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Protein

Interleukin-18

Gene

Il18

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

A proinflammatory cytokine primarily involved in polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells.By similarity

GO - Molecular functioni

  • cytokine activity Source: MGI
  • interleukin-18 receptor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processInflammatory response

Enzyme and pathway databases

ReactomeiR-MMU-448706 Interleukin-1 processing
R-MMU-9012546 Interleukin-18 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-18
Short name:
IL-18
Alternative name(s):
Interferon gamma-inducing factor
Short name:
IFN-gamma-inducing factor
Interleukin-1 gamma
Short name:
IL-1 gamma
Gene namesi
Name:Il18Imported
Synonyms:Igif
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:107936 Il18

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000153451 – 35Add BLAST35
ChainiPRO_000001534636 – 192Interleukin-18Add BLAST157

Post-translational modificationi

The pro-IL-18 precursor is processed by CASP1 or CASP4 to yield the active form.By similarity

Proteomic databases

PaxDbiP70380
PRIDEiP70380

PTM databases

PhosphoSitePlusiP70380

Expressioni

Gene expression databases

BgeeiENSMUSG00000039217 Expressed in 246 organ(s), highest expression level in epithelium of stomach
CleanExiMM_IL18
ExpressionAtlasiP70380 baseline and differential
GenevisibleiP70380 MM

Interactioni

Subunit structurei

Forms a ternary complex with ligand-binding receptor subunit IL18R1 and signaling receptor subunit IL18RAP at the plasma membrane. Mature IL18 first binds to IL18R1 forming a low affinity binary complex, which then interacts with IL18RAP to form a high affinity ternary complex that signals inside the cell.By similarity

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-950N
STRINGi10090.ENSMUSP00000137193

Structurei

3D structure databases

ProteinModelPortaliP70380
SMRiP70380
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-1 family.Curated

Phylogenomic databases

eggNOGiENOG410J3U9 Eukaryota
ENOG410ZGS8 LUCA
GeneTreeiENSGT00390000001053
HOGENOMiHOG000048723
HOVERGENiHBG000388
InParanoidiP70380
KOiK05482
OMAiYKGYFLA
OrthoDBiEOG091G0NGF
PhylomeDBiP70380

Family and domain databases

InterProiView protein in InterPro
IPR015529 IL-18
IPR000975 IL-1_fam
IPR008996 IL1/FGF
PANTHERiPTHR45200 PTHR45200, 1 hit
PfamiView protein in Pfam
PF00340 IL1, 1 hit
PIRSFiPIRSF015162 Interleukin_18, 1 hit
PRINTSiPR01933 INTRLEUKIN18
SUPFAMiSSF50353 SSF50353, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P70380-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAMSEDSCV NFKEMMFIDN TLYFIPEENG DLESDNFGRL HCTTAVIRNI
60 70 80 90 100
NDQVLFVDKR QPVFEDMTDI DQSASEPQTR LIIYMYKDSE VRGLAVTLSV
110 120 130 140 150
KDSKMSTLSC KNKIISFEEM DPPENIDDIQ SDLIFFQKRV PGHNKMEFES
160 170 180 190
SLYEGHFLAC QKEDDAFKLI LKKKDENGDK SVMFTLTNLH QS
Length:192
Mass (Da):22,135
Last modified:July 15, 1998 - v2
Checksum:i8FED938473874D63
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K3W4N2K3W4N2_MOUSE
Interleukin-18
Il18
192Annotation score:
A0A1L1STF5A0A1L1STF5_MOUSE
Interleukin-18
Il18
78Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti183 – 185MFT → IS in AAB49753 (PubMed:9022080).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49949 mRNA Translation: BAA08705.1
BC024384 mRNA Translation: AAH24384.1
U66244 mRNA Translation: AAB49753.1
CCDSiCCDS40622.1
PIRiS60226
RefSeqiNP_032386.1, NM_008360.1
XP_006510089.1, XM_006510026.1
XP_006510090.1, XM_006510027.3
XP_006510091.1, XM_006510028.3
UniGeneiMm.1410

Genome annotation databases

EnsembliENSMUST00000180021; ENSMUSP00000137193; ENSMUSG00000039217
ENSMUST00000214117; ENSMUSP00000151002; ENSMUSG00000039217
GeneIDi16173
KEGGimmu:16173
UCSCiuc009pju.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49949 mRNA Translation: BAA08705.1
BC024384 mRNA Translation: AAH24384.1
U66244 mRNA Translation: AAB49753.1
CCDSiCCDS40622.1
PIRiS60226
RefSeqiNP_032386.1, NM_008360.1
XP_006510089.1, XM_006510026.1
XP_006510090.1, XM_006510027.3
XP_006510091.1, XM_006510028.3
UniGeneiMm.1410

3D structure databases

ProteinModelPortaliP70380
SMRiP70380
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-950N
STRINGi10090.ENSMUSP00000137193

PTM databases

PhosphoSitePlusiP70380

Proteomic databases

PaxDbiP70380
PRIDEiP70380

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000180021; ENSMUSP00000137193; ENSMUSG00000039217
ENSMUST00000214117; ENSMUSP00000151002; ENSMUSG00000039217
GeneIDi16173
KEGGimmu:16173
UCSCiuc009pju.1 mouse

Organism-specific databases

CTDi3606
MGIiMGI:107936 Il18

Phylogenomic databases

eggNOGiENOG410J3U9 Eukaryota
ENOG410ZGS8 LUCA
GeneTreeiENSGT00390000001053
HOGENOMiHOG000048723
HOVERGENiHBG000388
InParanoidiP70380
KOiK05482
OMAiYKGYFLA
OrthoDBiEOG091G0NGF
PhylomeDBiP70380

Enzyme and pathway databases

ReactomeiR-MMU-448706 Interleukin-1 processing
R-MMU-9012546 Interleukin-18 signaling

Miscellaneous databases

PROiPR:P70380
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039217 Expressed in 246 organ(s), highest expression level in epithelium of stomach
CleanExiMM_IL18
ExpressionAtlasiP70380 baseline and differential
GenevisibleiP70380 MM

Family and domain databases

InterProiView protein in InterPro
IPR015529 IL-18
IPR000975 IL-1_fam
IPR008996 IL1/FGF
PANTHERiPTHR45200 PTHR45200, 1 hit
PfamiView protein in Pfam
PF00340 IL1, 1 hit
PIRSFiPIRSF015162 Interleukin_18, 1 hit
PRINTSiPR01933 INTRLEUKIN18
SUPFAMiSSF50353 SSF50353, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIL18_MOUSE
AccessioniPrimary (citable) accession number: P70380
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: November 7, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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