDi | 29767 |
RGDi | 61948, Tmod2 |
Phylogenomic databases
eggNOGi | KOG3735, Eukaryota |
GeneTreei | ENSGT00940000160631 |
HOGENOMi | CLU_031052_0_1_1 |
InParanoidi | P70566 |
OMAi | DCVPFTG |
OrthoDBi | 1025132at2759 |
PhylomeDBi | P70566 |
TreeFami | TF315841 |
Enzyme and pathway databases
Reactomei | R-RNO-390522, Striated Muscle Contraction |
Miscellaneous databases
PROi | PR:P70566 |
Gene expression databases
Bgeei | ENSRNOG00000010447, Expressed in brain and 21 other tissues |
Genevisiblei | P70566, RN |
Family and domain databases
Gene3Di | 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR032675, LRR_dom_sf IPR004934, TMOD IPR030130, TMOD2 |
PANTHERi | PTHR10901, PTHR10901, 1 hit PTHR10901:SF15, PTHR10901:SF15, 1 hit |
Pfami | View protein in Pfam PF03250, Tropomodulin, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TMOD2_RAT | |
Accessioni | P70566Primary (citable) accession number: P70566 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 19, 2002 |
Last sequence update: | February 1, 1997 | |
Last modified: | May 25, 2022 | |
This is version 129 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families