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Protein

Nuclear receptor subfamily 0 group B member 1

Gene

Nr0b1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity).By similarity

GO - Molecular functioni

  • DNA binding Source: HGNC
  • DNA hairpin binding Source: HGNC
  • double-stranded DNA binding Source: RGD
  • nuclear receptor activity Source: BHF-UCL
  • RNA binding Source: HGNC
  • sequence-specific DNA binding Source: RGD
  • steroid hormone receptor activity Source: InterPro
  • transcription corepressor activity Source: GO_Central
  • transcription factor binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionReceptor, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor subfamily 0 group B member 1
Alternative name(s):
Nuclear receptor DAX-1
Gene namesi
Name:Nr0b1
Synonyms:Ahch, Dax1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi62028 Nr0b1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000537511 – 472Nuclear receptor subfamily 0 group B member 1Add BLAST472

Proteomic databases

PaxDbiP70503
PRIDEiP70503

PTM databases

PhosphoSitePlusiP70503

Interactioni

Subunit structurei

Homodimer. Interacts with NR5A1, NR5A2, NR0B2 and with COPS2 (By similarity). Interacts with ESRRB; represses ESRRB activity at the GATA6 promoter (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005023

Structurei

3D structure databases

ProteinModelPortaliP70503
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati1 – 671Add BLAST67
Repeati68 – 1352Add BLAST68
Repeati136 – 2023Add BLAST67
Domaini190 – 471NR LBDPROSITE-ProRule annotationAdd BLAST282
Repeati203 – 2554; truncatedAdd BLAST53

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 2554 X 67 AA tandem repeatsAdd BLAST255

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi13 – 17LXXLL motif 15
Motifi80 – 84LXXLL motif 25
Motifi148 – 152LXXLL motif 35
Motifi463 – 468AF-2 motif6

Domaini

Homodimerization involved an interaction between amino and carboxy termini involving LXXLL motifs and steroid binding domain (AF-2 motif). Heterodimerizes with NR5A1 and NROB2 through its N-terminal LXXLL motifs (By similarity).By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
HOGENOMiHOG000231151
HOVERGENiHBG005453
InParanoidiP70503
KOiK08562
PhylomeDBiP70503

Family and domain databases

InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR033544 NR0B1
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR025900 Nuclear_receptor_repeat
PANTHERiPTHR24081:SF1 PTHR24081:SF1, 2 hits
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF14046 NR_Repeat, 4 hits
PRINTSiPR00398 STRDHORMONER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P70503-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGEDHPWHG SILYNLLMSA KQKHGSREER EVRLGAQCWG CACGTQPVLG
60 70 80 90 100
GEGLPGGQAL SLLYRCCFCG ENHPRQGGIL YSMLTNARQP SGATEAPRAR
110 120 130 140 150
FRTPCWGCAC SNAKPLVGRX GLPAGQVPSL LYRCCFCGKK HPRQGSILYS
160 170 180 190 200
LLTNAQQTHV SREVPEAHRG GEWWQLSYCT HNVGGPEGLQ STQAMAFLYR
210 220 230 240 250
SYVCCEEQPQ QSSVASDTPV RADQTPAAPQ EQPRAPWWDT SSGVQRPIAL
260 270 280 290 300
KDPQVVCEAA SAGLLKTLRF VKYLPCFQIL PLDQQLVLVR SCWAPLLMLE
310 320 330 340 350
LAQDHLHFEM MEISEPNLMH EMLTTRRQET EGPEPADPQA TEQPQTVSAE
360 370 380 390 400
AGHVLSVAAV QAIKSFFFKC WSLNIDTKEY AYLKGTVLFN PDLPGLQCVK
410 420 430 440 450
YIESLQWRTQ QILTEHIRLM QREYQIRSAE LNSALFLLRF INTDVVTELF
460 470
FRPIIGAVSM DDMMLEMLCA KL
Length:472
Mass (Da):52,756
Last modified:February 1, 1997 - v1
Checksum:iF9E0BBA1AFF55196
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V6H3G3V6H3_RAT
Nuclear receptor subfamily 0 group ...
Nr0b1 rCG_36349
472Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99470 mRNA Translation: CAA67832.1
RefSeqiNP_445769.1, NM_053317.1
UniGeneiRn.10596

Genome annotation databases

GeneIDi58850
KEGGirno:58850

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99470 mRNA Translation: CAA67832.1
RefSeqiNP_445769.1, NM_053317.1
UniGeneiRn.10596

3D structure databases

ProteinModelPortaliP70503
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005023

PTM databases

PhosphoSitePlusiP70503

Proteomic databases

PaxDbiP70503
PRIDEiP70503

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi58850
KEGGirno:58850

Organism-specific databases

CTDi190
RGDi62028 Nr0b1

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
HOGENOMiHOG000231151
HOVERGENiHBG005453
InParanoidiP70503
KOiK08562
PhylomeDBiP70503

Miscellaneous databases

PROiPR:P70503

Family and domain databases

InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR033544 NR0B1
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR025900 Nuclear_receptor_repeat
PANTHERiPTHR24081:SF1 PTHR24081:SF1, 2 hits
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF14046 NR_Repeat, 4 hits
PRINTSiPR00398 STRDHORMONER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNR0B1_RAT
AccessioniPrimary (citable) accession number: P70503
Secondary accession number(s): Q63152
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: February 1, 1997
Last modified: November 7, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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