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Protein

Homeobox protein MSX-3

Gene

Msx3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a potent transcriptional repressor of MSX1.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi87 – 146HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • multicellular organism development Source: UniProtKB-KW
  • negative regulation of histone acetylation Source: MGI
  • negative regulation of transcription by RNA polymerase II Source: MGI
  • regulation of transcription by RNA polymerase II Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein MSX-3
Gene namesi
Name:Msx3
Synonyms:Msx-3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:106587 Msx3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000491041 – 204Homeobox protein MSX-3Add BLAST204

Proteomic databases

PaxDbiP70354
PRIDEiP70354

Expressioni

Tissue specificityi

Restricted to the dorsal embryonic central nervous system.

Gene expression databases

BgeeiENSMUSG00000025469
CleanExiMM_MSX3
ExpressionAtlasiP70354 baseline and differential
GenevisibleiP70354 MM

Interactioni

Subunit structurei

Interacts with CREBBP/CBP, NOTCH1/p300 and HDAC1. Appears to exist in two distinct complexes in the cell, one which includes CREBBP and NOTCH1 and the other which contains HDAC1.1 Publication

Protein-protein interaction databases

BioGridi201538, 1 interactor
STRINGi10090.ENSMUSP00000133484

Structurei

3D structure databases

ProteinModelPortaliP70354
SMRiP70354
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Msh homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0492 Eukaryota
ENOG410YT2J LUCA
GeneTreeiENSGT00920000148979
HOGENOMiHOG000231922
HOVERGENiHBG005205
InParanoidiP70354
KOiK09341
OMAiGLRTCGG
OrthoDBiEOG091G0P1V
PhylomeDBiP70354
TreeFamiTF350699

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR000047 HTH_motif
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
PR00031 HTHREPRESSR
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P70354-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARATFDMNA AGLEARGGGH TEHGPLPFSV ESLLEAERVP GSESGELGVE
60 70 80 90 100
RPLGASKPGA WPPPVAHSCP PRAPSPPPCT LRKHKTNRKP RTPFTTAQLL
110 120 130 140 150
ALERKFHQKQ YLSIAERAEF SSSLSLTETQ VKIWFQNRRA KAKRLQEAEL
160 170 180 190 200
EKLKLAAKPL LPAAFALPFP LGTQLHSSAA TFGGNAVPGI LAGPVAAYGM

YYLS
Length:204
Mass (Da):21,971
Last modified:February 1, 1997 - v1
Checksum:iBC032991DECE4AA1
GO

Sequence cautioni

The sequence AAH51983 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti75S → I in CAA65367 (PubMed:8861099).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62523 mRNA Translation: AAB49935.1
AF060229 Genomic DNA Translation: AAC15459.1
BC051983 mRNA Translation: AAH51983.1 Different initiation.
X96518 Genomic DNA Translation: CAA65367.1
M38577 Genomic DNA Translation: AAA37825.1
CCDSiCCDS21961.1
PIRiPS0409
RefSeqiNP_034966.1, NM_010836.3
UniGeneiMm.4816

Genome annotation databases

EnsembliENSMUST00000172775; ENSMUSP00000133484; ENSMUSG00000025469
GeneIDi17703
KEGGimmu:17703
UCSCiuc012fwf.1 mouse

Similar proteinsi

Entry informationi

Entry nameiMSX3_MOUSE
AccessioniPrimary (citable) accession number: P70354
Secondary accession number(s): P70246, Q03360, Q80W10
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: June 20, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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