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Entry version 209 (07 Oct 2020)
Sequence version 3 (27 Sep 2005)
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Protein

Receptor tyrosine-protein kinase erbB-2

Gene

Erbb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity).By similarity
In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei754ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei846Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi727 – 735ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Kinase, Receptor, Transferase, Tyrosine-protein kinase
Biological processTranscription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.10.1, 3474

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-1227986, Signaling by ERBB2
R-MMU-1250196, SHC1 events in ERBB2 signaling
R-MMU-1257604, PIP3 activates AKT signaling
R-MMU-1306955, GRB7 events in ERBB2 signaling
R-MMU-1358803, Downregulation of ERBB2:ERBB3 signaling
R-MMU-1963640, GRB2 events in ERBB2 signaling
R-MMU-1963642, PI3K events in ERBB2 signaling
R-MMU-416572, Sema4D induced cell migration and growth-cone collapse
R-MMU-5673001, RAF/MAP kinase cascade
R-MMU-6785631, ERBB2 Regulates Cell Motility
R-MMU-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-MMU-8847993, ERBB2 Activates PTK6 Signaling
R-MMU-8863795, Downregulation of ERBB2 signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Receptor tyrosine-protein kinase erbB-2 (EC:2.7.10.1)
Alternative name(s):
Proto-oncogene Neu
Proto-oncogene c-ErbB-2
p185erbB2
CD_antigen: CD340
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Erbb2
Synonyms:Kiaa3023, Neu
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:95410, Erbb2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini23 – 653ExtracellularSequence analysisAdd BLAST631
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei654 – 674HelicalSequence analysisAdd BLAST21
Topological domaini675 – 1256CytoplasmicSequence analysisAdd BLAST582

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Endosome, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2311234

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000004218123 – 1256Receptor tyrosine-protein kinase erbB-2Add BLAST1234

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi26 ↔ 53By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi68N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi125N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi163 ↔ 193By similarity
Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi196 ↔ 205By similarity
Disulfide bondi200 ↔ 213By similarity
Disulfide bondi221 ↔ 228By similarity
Disulfide bondi225 ↔ 236By similarity
Disulfide bondi237 ↔ 245By similarity
Disulfide bondi241 ↔ 253By similarity
Disulfide bondi256 ↔ 265By similarity
Glycosylationi260N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi269 ↔ 296By similarity
Disulfide bondi300 ↔ 312By similarity
Disulfide bondi316 ↔ 332By similarity
Disulfide bondi335 ↔ 339By similarity
Disulfide bondi343 ↔ 368By similarity
Disulfide bondi476 ↔ 505By similarity
Disulfide bondi512 ↔ 521By similarity
Disulfide bondi516 ↔ 529By similarity
Glycosylationi531N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi532 ↔ 541By similarity
Disulfide bondi545 ↔ 561By similarity
Disulfide bondi564 ↔ 577By similarity
Disulfide bondi568 ↔ 585By similarity
Glycosylationi572N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi588 ↔ 597By similarity
Disulfide bondi601 ↔ 624By similarity
Disulfide bondi627 ↔ 635By similarity
Glycosylationi630N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi631 ↔ 643By similarity
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1055PhosphoserineBy similarity1
Modified residuei1079PhosphoserineBy similarity1
Modified residuei1084PhosphoserineBy similarity1
Modified residuei1108PhosphoserineBy similarity1
Modified residuei1113PhosphotyrosineBy similarity1
Modified residuei1140Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei1167PhosphothreonineBy similarity1
Modified residuei1197PhosphotyrosineBy similarity1
Modified residuei1249Phosphotyrosine; by autocatalysisBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylated. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Ligand-binding increases phosphorylation on tyrosine residues. Signaling via SEMA4C promotes phosphorylation at Tyr-1249. Dephosphorylated by PTPN12.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P70424

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P70424

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P70424

PeptideAtlas

More...
PeptideAtlasi
P70424

PRoteomics IDEntifications database

More...
PRIDEi
P70424

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

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GlyGeni
P70424, 7 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P70424

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P70424

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed predominantly in uterine epithelial cells. In the muscle, expression localizes to the synaptic sites of muscle fibers.

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

On days 1-4 of pregnancy, ERBB2 is detected primarily in epithelial cells, the day 1 uterus showing the highest accumulation. On day 5, the epithelium and the decidualizing stromal cells around the implanting blastocyst exhibit accumulation of this receptor. On days 6-8, the expression persists in the epithelium at both the implantation and interimplantation sites in addition to modest levels in the secondary decidual zone. On days 7 and 8, accumulation is also prominent in the trophoblastic giant cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000062312, Expressed in embryo and 225 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P70424, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Heterodimer with EGFR, ERBB3 and ERBB4.

Part of a complex with EGFR and either PIK3C2A or PIK3C2B. May interact with PIK3C2B when phosphorylated on Tyr-1197.

Interacts with PLXNB1.

Interacts (when phosphorylated on Tyr-1249) with MEMO1.

Interacts with MUC1.

Interacts (when phosphorylated on Tyr-1140) with GRB7 (via SH2 domain).

Interacts (when phosphorylated on Tyr-1249) with ERBIN.

Interacts with KPNB1, RANBP2, EEA1, CRM1, CLTC, PTK6, RPA194 and ACTB.

Interacts (preferentially with the tyrosine phosphorylated form) with CPNE3; this interaction occurs at the cell membrane and is increased in a growth factor heregulin-dependent manner.

Interacts with HSP90AA1 and HSP90AB1 in an ATP-dependent manner; the interaction suppresses ERBB2 kinase activity (By similarity).

Interacts with SRC (PubMed:7542762).

Interacts with MYOC (PubMed:23897819).

Interacts with PRKCABP (PubMed:11278603).

Interacts with SORL1; this interaction regulates ERBB2 subcellular distribution by promoting its recycling after internalization from endosomes back to the plasma membrane, hence stimulates ERBB2-mediated signaling (By similarity).

By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
199496, 8 interactors

Database of interacting proteins

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DIPi
DIP-40912N

Protein interaction database and analysis system

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IntActi
P70424, 6 interactors

Molecular INTeraction database

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MINTi
P70424

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000053897

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
P70424, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P70424

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini721 – 988Protein kinasePROSITE-ProRule annotationAdd BLAST268

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni677 – 690Required for interaction with KPNB1 and EEA1By similarityAdd BLAST14
Regioni1196 – 1198Interaction with PIK3C2BBy similarity3

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi677 – 690Nuclear localization signalBy similarityAdd BLAST14

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi193 – 269Cys-richAdd BLAST77
Compositional biasi1117 – 1163Pro-richAdd BLAST47

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1025, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000158232

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_003384_1_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P70424

KEGG Orthology (KO)

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KOi
K05083

Identification of Orthologs from Complete Genome Data

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OMAi
DRHCLPC

Database of Orthologous Groups

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OrthoDBi
81952at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P70424

TreeFam database of animal gene trees

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TreeFami
TF106002

Family and domain databases

Conserved Domains Database

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CDDi
cd00064, FU, 3 hits

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.80.20.20, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR006211, Furin-like_Cys-rich_dom
IPR006212, Furin_repeat
IPR032778, GF_recep_IV
IPR009030, Growth_fac_rcpt_cys_sf
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR000494, Rcpt_L-dom
IPR036941, Rcpt_L-dom_sf
IPR001245, Ser-Thr/Tyr_kinase_cat_dom
IPR008266, Tyr_kinase_AS
IPR020635, Tyr_kinase_cat_dom
IPR016245, Tyr_kinase_EGF/ERB/XmrK_rcpt

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00757, Furin-like, 1 hit
PF14843, GF_recep_IV, 1 hit
PF07714, PK_Tyr_Ser-Thr, 1 hit
PF01030, Recep_L_domain, 2 hits

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF000619, TyrPK_EGF-R, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00109, TYRKINASE

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00261, FU, 4 hits
SM00219, TyrKc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF56112, SSF56112, 1 hit
SSF57184, SSF57184, 2 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00109, PROTEIN_KINASE_TYR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P70424-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELAAWCRWG FLLALLSPGA AGTQVCTGTD MKLRLPASPE THLDMLRHLY
60 70 80 90 100
QGCQVVQGNL ELTYLPANAS LSFLQDIQEV QGYMLIAHNR VKHVPLQRLR
110 120 130 140 150
IVRGTQLFED KYALAVLDNR DPLDNVTTAA PGRTPEGLRE LQLRSLTEIL
160 170 180 190 200
KGGVLIRGNP QLCYQDMVLW KDVLRKNNQL APVDMDTNRS RACPPCAPTC
210 220 230 240 250
KDNHCWGESP EDCQILTGTI CTSGCARCKG RLPTDCCHEQ CAAGCTGPKH
260 270 280 290 300
SDCLACLHFN HSGICELHCP ALITYNTDTF ESMLNPEGRY TFGASCVTTC
310 320 330 340 350
PYNYLSTEVG SCTLVCPPNN QEVTAEDGTQ RCEKCSKPCA GVCYGLGMEH
360 370 380 390 400
LRGARAITSD NIQEFAGCKK IFGSLAFLPE SFDGNPSSGV APLKPEHLQV
410 420 430 440 450
FETLEEITGY LYISAWPESF QDLSVFQNLR VIRGRILHDG AYSLTLQGLG
460 470 480 490 500
IHSLGLRSLR ELGSGLALIH RNTHLCFVNT VPWDQLFRNP HQALLHSGNR
510 520 530 540 550
PEEACGLEGL VCNSLCARGH CWGPGPTQCV NCSQFLRGQE CVEECRVWKG
560 570 580 590 600
LPREYVRGKH CLPCHPECQP QNSSETCYGS EADQCEACAH YKDSSSCVAR
610 620 630 640 650
CPSGVKPDLS YMPIWKYPDE EGICQPCPIN CTHSCVDLDE RGCPAEQRAS
660 670 680 690 700
PVTFIIATVV GVLLFLIIVV VIGILIKRRR QKIRKYTMRR LLQETELVEP
710 720 730 740 750
LTPSGAVPNQ AQMRILKETE LRKLKVLGSG AFGTVYKGIW IPDGENVKIP
760 770 780 790 800
VAIKVLRENT SPKANKEILD EAYVMAGVGS PYVSRLLGIC LTSTVQLVTQ
810 820 830 840 850
LMPYGCLLDH VREHRGRLGS QDLLNWCVQI AKGMSYLEEV RLVHRDLAAR
860 870 880 890 900
NVLVKSPNHV KITDFGLARL LDIDETEYHA DGGKVPIKWM ALESILRRRF
910 920 930 940 950
THQSDVWSYG VTVWELMTFG AKPYDGIPAR EIPDLLEKGE RLPQPPICTI
960 970 980 990 1000
DVYMIMVKCW MIDSECRPRF RELVSEFSRM ARDPQRFVVI QNEDLGPSSP
1010 1020 1030 1040 1050
MDSTFYRSLL EDDDMGELVD AEEYLVPQQG FFSPDPALGT GSTAHRRHRS
1060 1070 1080 1090 1100
SSARSGGGEL TLGLEPSEEE PPRSPLAPSE GAGSDVFDGD LAVGVTKGLQ
1110 1120 1130 1140 1150
SLSPHDLSPL QRYSEDPTLP LPPETDGYVA PLACSPQPEY VNQPEVRPQS
1160 1170 1180 1190 1200
PLTPEGPPPP IRPAGATLER PKTLSPGKNG VVKDVFAFGG AVENPEYLAP
1210 1220 1230 1240 1250
RAGTASQPHP SPAFSPAFDN LYYWDQNSSE QGPPPSTFEG TPTAENPEYL

GLDVPV
Length:1,256
Mass (Da):138,579
Last modified:September 27, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6040978428B93A28
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC98297 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK129487 mRNA Translation: BAC98297.1 Different initiation.
U71126 mRNA Translation: AAB17380.1
L47239 mRNA Translation: AAA93532.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS25349.1

NCBI Reference Sequences

More...
RefSeqi
NP_001003817.1, NM_001003817.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000058295; ENSMUSP00000053897; ENSMUSG00000062312

Database of genes from NCBI RefSeq genomes

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GeneIDi
13866

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:13866

UCSC genome browser

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UCSCi
uc007lgi.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129487 mRNA Translation: BAC98297.1 Different initiation.
U71126 mRNA Translation: AAB17380.1
L47239 mRNA Translation: AAA93532.1
CCDSiCCDS25349.1
RefSeqiNP_001003817.1, NM_001003817.1

3D structure databases

SMRiP70424
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi199496, 8 interactors
DIPiDIP-40912N
IntActiP70424, 6 interactors
MINTiP70424
STRINGi10090.ENSMUSP00000053897

Chemistry databases

ChEMBLiCHEMBL2311234

PTM databases

GlyGeniP70424, 7 sites
iPTMnetiP70424
PhosphoSitePlusiP70424

Proteomic databases

jPOSTiP70424
MaxQBiP70424
PaxDbiP70424
PeptideAtlasiP70424
PRIDEiP70424

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
740, 5524 antibodies

Genome annotation databases

EnsembliENSMUST00000058295; ENSMUSP00000053897; ENSMUSG00000062312
GeneIDi13866
KEGGimmu:13866
UCSCiuc007lgi.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2064
MGIiMGI:95410, Erbb2

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG1025, Eukaryota
GeneTreeiENSGT00940000158232
HOGENOMiCLU_003384_1_1_1
InParanoidiP70424
KOiK05083
OMAiDRHCLPC
OrthoDBi81952at2759
PhylomeDBiP70424
TreeFamiTF106002

Enzyme and pathway databases

BRENDAi2.7.10.1, 3474
ReactomeiR-MMU-1227986, Signaling by ERBB2
R-MMU-1250196, SHC1 events in ERBB2 signaling
R-MMU-1257604, PIP3 activates AKT signaling
R-MMU-1306955, GRB7 events in ERBB2 signaling
R-MMU-1358803, Downregulation of ERBB2:ERBB3 signaling
R-MMU-1963640, GRB2 events in ERBB2 signaling
R-MMU-1963642, PI3K events in ERBB2 signaling
R-MMU-416572, Sema4D induced cell migration and growth-cone collapse
R-MMU-5673001, RAF/MAP kinase cascade
R-MMU-6785631, ERBB2 Regulates Cell Motility
R-MMU-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-MMU-8847993, ERBB2 Activates PTK6 Signaling
R-MMU-8863795, Downregulation of ERBB2 signaling

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
13866, 0 hits in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Erbb2, mouse

Protein Ontology

More...
PROi
PR:P70424
RNActiP70424, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000062312, Expressed in embryo and 225 other tissues
GenevisibleiP70424, MM

Family and domain databases

CDDicd00064, FU, 3 hits
Gene3Di3.80.20.20, 2 hits
InterProiView protein in InterPro
IPR006211, Furin-like_Cys-rich_dom
IPR006212, Furin_repeat
IPR032778, GF_recep_IV
IPR009030, Growth_fac_rcpt_cys_sf
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR000494, Rcpt_L-dom
IPR036941, Rcpt_L-dom_sf
IPR001245, Ser-Thr/Tyr_kinase_cat_dom
IPR008266, Tyr_kinase_AS
IPR020635, Tyr_kinase_cat_dom
IPR016245, Tyr_kinase_EGF/ERB/XmrK_rcpt
PfamiView protein in Pfam
PF00757, Furin-like, 1 hit
PF14843, GF_recep_IV, 1 hit
PF07714, PK_Tyr_Ser-Thr, 1 hit
PF01030, Recep_L_domain, 2 hits
PIRSFiPIRSF000619, TyrPK_EGF-R, 1 hit
PRINTSiPR00109, TYRKINASE
SMARTiView protein in SMART
SM00261, FU, 4 hits
SM00219, TyrKc, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
SSF57184, SSF57184, 2 hits
PROSITEiView protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00109, PROTEIN_KINASE_TYR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiERBB2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P70424
Secondary accession number(s): Q61525, Q6ZPE0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: September 27, 2005
Last modified: October 7, 2020
This is version 209 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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