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Protein

Serpin B5

Gene

Serpinb5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei340 – 341Reactive bond homologBy similarity2

GO - Molecular functioni

Protein family/group databases

MEROPSiI04.980

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin B5
Alternative name(s):
Maspin
Peptidase inhibitor 5
Short name:
PI-5
Gene namesi
Name:Serpinb5
Synonyms:Pi5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi69342 Serpinb5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000324881 – 375Serpin B5Add BLAST375

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi133N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi298N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi361N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP70564
PRIDEiP70564

PTM databases

iPTMnetiP70564
PhosphoSitePlusiP70564

Interactioni

Subunit structurei

Interacts with IRF6.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003625

Structurei

3D structure databases

ProteinModelPortaliP70564
SMRiP70564
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family. Ov-serpin subfamily.Curated

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
HOGENOMiHOG000238519
HOVERGENiHBG005957
InParanoidiP70564
KOiK10139
PhylomeDBiP70564

Family and domain databases

InterProiView protein in InterPro
IPR000240 Serpin_B9/Maspin
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
PRINTSiPR00676 MASPIN
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit

Sequencei

Sequence statusi: Complete.

P70564-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDALRLANSA FAVELFKQLC EKEPAGNILF SPICLSTSLS LAQVGAKGDT
60 70 80 90 100
ANEIGQVLHF ENVKDVPFGF KPITSDVNKL SSFYSLKLIK RLYIDKSLNL
110 120 130 140 150
STEFISSTKR PYANELETVD FKDKLEETKG QINSSIKELT DGHFEDILPE
160 170 180 190 200
NSISDQTKIL VVNAAYFVGK WMKKFPESET KECPFRINKT DTKPVQMMNL
210 220 230 240 250
EATFCLGNID DINCKIIELP FQNKHLSMLI VLPKDVEDES TGLEKIEKQL
260 270 280 290 300
NPETLLQWTN PSTMANAKVK LSLPKFKVEK MIDPKASLES LGLKSLFNES
310 320 330 340 350
TSDFSGMSET KGVSVSNVIH RVCLEITEDG GDSIEVPGSR ILQHKDEFKA
360 370
DHPFLFIVRH NKTRNIVFLG KFSSP
Length:375
Mass (Da):42,063
Last modified:February 1, 1997 - v1
Checksum:iE82C4EC6A0F2E482
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58857 mRNA Translation: AAB06043.1
RefSeqiNP_476449.1, NM_057108.2
UniGeneiRn.25752

Genome annotation databases

GeneIDi116589
KEGGirno:116589
UCSCiRGD:69342 rat

Similar proteinsi

Entry informationi

Entry nameiSPB5_RAT
AccessioniPrimary (citable) accession number: P70564
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: May 23, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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