Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

GTP-binding protein Rit1

Gene

Rit1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signaling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation (By similarity).By similarity

Miscellaneous

Stimulation of the NGF and EGF receptor signaling pathways results in rapid and prolonged activation.By similarity
Shows rapid uncatalyzed guanine nucleotide dissociation rates, which are very much 10-fold faster than those of most Ras subfamily members.By similarity

Activity regulationi

Alternates between an inactive form bound to GDP and an active form bound to GTP.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi28 – 35GTPBy similarity8
Nucleotide bindingi75 – 79GTPBy similarity5
Nucleotide bindingi134 – 137GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: MGI
  • GTP binding Source: MGI

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein Rit1
Alternative name(s):
Ras-like protein expressed in many tissues
Ras-like without CAAX protein 1
Gene namesi
Name:Rit1
Synonyms:Rit
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:108053 Rit1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000827261 – 219GTP-binding protein Rit1Add BLAST219

Proteomic databases

MaxQBiP70426
PaxDbiP70426
PeptideAtlasiP70426
PRIDEiP70426

PTM databases

iPTMnetiP70426
PhosphoSitePlusiP70426

Expressioni

Tissue specificityi

Expressed in many tissues.

Gene expression databases

BgeeiENSMUSG00000028057 Expressed in 281 organ(s), highest expression level in blood
CleanExiMM_RIT1
ExpressionAtlasiP70426 baseline and differential
GenevisibleiP70426 MM

Interactioni

Subunit structurei

Interacts with AFDN, the C-terminal domain of RALGDS and RLF, but not with RIN1 and PIK3CA. RLF binds exclusively to the active GTP-bound form. Strongly interacts with BRAF, but only weakly with RAF1. BARF and RAF1 association is dependent upon the GTP-bound state (By similarity). Interacts with RGL3.By similarity1 Publication

Protein-protein interaction databases

BioGridi202897, 2 interactors
IntActiP70426, 1 interactor
STRINGi10090.ENSMUSP00000029692

Structurei

3D structure databases

ProteinModelPortaliP70426
SMRiP70426
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00860000133678
HOGENOMiHOG000233973
HOVERGENiHBG009351
InParanoidiP70426
KOiK07832
OMAiEGPKRTM
OrthoDBiEOG091G0UAU
PhylomeDBiP70426
TreeFamiTF315072

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.iShow all

P70426-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESGARPIGS SCSSPAALSR EYKLVMLGAG GVGKSAMTMQ FISHRFPEDH
60 70 80 90 100
DPTIEDAYKI RIRIDDEPAN LDILDTAGQA EFTAMRDQYM RAGEGFIICY
110 120 130 140 150
SITDRRSFHE VREFKQLIYR VRRTDDTPVV LVGNKSDLKQ LRQVSKEEGL
160 170 180 190 200
SLAREFSCPF FETSAAYRYY IDDVFHALVR EIRKKEKELV LAMEKKAKPK
210
NSVWKRLKSP FRRKKDSVT
Length:219
Mass (Da):25,169
Last modified:February 1, 1997 - v1
Checksum:i3041ED75190C65AC
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q672E9Q672_MOUSE
GTP-binding protein Rit1
Rit1
183Annotation score:
E9Q3Z0E9Q3Z0_MOUSE
GTP-binding protein Rit1
Rit1
109Annotation score:
G5E8W6G5E8W6_MOUSE
GTP-binding protein Rit1
Rit1 mCG_8846
90Annotation score:
G3UWE0G3UWE0_MOUSE
GTP-binding protein Rit1
Rit1 mCG_8846
37Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U71205 mRNA Translation: AAB42215.1
AK005357 mRNA Translation: BAB23972.1
AK014126 mRNA Translation: BAB29168.1
BC012694 mRNA Translation: AAH12694.1
CCDSiCCDS17484.1
RefSeqiNP_033095.1, NM_009069.4
XP_006501223.1, XM_006501160.3
UniGeneiMm.4009

Genome annotation databases

EnsembliENSMUST00000029692; ENSMUSP00000029692; ENSMUSG00000028057
GeneIDi19769
KEGGimmu:19769
UCSCiuc008pwh.2 mouse

Similar proteinsi

Entry informationi

Entry nameiRIT1_MOUSE
AccessioniPrimary (citable) accession number: P70426
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: February 1, 1997
Last modified: September 12, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again