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Protein

Homeobox protein DLX-4

Gene

Dlx4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in determining the production of hemoglobin S. May act as a repressor. During embryonic development, plays a role in palatogenesis.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi116 – 175HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein DLX-4
Alternative name(s):
Homeobox protein DLX-7
Gene namesi
Name:Dlx4
Synonyms:Dlx7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:94904 Dlx4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000490291 – 240Homeobox protein DLX-4Add BLAST240

Proteomic databases

PaxDbiP70436
PeptideAtlasiP70436
PRIDEiP70436

Expressioni

Tissue specificityi

Branchial arches, molar and incisor teeth and limbs.

Developmental stagei

Expressed in the mesenchyme of the anterior palate at 12.5 dpc, prior to the time of palate closure. Expression levels decrease at later time periods after palate closure.1 Publication

Gene expression databases

BgeeiENSMUSG00000020871 Expressed in 56 organ(s), highest expression level in hair follicle
CleanExiMM_DLX4
GenevisibleiP70436 MM

Interactioni

Protein-protein interaction databases

BioGridi199237, 2 interactors
IntActiP70436, 1 interactor
STRINGi10090.ENSMUSP00000021241

Structurei

3D structure databases

ProteinModelPortaliP70436
SMRiP70436
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the distal-less homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0850 Eukaryota
ENOG410ZHZR LUCA
GeneTreeiENSGT00920000148979
HOGENOMiHOG000231941
HOVERGENiHBG005493
InParanoidiP70436
KOiK09314
OMAiYSGPYGH
OrthoDBiEOG091G0L8C
PhylomeDBiP70436
TreeFamiTF315720

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR000047 HTH_motif
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
PR00031 HTHREPRESSR
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P70436-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSLPCPLPD RGASNVVFPD LAPALSVVAA YPLGLSPGTA ASPDLSYSQS
60 70 80 90 100
YGHPRSYSHP GPATPGDSYL PRQQQLVAPS QPFHRPAEHP QELEAESEKL
110 120 130 140 150
ALSLVPSQQQ SLTRKLRKPR TIYSSLQLQH LNQRFQHTQY LALPERAQLA
160 170 180 190 200
AQLGLTQTQV KIWFQNKRSK YKKLLKQSSG EPEEDFSGRP PSLSPHSPAL
210 220 230 240
PFIWGLPKAD TLPSSGYDNS HFGAWYQHRS PDVLALPQMM
Length:240
Mass (Da):26,579
Last modified:January 24, 2006 - v2
Checksum:iECDC4D943E22364C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti132N → D in AAC52995 (PubMed:8975708).Curated1
Sequence conflicti194S → F in BAE26247 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73329 mRNA Translation: AAC52995.1
AF452637 Genomic DNA Translation: AAL99501.1
AK145123 mRNA Translation: BAE26247.1
AL645850 Genomic DNA Translation: CAI24123.1
BC106967 mRNA Translation: AAI06968.1
CCDSiCCDS25273.1
RefSeqiNP_031893.3, NM_007867.4
UniGeneiMm.439766

Genome annotation databases

EnsembliENSMUST00000021241; ENSMUSP00000021241; ENSMUSG00000020871
GeneIDi13394
KEGGimmu:13394
UCSCiuc007kzz.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73329 mRNA Translation: AAC52995.1
AF452637 Genomic DNA Translation: AAL99501.1
AK145123 mRNA Translation: BAE26247.1
AL645850 Genomic DNA Translation: CAI24123.1
BC106967 mRNA Translation: AAI06968.1
CCDSiCCDS25273.1
RefSeqiNP_031893.3, NM_007867.4
UniGeneiMm.439766

3D structure databases

ProteinModelPortaliP70436
SMRiP70436
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199237, 2 interactors
IntActiP70436, 1 interactor
STRINGi10090.ENSMUSP00000021241

Proteomic databases

PaxDbiP70436
PeptideAtlasiP70436
PRIDEiP70436

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021241; ENSMUSP00000021241; ENSMUSG00000020871
GeneIDi13394
KEGGimmu:13394
UCSCiuc007kzz.2 mouse

Organism-specific databases

CTDi1748
MGIiMGI:94904 Dlx4

Phylogenomic databases

eggNOGiKOG0850 Eukaryota
ENOG410ZHZR LUCA
GeneTreeiENSGT00920000148979
HOGENOMiHOG000231941
HOVERGENiHBG005493
InParanoidiP70436
KOiK09314
OMAiYSGPYGH
OrthoDBiEOG091G0L8C
PhylomeDBiP70436
TreeFamiTF315720

Miscellaneous databases

PROiPR:P70436
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020871 Expressed in 56 organ(s), highest expression level in hair follicle
CleanExiMM_DLX4
GenevisibleiP70436 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR000047 HTH_motif
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
PR00031 HTHREPRESSR
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDLX4_MOUSE
AccessioniPrimary (citable) accession number: P70436
Secondary accession number(s): Q3UM51, Q8R4I3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 24, 2006
Last modified: September 12, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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