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Protein

Telomeric repeat-binding factor 1

Gene

Terf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi390 – 415H-T-H motifPROSITE-ProRule annotationAdd BLAST26

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-MMU-171306 Packaging Of Telomere Ends
R-MMU-2559586 DNA Damage/Telomere Stress Induced Senescence

Names & Taxonomyi

Protein namesi
Recommended name:
Telomeric repeat-binding factor 1
Alternative name(s):
TTAGGG repeat-binding factor 1
Gene namesi
Name:Terf1
Synonyms:Trf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:109634 Terf1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Cytoplasm, Cytoskeleton, Nucleus, Telomere

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001971302 – 421Telomeric repeat-binding factor 1Add BLAST420

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Cross-linki200Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei206Phosphoserine; by ATMBy similarity1

Post-translational modificationi

Phosphorylated preferentially on Ser-219 in an ATM-dependent manner in response to ionizing DNA damage.By similarity
ADP-ribosylation by TNKS1 or TNKS2 diminishes its ability to bind to telomeric DNA.By similarity
Ubiquitinated by RLIM/RNF12, leading to its degradation by the proteasome. Ubiquitinated by a SCF (SKP1-CUL1-F-box protein) ubiquitin-protein ligase complex, leading to its degradation by the proteasome (By similarity).By similarity

Keywords - PTMi

Acetylation, ADP-ribosylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP70371
MaxQBiP70371
PaxDbiP70371
PeptideAtlasiP70371
PRIDEiP70371

PTM databases

iPTMnetiP70371
PhosphoSitePlusiP70371

Expressioni

Gene expression databases

BgeeiENSMUSG00000025925 Expressed in 273 organ(s), highest expression level in testis
CleanExiMM_TERF1
ExpressionAtlasiP70371 baseline and differential
GenevisibleiP70371 MM

Interactioni

Subunit structurei

Homodimer; can contain both isoforms. Found in a complex with POT1; TINF2 and TNKS1. Interacts with ATM, TINF2, TNKS1, TNKS2, PINX1, NEK2 and MAPRE1. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP ACD and POT1. Interacts with RLIM (via N-terminus). Interacts with FBXO4. Interaction with TINF2 protects against interaction with FBXO4 and subsequent polyubiquitination and proteasomal degradation (By similarity). Interacts with GNL3L; this interaction promotes homodimerization. Interacts with TIN2. Interactions with GNL3L and TIN2 are mutually exclusive. Interacts with RTEL1 (By similarity). Interacts with CCDC79/TERB1.By similarity2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204116, 11 interactors
ComplexPortaliCPX-153 Shelterin complex
DIPiDIP-44231N
IntActiP70371, 15 interactors
MINTiP70371
STRINGi10090.ENSMUSP00000027057

Structurei

3D structure databases

ProteinModelPortaliP70371
SMRiP70371
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini362 – 419HTH myb-typePROSITE-ProRule annotationAdd BLAST58

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni49 – 255TRFH dimerizationBy similarityAdd BLAST207
Regioni252 – 365Interaction with RLIMBy similarityAdd BLAST114

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi313 – 367Nuclear localization signalSequence analysisAdd BLAST55

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 67Asp/Glu-rich (acidic)Add BLAST66

Domaini

The acidic N-terminal domain binds to the ankyrin repeats of TNKS1 and TNKS2. The C-terminal domain binds microtubules (By similarity).By similarity
The TRFH dimerization region mediates the interaction with TINF2.By similarity
The HTH domain is an independent structural unit and mediates binding to telomeric DNA.By similarity

Phylogenomic databases

eggNOGiENOG410IIKA Eukaryota
ENOG4111QH9 LUCA
GeneTreeiENSGT00530000063796
HOGENOMiHOG000132847
HOVERGENiHBG054097
InParanoidiP70371
KOiK11110
OMAiQKAWLWE
OrthoDBiEOG091G04CC
PhylomeDBiP70371
TreeFamiTF333209

Family and domain databases

Gene3Di1.25.40.210, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017930 Myb_dom
IPR001005 SANT/Myb
IPR013867 Telomere_rpt-bd_fac_dimer_dom
IPR036507 Telomere_rpt-bd_fac_dimer_sf
IPR017357 TERF1/2
PfamiView protein in Pfam
PF00249 Myb_DNA-binding, 1 hit
PF08558 TRF, 1 hit
PIRSFiPIRSF038016 Telomere_bd-1_Pin2, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD014243 Telomere_repeat-bd_fac_dimer, 1 hit
SMARTiView protein in SMART
SM00717 SANT, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF63600 SSF63600, 1 hit
PROSITEiView protein in PROSITE
PS51294 HTH_MYB, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P70371-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAETVSSAAR DAPSREGWTD SDSPEQEEVG DDAELLQCQL QLGTPREMEN
60 70 80 90 100
AELVAEVEAV AAGWMLDFLC LSLCRAFRDG RSEDFRRTRD SAEAIIHGLH
110 120 130 140 150
RLTAYQLKTV YICQFLTRVA SGKALDAQFE VDERITPLES ALMIWNSIEK
160 170 180 190 200
EHDKLHDEIK NLIKIQAVAV CMEIGSFKEA EEVFERIFGD PEFYTPLERK
210 220 230 240 250
LLKIISQKDV FHSLFQHFSY SCMMEKIQSY VGDVLSEKSS TFLMKAATKV
260 270 280 290 300
VENEKARTQA SKDRPDATNT GMDTEVGLNK EKSVNGQQST ETEPLVDTVS
310 320 330 340 350
SIRSHKNALS QLKHRRAPSD FSRNEARTGT LQCETTMERN RRTSGRNRLC
360 370 380 390 400
VSENQPDTDD KSGRRKRQTW LWEEDRILKC GVKKYGEGNW AKILSHYKFN
410 420
NRTSVMLKDR WRTMKRLKLI S
Length:421
Mass (Da):48,224
Last modified:February 1, 1997 - v1
Checksum:i3F648F18C3ECF20A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3V252Q3V252_MOUSE
Telomeric repeat-binding factor
Terf1
392Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti283 – 312SVNGQ…ALSQL → RSFAPSLPYGSTSCDYHIRK QTGIYGIIIQ (PubMed:16141072).CuratedAdd BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65586 mRNA Translation: AAB53970.1
BC034866 mRNA Translation: AAH34866.1
U70994 Genomic DNA Translation: AAB17974.1
AK021235 mRNA Translation: BAB32340.1
CCDSiCCDS14827.1
RefSeqiNP_033378.1, NM_009352.3
UniGeneiMm.4306

Genome annotation databases

EnsembliENSMUST00000188371; ENSMUSP00000140744; ENSMUSG00000025925
GeneIDi21749
KEGGimmu:21749
UCSCiuc007ajf.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65586 mRNA Translation: AAB53970.1
BC034866 mRNA Translation: AAH34866.1
U70994 Genomic DNA Translation: AAB17974.1
AK021235 mRNA Translation: BAB32340.1
CCDSiCCDS14827.1
RefSeqiNP_033378.1, NM_009352.3
UniGeneiMm.4306

3D structure databases

ProteinModelPortaliP70371
SMRiP70371
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204116, 11 interactors
ComplexPortaliCPX-153 Shelterin complex
DIPiDIP-44231N
IntActiP70371, 15 interactors
MINTiP70371
STRINGi10090.ENSMUSP00000027057

PTM databases

iPTMnetiP70371
PhosphoSitePlusiP70371

Proteomic databases

EPDiP70371
MaxQBiP70371
PaxDbiP70371
PeptideAtlasiP70371
PRIDEiP70371

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000188371; ENSMUSP00000140744; ENSMUSG00000025925
GeneIDi21749
KEGGimmu:21749
UCSCiuc007ajf.2 mouse

Organism-specific databases

CTDi7013
MGIiMGI:109634 Terf1

Phylogenomic databases

eggNOGiENOG410IIKA Eukaryota
ENOG4111QH9 LUCA
GeneTreeiENSGT00530000063796
HOGENOMiHOG000132847
HOVERGENiHBG054097
InParanoidiP70371
KOiK11110
OMAiQKAWLWE
OrthoDBiEOG091G04CC
PhylomeDBiP70371
TreeFamiTF333209

Enzyme and pathway databases

ReactomeiR-MMU-171306 Packaging Of Telomere Ends
R-MMU-2559586 DNA Damage/Telomere Stress Induced Senescence

Miscellaneous databases

PROiPR:P70371
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025925 Expressed in 273 organ(s), highest expression level in testis
CleanExiMM_TERF1
ExpressionAtlasiP70371 baseline and differential
GenevisibleiP70371 MM

Family and domain databases

Gene3Di1.25.40.210, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017930 Myb_dom
IPR001005 SANT/Myb
IPR013867 Telomere_rpt-bd_fac_dimer_dom
IPR036507 Telomere_rpt-bd_fac_dimer_sf
IPR017357 TERF1/2
PfamiView protein in Pfam
PF00249 Myb_DNA-binding, 1 hit
PF08558 TRF, 1 hit
PIRSFiPIRSF038016 Telomere_bd-1_Pin2, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD014243 Telomere_repeat-bd_fac_dimer, 1 hit
SMARTiView protein in SMART
SM00717 SANT, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF63600 SSF63600, 1 hit
PROSITEiView protein in PROSITE
PS51294 HTH_MYB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTERF1_MOUSE
AccessioniPrimary (citable) accession number: P70371
Secondary accession number(s): Q9CY71
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 7, 2018
This is version 167 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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