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Entry version 136 (29 Sep 2021)
Sequence version 3 (07 Jun 2017)
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Protein

Myelin transcription factor 1-like protein

Gene

Myt1l

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor that plays a key role in neuronal differentiation (PubMed:9373037).

Acts by specifically repressing expression of non-neuronal genes during neuron differentiation (By similarity).

In contrast to other transcription repressors that inhibit specific lineages, mediates repression of multiple differentiation programs (By similarity).

Also represses expression of negative regulators of neurogenesis, such as members of the Notch signaling pathway, including HES1 (By similarity).

The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro (By similarity).

Directly binds the 5'-AAGTT-3' core motif present on the promoter of target genes and represses transcription by recruiting a multiprotein complex containing SIN3B (By similarity).

The 5'-AAGTT-3' core motif is absent from the promoter of neural genes (By similarity).

By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi31Zinc 1PROSITE-ProRule annotation1
Metal bindingi36Zinc 1PROSITE-ProRule annotation1
Metal bindingi49Zinc 1PROSITE-ProRule annotation1
Metal bindingi55Zinc 1PROSITE-ProRule annotation1
Metal bindingi505Zinc 2PROSITE-ProRule annotation1
Metal bindingi510Zinc 2PROSITE-ProRule annotation1
Metal bindingi523Zinc 2PROSITE-ProRule annotation1
Metal bindingi529Zinc 2PROSITE-ProRule annotation1
Metal bindingi549Zinc 3PROSITE-ProRule annotation1
Metal bindingi554Zinc 3PROSITE-ProRule annotation1
Metal bindingi567Zinc 3PROSITE-ProRule annotation1
Metal bindingi573Zinc 3PROSITE-ProRule annotation1
Metal bindingi904Zinc 4PROSITE-ProRule annotation1
Metal bindingi909Zinc 4PROSITE-ProRule annotation1
Metal bindingi922Zinc 4PROSITE-ProRule annotation1
Metal bindingi928Zinc 4PROSITE-ProRule annotation1
Metal bindingi953Zinc 5PROSITE-ProRule annotation1
Metal bindingi958Zinc 5PROSITE-ProRule annotation1
Metal bindingi971Zinc 5PROSITE-ProRule annotation1
Metal bindingi977Zinc 5PROSITE-ProRule annotation1
Metal bindingi1006Zinc 6PROSITE-ProRule annotation1
Metal bindingi1011Zinc 6PROSITE-ProRule annotation1
Metal bindingi1024Zinc 6PROSITE-ProRule annotation1
Metal bindingi1030Zinc 6PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri22 – 65CCHHC-type 1PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri496 – 539CCHHC-type 2PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri540 – 583CCHHC-type 3PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri895 – 938CCHHC-type 4PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri944 – 987CCHHC-type 5PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri997 – 1040CCHHC-type 6PROSITE-ProRule annotationAdd BLAST44

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Repressor
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myelin transcription factor 1-like protein
Short name:
MyT1-L
Short name:
MyT1L
Alternative name(s):
Neural zinc finger factor 11 Publication
Short name:
NZF-11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Myt1l
Synonyms:Nzf11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
620550, Myt1l

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000966751 – 1187Myelin transcription factor 1-like proteinAdd BLAST1187

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei251PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P70475

PRoteomics IDEntifications database

More...
PRIDEi
P70475

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P70475

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P70475

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Brain, testis and pituitary gland. Expression is higher in the brain than in the testis and pituitary gland. Highest level expression seen in the developing CNS.2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Detected at E11.5 and expression is seen throughout the proliferating cortex neuroepithelium, developing medulla, and spinal cord. At E12.5 found in the nasal epithelium and at E13.5 detected in the trigeminal ganglia, dorsal root ganglia and the ganglion cell layer of the retina. At E14-E15 expressed at high levels in the brain and spinal cord and then levels subsequently decrease.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000004269, Expressed in frontal cortex and 17 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SIN3B.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
250552, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000005905

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11187
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P70475

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P70475

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 20DisorderedSequence analysisAdd BLAST20
Regioni56 – 178DisorderedSequence analysisAdd BLAST123
Regioni221 – 248DisorderedSequence analysisAdd BLAST28
Regioni343 – 422DisorderedSequence analysisAdd BLAST80
Regioni450 – 509DisorderedSequence analysisAdd BLAST60
Regioni684 – 708DisorderedSequence analysisAdd BLAST25

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1055 – 1131Sequence analysisAdd BLAST77

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 17Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi90 – 172Acidic residuesSequence analysisAdd BLAST83
Compositional biasi343 – 359Polar residuesSequence analysisAdd BLAST17
Compositional biasi400 – 422Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi450 – 506Basic and acidic residuesSequence analysisAdd BLAST57

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MYT1 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri22 – 65CCHHC-type 1PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri496 – 539CCHHC-type 2PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri540 – 583CCHHC-type 3PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri895 – 938CCHHC-type 4PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri944 – 987CCHHC-type 5PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri997 – 1040CCHHC-type 6PROSITE-ProRule annotationAdd BLAST44

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3803, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P70475

Database of Orthologous Groups

More...
OrthoDBi
116799at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P70475

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013681, Myelin_TF
IPR002515, Znf_C2H2C
IPR036060, Znf_C2H2C_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08474, MYT1, 1 hit
PF01530, zf-C2HC, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103637, SSF103637, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51802, ZF_CCHHC, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P70475-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDVDAEEKRH RTRSKGVRVP VEPAIQELFS CPTPGCDGSG HVSGKYARHR
60 70 80 90 100
SVYGCPLAKK RKTQDKQPQE PAPKRKPFAV KADSSSVDEC YESDGTEDMD
110 120 130 140 150
DKEEDDDEEF SEDNDEQGDD DDEDEVDRED EEEIEEEDDE DDEDDDDGDD
160 170 180 190 200
VEEEEDDDDE EEEEEEEEEE NEDHQMSCTR IMQDPEKDDN NNDEYDNYDE
210 220 230 240 250
LVAKSLLNLG KIAEDAAYRA RTESEMNSNT SNSLEDDSDK NENLGRKSEL
260 270 280 290 300
SLDLDSDVVR ETVDSLKLLA QGHGVVLSEN ISDRSYAEGM SQQDSRNMNY
310 320 330 340 350
VMLGKPMNNG LMEKMVEESD EEVCLSSLEC LRNQCFDLAR KLSETNPQDR
360 370 380 390 400
SQPPNMSVRQ HVRQEDDFPG RTPDRSYSDM MNLMRLEEQL SPRSRTFSSC
410 420 430 440 450
AKEDGCHERD DDTTSVNSDR SEEVFDMTKG NLTLLEKAIA LETERAKAMR
460 470 480 490 500
EKMAMDAGRR DNLRSYEDQS PRQLAGEDRK SKSSDSHVKK PYYDPSRTEK
510 520 530 540 550
RESKCPTPGC DGTGHVTGLY PHHRSLSGCP HKDRVPPEIL AMHENVLKCP
560 570 580 590 600
TPGCTGRGHV NSNRNSHRSL SGCPIAAAEK LAKAQEKHQS CDVSKSNQAS
610 620 630 640 650
DRVLRPMCFV KQLEIPQYGY RNNVPTTTPR SNLAKELEKY SKTSFEYNSY
660 670 680 690 700
DNHTYGKRAI APKVQTRDIS PKGYDDAKRY CKNASPSSST TSSYAPSSSS
710 720 730 740 750
NLSCGGGSSA SSTCSKSSFD YTHDMEAAHM AATAILNLST RCREMPQNLS
760 770 780 790 800
TKPQDLCTAR NPDMEVDENG TLDLSMNKQR PRDSCCPVLT PLEPMSPQQQ
810 820 830 840 850
AVMSSRCFQL SEGDCWDLPV DYTKMKPRRV DEEDPKEITP EDLDPFQEAL
860 870 880 890 900
EERRYPGEVT IPSPKPKYPQ CKESKKDLIT LSGCPLADKS IRSMLATSSQ
910 920 930 940 950
ELKCPTPGCD GSGHITGNYA SHRSLSGCPR AKKSGIRIAQ SKEDKEDQEP
960 970 980 990 1000
IRCPVPGCDG QGHITGKYAS HRSASGCPLA AKRQKDGYLN GSQFSWKSVK
1010 1020 1030 1040 1050
TEGMSCPTPG CDGSGHVSGS FLTHRSLSGC PRATSAMKKA KLSGEQMLTI
1060 1070 1080 1090 1100
KQRASNGIEN DEEIKQLDEE IKELNESNSQ MEADMIKLRT QVTITTMESN
1110 1120 1130 1140 1150
LKTIEEENKV IEQQNESLLH ELANLSQSLI HSLANIQLPH MDPINEQNFD
1160 1170 1180
AYVTTLTEMY TNQDRYQSPE NKALLENIKQ AVRGIQV
Length:1,187
Mass (Da):132,926
Last modified:June 7, 2017 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i10B2616415195DD1
GO
Isoform 2 (identifier: P70475-2)
Sequence is not available
Length:
Mass (Da):
Isoform 3 (identifier: P70475-3)
Sequence is not available
Length:
Mass (Da):

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A5H1ZRT6A0A5H1ZRT6_RAT
Myelin transcription factor 1-like ...
Myt1l
1,182Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1M8L4F1M8L4_RAT
Myelin transcription factor 1-like ...
Myt1l
952Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AABR07063792 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AABR07063793 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AABR07063794 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AABR07063795 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AABR07063796 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AABR07063797 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAC52728 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti39S → T in AAC52728 (PubMed:8631881).Curated1
Sequence conflicti226M → V in AAC52728 (PubMed:8631881).Curated1
Sequence conflicti237 – 239DSD → HSS in AAC52728 (PubMed:8631881).Curated3
Sequence conflicti415S → T in AAC52728 (PubMed:8631881).Curated1
Sequence conflicti517T → N in AAC52728 (PubMed:8631881).Curated1
Sequence conflicti561N → H in AAB40718 (PubMed:8980226).Curated1
Sequence conflicti804S → T in AAB40718 (PubMed:8980226).Curated1
Sequence conflicti918N → I in AAB40718 (PubMed:8980226).Curated1
Sequence conflicti1019G → A in AAB40718 (PubMed:8980226).Curated1
Sequence conflicti1092 – 1098VTITTME → ITTMD in AAB40718 (PubMed:8980226).Curated7

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U48809 mRNA Translation: AAC52728.1 Frameshift.
AABR07063792 Genomic DNA No translation available.
AABR07063793 Genomic DNA No translation available.
AABR07063794 Genomic DNA No translation available.
AABR07063795 Genomic DNA No translation available.
AABR07063796 Genomic DNA No translation available.
AABR07063797 Genomic DNA No translation available.
U67081 mRNA Translation: AAB40718.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T46637

NCBI Reference Sequences

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RefSeqi
NP_446340.1, NM_053888.1 [P70475-1]

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
116668

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
rno:116668

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48809 mRNA Translation: AAC52728.1 Frameshift.
AABR07063792 Genomic DNA No translation available.
AABR07063793 Genomic DNA No translation available.
AABR07063794 Genomic DNA No translation available.
AABR07063795 Genomic DNA No translation available.
AABR07063796 Genomic DNA No translation available.
AABR07063797 Genomic DNA No translation available.
U67081 mRNA Translation: AAB40718.1
PIRiT46637
RefSeqiNP_446340.1, NM_053888.1 [P70475-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PXENMR-A487-548[»]
SMRiP70475
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi250552, 1 interactor
STRINGi10116.ENSRNOP00000005905

PTM databases

iPTMnetiP70475
PhosphoSitePlusiP70475

Proteomic databases

PaxDbiP70475
PRIDEiP70475

Genome annotation databases

GeneIDi116668
KEGGirno:116668

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23040
RGDi620550, Myt1l

Phylogenomic databases

eggNOGiKOG3803, Eukaryota
InParanoidiP70475
OrthoDBi116799at2759
PhylomeDBiP70475

Miscellaneous databases

EvolutionaryTraceiP70475

Protein Ontology

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PROi
PR:P70475

Gene expression databases

BgeeiENSRNOG00000004269, Expressed in frontal cortex and 17 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR013681, Myelin_TF
IPR002515, Znf_C2H2C
IPR036060, Znf_C2H2C_sf
PfamiView protein in Pfam
PF08474, MYT1, 1 hit
PF01530, zf-C2HC, 6 hits
SUPFAMiSSF103637, SSF103637, 6 hits
PROSITEiView protein in PROSITE
PS51802, ZF_CCHHC, 6 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYT1L_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P70475
Secondary accession number(s): D4A9W2, P70589
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: June 7, 2017
Last modified: September 29, 2021
This is version 136 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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