Irf7

Functionⁱ

Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages.4 Publications

Activity regulationⁱ

In the absence of viral infection, maintained as a monomer in an autoinhibited state and phosphorylation disrupts this autoinhibition leading to the liberation of the DNA-binding and dimerization activities and its nuclear localization where it can activate type I IFN and ISG genes.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	9 – 126	IRF tryptophan pentad repeatPROSITE-ProRule annotationAdd BLAST		118

GO - Molecular functionⁱ

DNA binding Source: UniProtKB
RNA polymerase II proximal promoter sequence-specific DNA binding Source: MGI
transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
Source: MGI
Inferred from direct assayⁱ
- 23042151

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

defense response to virus Source: MGI
immunoglobulin mediated immune response
Source: MGI
Inferred from mutant phenotypeⁱ
- 15800576
innate immune response Source: UniProtKB-KW
interferon-alpha production
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15800576
interferon-beta production
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15800576
positive regulation of interferon-alpha production Source: MGI
positive regulation of interferon-beta production Source: MGI
positive regulation of transcription, DNA-templated Source: UniProtKB
positive regulation of transcription by RNA polymerase II Source: UniProtKB
positive regulation of type I interferon-mediated signaling pathway
Source: MGI
Inferred from mutant phenotypeⁱ
- 17618271
positive regulation of type I interferon production
Source: MGI
Inferred from genetic interactionⁱ
- 23956435
regulation of adaptive immune response Source: UniProtKB
regulation of innate immune response
Source: UniProtKB
Traceable author statementⁱ
- 15800576
regulation of MyD88-dependent toll-like receptor signaling pathway
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15800576
regulation of MyD88-independent toll-like receptor signaling pathway
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15800576
transcription, DNA-templated Source: UniProtKB-KW
type I interferon biosynthetic process
Source: MGI
Inferred from mutant phenotypeⁱ
- 15800576

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Immunity, Innate immunity, Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-MMU-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-MMU-9013973 TICAM1-dependent activation of IRF3/IRF7 R-MMU-918233 TRAF3-dependent IRF activation pathway R-MMU-933541 TRAF6 mediated IRF7 activation R-MMU-936964 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon R-MMU-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling

Reactomeⁱ

R-MMU-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production
R-MMU-9013973 TICAM1-dependent activation of IRF3/IRF7
R-MMU-918233 TRAF3-dependent IRF activation pathway
R-MMU-933541 TRAF6 mediated IRF7 activation
R-MMU-936964 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
R-MMU-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Interferon regulatory factor 7 Short name: IRF-7
Gene namesⁱ	Name:Irf7
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 7

Organism-specific databases

MGIⁱ	MGI:1859212 Irf7

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	425	S → A: Strongly decreased transcriptional activation in response to viral infection; when associated with A-426. 1 Publication	1
Mutagenesisⁱ	425	S → D: Strongly decreased transcriptional activation in response to viral infection; when associated with D-426. 1 Publication	1
Mutagenesisⁱ	426	S → A: Strongly decreased transcriptional activation in response to viral infection; when associated with A-425. 1 Publication	1
Mutagenesisⁱ	426	S → D: Strongly decreased transcriptional activation in response to viral infection; when associated with D-425. 1 Publication	1
Mutagenesisⁱ	427	L → A: Strongly decreased transcriptional activation in response to viral infection. 1 Publication	1
Mutagenesisⁱ	427	L → D: No effect on transcriptional activation in response to viral infection. 1 Publication	1
Mutagenesisⁱ	429	S → A: Almost no effect on transcriptional activation in response to viral infection; when associated with A-430 and A-431. 1 Publication	1
Mutagenesisⁱ	429	S → D: Strongly increased transcriptional activation in response to viral infection; when associated with D-430 and A-431. 1 Publication	1
Mutagenesisⁱ	430	S → A: Almost no effect on transcriptional activation in response to viral infection; when associated with A-429 and A-431.	1
Mutagenesisⁱ	430	S → D: Strongly increased transcriptional activation in response to viral infection; when associated with D-429 and A-431.	1
Mutagenesisⁱ	431	S → A: Almost no effect on transcriptional activation in response to viral infection; when associated with A-429 and A-430. 1 Publication	1
Mutagenesisⁱ	431	S → D: Strongly increased transcriptional activation in response to viral infection; when associated with D-429 and A-430. 1 Publication	1
Mutagenesisⁱ	437	S → A: Almost complete loss of transcriptional activation; when associated with A-438. 1 Publication	1
Mutagenesisⁱ	437	S → D: Increased transcriptional activation; when associated with D-438. 1 Publication	1
Mutagenesisⁱ	438	S → A: Almost complete loss of transcriptional activation; when associated with A-437. 1 Publication	1
Mutagenesisⁱ	438	S → D: Increased transcriptional activation; when associated with D-437. 1 Publication	1
Mutagenesisⁱ	441	S → A: Almost no effect on transcriptional activation in response to viral infection. 1 Publication	1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000154563	1 – 457	Interferon regulatory factor 7Add BLAST		457

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	92	N6-acetyllysine; by KAT2A and KAT2BBy similarity	1
Cross-linkⁱ	398	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Cross-linkⁱ	400	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Modified residueⁱ	425	Phosphoserine1 Publication	1
Modified residueⁱ	426	Phosphoserine1 Publication	1
Modified residueⁱ	429	Phosphoserine1 Publication	1
Modified residueⁱ	431	Phosphoserine; by TBK1 and IKKEBy similarity	1
Modified residueⁱ	437	Phosphoserine1 Publication	1
Modified residueⁱ	438	Phosphoserine1 Publication	1
Modified residueⁱ	441	Phosphoserine1 Publication	1

Post-translational modificationⁱ

Acetylation inhibits its DNA-binding ability and activity.By similarity

In response to a viral infection, phosphorylated by TBK1 and IKBKE1. Phosphorylation, and subsequent activation is inhibited by vaccinia virus protein E3. In TLR7- and TLR9-mediated signaling pathway, phosphorylated by IRAK1 (By similarity).By similarity

TRAF6-mediated ubiquitination is required for IRF7 activation.1 Publication

Sumoylated by TRIM28, which inhibits its transactivation activity.By similarity

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	P70434
PRIDEⁱ	P70434

PTM databases

iPTMnetⁱ	P70434
PhosphoSitePlusⁱ	P70434

Expressionⁱ

Inductionⁱ

By type I interferon (IFN) and viruses.

Gene expression databases

Bgeeⁱ	ENSMUSG00000025498 Expressed in 101 organ(s), highest expression level in blood
CleanExⁱ	MM_IRF7
ExpressionAtlasⁱ	P70434 baseline and differential
Genevisibleⁱ	P70434 MM

Interactionⁱ

Subunit structureⁱ

Monomer. Homodimer; phosphorylation-induced. Heterodimer with IRF3. Interacts with TICAM1 and TICAM2. Interacts with MYD88 AND TRAF6.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Chuk	Q60680	3	EBI-997907,EBI-646245
Trim35	Q8C006	2	EBI-997907,EBI-2536044

Protein-protein interaction databases

BioGridⁱ	207563, 9 interactors
Database of interacting proteins More...DIPⁱ	DIP-37903N
IntActⁱ	P70434, 6 interactors
Molecular INTeraction database More...MINTⁱ	P70434
STRINGⁱ	10090.ENSMUSP00000026571

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	12 – 22	Combined sources	11
Beta strandⁱ	29 – 32	Combined sources	4
Beta strandⁱ	37 – 41	Combined sources	5
Helixⁱ	52 – 55	Combined sources	4
Helixⁱ	56 – 64	Combined sources	9
Helixⁱ	77 – 85	Combined sources	9
Helixⁱ	88 – 100	Combined sources	13
Beta strandⁱ	105 – 111	Combined sources	7
Beta strandⁱ	119 – 124	Combined sources	6

Show more details

3D structure databases

ProteinModelPortalⁱ	P70434
SMRⁱ	P70434
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the IRF family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG410IWNR Eukaryota ENOG4111G85 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119093
HOGENOMⁱ	HOG000111812
HOVERGENⁱ	HBG105600
InParanoidⁱ	P70434
KEGG Orthology (KO) More...KOⁱ	K09447
OMAⁱ	VARGRWP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G067P
PhylomeDBⁱ	P70434
TreeFamⁱ	TF328512

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00103 IRF, 1 hit
Gene3Dⁱ	1.10.10.10, 1 hit 2.60.200.10, 1 hit
InterProⁱ	View protein in InterPro IPR019817 Interferon_reg_fac_CS IPR001346 Interferon_reg_fact_DNA-bd_dom IPR019471 Interferon_reg_factor-3 IPR017855 SMAD-like_dom_sf IPR008984 SMAD_FHA_dom_sf IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
PANTHERⁱ	PTHR11949 PTHR11949, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00605 IRF, 1 hit PF10401 IRF-3, 1 hit
PRINTSⁱ	PR00267 INTFRNREGFCT
SMARTⁱ	View protein in SMART SM00348 IRF, 1 hit SM01243 IRF-3, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit SSF49879 SSF49879, 1 hit
PROSITEⁱ	View protein in PROSITE PS00601 IRF_1, 1 hit PS51507 IRF_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show all Align All

P70434-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAEVRGVQRV LFGDWLLGEV SSGQYEGLQW LNEARTVFRV PWKHFGRRDL 
        60         70         80         90        100
DEEDAQIFKA WAVARGRWPP SGVNLPPPEA EAAERRERRG WKTNFRCALH 
       110        120        130        140        150
STGRFILRQD NSGDPVDPHK VYELSRELGS TVGPATENRE EVSLSNALPT 
       160        170        180        190        200
QGVSPGSFLA RENAGLQTPS PLLSSDAGDL LLQVLQYSHI LESESGADPV 
       210        220        230        240        250
PPQAPGQEQD RVYEEPYAAW QVEAVPSPRP QQPALTERSL GFLDVTIMYK 
       260        270        280        290        300
GRTVLQAVVG HPRCVFLYSP MAPAVRTSEP QPVIFPSPAE LPDQKQLHYT 
       310        320        330        340        350
ETLLQHVSPG LQLELRGPSL WALRMGKCKV YWEVGSPMGT TGPSTPPQLL 
       360        370        380        390        400
ERNRHTPIFD FSTFFRELEE FRARRRQGSP HYTIYLGFGQ DLSAGRPKEK 
       410        420        430        440        450
TLILVKLEPW VCKAYLEGVQ REGVSSLDSS SLGLCLSSTN SLYEDIEHFL 

MDLGQWP

Length:457

Mass (Da):51,222

Last modified:February 1, 1997 - v1

Checksum:ⁱ30B102C668F56142

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q3TW14	Q3TW14_MOUSE	Interferon regulatory factor 7 Interferon regulatory factor 7 (Interferon regulatory factor 7, isoform CRA_b)	Irf7 mCG_23297	426	Annotation score:
D3Z4U9	D3Z4U9_MOUSE	Interferon regulatory factor 7 Interferon regulatory factor 7 (Interferon regulatory factor 7, isoform CRA_a)	Irf7 mCG_23297	425	Annotation score:
F6TQ89	F6TQ89_MOUSE	Interferon regulatory factor 7 Interferon regulatory factor 7	Irf7	251	Annotation score:
A0A1B0GRH7	A0A1B0GRH7_MOUSE	Interferon regulatory factor 7 Interferon regulatory factor 7	Irf7	237	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U73037 mRNA Translation: AAB18626.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS22005.1
NCBI Reference Sequences More...RefSeqⁱ	NP_058546.1, NM_016850.3
UniGeneⁱ	Mm.3233

Genome annotation databases

Ensemblⁱ	ENSMUST00000026571; ENSMUSP00000026571; ENSMUSG00000025498
GeneIDⁱ	54123
KEGGⁱ	mmu:54123
UCSC genome browser More...UCSCⁱ	uc009kkg.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P70434	Interferon regulatory factor 7		MOUSE		457	UniRef100_P70434

Protein	Similar proteins		Species	Score	Length	Source
P70434	Interferon regulatory factor 7		MOUSE		457	UniRef90_P70434
UPI000A31176A		MUSPA		457
UPI000A3170D2		MUSCR		457

Protein	Similar proteins		Species	Score	Length	Source
P70434	Interferon regulatory factor 7		MOUSE		457	UniRef50_P70434
Uncharacterized protein		MACNE		393
Uncharacterized protein		PAPAN		393
Uncharacterized protein		RHIBE		393
Uncharacterized protein		MANLE		393
+45

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U73037 mRNA Translation: AAB18626.1
CCDSⁱ	CCDS22005.1
RefSeqⁱ	NP_058546.1, NM_016850.3
UniGeneⁱ	Mm.3233

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3QU3	X-ray	1.30	A/B/C	1-134	[»]
ProteinModelPortalⁱ	P70434
SMRⁱ	P70434
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	207563, 9 interactors
DIPⁱ	DIP-37903N
IntActⁱ	P70434, 6 interactors
MINTⁱ	P70434
STRINGⁱ	10090.ENSMUSP00000026571

PTM databases

iPTMnetⁱ	P70434
PhosphoSitePlusⁱ	P70434

Proteomic databases

PaxDbⁱ	P70434
PRIDEⁱ	P70434

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000026571; ENSMUSP00000026571; ENSMUSG00000025498
GeneIDⁱ	54123
KEGGⁱ	mmu:54123
UCSCⁱ	uc009kkg.2 mouse

Organism-specific databases

CTDⁱ	3665
MGIⁱ	MGI:1859212 Irf7

Phylogenomic databases

eggNOGⁱ	ENOG410IWNR Eukaryota ENOG4111G85 LUCA
GeneTreeⁱ	ENSGT00760000119093
HOGENOMⁱ	HOG000111812
HOVERGENⁱ	HBG105600
InParanoidⁱ	P70434
KOⁱ	K09447
OMAⁱ	VARGRWP
OrthoDBⁱ	EOG091G067P
PhylomeDBⁱ	P70434
TreeFamⁱ	TF328512

Enzyme and pathway databases

Reactomeⁱ	R-MMU-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-MMU-9013973 TICAM1-dependent activation of IRF3/IRF7 R-MMU-918233 TRAF3-dependent IRF activation pathway R-MMU-933541 TRAF6 mediated IRF7 activation R-MMU-936964 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon R-MMU-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling

Reactomeⁱ

R-MMU-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production
R-MMU-9013973 TICAM1-dependent activation of IRF3/IRF7
R-MMU-918233 TRAF3-dependent IRF activation pathway
R-MMU-933541 TRAF6 mediated IRF7 activation
R-MMU-936964 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
R-MMU-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P70434
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000025498 Expressed in 101 organ(s), highest expression level in blood
CleanExⁱ	MM_IRF7
ExpressionAtlasⁱ	P70434 baseline and differential
Genevisibleⁱ	P70434 MM

Family and domain databases

CDDⁱ	cd00103 IRF, 1 hit
Gene3Dⁱ	1.10.10.10, 1 hit 2.60.200.10, 1 hit
InterProⁱ	View protein in InterPro IPR019817 Interferon_reg_fac_CS IPR001346 Interferon_reg_fact_DNA-bd_dom IPR019471 Interferon_reg_factor-3 IPR017855 SMAD-like_dom_sf IPR008984 SMAD_FHA_dom_sf IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
PANTHERⁱ	PTHR11949 PTHR11949, 1 hit
Pfamⁱ	View protein in Pfam PF00605 IRF, 1 hit PF10401 IRF-3, 1 hit
PRINTSⁱ	PR00267 INTFRNREGFCT
SMARTⁱ	View protein in SMART SM00348 IRF, 1 hit SM01243 IRF-3, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit SSF49879 SSF49879, 1 hit
PROSITEⁱ	View protein in PROSITE PS00601 IRF_1, 1 hit PS51507 IRF_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IRF7_MOUSE
Accessionⁱ	P70434Primary (citable) accession number: P70434
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	February 1, 1997
	Last modified:	September 12, 2018
	This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - P70434 (IRF7_MOUSE)

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Interferon regulatory factor 7

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ