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Protein

Cadherin-10

Gene

Cdh10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

GO - Molecular functioni

  • cadherin binding Source: GO_Central
  • calcium ion binding Source: GO_Central
  • cytoskeletal protein binding Source: GO_Central
  • protein homodimerization activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processCell adhesion
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-418990 Adherens junctions interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-10
Alternative name(s):
T2-cadherin
Gene namesi
Name:Cdh10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:107436 Cdh10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 613ExtracellularSequence analysisAdd BLAST591
Transmembranei614 – 634HelicalSequence analysisAdd BLAST21
Topological domaini635 – 788CytoplasmicSequence analysisAdd BLAST154

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000026966223 – 54Sequence analysisAdd BLAST32
ChainiPRO_000012664655 – 788Cadherin-10Add BLAST734

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi256N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi456N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi534N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei784PhosphoserineCombined sources1

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP70408
PaxDbiP70408
PeptideAtlasiP70408
PRIDEiP70408

PTM databases

iPTMnetiP70408
PhosphoSitePlusiP70408

Expressioni

Developmental stagei

Expressed at all stages of testicular development with highest levels found in fetal gonad.1 Publication

Gene expression databases

BgeeiENSMUSG00000022321 Expressed in 166 organ(s), highest expression level in retina
CleanExiMM_CDH10
ExpressionAtlasiP70408 baseline and differential
GenevisibleiP70408 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi236359, 4 interactors
IntActiP70408, 3 interactors
STRINGi10090.ENSMUSP00000042199

Structurei

Secondary structure

1788
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP70408
SMRiP70408
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 160Cadherin 1PROSITE-ProRule annotationAdd BLAST105
Domaini161 – 269Cadherin 2PROSITE-ProRule annotationAdd BLAST109
Domaini270 – 384Cadherin 3PROSITE-ProRule annotationAdd BLAST115
Domaini385 – 489Cadherin 4PROSITE-ProRule annotationAdd BLAST105
Domaini489 – 603Cadherin 5PROSITE-ProRule annotationAdd BLAST115

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00760000118954
HOGENOMiHOG000231252
HOVERGENiHBG005217
InParanoidiP70408
KOiK06802
OMAiLWVCLPH
OrthoDBiEOG091G0298
TreeFamiTF329887

Family and domain databases

Gene3Di4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR039808 Cadherin
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR000233 Cadherin_cytoplasmic-dom
IPR027397 Catenin_binding_dom_sf
PANTHERiPTHR24027 PTHR24027, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF01049 Cadherin_C, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 5 hits
SUPFAMiSSF49313 SSF49313, 5 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 3 hits
PS50268 CADHERIN_2, 5 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P70408-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTIYQFLRLF VLWACLPHFC CPELTFRRTP GIQQMTAESR APRSDGKILH
60 70 80 90 100
RQKRGWMWNQ FFLLEEYTGS DYQYVGKLHS DQDKGDGSLK YILSGDGAGT
110 120 130 140 150
LFIIDEKTGD IHATRRIDRE EKAFYTLRAQ AINRRTLRPV EPESEFVIKI
160 170 180 190 200
HDINDNEPTF PEEIYTASVP EMSVVGTSVV QVTATDADDP SYGNSARVIY
210 220 230 240 250
SILQGQPYFS VEPETGIIRT ALPNMNRENK EQYQVVIQAK DMGGQMGGLS
260 270 280 290 300
GTTTVNITLT DVNDNPPRFP QNTIHLRVLE SSPVGTAVGS VKATDADTGK
310 320 330 340 350
NAEVDYRIID GDGTDMFDII TEKDTQEGII TVKKPLDYEN RRLYTLKVEA
360 370 380 390 400
ENTHVDPRFY YLGPFKDTTI VKISIEDVDE PPVFSRSSYL FEVHEDIEVG
410 420 430 440 450
TIIGTVMARD PDSTSSPIRF TLDRHTDLDR IFNIHSGNGS LYTSKPLDRE
460 470 480 490 500
LSQWHNLTVI AAEINNPKET TRVSVFVRIL DVNDNAPQFA VFYDTFVCEN
510 520 530 540 550
ARPGQLIQTI SAVDKDDPLG GQKFFFSLAA VNPNFTVQDN EDNTARILTR
560 570 580 590 600
KNGFNRHEIS TYLLPVVISD NDYPIQSSTG TLTIRVCACD SQGNMQSCSA
610 620 630 640 650
EALLLPAGLS TGALIAILLC IIILLVIVVL FAALKRQRKK EPLILSKEDI
660 670 680 690 700
RDNIVSYNDE GGGEEDTQAF DIGTLRNPAA IEEKKLRRDI IPETLFIPRR
710 720 730 740 750
TPTAPDNTDV RDFINERLKE HDLDPTAPPY DSLATYAYEG NDSVAESLSS
760 770 780
LESGTTEGDQ NYDYLREWGP RFNKLAEMYG GGESDKDA
Length:788
Mass (Da):88,312
Last modified:July 27, 2011 - v3
Checksum:i4066D21DBB038AE1
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BKV8H3BKV8_MOUSE
Cadherin-10
Cdh10
419Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti142P → S in AAH52056 (PubMed:15489334).Curated1
Sequence conflicti142P → S in AAH62962 (PubMed:15489334).Curated1
Sequence conflicti518 – 525PLGGQKFF → VDRRSFS in AAB87708 (PubMed:8879495).Curated8
Sequence conflicti549T → A in AAB87708 (PubMed:8879495).Curated1
Sequence conflicti607 – 610AGLS → WPH in AAB87708 (PubMed:8879495).Curated4
Sequence conflicti635 – 639Missing in AAB87708 (PubMed:8879495).Curated5
Sequence conflicti699Missing in AAB87708 (PubMed:8879495).Curated1
Sequence conflicti706D → G in AAB87708 (PubMed:8879495).Curated1
Sequence conflicti773N → K in AAB87708 (PubMed:8879495).Curated1
Sequence conflicti788A → S in AAB87708 (PubMed:8879495).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK138606 mRNA Translation: BAE23714.1
BC052056 mRNA Translation: AAH52056.1
BC062962 mRNA Translation: AAH62962.1
U69137 mRNA Translation: AAB87708.1
CCDSiCCDS37047.1
RefSeqiNP_001303687.1, NM_001316758.1
NP_033995.1, NM_009865.3
UniGeneiMm.117794
Mm.446240

Genome annotation databases

EnsembliENSMUST00000040562; ENSMUSP00000042199; ENSMUSG00000022321
ENSMUST00000166873; ENSMUSP00000128782; ENSMUSG00000022321
GeneIDi320873
KEGGimmu:320873
UCSCiuc007vik.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK138606 mRNA Translation: BAE23714.1
BC052056 mRNA Translation: AAH52056.1
BC062962 mRNA Translation: AAH62962.1
U69137 mRNA Translation: AAB87708.1
CCDSiCCDS37047.1
RefSeqiNP_001303687.1, NM_001316758.1
NP_033995.1, NM_009865.3
UniGeneiMm.117794
Mm.446240

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6CG6X-ray2.71A55-261[»]
ProteinModelPortaliP70408
SMRiP70408
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi236359, 4 interactors
IntActiP70408, 3 interactors
STRINGi10090.ENSMUSP00000042199

PTM databases

iPTMnetiP70408
PhosphoSitePlusiP70408

Proteomic databases

MaxQBiP70408
PaxDbiP70408
PeptideAtlasiP70408
PRIDEiP70408

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040562; ENSMUSP00000042199; ENSMUSG00000022321
ENSMUST00000166873; ENSMUSP00000128782; ENSMUSG00000022321
GeneIDi320873
KEGGimmu:320873
UCSCiuc007vik.1 mouse

Organism-specific databases

CTDi1008
MGIiMGI:107436 Cdh10

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00760000118954
HOGENOMiHOG000231252
HOVERGENiHBG005217
InParanoidiP70408
KOiK06802
OMAiLWVCLPH
OrthoDBiEOG091G0298
TreeFamiTF329887

Enzyme and pathway databases

ReactomeiR-MMU-418990 Adherens junctions interactions

Miscellaneous databases

PROiPR:P70408
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022321 Expressed in 166 organ(s), highest expression level in retina
CleanExiMM_CDH10
ExpressionAtlasiP70408 baseline and differential
GenevisibleiP70408 MM

Family and domain databases

Gene3Di4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR039808 Cadherin
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR000233 Cadherin_cytoplasmic-dom
IPR027397 Catenin_binding_dom_sf
PANTHERiPTHR24027 PTHR24027, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF01049 Cadherin_C, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 5 hits
SUPFAMiSSF49313 SSF49313, 5 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 3 hits
PS50268 CADHERIN_2, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCAD10_MOUSE
AccessioniPrimary (citable) accession number: P70408
Secondary accession number(s): Q3UUB3, Q80WS7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 130 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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