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Protein

Cadherin-9

Gene

Cdh9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

GO - Molecular functioni

  • cadherin binding Source: GO_Central
  • cadherin binding involved in cell-cell adhesion Source: SynGO-UCL
  • calcium ion binding Source: GO_Central
  • cytoskeletal protein binding Source: GO_Central
  • identical protein binding Source: SynGO-UCL
  • protein homodimerization activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processCell adhesion
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-9
Alternative name(s):
T1-cadherin
Gene namesi
Name:Cdh9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:107433 Cdh9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 614ExtracellularSequence analysisAdd BLAST593
Transmembranei615 – 635HelicalSequence analysisAdd BLAST21
Topological domaini636 – 786CytoplasmicSequence analysisAdd BLAST151

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000026966122 – 52Sequence analysisAdd BLAST31
ChainiPRO_000012664553 – 786Cadherin-9Add BLAST734

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi21N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi254N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi454N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi535N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei785PhosphoserineBy similarity1

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP70407
PRIDEiP70407

PTM databases

iPTMnetiP70407
PhosphoSitePlusiP70407

Expressioni

Developmental stagei

Not detected in fetal, newborn or 7-day-old testis. Present in 21-day-old and adult testes. Levels are 10-fold higher in adult testis than in testis of 21-day-old animals.1 Publication

Gene expression databases

CleanExiMM_CDH9

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026432

Structurei

3D structure databases

ProteinModelPortaliP70407
SMRiP70407
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 158Cadherin 1PROSITE-ProRule annotationAdd BLAST105
Domaini159 – 267Cadherin 2PROSITE-ProRule annotationAdd BLAST109
Domaini268 – 382Cadherin 3PROSITE-ProRule annotationAdd BLAST115
Domaini383 – 487Cadherin 4PROSITE-ProRule annotationAdd BLAST105
Domaini487 – 604Cadherin 5PROSITE-ProRule annotationAdd BLAST118

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
HOGENOMiHOG000231252
HOVERGENiHBG005217
InParanoidiP70407
PhylomeDBiP70407

Family and domain databases

Gene3Di4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR039808 Cadherin
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR000233 Cadherin_cytoplasmic-dom
IPR027397 Catenin_binding_dom_sf
PANTHERiPTHR24027 PTHR24027, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF01049 Cadherin_C, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 5 hits
SUPFAMiSSF49313 SSF49313, 5 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 2 hits
PS50268 CADHERIN_2, 5 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P70407-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRTYSCLQLV IWTCIFHMVD NSTLQGKDSS HFLRRIVNLK KDEGKMLHRA
60 70 80 90 100
KRGWMWNQFF LLEEYTGTDT QYVGKLHTDQ DKGDGNLKYI LTGDGAGNLF
110 120 130 140 150
VIDENTGDIH AAKRLDREEK SLYILRAKAI DRKTGRQVEP ESEFIIKIHD
160 170 180 190 200
INDNEPKFTK DLYTASVPEM SGVGTSVIQV TATDADDANY GNSAKVVYSI
210 220 230 240 250
LQGQPYFSVD PESGIIKTAL PDMSRENKEQ YQVVIQAKDM GGQMGGLSGT
260 270 280 290 300
TTVNITLTDV NNNPPRFPQS TYQFNSLESA PLGTHLGRIK ANDPDMGENA
310 320 330 340 350
ELEYSIAEGE GSDMFDVITD KDTQEGIITV KQNLDFEKKM LYTLRVDASN
360 370 380 390 400
THPDPRFLHL GPFKDSAMVK ISVEDVDEPP VFSKLSYLME VDEDVKEGSI
410 420 430 440 450
IGQVTAYDPD AMNNIIKYSV DRHTDMDRVF SIHSENGSIF TLKPLDRESS
460 470 480 490 500
PWHNITITAT EINNPKQSSQ IPVFIRILDI NDHAPEFATY YETFVCENAK
510 520 530 540 550
SGQLIQTISV MDKDDPPRGH KFFFEPVPEF PLNPNFTIVD NKDNTAGIVT
560 570 580 590 600
RKDGYSRNKM NTYLLPVLIF DNDYPIQSST GTLTIRVCAC DNLGNMQSCN
610 620 630 640 650
AEALMLAAGL STGALIAILL CVVILLTLIV LFAALKRQRK KEPLIISKDD
660 670 680 690 700
VRDNIVTYND EGGGEEDTQA FDIGTLRNPE AREDSKLRRD VMPETIFQIR
710 720 730 740 750
RTVPLWENID VQDFIHRRLK ENDSDPSAPP YDSLATYAYE GNDSVANSLS
760 770 780
SLESLTADCN QDYDYLSDWG PRFKKLAEMY GGNDSD
Length:786
Mass (Da):88,301
Last modified:December 12, 2006 - v2
Checksum:iD9B1CE63502F87C2
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WHU6F8WHU6_MOUSE
Cadherin-9
Cdh9
788Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti681A → AK in AAB87707 (PubMed:8879495).Curated1
Sequence conflicti692M → S in AAB87707 (PubMed:8879495).Curated1
Sequence conflicti725 – 727DPS → T in AAB87707 (PubMed:8879495).Curated3
Sequence conflicti786D → DLN in AAB87707 (PubMed:8879495).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC116724 Genomic DNA No translation available.
U69136 mRNA Translation: AAB87707.1
UniGeneiMm.439758

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC116724 Genomic DNA No translation available.
U69136 mRNA Translation: AAB87707.1
UniGeneiMm.439758

3D structure databases

ProteinModelPortaliP70407
SMRiP70407
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026432

PTM databases

iPTMnetiP70407
PhosphoSitePlusiP70407

Proteomic databases

PaxDbiP70407
PRIDEiP70407

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:107433 Cdh9

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
HOGENOMiHOG000231252
HOVERGENiHBG005217
InParanoidiP70407
PhylomeDBiP70407

Miscellaneous databases

PROiPR:P70407
SOURCEiSearch...

Gene expression databases

CleanExiMM_CDH9

Family and domain databases

Gene3Di4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR039808 Cadherin
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR000233 Cadherin_cytoplasmic-dom
IPR027397 Catenin_binding_dom_sf
PANTHERiPTHR24027 PTHR24027, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF01049 Cadherin_C, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 5 hits
SUPFAMiSSF49313 SSF49313, 5 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 2 hits
PS50268 CADHERIN_2, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCADH9_MOUSE
AccessioniPrimary (citable) accession number: P70407
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: December 12, 2006
Last modified: November 7, 2018
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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