UniProtKB - P70423 (CTR3_MOUSE)
Protein
Cationic amino acid transporter 3
Gene
Slc7a3
Organism
Mus musculus (Mouse)
Status
Functioni
Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner.1 Publication
GO - Molecular functioni
- amino acid transmembrane transporter activity Source: GO_Central
- arginine transmembrane transporter activity Source: MGI
- basic amino acid transmembrane transporter activity Source: MGI
- L-arginine transmembrane transporter activity Source: MGI
- L-lysine transmembrane transporter activity Source: MGI
- L-ornithine transmembrane transporter activity Source: MGI
GO - Biological processi
- amino acid transport Source: GO_Central
- arginine transport Source: MGI
- L-arginine import across plasma membrane Source: MGI
- L-lysine import across plasma membrane Source: MGI
- L-ornithine import across plasma membrane Source: MGI
- L-ornithine transmembrane transport Source: GO_Central
- lysine transport Source: MGI
- ornithine transport Source: MGI
- regulation of TOR signaling Source: MGI
Keywordsi
Biological process | Amino-acid transport, Transport |
Enzyme and pathway databases
Reactomei | R-MMU-352230, Amino acid transport across the plasma membrane |
Protein family/group databases
TCDBi | 2.A.3.3.5, the amino acid-polyamine-organocation (apc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Cationic amino acid transporter 3Short name: CAT-3 Short name: CAT3 Alternative name(s): Cationic amino acid transporter y+ Solute carrier family 7 member 3 |
Gene namesi | Name:Slc7a3 Synonyms:Atrc3, Cat3 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1100521, Slc7a3 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: MGI
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 36 | CytoplasmicSequence analysisAdd BLAST | 36 | |
Transmembranei | 37 – 57 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 58 – 61 | ExtracellularSequence analysis | 4 | |
Transmembranei | 62 – 82 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 83 – 107 | CytoplasmicSequence analysisAdd BLAST | 25 | |
Transmembranei | 108 – 128 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 129 – 162 | ExtracellularSequence analysisAdd BLAST | 34 | |
Transmembranei | 163 – 183 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 184 – 191 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 192 – 212 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 213 – 244 | ExtracellularSequence analysisAdd BLAST | 32 | |
Transmembranei | 245 – 265 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 266 – 285 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 286 – 306 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 307 – 335 | ExtracellularSequence analysisAdd BLAST | 29 | |
Transmembranei | 336 – 356 | Helical; Name=8Sequence analysisAdd BLAST | 21 | |
Topological domaini | 357 – 380 | CytoplasmicSequence analysisAdd BLAST | 24 | |
Transmembranei | 381 – 401 | Helical; Name=9Sequence analysisAdd BLAST | 21 | |
Topological domaini | 402 – 406 | ExtracellularSequence analysis | 5 | |
Transmembranei | 407 – 427 | Helical; Name=10Sequence analysisAdd BLAST | 21 | |
Topological domaini | 428 – 474 | CytoplasmicSequence analysisAdd BLAST | 47 | |
Transmembranei | 475 – 495 | Helical; Name=11Sequence analysisAdd BLAST | 21 | |
Topological domaini | 496 – 506 | ExtracellularSequence analysisAdd BLAST | 11 | |
Transmembranei | 507 – 527 | Helical; Name=12Sequence analysisAdd BLAST | 21 | |
Topological domaini | 528 – 539 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 540 – 560 | Helical; Name=13Sequence analysisAdd BLAST | 21 | |
Topological domaini | 561 – 568 | ExtracellularSequence analysis | 8 | |
Transmembranei | 569 – 589 | Helical; Name=14Sequence analysisAdd BLAST | 21 | |
Topological domaini | 590 – 618 | CytoplasmicSequence analysisAdd BLAST | 29 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000054267 | 1 – 618 | Cationic amino acid transporter 3Add BLAST | 618 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 232 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 605 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 617 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
EPDi | P70423 |
MaxQBi | P70423 |
PaxDbi | P70423 |
PeptideAtlasi | P70423 |
PRIDEi | P70423 |
PTM databases
GlyGeni | P70423, 1 site |
iPTMneti | P70423 |
PhosphoSitePlusi | P70423 |
SwissPalmi | P70423 |
Expressioni
Tissue specificityi
Expressed in adult brain and in a wide variety of embryonic tissues.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000031297, Expressed in epiblast (generic) and 147 other tissues |
Genevisiblei | P70423, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 198277, 1 interactor |
IntActi | P70423, 1 interactor |
STRINGi | 10090.ENSMUSP00000098914 |
Miscellaneous databases
RNActi | P70423, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1286, Eukaryota |
GeneTreei | ENSGT00940000154651 |
HOGENOMi | CLU_007946_15_7_1 |
InParanoidi | P70423 |
OMAi | RTPVMAT |
OrthoDBi | 439017at2759 |
PhylomeDBi | P70423 |
TreeFami | TF315212 |
Family and domain databases
InterProi | View protein in InterPro IPR002293, AA/rel_permease1 IPR015606, CAT3 IPR004755, Cat_AA_permease IPR029485, CAT_C |
PANTHERi | PTHR43243:SF20, PTHR43243:SF20, 1 hit |
Pfami | View protein in Pfam PF13520, AA_permease_2, 1 hit PF13906, AA_permease_C, 1 hit |
TIGRFAMsi | TIGR00906, 2A0303, 1 hit |
i Sequence
Sequence statusi: Complete.
P70423-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLWQALRRFG QKLVRRRVLE LGMGETRLAR CLSTLDLVAL GVGSTLGAGV
60 70 80 90 100
YVLAGEVAKD KAGPSIVICF LVAALSSVLA GLCYAEFGAR VPGSGSAYLY
110 120 130 140 150
SYVTVGELWA FTTGWNLILS YVIGTASVAR AWSSAFDNLI GNHISRTLKG
160 170 180 190 200
TILLKMPHVL AEYPDFFALA LVLLLTGLLV LGASKSALVT KVFTGMNLLV
210 220 230 240 250
LSFVIISGFI KGELRNWKLT KEDYCLTMSE SNGTCSLDSM GSGGFMPFGL
260 270 280 290 300
EGILRGAATC FYAFVGFDCI ATTGEEAQNP QRSIPMGIVI SMFICFLAYF
310 320 330 340 350
GVSSALTLMM PYYKLHPESP LPEAFSYVGW EPARYLVAIG SLCALSTSLL
360 370 380 390 400
GSMFPMPRVM YSMAEDGLLF RVLAKVHSVT HIPIVATLVS GVIAAFMAFL
410 420 430 440 450
FELTDLVDLM SIGTLLAHSL VSICVLILRY QPDQEMKSVE EEMELQEETL
460 470 480 490 500
EAEKLTVQAL FCPVNSIPTL LSGRVVYVCS SLLAVLLTVL CLVLTWWTTP
510 520 530 540 550
LRSGDPVWVT VVVLILGLIL AISGVIWRQP QNRTPLHFKV PAVPLLPLVS
560 570 580 590 600
IFVNVYLMMQ MTAGTWARFG IWMLIGFAIY FGYGIQHSMK EVKNHQTLPK
610
TRAQTIDLDL TTSCVHSI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U70859 mRNA Translation: AAB09593.1 AK077593 mRNA Translation: BAC36884.1 AL672308 Genomic DNA No translation available. BC050195 mRNA Translation: AAH50195.1 |
CCDSi | CCDS30309.1 |
RefSeqi | NP_001288769.1, NM_001301840.1 NP_031541.1, NM_007515.3 XP_006527816.1, XM_006527753.2 XP_011245812.1, XM_011247510.1 XP_011245813.1, XM_011247511.1 XP_011245814.1, XM_011247512.1 XP_011245815.1, XM_011247513.1 XP_017173852.1, XM_017318363.1 XP_017173853.1, XM_017318364.1 |
Genome annotation databases
Ensembli | ENSMUST00000073927; ENSMUSP00000073582; ENSMUSG00000031297 ENSMUST00000101362; ENSMUSP00000098914; ENSMUSG00000031297 ENSMUST00000113710; ENSMUSP00000109339; ENSMUSG00000031297 |
GeneIDi | 11989 |
KEGGi | mmu:11989 |
UCSCi | uc009twt.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U70859 mRNA Translation: AAB09593.1 AK077593 mRNA Translation: BAC36884.1 AL672308 Genomic DNA No translation available. BC050195 mRNA Translation: AAH50195.1 |
CCDSi | CCDS30309.1 |
RefSeqi | NP_001288769.1, NM_001301840.1 NP_031541.1, NM_007515.3 XP_006527816.1, XM_006527753.2 XP_011245812.1, XM_011247510.1 XP_011245813.1, XM_011247511.1 XP_011245814.1, XM_011247512.1 XP_011245815.1, XM_011247513.1 XP_017173852.1, XM_017318363.1 XP_017173853.1, XM_017318364.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 198277, 1 interactor |
IntActi | P70423, 1 interactor |
STRINGi | 10090.ENSMUSP00000098914 |
Protein family/group databases
TCDBi | 2.A.3.3.5, the amino acid-polyamine-organocation (apc) family |
PTM databases
GlyGeni | P70423, 1 site |
iPTMneti | P70423 |
PhosphoSitePlusi | P70423 |
SwissPalmi | P70423 |
Proteomic databases
EPDi | P70423 |
MaxQBi | P70423 |
PaxDbi | P70423 |
PeptideAtlasi | P70423 |
PRIDEi | P70423 |
Protocols and materials databases
Antibodypediai | 586, 68 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000073927; ENSMUSP00000073582; ENSMUSG00000031297 ENSMUST00000101362; ENSMUSP00000098914; ENSMUSG00000031297 ENSMUST00000113710; ENSMUSP00000109339; ENSMUSG00000031297 |
GeneIDi | 11989 |
KEGGi | mmu:11989 |
UCSCi | uc009twt.2, mouse |
Organism-specific databases
CTDi | 84889 |
MGIi | MGI:1100521, Slc7a3 |
Phylogenomic databases
eggNOGi | KOG1286, Eukaryota |
GeneTreei | ENSGT00940000154651 |
HOGENOMi | CLU_007946_15_7_1 |
InParanoidi | P70423 |
OMAi | RTPVMAT |
OrthoDBi | 439017at2759 |
PhylomeDBi | P70423 |
TreeFami | TF315212 |
Enzyme and pathway databases
Reactomei | R-MMU-352230, Amino acid transport across the plasma membrane |
Miscellaneous databases
BioGRID-ORCSi | 11989, 0 hits in 17 CRISPR screens |
PROi | PR:P70423 |
RNActi | P70423, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000031297, Expressed in epiblast (generic) and 147 other tissues |
Genevisiblei | P70423, MM |
Family and domain databases
InterProi | View protein in InterPro IPR002293, AA/rel_permease1 IPR015606, CAT3 IPR004755, Cat_AA_permease IPR029485, CAT_C |
PANTHERi | PTHR43243:SF20, PTHR43243:SF20, 1 hit |
Pfami | View protein in Pfam PF13520, AA_permease_2, 1 hit PF13906, AA_permease_C, 1 hit |
TIGRFAMsi | TIGR00906, 2A0303, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CTR3_MOUSE | |
Accessioni | P70423Primary (citable) accession number: P70423 Secondary accession number(s): B1AVE2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 16, 2004 |
Last sequence update: | February 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 163 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families