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Protein

Oxytocin receptor

Gene

Oxtr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  • oxytocin receptor activity Source: RGD
  • peptide hormone binding Source: RGD
  • vasopressin receptor activity Source: GO_Central

GO - Biological processi

  • cellular response to hormone stimulus Source: GO_Central
  • digestive tract development Source: RGD
  • eating behavior Source: RGD
  • ERK1 and ERK2 cascade Source: RGD
  • estrous cycle Source: RGD
  • female pregnancy Source: RGD
  • G-protein coupled receptor signaling pathway Source: RGD
  • heart development Source: RGD
  • lactation Source: GO_Central
  • maternal behavior Source: RGD
  • maternal process involved in parturition Source: RGD
  • memory Source: RGD
  • negative regulation of gastric acid secretion Source: RGD
  • positive regulation of blood pressure Source: Ensembl
  • positive regulation of cytosolic calcium ion concentration Source: RGD
  • positive regulation of norepinephrine secretion Source: RGD
  • positive regulation of penile erection Source: RGD
  • positive regulation of synapse assembly Source: RGD
  • positive regulation of synaptic transmission, GABAergic Source: RGD
  • positive regulation of synaptic transmission, glutamatergic Source: RGD
  • positive regulation of uterine smooth muscle contraction Source: RGD
  • positive regulation of vasoconstriction Source: GO_Central
  • regulation of digestive system process Source: RGD
  • regulation of systemic arterial blood pressure by vasopressin Source: GO_Central
  • response to amphetamine Source: RGD
  • response to anoxia Source: RGD
  • response to cocaine Source: RGD
  • response to cytokine Source: RGD
  • response to drug Source: RGD
  • response to estradiol Source: RGD
  • response to organic cyclic compound Source: RGD
  • response to peptide hormone Source: RGD
  • response to progesterone Source: RGD
  • response to steroid hormone Source: RGD
  • sleep Source: RGD
  • social behavior Source: RGD
  • sperm ejaculation Source: RGD
  • suckling behavior Source: RGD
  • telencephalon development Source: RGD

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-388479 Vasopressin-like receptors
R-RNO-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Oxytocin receptor
Short name:
OT-R
Gene namesi
Name:Oxtr
Synonyms:Otr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi3239 Oxtr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38ExtracellularSequence analysisAdd BLAST38
Transmembranei39 – 63Helical; Name=1Sequence analysisAdd BLAST25
Topological domaini64 – 74CytoplasmicSequence analysisAdd BLAST11
Transmembranei75 – 97Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini98 – 113ExtracellularSequence analysisAdd BLAST16
Transmembranei114 – 135Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini136 – 154CytoplasmicSequence analysisAdd BLAST19
Transmembranei155 – 175Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini176 – 202ExtracellularSequence analysisAdd BLAST27
Transmembranei203 – 225Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini226 – 274CytoplasmicSequence analysisAdd BLAST49
Transmembranei275 – 293Helical; Name=6Sequence analysisAdd BLAST19
Topological domaini294 – 308ExtracellularSequence analysisAdd BLAST15
Transmembranei309 – 331Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini332 – 388CytoplasmicSequence analysisAdd BLAST57

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3996
GuidetoPHARMACOLOGYi369

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700021 – 388Oxytocin receptorAdd BLAST388

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi8N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi26N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi112 ↔ 187PROSITE-ProRule annotation
Modified residuei365PhosphoserineCombined sources1
Modified residuei367PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP70536
PRIDEiP70536

PTM databases

iPTMnetiP70536
PhosphoSitePlusiP70536

Expressioni

Gene expression databases

BgeeiENSRNOG00000005806
GenevisibleiP70536 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007724

Chemistry databases

BindingDBiP70536

Structurei

3D structure databases

ProteinModelPortaliP70536
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi129 – 132Poly-Leu4
Compositional biasi236 – 242Poly-Ala7

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000119156
HOGENOMiHOG000237331
HOVERGENiHBG105710
InParanoidiP70536
KOiK04229
OMAiGPPRRNE
OrthoDBiEOG091G0DB6
PhylomeDBiP70536
TreeFamiTF106499

Family and domain databases

CDDicd15387 7tmA_OT_R, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR002062 Oxytocn_rcpt
IPR001817 Vasoprsn_rcpt
PANTHERiPTHR24241:SF19 PTHR24241:SF19, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00665 OXYTOCINR
PR00896 VASOPRESSINR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P70536-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGTPAANWS VELDLGSGVP PGEEGNRTAG PPQRNEALAR VEVAVLCLIL
60 70 80 90 100
FLALSGNACV LLALRTTRHK HSRLFFFMKH LSIADLVVAV FQVLPQLLWD
110 120 130 140 150
ITFRFYGPDL LCRLVKYLQV VGMFASTYLL LLMSLDRCLA ICQPLRSLRR
160 170 180 190 200
RTDRLAVLGT WLGCLVASAP QVHIFSLREV ADGVFDCWAV FIQPWGPKAY
210 220 230 240 250
VTWITLAVYI VPVIVLAACY GLISFKIWQN LRLKTAAAAA AAEGNDAAGG
260 270 280 290 300
AGRAALARVS SVKLISKAKI RTVKMTFIIV LAFIVCWTPF FFVQMWSVWD
310 320 330 340 350
VNAPKEASAF IIAMLLASLN SCCNPWIYML FTGHLFHELV QRFFCCSARY
360 370 380
LKGSRPGETS VSKKSNSSTF VLSRRSSSQR SCSQPSSA
Length:388
Mass (Da):42,869
Last modified:August 14, 2001 - v2
Checksum:iFC738B254005CDD0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15280, U15169 Genomic DNA Translation: AAC53245.2
AY338194 mRNA Translation: AAQ01564.1
RefSeqiNP_037003.2, NM_012871.3
XP_006237070.1, XM_006237008.3
XP_008761401.1, XM_008763179.2
XP_008761402.1, XM_008763180.2
XP_008761403.1, XM_008763181.2
XP_008761404.1, XM_008763182.2
UniGeneiRn.6841

Genome annotation databases

EnsembliENSRNOT00000007724; ENSRNOP00000007724; ENSRNOG00000005806
GeneIDi25342
KEGGirno:25342
UCSCiRGD:3239 rat

Similar proteinsi

Entry informationi

Entry nameiOXYR_RAT
AccessioniPrimary (citable) accession number: P70536
Secondary accession number(s): Q53ZC5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: August 14, 2001
Last modified: May 23, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

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