Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Homeobox protein DLX-6

Gene

Dlx6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi49 – 108HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein DLX-6
Gene namesi
Name:Dlx6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:101927 Dlx6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000490351 – 175Homeobox protein DLX-6Add BLAST175

Proteomic databases

PaxDbiP70397
PeptideAtlasiP70397
PRIDEiP70397

PTM databases

iPTMnetiP70397
PhosphoSitePlusiP70397

Expressioni

Gene expression databases

BgeeiENSMUSG00000029754 Expressed in 107 organ(s), highest expression level in retina
CleanExiMM_DLX6
ExpressionAtlasiP70397 baseline and differential
GenevisibleiP70397 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000124204

Structurei

3D structure databases

ProteinModelPortaliP70397
SMRiP70397
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the distal-less homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0850 Eukaryota
ENOG410ZHZR LUCA
GeneTreeiENSGT00920000148979
HOGENOMiHOG000231941
HOVERGENiHBG005493
InParanoidiP70397
KOiK09314
OMAiHQDSMQR
OrthoDBiEOG091G0P17
PhylomeDBiP70397
TreeFamiTF315720

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR000047 HTH_motif
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
PR00031 HTHREPRESSR
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P70397-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSHSQHSPYL QSYHNSSAAA QTRGDDTDQQ KTTVIENGEI RFNGKGKKIR
60 70 80 90 100
KPRTIYSSLQ LQALNHRFQQ TQYLALPERA ELAASLGLTQ TQVKIWFQNK
110 120 130 140 150
RSKFKKLLKQ GSNPHESDPL PGSAALSPRS PALPPVWDVS ASAKGVSMPP
160 170
NSYMPGYSHW YSSPHQDTMQ RPQMM
Length:175
Mass (Da):19,677
Last modified:July 10, 2007 - v3
Checksum:i55542638D7E0CA42
GO
Isoform 2 (identifier: P70397-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MMTMTTMADG...HRSLAAYPYM

Show »
Length:297
Mass (Da):33,011
Checksum:i4C6B6988CC62805E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J0C1A0A0R4J0C1_MOUSE
Homeobox protein DLX-6
Dlx6
158Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0407331M → MMTMTTMADGLEGQDSSKSA FMEFGQQQQQQQQQQQQQQQ QQQQQQQPPPPPPPPPPQPH SQQTSPAMAGAHYPLHCLHS AAAAAAAAGSHHHHHQHHHH GSPYASSGGNSYNHRSLAAY PYM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF535989 mRNA Translation: ABQ10645.1
AC122240 Genomic DNA No translation available.
BC114342 mRNA Translation: AAI14343.1
AF022078 mRNA Translation: AAB94583.1
U67841 mRNA Translation: AAC52844.1
CCDSiCCDS51719.1 [P70397-2]
RefSeqiNP_034187.1, NM_010057.2 [P70397-2]
UniGeneiMm.439763

Genome annotation databases

EnsembliENSMUST00000160937; ENSMUSP00000124204; ENSMUSG00000029754 [P70397-2]
ENSMUST00000171311; ENSMUSP00000128585; ENSMUSG00000029754 [P70397-2]
GeneIDi13396
KEGGimmu:13396
UCSCiuc009aww.1 mouse [P70397-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF535989 mRNA Translation: ABQ10645.1
AC122240 Genomic DNA No translation available.
BC114342 mRNA Translation: AAI14343.1
AF022078 mRNA Translation: AAB94583.1
U67841 mRNA Translation: AAC52844.1
CCDSiCCDS51719.1 [P70397-2]
RefSeqiNP_034187.1, NM_010057.2 [P70397-2]
UniGeneiMm.439763

3D structure databases

ProteinModelPortaliP70397
SMRiP70397
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000124204

PTM databases

iPTMnetiP70397
PhosphoSitePlusiP70397

Proteomic databases

PaxDbiP70397
PeptideAtlasiP70397
PRIDEiP70397

Protocols and materials databases

DNASUi13396
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000160937; ENSMUSP00000124204; ENSMUSG00000029754 [P70397-2]
ENSMUST00000171311; ENSMUSP00000128585; ENSMUSG00000029754 [P70397-2]
GeneIDi13396
KEGGimmu:13396
UCSCiuc009aww.1 mouse [P70397-2]

Organism-specific databases

CTDi1750
MGIiMGI:101927 Dlx6

Phylogenomic databases

eggNOGiKOG0850 Eukaryota
ENOG410ZHZR LUCA
GeneTreeiENSGT00920000148979
HOGENOMiHOG000231941
HOVERGENiHBG005493
InParanoidiP70397
KOiK09314
OMAiHQDSMQR
OrthoDBiEOG091G0P17
PhylomeDBiP70397
TreeFamiTF315720

Miscellaneous databases

PROiPR:P70397
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029754 Expressed in 107 organ(s), highest expression level in retina
CleanExiMM_DLX6
ExpressionAtlasiP70397 baseline and differential
GenevisibleiP70397 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR000047 HTH_motif
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
PR00031 HTHREPRESSR
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDLX6_MOUSE
AccessioniPrimary (citable) accession number: P70397
Secondary accession number(s): A0AUM1, A5HKN2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 10, 2007
Last modified: September 12, 2018
This is version 143 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again