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Protein

Ubiquitin recognition factor in ER-associated degradation protein 1

Gene

Ufd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and NPLOC4, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I (By similarity).By similarity

Pathwayi: proteasomal ubiquitin-dependent pathway

This protein is involved in the pathway proteasomal ubiquitin-dependent pathway, which is part of Protein degradation.By similarity
View all proteins of this organism that are known to be involved in the pathway proteasomal ubiquitin-dependent pathway and in Protein degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-110320 Translesion Synthesis by POLH
R-MMU-5689880 Ub-specific processing proteases
UniPathwayi
UPA00144

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin recognition factor in ER-associated degradation protein 1
Alternative name(s):
Ubiquitin fusion degradation protein 1 homolog
Short name:
UB fusion protein 1
Gene namesi
Name:Ufd1Imported
Synonyms:Ufd1l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:109353 Ufd1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001949851 – 307Ubiquitin recognition factor in ER-associated degradation protein 1Add BLAST307

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei129PhosphoserineBy similarity1
Modified residuei231PhosphoserineBy similarity1
Modified residuei245PhosphoserineBy similarity1
Modified residuei247PhosphoserineCombined sources1
Modified residuei299PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP70362
MaxQBiP70362
PaxDbiP70362
PeptideAtlasiP70362
PRIDEiP70362

2D gel databases

REPRODUCTION-2DPAGEiP70362

PTM databases

iPTMnetiP70362
PhosphoSitePlusiP70362

Expressioni

Developmental stagei

Expressed at high levels in the otocyst (between E9.5 and E11.5 embryos fading away after E12) and in the developing eye. Lower expression is found in different sites of the embryos such as developing brain, the lungs and the cardiac outflow tract.

Gene expression databases

BgeeiENSMUSG00000005262 Expressed in 291 organ(s), highest expression level in dorsomedial nucleus of hypothalamus
CleanExiMM_UFD1L
ExpressionAtlasiP70362 baseline and differential
GenevisibleiP70362 MM

Interactioni

Subunit structurei

Heterodimer with NPLOC4, this heterodimer binds VCP and inhibits Golgi membrane fusion. Interacts with USP13 (By similarity). Interacts with ZFAND2B; probably through VCP (PubMed:24160817).By similarity1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204430, 6 interactors
ComplexPortaliCPX-136 Vcp-Npl4-Ufd1 AAA ATPase complex
CORUMiP70362
DIPiDIP-60008N
IntActiP70362, 4 interactors
MINTiP70362
STRINGi10090.ENSMUSP00000005394

Structurei

3D structure databases

ProteinModelPortaliP70362
SMRiP70362
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UFD1 family.Curated

Phylogenomic databases

eggNOGiKOG1816 Eukaryota
COG5140 LUCA
GeneTreeiENSGT00390000002408
HOGENOMiHOG000212737
HOVERGENiHBG001266
InParanoidiP70362
KOiK14016
OMAiPNYDFKI
OrthoDBiEOG091G0KO7
PhylomeDBiP70362
TreeFamiTF314581

Family and domain databases

InterProiView protein in InterPro
IPR004854 Ufd1-like
PANTHERiPTHR12555 PTHR12555, 1 hit
PfamiView protein in Pfam
PF03152 UFD1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P70362-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFSFNMFDHP IPRVFQNRFS TQYRCFSVSM LAGPNDRSDV EKGGKIIMPP
60 70 80 90 100
SALDQLSRLN ITYPMLFKLT NKNSDRMTHC GVLEFVADEG ICYLPHWMMQ
110 120 130 140 150
NLLLEEGGLV QVESVNLQVA TYSKFQPQSP DFLDITNPKA VLENALRNFA
160 170 180 190 200
CLTTGDVIAI NYNEKIYELR VMETKPDKAV SIIECDMNVD FDAPLGYKEP
210 220 230 240 250
ERPVQHEESI EGEADHSGYA GEVGFRAFSG SGNRLDGKKK GVEPSPSPIK
260 270 280 290 300
PGDIKRGIPN YEFKLGKITF IRNSRPLVKK VEEDEAGGRF IAFSGEGQSL

RKKGRKP
Length:307
Mass (Da):34,481
Last modified:July 27, 2011 - v2
Checksum:iC85E06B1B910485D
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q0Y6E9Q0Y6_MOUSE
Ubiquitin recognition factor in ER-...
Ufd1 Ufd1l
72Annotation score:
E9Q475E9Q475_MOUSE
Ubiquitin recognition factor in ER-...
Ufd1 Ufd1l
48Annotation score:
E9Q646E9Q646_MOUSE
Ubiquitin recognition factor in ER-...
Ufd1 Ufd1l
58Annotation score:
F6SYJ2F6SYJ2_MOUSE
Ubiquitin recognition factor in ER-...
Ufd1 Ufd1l
45Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti152L → M in AAD08719 (PubMed:9063746).Curated1
Sequence conflicti201E → K in AAD08719 (PubMed:9063746).Curated1
Sequence conflicti291I → V in AAD08719 (PubMed:9063746).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U64445 mRNA Translation: AAD08719.1
AK147138 mRNA Translation: BAE27708.1
AK169062 mRNA Translation: BAE40849.1
CH466521 Genomic DNA Translation: EDK97535.1
BC006630 mRNA Translation: AAH06630.1
CCDSiCCDS28028.1
RefSeqiNP_035802.3, NM_011672.4
XP_006522068.1, XM_006522005.3
UniGeneiMm.237594

Genome annotation databases

EnsembliENSMUST00000005394; ENSMUSP00000005394; ENSMUSG00000005262
ENSMUST00000115578; ENSMUSP00000111241; ENSMUSG00000005262
GeneIDi22230
KEGGimmu:22230
UCSCiuc007yon.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U64445 mRNA Translation: AAD08719.1
AK147138 mRNA Translation: BAE27708.1
AK169062 mRNA Translation: BAE40849.1
CH466521 Genomic DNA Translation: EDK97535.1
BC006630 mRNA Translation: AAH06630.1
CCDSiCCDS28028.1
RefSeqiNP_035802.3, NM_011672.4
XP_006522068.1, XM_006522005.3
UniGeneiMm.237594

3D structure databases

ProteinModelPortaliP70362
SMRiP70362
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204430, 6 interactors
ComplexPortaliCPX-136 Vcp-Npl4-Ufd1 AAA ATPase complex
CORUMiP70362
DIPiDIP-60008N
IntActiP70362, 4 interactors
MINTiP70362
STRINGi10090.ENSMUSP00000005394

PTM databases

iPTMnetiP70362
PhosphoSitePlusiP70362

2D gel databases

REPRODUCTION-2DPAGEiP70362

Proteomic databases

EPDiP70362
MaxQBiP70362
PaxDbiP70362
PeptideAtlasiP70362
PRIDEiP70362

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000005394; ENSMUSP00000005394; ENSMUSG00000005262
ENSMUST00000115578; ENSMUSP00000111241; ENSMUSG00000005262
GeneIDi22230
KEGGimmu:22230
UCSCiuc007yon.2 mouse

Organism-specific databases

CTDi7353
MGIiMGI:109353 Ufd1

Phylogenomic databases

eggNOGiKOG1816 Eukaryota
COG5140 LUCA
GeneTreeiENSGT00390000002408
HOGENOMiHOG000212737
HOVERGENiHBG001266
InParanoidiP70362
KOiK14016
OMAiPNYDFKI
OrthoDBiEOG091G0KO7
PhylomeDBiP70362
TreeFamiTF314581

Enzyme and pathway databases

UniPathwayi
UPA00144

ReactomeiR-MMU-110320 Translesion Synthesis by POLH
R-MMU-5689880 Ub-specific processing proteases

Miscellaneous databases

PROiPR:P70362
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000005262 Expressed in 291 organ(s), highest expression level in dorsomedial nucleus of hypothalamus
CleanExiMM_UFD1L
ExpressionAtlasiP70362 baseline and differential
GenevisibleiP70362 MM

Family and domain databases

InterProiView protein in InterPro
IPR004854 Ufd1-like
PANTHERiPTHR12555 PTHR12555, 1 hit
PfamiView protein in Pfam
PF03152 UFD1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUFD1_MOUSE
AccessioniPrimary (citable) accession number: P70362
Secondary accession number(s): Q923C4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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