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Protein

Myosin-binding protein H

Gene

Mybph

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds to myosin; probably involved in interaction with thick myofilaments in the A-band.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMuscle protein
Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-binding protein H
Short name:
MyBP-H
Alternative name(s):
H-protein
Gene namesi
Name:Mybph
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1858196 Mybph

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Thick filament

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000726991 – 483Myosin-binding protein HAdd BLAST483

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2PhosphothreonineBy similarity1
Modified residuei6PhosphothreonineBy similarity1
Modified residuei26PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP70402
PaxDbiP70402
PRIDEiP70402

2D gel databases

SWISS-2DPAGEiP70402

PTM databases

iPTMnetiP70402
PhosphoSitePlusiP70402

Expressioni

Tissue specificityi

Skeletal muscle.

Gene expression databases

BgeeiENSMUSG00000042451 Expressed in 77 organ(s), highest expression level in gastrocnemius medialis
CleanExiMM_MYBPH
GenevisibleiP70402 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi207275, 2 interactors
STRINGi10090.ENSMUSP00000042195

Structurei

3D structure databases

ProteinModelPortaliP70402
SMRiP70402
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini79 – 174Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST96
Domaini178 – 266Ig-like C2-type 1Add BLAST89
Domaini275 – 370Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST96
Domaini388 – 472Ig-like C2-type 2Add BLAST85

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. MyBP family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGiENOG410IF9Q Eukaryota
ENOG410YAE6 LUCA
GeneTreeiENSGT00860000133685
HOGENOMiHOG000290713
HOVERGENiHBG056788
InParanoidiP70402
OMAiTCKAVNV
OrthoDBiEOG091G07IP
TreeFamiTF334735

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF00041 fn3, 2 hits
PF07679 I-set, 2 hits
SMARTiView protein in SMART
SM00060 FN3, 2 hits
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits
SSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 2 hits
PS50835 IG_LIKE, 2 hits

Sequencei

Sequence statusi: Complete.

P70402-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTGKATSEAS VSTPEETAPE PAKVPTTEPS GEVAASESTG QEQAPEPQKP
60 70 80 90 100
QAQDPAAPAA SAMPAATKPE PPSEDVPSAP LRLTLEDVSH SSLTVSWEPP
110 120 130 140 150
EKLGKLGLQG YVLEFCREGA SEWVPVNPRP VMVTQQTVRN LALGDKFFLR
160 170 180 190 200
VTAVSSAGAG PPAVLDQPVH IQEITEAPKI RVPRHLRQTY IRQVGESVNL
210 220 230 240 250
QIPFQGKPKP QVSWTHNGHA LDNQRVNVRS GDQDSILFIR SAQRADSGRY
260 270 280 290 300
ELTVHLEGLE AKASIDILVI EKPGPPSSIK LLDVWGCNAA LEWTPPQDTG
310 320 330 340 350
NTELLGYTVQ KADKRTGQWF TVLERYHPTT CTISDLIIGN SYSFRVFSEN
360 370 380 390 400
LCGLSDLATT TKELAHIHKA DITAKPREFI ERDFSEAPSF TQPLADHTST
410 420 430 440 450
PGYSTQLFCS VRASPKPKII WMKNKMDIQG DPKYRAVSEQ GVCTLEIRKP
460 470 480
SPFDSGVYTC KAINVLGEAS VDCRLEVKAS ATH
Length:483
Mass (Da):52,641
Last modified:July 27, 2011 - v2
Checksum:iC8E8653EBEC6F169
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti249R → C in AAB08426 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U68267 mRNA Translation: AAB08426.1
AC137104 Genomic DNA No translation available.
CCDSiCCDS35713.1
RefSeqiNP_058029.2, NM_016749.2
XP_006529817.1, XM_006529754.2
XP_017177184.1, XM_017321695.1
UniGeneiMm.379067

Genome annotation databases

EnsembliENSMUST00000038445; ENSMUSP00000042195; ENSMUSG00000042451
ENSMUST00000191577; ENSMUSP00000141104; ENSMUSG00000042451
GeneIDi53311
KEGGimmu:53311
UCSCiuc007crh.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U68267 mRNA Translation: AAB08426.1
AC137104 Genomic DNA No translation available.
CCDSiCCDS35713.1
RefSeqiNP_058029.2, NM_016749.2
XP_006529817.1, XM_006529754.2
XP_017177184.1, XM_017321695.1
UniGeneiMm.379067

3D structure databases

ProteinModelPortaliP70402
SMRiP70402
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207275, 2 interactors
STRINGi10090.ENSMUSP00000042195

PTM databases

iPTMnetiP70402
PhosphoSitePlusiP70402

2D gel databases

SWISS-2DPAGEiP70402

Proteomic databases

MaxQBiP70402
PaxDbiP70402
PRIDEiP70402

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038445; ENSMUSP00000042195; ENSMUSG00000042451
ENSMUST00000191577; ENSMUSP00000141104; ENSMUSG00000042451
GeneIDi53311
KEGGimmu:53311
UCSCiuc007crh.1 mouse

Organism-specific databases

CTDi4608
MGIiMGI:1858196 Mybph

Phylogenomic databases

eggNOGiENOG410IF9Q Eukaryota
ENOG410YAE6 LUCA
GeneTreeiENSGT00860000133685
HOGENOMiHOG000290713
HOVERGENiHBG056788
InParanoidiP70402
OMAiTCKAVNV
OrthoDBiEOG091G07IP
TreeFamiTF334735

Miscellaneous databases

ChiTaRSiMybph mouse
PROiPR:P70402
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042451 Expressed in 77 organ(s), highest expression level in gastrocnemius medialis
CleanExiMM_MYBPH
GenevisibleiP70402 MM

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF00041 fn3, 2 hits
PF07679 I-set, 2 hits
SMARTiView protein in SMART
SM00060 FN3, 2 hits
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits
SSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 2 hits
PS50835 IG_LIKE, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMYBPH_MOUSE
AccessioniPrimary (citable) accession number: P70402
Secondary accession number(s): E9QKH7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 27, 2011
Last modified: September 12, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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