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UniProtKB - P70397 (DLX6_MOUSE)
Protein
Homeobox protein DLX-6
Gene
Dlx6
Organism
Mus musculus (Mouse)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 49 – 108 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- anatomical structure formation involved in morphogenesis Source: MGI
- cell differentiation Source: GO_Central
- embryonic limb morphogenesis Source: MGI
- epithelial cell differentiation Source: MGI
- head development Source: MGI
- inner ear morphogenesis Source: MGI
- positive regulation of epithelial cell proliferation Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
- roof of mouth development Source: MGI
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Homeobox protein DLX-6 |
Gene namesi | Name:Dlx6 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:101927, Dlx6 |
VEuPathDBi | HostDB:ENSMUSG00000029754 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000049035 | 1 – 175 | Homeobox protein DLX-6Add BLAST | 175 |
Proteomic databases
PaxDbi | P70397 |
PeptideAtlasi | P70397 |
PRIDEi | P70397 |
ProteomicsDBi | 279556 [P70397-1] 279557 [P70397-2] |
PTM databases
iPTMneti | P70397 |
PhosphoSitePlusi | P70397 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000029754, Expressed in striatum and 138 other tissues |
ExpressionAtlasi | P70397, baseline and differential |
Genevisiblei | P70397, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000124204 |
Miscellaneous databases
RNActi | P70397, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 31 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 109 – 131 | DisorderedSequence analysisAdd BLAST | 23 |
Sequence similaritiesi
Belongs to the distal-less homeobox family.Curated
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0850, Eukaryota |
GeneTreei | ENSGT00940000157683 |
HOGENOMi | CLU_074733_2_0_1 |
InParanoidi | P70397 |
OMAi | MAGGHYP |
OrthoDBi | 1416398at2759 |
PhylomeDBi | P70397 |
TreeFami | TF315720 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa IPR000047, HTH_motif |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX PR00031, HTHREPRESSR |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: P70397-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSHSQHSPYL QSYHNSSAAA QTRGDDTDQQ KTTVIENGEI RFNGKGKKIR
60 70 80 90 100
KPRTIYSSLQ LQALNHRFQQ TQYLALPERA ELAASLGLTQ TQVKIWFQNK
110 120 130 140 150
RSKFKKLLKQ GSNPHESDPL PGSAALSPRS PALPPVWDVS ASAKGVSMPP
160 170
NSYMPGYSHW YSSPHQDTMQ RPQMM
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0R4J0C1 | A0A0R4J0C1_MOUSE | Homeobox protein DLX-6 | Dlx6 | 158 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_040733 | 1 | M → MMTMTTMADGLEGQDSSKSA FMEFGQQQQQQQQQQQQQQQ QQQQQQQPPPPPPPPPPQPH SQQTSPAMAGAHYPLHCLHS AAAAAAAAGSHHHHHQHHHH GSPYASSGGNSYNHRSLAAY PYM in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF535989 mRNA Translation: ABQ10645.1 AC122240 Genomic DNA No translation available. BC114342 mRNA Translation: AAI14343.1 AF022078 mRNA Translation: AAB94583.1 U67841 mRNA Translation: AAC52844.1 |
CCDSi | CCDS51719.1 [P70397-2] |
RefSeqi | NP_034187.1, NM_010057.2 [P70397-2] |
Genome annotation databases
Ensembli | ENSMUST00000160937; ENSMUSP00000124204; ENSMUSG00000029754 [P70397-2] ENSMUST00000171311; ENSMUSP00000128585; ENSMUSG00000029754 [P70397-2] |
GeneIDi | 13396 |
KEGGi | mmu:13396 |
UCSCi | uc009aww.1, mouse [P70397-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF535989 mRNA Translation: ABQ10645.1 AC122240 Genomic DNA No translation available. BC114342 mRNA Translation: AAI14343.1 AF022078 mRNA Translation: AAB94583.1 U67841 mRNA Translation: AAC52844.1 |
CCDSi | CCDS51719.1 [P70397-2] |
RefSeqi | NP_034187.1, NM_010057.2 [P70397-2] |
3D structure databases
SMRi | P70397 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000124204 |
PTM databases
iPTMneti | P70397 |
PhosphoSitePlusi | P70397 |
Proteomic databases
PaxDbi | P70397 |
PeptideAtlasi | P70397 |
PRIDEi | P70397 |
ProteomicsDBi | 279556 [P70397-1] 279557 [P70397-2] |
Protocols and materials databases
Antibodypediai | 30192, 184 antibodies from 24 providers |
DNASUi | 13396 |
Genome annotation databases
Ensembli | ENSMUST00000160937; ENSMUSP00000124204; ENSMUSG00000029754 [P70397-2] ENSMUST00000171311; ENSMUSP00000128585; ENSMUSG00000029754 [P70397-2] |
GeneIDi | 13396 |
KEGGi | mmu:13396 |
UCSCi | uc009aww.1, mouse [P70397-2] |
Organism-specific databases
CTDi | 1750 |
MGIi | MGI:101927, Dlx6 |
VEuPathDBi | HostDB:ENSMUSG00000029754 |
Phylogenomic databases
eggNOGi | KOG0850, Eukaryota |
GeneTreei | ENSGT00940000157683 |
HOGENOMi | CLU_074733_2_0_1 |
InParanoidi | P70397 |
OMAi | MAGGHYP |
OrthoDBi | 1416398at2759 |
PhylomeDBi | P70397 |
TreeFami | TF315720 |
Miscellaneous databases
BioGRID-ORCSi | 13396, 0 hits in 64 CRISPR screens |
PROi | PR:P70397 |
RNActi | P70397, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000029754, Expressed in striatum and 138 other tissues |
ExpressionAtlasi | P70397, baseline and differential |
Genevisiblei | P70397, MM |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa IPR000047, HTH_motif |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX PR00031, HTHREPRESSR |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DLX6_MOUSE | |
Accessioni | P70397Primary (citable) accession number: P70397 Secondary accession number(s): A0AUM1, A5HKN2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | July 10, 2007 | |
Last modified: | February 23, 2022 | |
This is version 160 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families