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Protein

Translation initiation factor eIF-2B subunit gamma

Gene

Eif2b3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.

GO - Molecular functioni

GO - Biological processi

  • hippocampus development Source: RGD
  • oligodendrocyte development Source: UniProtKB
  • response to glucose Source: UniProtKB
  • response to heat Source: UniProtKB
  • response to peptide hormone Source: UniProtKB
  • T cell receptor signaling pathway Source: UniProtKB
  • translation Source: RGD
  • translational initiation Source: UniProtKB

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

Enzyme and pathway databases

ReactomeiR-RNO-72731 Recycling of eIF2:GDP

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor eIF-2B subunit gamma
Alternative name(s):
eIF-2B GDP-GTP exchange factor subunit gamma
Gene namesi
Name:Eif2b3
Synonyms:Eif2bg
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi620821 Eif2b3

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001560801 – 452Translation initiation factor eIF-2B subunit gammaAdd BLAST452

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei260PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP70541
PRIDEiP70541

Expressioni

Tissue specificityi

Brain, heart, liver, muscle and testis.

Gene expression databases

BgeeiENSRNOG00000018375 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue
GenevisibleiP70541 RN

Interactioni

Subunit structurei

Complex of five different subunits; alpha, beta, gamma, delta and epsilon.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024841

Structurei

3D structure databases

ProteinModelPortaliP70541
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1462 Eukaryota
COG1208 LUCA
GeneTreeiENSGT00510000047486
HOVERGENiHBG051461
InParanoidiP70541
KOiK03241
OMAiVLPCDLV
OrthoDBiEOG091G0BQX
PhylomeDBiP70541

Family and domain databases

InterProiView protein in InterPro
IPR005835 NTP_transferase_dom
IPR029044 Nucleotide-diphossugar_trans
PfamiView protein in Pfam
PF00483 NTP_transferase, 1 hit
SUPFAMiSSF53448 SSF53448, 4 hits

Sequencei

Sequence statusi: Complete.

P70541-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEFQAVVMAV GGGSRMTDLT SSIPKPLLPV GNKPLIWYPL NLLERVGFEE
60 70 80 90 100
VIVVTTKDVQ KALCAEFKMK LKPDIVCIPD EADMGTADSL RHIYPKLKTD
110 120 130 140 150
VLVLGCDLIT DVALHEVVDL FRAYDASLAM LMRKGQESTE PVPGQKGKKK
160 170 180 190 200
TVEQRDFIGV DSTGKRLLFM ANEADLDEEL VIKGSILQKH PRIHFQTGLV
210 220 230 240 250
DAHLYCLKKY VVDFLMENKS ITSIRSELIP YLVRKQFSSA SSQQRQEDKE
260 270 280 290 300
EDLKKKEPKS LDIYSFIKKD NTLTLAPYDA CWNAFRRDKW EDLSRSQVRC
310 320 330 340 350
YVHIMKEGLC SRVSTLGLYM EANRQVPKLL SVLCPEESMI HPSAQIANKH
360 370 380 390 400
LIGADSLIGS DTQVGEKSSI KRSVIGSSCV IRDRVTVTNC LLMNSVTVEE
410 420 430 440 450
GSSIHGSVIC NNAVVEAGAE IRDCLIGSGQ RIEAKAKRMN EVIVGNDQLM

EI
Length:452
Mass (Da):50,435
Last modified:June 13, 2006 - v2
Checksum:iBA33492D1700BE4F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti399E → G in AAC52788 (PubMed:8809057).Curated1
Sequence conflicti410C → F in AAC52788 (PubMed:8809057).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38253 mRNA Translation: AAC52788.1
BC072507 mRNA Translation: AAH72507.1
PIRiS72266
RefSeqiNP_598293.2, NM_133609.2
XP_006238692.1, XM_006238630.3
UniGeneiRn.10577

Genome annotation databases

EnsembliENSRNOT00000024841; ENSRNOP00000024841; ENSRNOG00000018375
GeneIDi171145
KEGGirno:171145
UCSCiRGD:620821 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38253 mRNA Translation: AAC52788.1
BC072507 mRNA Translation: AAH72507.1
PIRiS72266
RefSeqiNP_598293.2, NM_133609.2
XP_006238692.1, XM_006238630.3
UniGeneiRn.10577

3D structure databases

ProteinModelPortaliP70541
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024841

Proteomic databases

PaxDbiP70541
PRIDEiP70541

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000024841; ENSRNOP00000024841; ENSRNOG00000018375
GeneIDi171145
KEGGirno:171145
UCSCiRGD:620821 rat

Organism-specific databases

CTDi8891
RGDi620821 Eif2b3

Phylogenomic databases

eggNOGiKOG1462 Eukaryota
COG1208 LUCA
GeneTreeiENSGT00510000047486
HOVERGENiHBG051461
InParanoidiP70541
KOiK03241
OMAiVLPCDLV
OrthoDBiEOG091G0BQX
PhylomeDBiP70541

Enzyme and pathway databases

ReactomeiR-RNO-72731 Recycling of eIF2:GDP

Miscellaneous databases

PROiPR:P70541

Gene expression databases

BgeeiENSRNOG00000018375 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue
GenevisibleiP70541 RN

Family and domain databases

InterProiView protein in InterPro
IPR005835 NTP_transferase_dom
IPR029044 Nucleotide-diphossugar_trans
PfamiView protein in Pfam
PF00483 NTP_transferase, 1 hit
SUPFAMiSSF53448 SSF53448, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiEI2BG_RAT
AccessioniPrimary (citable) accession number: P70541
Secondary accession number(s): Q6IN08
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 13, 2006
Last modified: September 12, 2018
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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