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UniProtKB - P70447 (NGN2_MOUSE)
Protein
Neurogenin-2
Gene
Neurog2
Organism
Mus musculus (Mouse)
Status
Functioni
Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3').
1 PublicationGO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- E-box binding Source: UniProtKB
- protein dimerization activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific DNA binding Source: MGI
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- axon guidance Source: MGI
- cell fate commitment Source: MGI
- cell maturation Source: MGI
- central nervous system neuron development Source: MGI
- forebrain development Source: MGI
- neurogenesis Source: MGI
- neuron differentiation Source: MGI
- neuron migration Source: MGI
- positive regulation of DNA-binding transcription factor activity Source: UniProtKB
- positive regulation of neuron differentiation Source: MGI
- positive regulation of transcription by RNA polymerase II Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator, Developmental protein, DNA-binding |
Biological process | Differentiation, Neurogenesis, Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Neurogenin-2Short name: NGN-2 Alternative name(s): Helix-loop-helix protein mATH-4A Short name: mATH4A Protein atonal homolog 4 |
Gene namesi | Name:Neurog2 Synonyms:Ath4a, Atoh4, Ngn2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:109619, Neurog2 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nucleus Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000127401 | 1 – 263 | Neurogenin-2Add BLAST | 263 |
Proteomic databases
PaxDbi | P70447 |
PRIDEi | P70447 |
PTM databases
iPTMneti | P70447 |
PhosphoSitePlusi | P70447 |
Interactioni
Subunit structurei
Efficient DNA binding requires dimerization with another bHLH protein.
GO - Molecular functioni
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
BioGRIDi | 198240, 5 interactors |
STRINGi | 10090.ENSMUSP00000029587 |
Miscellaneous databases
RNActi | P70447, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 112 – 164 | bHLHPROSITE-ProRule annotationAdd BLAST | 53 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 20 – 76 | DisorderedSequence analysisAdd BLAST | 57 | |
Regioni | 197 – 253 | DisorderedSequence analysisAdd BLAST | 57 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 202 – 236 | Polar residuesSequence analysisAdd BLAST | 35 |
Phylogenomic databases
eggNOGi | KOG3898, Eukaryota |
InParanoidi | P70447 |
OrthoDBi | 1524429at2759 |
Family and domain databases
DisProti | DP02061 |
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR032655, Ngn2 |
PANTHERi | PTHR19290:SF105, PTHR19290:SF105, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P70447-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFVKSETLEL KEEEEVLMLL GSASPASATL TPMSSSADEE EDEELRRPGS
60 70 80 90 100
ARGQRGAEAE QGVQGSPASG AGGCRPGRLL GLMHECKRRP SRSRAVSRGA
110 120 130 140 150
KTAETVQRIK KTRRLKANNR ERNRMHNLNA ALDALREVLP TFPEDAKLTK
160 170 180 190 200
IETLRFAHNY IWALTETLRL ADHCAGAGGL QGALFTEAVL LSPGAALGAS
210 220 230 240 250
GDSPSPPSSW SCTNSPASSS NSTSPYSCTL SPASPGSDVD YWQPPPPEKH
260
RYAPHLPLAR DCI
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ6GTH9 | Q6GTH9_MOUSE | Neurogenin-2 | Neurog2 | 263 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 60 | E → G in CAA68900 (PubMed:8948587).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U76207 Genomic DNA Translation: AAC53028.1 Y07621 mRNA Translation: CAA68900.1 AF303001 Genomic DNA Translation: AAG40769.1 |
CCDSi | CCDS17825.1 |
RefSeqi | NP_033848.1, NM_009718.2 |
Genome annotation databases
GeneIDi | 11924 |
KEGGi | mmu:11924 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U76207 Genomic DNA Translation: AAC53028.1 Y07621 mRNA Translation: CAA68900.1 AF303001 Genomic DNA Translation: AAG40769.1 |
CCDSi | CCDS17825.1 |
RefSeqi | NP_033848.1, NM_009718.2 |
3D structure databases
SMRi | P70447 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 198240, 5 interactors |
STRINGi | 10090.ENSMUSP00000029587 |
PTM databases
iPTMneti | P70447 |
PhosphoSitePlusi | P70447 |
Proteomic databases
PaxDbi | P70447 |
PRIDEi | P70447 |
Protocols and materials databases
DNASUi | 11924 |
Genome annotation databases
GeneIDi | 11924 |
KEGGi | mmu:11924 |
Organism-specific databases
CTDi | 63973 |
MGIi | MGI:109619, Neurog2 |
Phylogenomic databases
eggNOGi | KOG3898, Eukaryota |
InParanoidi | P70447 |
OrthoDBi | 1524429at2759 |
Miscellaneous databases
BioGRID-ORCSi | 11924, 1 hit in 65 CRISPR screens |
PROi | PR:P70447 |
RNActi | P70447, protein |
SOURCEi | Search... |
Family and domain databases
DisProti | DP02061 |
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR032655, Ngn2 |
PANTHERi | PTHR19290:SF105, PTHR19290:SF105, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NGN2_MOUSE | |
Accessioni | P70447Primary (citable) accession number: P70447 Secondary accession number(s): P70237 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | February 1, 1997 | |
Last modified: | February 23, 2022 | |
This is version 143 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot