Neurog2

Functionⁱ

Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3').1 Publication

GO - Molecular functionⁱ

E-box binding
Source: UniProtKB
Inferred from direct assayⁱ
- 14697366
protein dimerization activity Source: InterPro
sequence-specific DNA binding
Source: MGI
Inferred from direct assayⁱ
- 17141158

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

axon guidance
Source: MGI
Inferred from mutant phenotypeⁱ
- 12895419
- 15328020
cell fate commitment
Source: MGI
Inferred from genetic interactionⁱ
- 15229646
cell maturation
Source: MGI
Inferred from mutant phenotypeⁱ
- 16766700
central nervous system neuron development
Source: MGI
Inferred from mutant phenotypeⁱ
- 16410412
forebrain development
Source: MGI
Inferred from mutant phenotypeⁱ
- 15328020
neurogenesis
Source: MGI
Inferred from direct assayⁱ
- 19050759
neuron differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 16396906
neuron migration
Source: MGI
Inferred from mutant phenotypeⁱ
- 16396906
positive regulation of DNA-binding transcription factor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 14697366
positive regulation of neuron differentiation
Source: MGI
Inferred from direct assayⁱ
- 18579678
positive regulation of transcription by RNA polymerase II
Source: MGI
Inferred from direct assayⁱ
- 15655114
- 23434913

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, Developmental protein, DNA-binding
Biological process	Differentiation, Neurogenesis, Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Neurogenin-2 Short name: NGN-2 Alternative name(s): Helix-loop-helix protein mATH-4A Short name: mATH4A Protein atonal homolog 4
Gene namesⁱ	Name:Neurog2 Synonyms:Ath4a, Atoh4, Ngn2
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Unplaced

Organism-specific databases

MGIⁱ	MGI:109619 Neurog2

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000127401	1 – 263	Neurogenin-2Add BLAST		263

Proteomic databases

PaxDbⁱ	P70447
PRIDEⁱ	P70447

PTM databases

iPTMnetⁱ	P70447
PhosphoSitePlusⁱ	P70447

Expressionⁱ

Gene expression databases

CleanExⁱ	MM_NEUROG2

CleanExⁱ

MM_NEUROG2

Interactionⁱ

Subunit structureⁱ

Efficient DNA binding requires dimerization with another bHLH protein.

GO - Molecular functionⁱ

protein dimerization activity Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	198240, 4 interactors
STRINGⁱ	10090.ENSMUSP00000029587

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P70447
SMRⁱ	P70447
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	112 – 164	bHLHPROSITE-ProRule annotationAdd BLAST		53

Phylogenomic databases

eggNOGⁱ	ENOG410IQ4B Eukaryota ENOG410XZ4C LUCA
HOGENOMⁱ	HOG000063655
HOVERGENⁱ	HBG101129
InParanoidⁱ	P70447
KEGG Orthology (KO) More...KOⁱ	K09082

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR032655 Ngn2
PANTHERⁱ	PTHR19290:SF105 PTHR19290:SF105, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P70447-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MFVKSETLEL KEEEEVLMLL GSASPASATL TPMSSSADEE EDEELRRPGS 
        60         70         80         90        100
ARGQRGAEAE QGVQGSPASG AGGCRPGRLL GLMHECKRRP SRSRAVSRGA 
       110        120        130        140        150
KTAETVQRIK KTRRLKANNR ERNRMHNLNA ALDALREVLP TFPEDAKLTK 
       160        170        180        190        200
IETLRFAHNY IWALTETLRL ADHCAGAGGL QGALFTEAVL LSPGAALGAS 
       210        220        230        240        250
GDSPSPPSSW SCTNSPASSS NSTSPYSCTL SPASPGSDVD YWQPPPPEKH 
       260 
RYAPHLPLAR DCI

Length:263

Mass (Da):28,216

Last modified:February 1, 1997 - v1

Checksum:ⁱ817EF8246BD8CABE

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	Q6GTH9	Q6GTH9_MOUSE		Neurogenin-2 Neurogenin-2	Neurog2 mCG_20249	263	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	60	E → G in CAA68900 (PubMed:8948587).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U76207 Genomic DNA Translation: AAC53028.1 Y07621 mRNA Translation: CAA68900.1 AF303001 Genomic DNA Translation: AAG40769.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS17825.1
NCBI Reference Sequences More...RefSeqⁱ	NP_033848.1, NM_009718.2
UniGeneⁱ	Mm.42017

Genome annotation databases

GeneIDⁱ	11924
KEGGⁱ	mmu:11924

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P70447	NEUROG2		MOUSE		263	UniRef100_P70447

Protein	Similar proteins		Species	Score	Length	Source
P70447	NEUROG2		MOUSE		263	UniRef90_P70447
Uncharacterized protein		NEOLE		284
neurogenin-2		MESAU		267
Neurogenin 2		RAT		263
UPI000B4F57D6		MERUN		269
+5

Protein	Similar proteins		Species	Score	Length	Source
P70447	Neurogenin-2		HUMAN		272	UniRef50_P70447
NEUROG2		MOUSE		263
Uncharacterized protein		NEOLE		284
neurogenin-2		MESAU		267
Neurogenin 2		RAT		263
+88

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U76207 Genomic DNA Translation: AAC53028.1 Y07621 mRNA Translation: CAA68900.1 AF303001 Genomic DNA Translation: AAG40769.1
CCDSⁱ	CCDS17825.1
RefSeqⁱ	NP_033848.1, NM_009718.2
UniGeneⁱ	Mm.42017

3D structure databases

ProteinModelPortalⁱ	P70447
SMRⁱ	P70447
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	198240, 4 interactors
STRINGⁱ	10090.ENSMUSP00000029587

PTM databases

iPTMnetⁱ	P70447
PhosphoSitePlusⁱ	P70447

Proteomic databases

PaxDbⁱ	P70447
PRIDEⁱ	P70447

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	11924
KEGGⁱ	mmu:11924

Organism-specific databases

CTDⁱ	63973
MGIⁱ	MGI:109619 Neurog2

Phylogenomic databases

eggNOGⁱ	ENOG410IQ4B Eukaryota ENOG410XZ4C LUCA
HOGENOMⁱ	HOG000063655
HOVERGENⁱ	HBG101129
InParanoidⁱ	P70447
KOⁱ	K09082

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P70447
SOURCEⁱ	Search...

Gene expression databases

CleanExⁱ	MM_NEUROG2

CleanExⁱ

MM_NEUROG2

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR032655 Ngn2
PANTHERⁱ	PTHR19290:SF105 PTHR19290:SF105, 1 hit
Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NGN2_MOUSE
Accessionⁱ	P70447Primary (citable) accession number: P70447 Secondary accession number(s): P70237
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
	Last sequence update:	February 1, 1997
	Last modified:	November 7, 2018
	This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P70447 (NGN2_MOUSE)

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Neurogenin-2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ