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Protein

Insulin-like growth factor-binding protein complex acid labile subunit

Gene

Igfals

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May have an important role in regulating the access of circulating IGFs to the tissues.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein complex acid labile subunit
Short name:
ALS
Gene namesi
Name:Igfals
Synonyms:Albs, Als
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:107973 Igfals

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23By similarityAdd BLAST23
ChainiPRO_000002069624 – 603Insulin-like growth factor-binding protein complex acid labile subunitAdd BLAST580

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi64N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi85N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi96N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi368N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi515N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi578N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi586N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP70389
PaxDbiP70389
PeptideAtlasiP70389
PRIDEiP70389

PTM databases

iPTMnetiP70389
PhosphoSitePlusiP70389

Interactioni

Subunit structurei

Forms a ternary complex of about 140 to 150 kDa with IGF-I or IGF-II and IGFBP-3.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiP70389, 2 interactors
MINTiP70389
STRINGi10090.ENSMUSP00000060169

Structurei

3D structure databases

ProteinModelPortaliP70389
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 74LRRNTAdd BLAST43
Repeati75 – 96LRR 1Add BLAST22
Repeati99 – 120LRR 2Add BLAST22
Repeati123 – 144LRR 3Add BLAST22
Repeati147 – 168LRR 4Add BLAST22
Repeati171 – 192LRR 5Add BLAST22
Repeati195 – 216LRR 6Add BLAST22
Repeati219 – 240LRR 7Add BLAST22
Repeati243 – 264LRR 8Add BLAST22
Repeati267 – 288LRR 9Add BLAST22
Repeati291 – 312LRR 10Add BLAST22
Repeati315 – 336LRR 11Add BLAST22
Repeati339 – 360LRR 12Add BLAST22
Repeati363 – 384LRR 13Add BLAST22
Repeati387 – 408LRR 14Add BLAST22
Repeati411 – 432LRR 15Add BLAST22
Repeati435 – 456LRR 16Add BLAST22
Repeati459 – 480LRR 17Add BLAST22
Repeati483 – 504LRR 18Add BLAST22
Repeati507 – 528LRR 19Add BLAST22
Domaini535 – 603LRRCTAdd BLAST69

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
HOVERGENiHBG000327
InParanoidiP70389
KOiK17256
PhylomeDBiP70389
TreeFamiTF351124

Family and domain databases

Gene3Di3.80.10.10, 4 hits
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
PfamiView protein in Pfam
PF13855 LRR_8, 4 hits
PF01462 LRRNT, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 19 hits
SM00082 LRRCT, 1 hit
SM00013 LRRNT, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P70389-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALRTGSPAL VVLLAFWVAL GPCYLQGTDP GASADAEGPQ CPVTCTCSYD
60 70 80 90 100
DYTDELSVFC SSRNLTQLPD GIPVSTRALW LDGNNLSSIP SAAFQNLSSL
110 120 130 140 150
DFLNLQGSWL RSLEPQALLG LQNLYHLHLE RNLLRSLAAG LFRHTPSLAS
160 170 180 190 200
LSLGNNLLGR LEEGLFRGLS HLWDLNLGWN SLVVLPDTVF QGLGNLHELV
210 220 230 240 250
LAGNKLTYLQ PALLCGLGEL RELDLSRNAL RSVKANVFIH LPRLQKLYLD
260 270 280 290 300
RNLITAVAPR AFLGMKALRW LDLSHNRVAG LLEDTFPGLL GLHVLRLAHN
310 320 330 340 350
AITSLRPRTF KDLHFLEELQ LGHNRIRQLG EKTFEGLGQL EVLTLNDNQI
360 370 380 390 400
HEVKVGAFFG LFNVAVMNLS GNCLRSLPEH VFQGLGRLHS LHLEHSCLGR
410 420 430 440 450
IRLHTFAGLS GLRRLFLRDN SISSIEEQSL AGLSELLELD LTANQLTHLP
460 470 480 490 500
RQLFQGLGQL EYLLLSNNQL TMLSEDVLGP LQRAFWLDLS HNRLETPAEG
510 520 530 540 550
LFSSLGRLRY LNLRNNSLQT FVPQPGLERL WLDANPWDCS CPLKALRDFA
560 570 580 590 600
LQNPGVVPRF VQTVCEGDDC QPVYTYNNIT CAGPANVSGL DLRDISETLF

VHC
Length:603
Mass (Da):66,960
Last modified:February 1, 1997 - v1
Checksum:i4A6223AEC7026BCC
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J0S2A0A0R4J0S2_MOUSE
Insulin-like growth factor-binding ...
Igfals
603Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti71G → S in BAB23677 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66900 Genomic DNA Translation: AAB17270.1
AK004926 mRNA Translation: BAB23677.1
CCDSiCCDS37497.1
PIRiJC6128
RefSeqiNP_032366.2, NM_008340.3
UniGeneiMm.3135

Genome annotation databases

GeneIDi16005
KEGGimmu:16005

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66900 Genomic DNA Translation: AAB17270.1
AK004926 mRNA Translation: BAB23677.1
CCDSiCCDS37497.1
PIRiJC6128
RefSeqiNP_032366.2, NM_008340.3
UniGeneiMm.3135

3D structure databases

ProteinModelPortaliP70389
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP70389, 2 interactors
MINTiP70389
STRINGi10090.ENSMUSP00000060169

PTM databases

iPTMnetiP70389
PhosphoSitePlusiP70389

Proteomic databases

MaxQBiP70389
PaxDbiP70389
PeptideAtlasiP70389
PRIDEiP70389

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi16005
KEGGimmu:16005

Organism-specific databases

CTDi3483
MGIiMGI:107973 Igfals

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
HOVERGENiHBG000327
InParanoidiP70389
KOiK17256
PhylomeDBiP70389
TreeFamiTF351124

Miscellaneous databases

PROiPR:P70389
SOURCEiSearch...

Family and domain databases

Gene3Di3.80.10.10, 4 hits
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
PfamiView protein in Pfam
PF13855 LRR_8, 4 hits
PF01462 LRRNT, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 19 hits
SM00082 LRRCT, 1 hit
SM00013 LRRNT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiALS_MOUSE
AccessioniPrimary (citable) accession number: P70389
Secondary accession number(s): Q9DBI7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: July 18, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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