Dlx6

Functionⁱ

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	49 – 108	HomeoboxPROSITE-ProRule annotationAdd BLAST		60

GO - Molecular functionⁱ

sequence-specific DNA binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

anatomical structure formation involved in morphogenesis
Source: MGI
Inferred from genetic interactionⁱ
- 17878916
embryonic limb morphogenesis
Source: MGI
Inferred from genetic interactionⁱ
- 12112878
- 18326838
epithelial cell differentiation
Source: MGI
Inferred from genetic interactionⁱ
- 17878916
head development
Source: MGI
Inferred from genetic interactionⁱ
- 15306564
inner ear morphogenesis
Source: MGI
Inferred from genetic interactionⁱ
- 16900517
positive regulation of epithelial cell proliferation
Source: MGI
Inferred from genetic interactionⁱ
- 16900517
regulation of transcription, DNA-templated Source: InterPro
roof of mouth development
Source: MGI
Inferred from genetic interactionⁱ
- 17420000

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, DNA-binding

Molecular function

Developmental protein, DNA-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Homeobox protein DLX-6
Gene namesⁱ	Name:Dlx6
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 6

Organism-specific databases

MGIⁱ	MGI:101927 Dlx6

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000049035	1 – 175	Homeobox protein DLX-6Add BLAST		175

Proteomic databases

PaxDbⁱ	P70397
PeptideAtlas More...PeptideAtlasⁱ	P70397
PRIDEⁱ	P70397

PTM databases

iPTMnetⁱ	P70397
PhosphoSitePlusⁱ	P70397

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000029754 Expressed in 107 organ(s), highest expression level in retina
CleanExⁱ	MM_DLX6
ExpressionAtlasⁱ	P70397 baseline and differential
Genevisibleⁱ	P70397 MM

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000124204

STRINGⁱ

10090.ENSMUSP00000124204

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P70397
SMRⁱ	P70397
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the distal-less homeobox family.Curated

Keywords - Domainⁱ

Homeobox

Phylogenomic databases

eggNOGⁱ	KOG0850 Eukaryota ENOG410ZHZR LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000148979
HOGENOMⁱ	HOG000231941
HOVERGENⁱ	HBG005493
InParanoidⁱ	P70397
KEGG Orthology (KO) More...KOⁱ	K09314
OMAⁱ	HQDSMQR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0P17
PhylomeDBⁱ	P70397
TreeFamⁱ	TF315720

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR020479 Homeobox_metazoa IPR000047 HTH_motif
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit
PRINTSⁱ	PR00024 HOMEOBOX PR00031 HTHREPRESSR
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: P70397-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSHSQHSPYL QSYHNSSAAA QTRGDDTDQQ KTTVIENGEI RFNGKGKKIR 
        60         70         80         90        100
KPRTIYSSLQ LQALNHRFQQ TQYLALPERA ELAASLGLTQ TQVKIWFQNK 
       110        120        130        140        150
RSKFKKLLKQ GSNPHESDPL PGSAALSPRS PALPPVWDVS ASAKGVSMPP 
       160        170 
NSYMPGYSHW YSSPHQDTMQ RPQMM

Length:175

Mass (Da):19,677

Last modified:July 10, 2007 - v3

Checksum:ⁱ55542638D7E0CA42

GO

Isoform 2 (identifier: P70397-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MMTMTTMADG...HRSLAAYPYM

« Hide

        10         20         30         40         50
MMTMTTMADG LEGQDSSKSA FMEFGQQQQQ QQQQQQQQQQ QQQQQQQPPP 
        60         70         80         90        100
PPPPPPPQPH SQQTSPAMAG AHYPLHCLHS AAAAAAAAGS HHHHHQHHHH 
       110        120        130        140        150
GSPYASSGGN SYNHRSLAAY PYMSHSQHSP YLQSYHNSSA AAQTRGDDTD 
       160        170        180        190        200
QQKTTVIENG EIRFNGKGKK IRKPRTIYSS LQLQALNHRF QQTQYLALPE 
       210        220        230        240        250
RAELAASLGL TQTQVKIWFQ NKRSKFKKLL KQGSNPHESD PLPGSAALSP 
       260        270        280        290 
RSPALPPVWD VSASAKGVSM PPNSYMPGYS HWYSSPHQDT MQRPQMM

Show »

Length:297

Mass (Da):33,011

Checksum:ⁱ4C6B6988CC62805E

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A0R4J0C1	A0A0R4J0C1_MOUSE		Homeobox protein DLX-6 Homeobox protein DLX-6	Dlx6	158	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_040733	1	M → MMTMTTMADGLEGQDSSKSA FMEFGQQQQQQQQQQQQQQQ QQQQQQQPPPPPPPPPPQPH SQQTSPAMAGAHYPLHCLHS AAAAAAAAGSHHHHHQHHHH GSPYASSGGNSYNHRSLAAY PYM in isoform 2. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	EF535989 mRNA Translation: ABQ10645.1 AC122240 Genomic DNA No translation available. BC114342 mRNA Translation: AAI14343.1 AF022078 mRNA Translation: AAB94583.1 U67841 mRNA Translation: AAC52844.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS51719.1 [P70397-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_034187.1, NM_010057.2 [P70397-2]
UniGeneⁱ	Mm.439763

Genome annotation databases

Ensemblⁱ	ENSMUST00000160937; ENSMUSP00000124204; ENSMUSG00000029754 [P70397-2] ENSMUST00000171311; ENSMUSP00000128585; ENSMUSG00000029754 [P70397-2]
GeneIDⁱ	13396
KEGGⁱ	mmu:13396
UCSC genome browser More...UCSCⁱ	uc009aww.1 mouse [P70397-2]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P70397	Homeobox protein DLX-6 (Fragment)		MOUSE		158	UniRef100_P70397
Uncharacterized protein		PIG		175
Similar to Homeobox protein DLX-6 (Predicted)		RAT		175
Distal-less homeobox 6		ICTTR		175
UPI000DC66A50		dingo		373
+1

Protein	Similar proteins		Species	Score	Length	Source
P70397	Homeobox protein DLX-6 (Fragment)		MOUSE		158	UniRef90_P70397
Uncharacterized protein		PIG		175
Similar to Homeobox protein DLX-6 (Predicted)		RAT		175
Distal-less homeobox 6		ICTTR		175
UPI000DC66A50		dingo		373
+6
P70397-2	Homeobox protein DLX-6		HUMAN		175	UniRef90_P70397-2
homeobox protein DLX-6		PHYCD		298
homeobox protein DLX-6		MESAU		298
homeobox protein DLX-6		TURTR		297
homeobox protein DLX-6		DELLE		296
+54

Protein	Similar proteins		Species	Score	Length	Source
P70397	Homeobox protein DLX-6 (Fragment)		MOUSE		158	UniRef50_P70397
Uncharacterized protein		PIG		175
Similar to Homeobox protein DLX-6 (Predicted)		RAT		175
Distal-less homeobox 6		ICTTR		175
Uncharacterized protein		CALSU		311
+18
P70397-2	Homeobox protein DLX-6		HUMAN		175	UniRef50_P70397-2
Homeobox protein Dlx6a		DANRE		247
Homeobox protein DLL-1		XENLA		250
homeobox protein DLX-6		MESAU		298
homeobox protein DLX-6		PHYCD		298
+267

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	EF535989 mRNA Translation: ABQ10645.1 AC122240 Genomic DNA No translation available. BC114342 mRNA Translation: AAI14343.1 AF022078 mRNA Translation: AAB94583.1 U67841 mRNA Translation: AAC52844.1
CCDSⁱ	CCDS51719.1 [P70397-2]
RefSeqⁱ	NP_034187.1, NM_010057.2 [P70397-2]
UniGeneⁱ	Mm.439763

3D structure databases

ProteinModelPortalⁱ	P70397
SMRⁱ	P70397
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000124204

STRINGⁱ

10090.ENSMUSP00000124204

PTM databases

iPTMnetⁱ	P70397
PhosphoSitePlusⁱ	P70397

Proteomic databases

PaxDbⁱ	P70397
PeptideAtlasⁱ	P70397
PRIDEⁱ	P70397

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	13396
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000160937; ENSMUSP00000124204; ENSMUSG00000029754 [P70397-2] ENSMUST00000171311; ENSMUSP00000128585; ENSMUSG00000029754 [P70397-2]
GeneIDⁱ	13396
KEGGⁱ	mmu:13396
UCSCⁱ	uc009aww.1 mouse [P70397-2]

Organism-specific databases

CTDⁱ	1750
MGIⁱ	MGI:101927 Dlx6

Phylogenomic databases

eggNOGⁱ	KOG0850 Eukaryota ENOG410ZHZR LUCA
GeneTreeⁱ	ENSGT00920000148979
HOGENOMⁱ	HOG000231941
HOVERGENⁱ	HBG005493
InParanoidⁱ	P70397
KOⁱ	K09314
OMAⁱ	HQDSMQR
OrthoDBⁱ	EOG091G0P17
PhylomeDBⁱ	P70397
TreeFamⁱ	TF315720

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P70397
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000029754 Expressed in 107 organ(s), highest expression level in retina
CleanExⁱ	MM_DLX6
ExpressionAtlasⁱ	P70397 baseline and differential
Genevisibleⁱ	P70397 MM

Family and domain databases

CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR020479 Homeobox_metazoa IPR000047 HTH_motif
Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit
PRINTSⁱ	PR00024 HOMEOBOX PR00031 HTHREPRESSR
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DLX6_MOUSE
Accessionⁱ	P70397Primary (citable) accession number: P70397 Secondary accession number(s): A0AUM1, A5HKN2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	July 10, 2007
	Last modified:	September 12, 2018
	This is version 143 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P70397 (DLX6_MOUSE)

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Homeobox protein DLX-6

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ