UniProtKB - P70365 (NCOA1_MOUSE)
Nuclear receptor coactivator 1
Ncoa1
Functioni
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.
4 PublicationsCatalytic activityi
- EC:2.3.1.48
GO - Molecular functioni
- aryl hydrocarbon receptor binding Source: MGI
- chromatin binding Source: MGI
- DNA binding Source: MGI
- enzyme binding Source: MGI
- estrogen receptor binding Source: MGI
- histone acetyltransferase activity Source: UniProtKB-EC
- nuclear receptor binding Source: MGI
- nuclear receptor coactivator activity Source: MGI
- progesterone receptor binding Source: MGI
- protein-containing complex binding Source: MGI
- protein dimerization activity Source: InterPro
- protein N-terminus binding Source: MGI
- retinoic acid receptor binding Source: MGI
- retinoid X receptor binding Source: MGI
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: MGI
- transcription coactivator activity Source: UniProtKB
GO - Biological processi
- cellular response to hormone stimulus Source: MGI
- cellular response to Thyroglobulin triiodothyronine Source: MGI
- histone H4 acetylation Source: UniProtKB
- labyrinthine layer morphogenesis Source: MGI
- male mating behavior Source: MGI
- mRNA transcription by RNA polymerase II Source: MGI
- peroxisome proliferator activated receptor signaling pathway Source: ComplexPortal
- positive regulation of adipose tissue development Source: ComplexPortal
- positive regulation of apoptotic process Source: UniProtKB
- positive regulation of female receptivity Source: MGI
- positive regulation of neuron differentiation Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: MGI
- positive regulation of transcription from RNA polymerase II promoter by galactose Source: UniProtKB
- regulation of cellular response to insulin stimulus Source: ComplexPortal
- regulation of thyroid hormone mediated signaling pathway Source: MGI
- response to estradiol Source: MGI
- response to progesterone Source: MGI
- response to retinoic acid Source: MGI
Keywordsi
Molecular function | Activator, Acyltransferase, Transferase |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-MMU-159418, Recycling of bile acids and salts R-MMU-192105, Synthesis of bile acids and bile salts R-MMU-193368, Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-MMU-193807, Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-MMU-211976, Endogenous sterols R-MMU-3214847, HATs acetylate histones R-MMU-3899300, SUMOylation of transcription cofactors R-MMU-400206, Regulation of lipid metabolism by PPARalpha R-MMU-9018519, Estrogen-dependent gene expression R-MMU-9029569, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-MMU-9623433, NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-MMU-9707564, Cytoprotection by HMOX1 |
Names & Taxonomyi
Protein namesi | Recommended name: Nuclear receptor coactivator 1 (EC:2.3.1.48)Short name: NCoA-1 Alternative name(s): Nuclear receptor coactivator protein 1 Short name: mNRC-1 Steroid receptor coactivator 1 Short name: SRC-1 |
Gene namesi | Name:Ncoa1 Synonyms:Src1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1276523, Ncoa1 |
VEuPathDBi | HostDB:ENSMUSG00000020647 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation1 Publication
Cytosol
- cytosol Source: MGI
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: MGI
- RNA polymerase II transcription regulator complex Source: MGI
Plasma Membrane
- plasma membrane Source: MGI
Other locations
- chromatin Source: MGI
- cytoplasm Source: MGI
- neuron projection Source: MGI
- protein-containing complex Source: MGI
- transcription regulator complex Source: MGI
Keywords - Cellular componenti
NucleusPathology & Biotechi
Disruption phenotypei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 695 – 698 | HRLL → AAAA: Abolishes the interactions with estrogen and retinoid-acids receptors. 1 Publication | 4 | |
Mutagenesisi | 756 – 759 | RYLL → AAAA: Abolishes the interactions with estrogen and retinoid-acids receptors. 1 Publication | 4 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000094401 | 2 – 1447 | Nuclear receptor coactivator 1Add BLAST | 1446 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineBy similarity | 1 | |
Modified residuei | 22 | PhosphoserineCombined sources | 1 | |
Modified residuei | 372 | PhosphoserineCombined sources | 1 | |
Modified residuei | 395 | PhosphoserineBy similarity | 1 | |
Modified residuei | 518 | PhosphoserineBy similarity | 1 | |
Modified residuei | 559 | PhosphoserineCombined sources | 1 | |
Modified residuei | 570 | PhosphoserineBy similarity | 1 | |
Modified residuei | 702 | PhosphoserineCombined sources | 1 | |
Cross-linki | 738 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity | ||
Cross-linki | 780 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity | ||
Cross-linki | 852 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 1039 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1079 | Asymmetric dimethylarginineCombined sources | 1 | |
Modified residuei | 1097 | Asymmetric dimethylarginineCombined sources | 1 | |
Modified residuei | 1130 | Asymmetric dimethylarginineCombined sources | 1 | |
Modified residuei | 1137 | Asymmetric dimethylarginineCombined sources | 1 | |
Modified residuei | 1185 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 1191 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1378 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P70365 |
jPOSTi | P70365 |
MaxQBi | P70365 |
PaxDbi | P70365 |
PeptideAtlasi | P70365 |
PRIDEi | P70365 |
ProteomicsDBi | 293632 [P70365-1] 293633 [P70365-2] 293634 [P70365-3] 293635 [P70365-4] |
PTM databases
iPTMneti | P70365 |
PhosphoSitePlusi | P70365 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000020647, Expressed in rostral migratory stream and 325 other tissues |
ExpressionAtlasi | P70365, baseline and differential |
Genevisiblei | P70365, MM |
Interactioni
Subunit structurei
Interacts with NCOA6 and NCOA2.
Interacts with the FDL motif of STAT5A and STAT5B.
Interacts with the LXXLL motif of STAT6.
Interacts with STAT3 following IL-6 stimulation.
Interacts with the basal transcription factor GTF2B.
Interacts with COPS5, NR3C1, PCAF and TTLL5/STAMP.
Interacts with the histone acetyltransferases EP300 and CREBBP, and the methyltransferase CARM1.
Interacts with PSMB9.
Interacts with UBE2L3; they functionally interact to regulate progesterone receptor transcriptional activity.
Interacts with PRMT2 and DDX5.
Interacts with ASXL1.
Interacts with PRMT6.
Interacts (via LXXLL 1, 2 and 3 motifs) with RORC (via AF-2 motif).
Interacts in a ligand-dependent fashion with RXRA.
Interacts with TRIP4.
Interacts with NR4A3 (PubMed:12709428).
Interacts with VDR (By similarity).
By similarity6 PublicationsGO - Molecular functioni
- aryl hydrocarbon receptor binding Source: MGI
- enzyme binding Source: MGI
- estrogen receptor binding Source: MGI
- nuclear receptor binding Source: MGI
- progesterone receptor binding Source: MGI
- protein dimerization activity Source: InterPro
- protein N-terminus binding Source: MGI
- retinoic acid receptor binding Source: MGI
- retinoid X receptor binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 201707, 14 interactors |
ComplexPortali | CPX-5343, RXRalpha-NCOA1 activated retinoic acid receptor complex CPX-644, PXR-NCOA1 activated nuclear receptor complex CPX-667, RARalpha-NCOA1 activated retinoic acid receptor complex CPX-864, PPARgamma-NCOA1 activated nuclear receptor complex |
CORUMi | P70365 |
IntActi | P70365, 3 interactors |
MINTi | P70365 |
STRINGi | 10090.ENSMUSP00000082971 |
Miscellaneous databases
RNActi | P70365, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P70365 |
SMRi | P70365 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P70365 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 23 – 80 | bHLHPROSITE-ProRule annotationAdd BLAST | 58 | |
Domaini | 109 – 180 | PASPROSITE-ProRule annotationAdd BLAST | 72 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 39 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 83 – 105 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 361 – 568 | Interaction with STAT3Add BLAST | 208 | |
Regioni | 368 – 446 | DisorderedSequence analysisAdd BLAST | 79 | |
Regioni | 459 – 478 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 548 – 632 | DisorderedSequence analysisAdd BLAST | 85 | |
Regioni | 663 – 688 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 700 – 735 | DisorderedSequence analysisAdd BLAST | 36 | |
Regioni | 787 – 994 | Interaction with CREBBP1 PublicationAdd BLAST | 208 | |
Regioni | 1166 – 1195 | DisorderedSequence analysisAdd BLAST | 30 | |
Regioni | 1268 – 1287 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 1415 – 1447 | DisorderedSequence analysisAdd BLAST | 33 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 46 – 50 | LXXLL motif 1 | 5 | |
Motifi | 112 – 116 | LXXLL motif 2 | 5 | |
Motifi | 637 – 641 | LXXLL motif 3 | 5 | |
Motifi | 694 – 698 | LXXLL motif 4 | 5 | |
Motifi | 755 – 759 | LXXLL motif 5 | 5 | |
Motifi | 919 – 923 | LXXLL motif 6 | 5 | |
Motifi | 1441 – 1445 | LXXLL motif 7 | 5 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 373 – 446 | Polar residuesSequence analysisAdd BLAST | 74 | |
Compositional biasi | 548 – 579 | Polar residuesSequence analysisAdd BLAST | 32 | |
Compositional biasi | 592 – 609 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 663 – 687 | Polar residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 721 – 735 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1169 – 1183 | Pro residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1420 – 1447 | Polar residuesSequence analysisAdd BLAST | 28 |
Domaini
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG3561, Eukaryota |
GeneTreei | ENSGT00950000183021 |
HOGENOMi | CLU_001988_0_0_1 |
InParanoidi | P70365 |
OMAi | GVQGQFN |
OrthoDBi | 59971at2759 |
PhylomeDBi | P70365 |
TreeFami | TF332652 |
Family and domain databases
CDDi | cd00130, PAS, 1 hit |
Gene3Di | 4.10.280.10, 1 hit 6.10.140.410, 1 hit |
IDEALi | IID50084 |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR010011, NCO_DUF1518 IPR028819, NCOA1 IPR009110, Nuc_rcpt_coact IPR014920, Nuc_rcpt_coact_Ncoa-typ IPR037077, Nuc_rcpt_coact_Ncoa_int_sf IPR017426, Nuclear_rcpt_coactivator IPR000014, PAS IPR035965, PAS-like_dom_sf IPR013767, PAS_fold IPR014935, SRC/p160_LXXLL |
PANTHERi | PTHR10684, PTHR10684, 1 hit PTHR10684:SF1, PTHR10684:SF1, 1 hit |
Pfami | View protein in Pfam PF07469, DUF1518, 2 hits PF00010, HLH, 1 hit PF08815, Nuc_rec_co-act, 1 hit PF00989, PAS, 1 hit PF08832, SRC-1, 1 hit |
PIRSFi | PIRSF038181, Nuclear_receptor_coactivator, 1 hit |
SMARTi | View protein in SMART SM01151, DUF1518, 2 hits SM00353, HLH, 1 hit SM00091, PAS, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit SSF55785, SSF55785, 2 hits SSF69125, SSF69125, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS50112, PAS, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSGLGDSSSD PANPDSHKRK GSPCDTLASS TEKRRREQEN KYLEELAELL
60 70 80 90 100
SANISDIDSL SVKPDKCKIL KKTVDQIQLM KRMEQEKSTT DDDVQKSDIS
110 120 130 140 150
SSSQGVIEKE SLGPLLLEAL DGFFFVVNCE GRIVFVSENV TSYLGYNQEE
160 170 180 190 200
LMNTSVYSIL HVGDHAEFVK NLLPKSLVNG VPWPQEATRR NSHTFNCRML
210 220 230 240 250
IHPPEDPGTE NQEACQRYEV MQCFTVSQPK SIQEDGEDFQ SCLICIARRL
260 270 280 290 300
PRPPAITGVE SFMTKQDTTG KIISIDTSSL RAAGRTGWED LVRKCIYAFF
310 320 330 340 350
QPQGREPSYA RQLFQEVMTR GTASSPSYRF ILNDGTMLSA HTKCKLCYPQ
360 370 380 390 400
SPDMQPFIMG IHIIDREHSG LSPQDDSNSG MSIPRINPSV NPGISPAHGV
410 420 430 440 450
TRSSTLPPSN NNMVSARVNR QQSSDLNSSS SHTNSSNNQG NFGCSPGNQI
460 470 480 490 500
VANVALNQGQ AGSQSSNPSL NLNNSPMEGT GIALSQFMSP RRQANSGLAT
510 520 530 540 550
RARMSNNSFP PNIPTLSSPV GITSGACNNN NRSYSNIPVT SLQGMNEGPN
560 570 580 590 600
NSVGFSAGSP VLRQMSSQNS PSRLSMQPAK AESKDSKEIA SILNEMIQSD
610 620 630 640 650
NSDNSANEGK PLDSGLLHNN DRLSEGDSKY SQTSHKLVQL LTTTAEQQLR
660 670 680 690 700
HADIDTSCKD VLSCTGTSSS ASSNPSGGTC PSSHSSLTER HKILHRLLQE
710 720 730 740 750
GSPSDITTLS VEPEKKDSVP ASTAVSVSGQ SQGSASIKLE LDAAKKKESK
760 770 780 790 800
DHQLLRYLLD KDEKDLRSTP NLCLDDVKVK VEKKEQMDPC NTNPTPMTKP
810 820 830 840 850
APEEVKLESQ SQFTADLDQF DQLLPTLEKA AQLPSLCETD RMDGAVTGVS
860 870 880 890 900
IKAEVLPASL QPTTARAAPR LSRLPELELE AIDNQFGQPG AGDQIPWANN
910 920 930 940 950
TLTTINQNKP EDQCISSQLD ELLCPPTTVE GRNDEKALLE QLVSFLSGKD
960 970 980 990 1000
ETELAELDRA LGIDKLVQGG GLDVLSERFP PQQATPPLMM EDRPTLYSQP
1010 1020 1030 1040 1050
YSSPSPTAGL SGPFQGMVRQ KPSLGAMPVQ VTPPRGTFSP NMGMQPRQTL
1060 1070 1080 1090 1100
NRPPAAPNQL RLQLQQRLQG QQQLMHQNRQ AILNQFAANA PVGMNMRSGM
1110 1120 1130 1140 1150
QQQITPQPPL NAQMLAQRQR ELYSQQHRQR QIIQQQRAML MRHQSFGNNI
1160 1170 1180 1190 1200
PPSSGLPVQM GTPRLPQGAP QQFPYPPNYG TNPGTPPAST SPFSQLAANP
1210 1220 1230 1240 1250
EASLATRSSM VNRGMAGNMG GQFGAGISPQ MQQNVFQYPG PGLVPQGEAT
1260 1270 1280 1290 1300
FAPSLSPGSS MVPMPVPPPQ SSLLQQTPPT SGYQSPDMKA WQQGTMGNNN
1310 1320 1330 1340 1350
VFSQAVQSQP APAQPGVYNN MSITVSMAGG NANIQNMNPM MGQMQMSSLQ
1360 1370 1380 1390 1400
MPGMNTVCSE QMNDPALRHT GLYCNQLSST DLLKTDADGN QQVQQVQVFA
1410 1420 1430 1440
DVQCTVNLVG GDPYLNQPGP LGTQKPTSGP QTPQAQQKSL LQQLLTE
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1W2P7C1 | A0A1W2P7C1_MOUSE | Nuclear receptor coactivator 1 | Ncoa1 | 922 | Annotation score: | ||
A0A1W2P7S6 | A0A1W2P7S6_MOUSE | Nuclear receptor coactivator 1 | Ncoa1 | 430 | Annotation score: | ||
A0A1W2P7D7 | A0A1W2P7D7_MOUSE | Nuclear receptor coactivator 1 | Ncoa1 | 154 | Annotation score: | ||
A0A1W2P6K7 | A0A1W2P6K7_MOUSE | Nuclear receptor coactivator 1 | Ncoa1 | 54 | Annotation score: | ||
A0A1W2P881 | A0A1W2P881_MOUSE | Nuclear receptor coactivator 1 | Ncoa1 | 99 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 45 | E → G in AAB01228 (PubMed:8616895).Curated | 1 | |
Sequence conflicti | 223 | C → R in AAB06177 (PubMed:9041124).Curated | 1 | |
Sequence conflicti | 234 | E → G in AAB06177 (PubMed:9041124).Curated | 1 | |
Sequence conflicti | 237 | E → K in AAH80866 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 465 – 466 | SS → TT in AAB01228 (PubMed:8616895).Curated | 2 | |
Sequence conflicti | 699 | Q → P in AAB06177 (PubMed:9041124).Curated | 1 | |
Sequence conflicti | 1115 | L → M in BAC29244 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 1130 | R → K in AAB01228 (PubMed:8616895).Curated | 1 | |
Sequence conflicti | 1137 – 1138 | RA → KP in AAB01228 (PubMed:8616895).Curated | 2 | |
Sequence conflicti | 1142 | R → K in AAB01228 (PubMed:8616895).Curated | 1 | |
Sequence conflicti | 1162 | T → D in AAB01228 (PubMed:8616895).Curated | 1 | |
Sequence conflicti | 1164 | R → S in AAB06177 (PubMed:9041124).Curated | 1 | |
Sequence conflicti | 1166 | P → L in AAB01228 (PubMed:8616895).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_027855 | 1300 – 1376 | NVFSQ…LYCNQ → KWKRKHSEHESNDGPDANEL SADARDEYCVL in isoform 4. 1 PublicationAdd BLAST | 77 | |
Alternative sequenceiVSP_027856 | 1377 – 1447 | Missing in isoform 4. 1 PublicationAdd BLAST | 71 | |
Alternative sequenceiVSP_011740 | 1392 – 1447 | QVQQV…QLLTE → DKKTEEFFSVVTTD in isoform 2. 3 PublicationsAdd BLAST | 56 | |
Alternative sequenceiVSP_011741 | 1392 – 1447 | QVQQV…QLLTE → VSKKDNPSAELADSITLDTW RTSHGIC in isoform 3. 1 PublicationAdd BLAST | 56 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U56920 mRNA Translation: AAB01228.1 U64606 mRNA Translation: AAB06177.1 U64828 mRNA Translation: AAB38841.1 AK035922 mRNA Translation: BAC29244.1 BC068177 mRNA Translation: AAH68177.1 BC080866 mRNA Translation: AAH80866.1 |
CCDSi | CCDS25789.1 [P70365-2] |
RefSeqi | NP_035011.1, NM_010881.2 [P70365-2] XP_006515068.1, XM_006515005.3 [P70365-1] XP_006515069.1, XM_006515006.3 [P70365-1] XP_006515070.1, XM_006515007.3 [P70365-1] XP_011242143.1, XM_011243841.2 |
Genome annotation databases
Ensembli | ENSMUST00000085814; ENSMUSP00000082971; ENSMUSG00000020647 [P70365-2] ENSMUST00000217794; ENSMUSP00000151716; ENSMUSG00000020647 [P70365-4] ENSMUST00000220434; ENSMUSP00000151358; ENSMUSG00000020647 [P70365-1] |
GeneIDi | 17977 |
KEGGi | mmu:17977 |
UCSCi | uc007mxr.2, mouse [P70365-1] uc007mxs.2, mouse [P70365-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U56920 mRNA Translation: AAB01228.1 U64606 mRNA Translation: AAB06177.1 U64828 mRNA Translation: AAB38841.1 AK035922 mRNA Translation: BAC29244.1 BC068177 mRNA Translation: AAH68177.1 BC080866 mRNA Translation: AAH80866.1 |
CCDSi | CCDS25789.1 [P70365-2] |
RefSeqi | NP_035011.1, NM_010881.2 [P70365-2] XP_006515068.1, XM_006515005.3 [P70365-1] XP_006515069.1, XM_006515006.3 [P70365-1] XP_006515070.1, XM_006515007.3 [P70365-1] XP_011242143.1, XM_011243841.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1OJ5 | X-ray | 2.20 | A | 257-385 | [»] | |
2O9I | X-ray | 2.80 | C/D | 686-700 | [»] | |
4DMA | X-ray | 2.30 | E/F | 690-704 | [»] | |
5NWX | X-ray | 2.51 | A | 257-385 | [»] | |
5Y7W | X-ray | 2.25 | A/B | 257-367 | [»] | |
AlphaFoldDBi | P70365 | |||||
SMRi | P70365 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 201707, 14 interactors |
ComplexPortali | CPX-5343, RXRalpha-NCOA1 activated retinoic acid receptor complex CPX-644, PXR-NCOA1 activated nuclear receptor complex CPX-667, RARalpha-NCOA1 activated retinoic acid receptor complex CPX-864, PPARgamma-NCOA1 activated nuclear receptor complex |
CORUMi | P70365 |
IntActi | P70365, 3 interactors |
MINTi | P70365 |
STRINGi | 10090.ENSMUSP00000082971 |
PTM databases
iPTMneti | P70365 |
PhosphoSitePlusi | P70365 |
Proteomic databases
EPDi | P70365 |
jPOSTi | P70365 |
MaxQBi | P70365 |
PaxDbi | P70365 |
PeptideAtlasi | P70365 |
PRIDEi | P70365 |
ProteomicsDBi | 293632 [P70365-1] 293633 [P70365-2] 293634 [P70365-3] 293635 [P70365-4] |
Protocols and materials databases
Antibodypediai | 27525, 422 antibodies from 39 providers |
DNASUi | 17977 |
Genome annotation databases
Ensembli | ENSMUST00000085814; ENSMUSP00000082971; ENSMUSG00000020647 [P70365-2] ENSMUST00000217794; ENSMUSP00000151716; ENSMUSG00000020647 [P70365-4] ENSMUST00000220434; ENSMUSP00000151358; ENSMUSG00000020647 [P70365-1] |
GeneIDi | 17977 |
KEGGi | mmu:17977 |
UCSCi | uc007mxr.2, mouse [P70365-1] uc007mxs.2, mouse [P70365-2] |
Organism-specific databases
CTDi | 8648 |
MGIi | MGI:1276523, Ncoa1 |
VEuPathDBi | HostDB:ENSMUSG00000020647 |
Phylogenomic databases
eggNOGi | KOG3561, Eukaryota |
GeneTreei | ENSGT00950000183021 |
HOGENOMi | CLU_001988_0_0_1 |
InParanoidi | P70365 |
OMAi | GVQGQFN |
OrthoDBi | 59971at2759 |
PhylomeDBi | P70365 |
TreeFami | TF332652 |
Enzyme and pathway databases
Reactomei | R-MMU-159418, Recycling of bile acids and salts R-MMU-192105, Synthesis of bile acids and bile salts R-MMU-193368, Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-MMU-193807, Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-MMU-211976, Endogenous sterols R-MMU-3214847, HATs acetylate histones R-MMU-3899300, SUMOylation of transcription cofactors R-MMU-400206, Regulation of lipid metabolism by PPARalpha R-MMU-9018519, Estrogen-dependent gene expression R-MMU-9029569, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-MMU-9623433, NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-MMU-9707564, Cytoprotection by HMOX1 |
Miscellaneous databases
BioGRID-ORCSi | 17977, 3 hits in 76 CRISPR screens |
ChiTaRSi | Ncoa1, mouse |
EvolutionaryTracei | P70365 |
PROi | PR:P70365 |
RNActi | P70365, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000020647, Expressed in rostral migratory stream and 325 other tissues |
ExpressionAtlasi | P70365, baseline and differential |
Genevisiblei | P70365, MM |
Family and domain databases
CDDi | cd00130, PAS, 1 hit |
Gene3Di | 4.10.280.10, 1 hit 6.10.140.410, 1 hit |
IDEALi | IID50084 |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR010011, NCO_DUF1518 IPR028819, NCOA1 IPR009110, Nuc_rcpt_coact IPR014920, Nuc_rcpt_coact_Ncoa-typ IPR037077, Nuc_rcpt_coact_Ncoa_int_sf IPR017426, Nuclear_rcpt_coactivator IPR000014, PAS IPR035965, PAS-like_dom_sf IPR013767, PAS_fold IPR014935, SRC/p160_LXXLL |
PANTHERi | PTHR10684, PTHR10684, 1 hit PTHR10684:SF1, PTHR10684:SF1, 1 hit |
Pfami | View protein in Pfam PF07469, DUF1518, 2 hits PF00010, HLH, 1 hit PF08815, Nuc_rec_co-act, 1 hit PF00989, PAS, 1 hit PF08832, SRC-1, 1 hit |
PIRSFi | PIRSF038181, Nuclear_receptor_coactivator, 1 hit |
SMARTi | View protein in SMART SM01151, DUF1518, 2 hits SM00353, HLH, 1 hit SM00091, PAS, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit SSF55785, SSF55785, 2 hits SSF69125, SSF69125, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS50112, PAS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NCOA1_MOUSE | |
Accessioni | P70365Primary (citable) accession number: P70365 Secondary accession number(s): P70366 Q8CBI9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 11, 2004 |
Last sequence update: | October 11, 2004 | |
Last modified: | May 25, 2022 | |
This is version 202 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families