UniProtKB - P70354 (MSX3_MOUSE)
Protein
Homeobox protein MSX-3
Gene
Msx3
Organism
Mus musculus (Mouse)
Status
Functioni
Acts as a potent transcriptional repressor of MSX1.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 87 – 146 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- embryonic morphogenesis Source: GO_Central
- negative regulation of histone acetylation Source: MGI
- negative regulation of transcription by RNA polymerase II Source: MGI
- regulation of transcription by RNA polymerase II Source: MGI
Keywordsi
Molecular function | Developmental protein, DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Homeobox protein MSX-3 |
Gene namesi | Name:Msx3 Synonyms:Msx-3 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:106587, Msx3 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000049104 | 1 – 204 | Homeobox protein MSX-3Add BLAST | 204 |
Proteomic databases
PaxDbi | P70354 |
PRIDEi | P70354 |
Expressioni
Tissue specificityi
Restricted to the dorsal embryonic central nervous system.
Gene expression databases
Bgeei | ENSMUSG00000025469, Expressed in neural tube and 70 other tissues |
Genevisiblei | P70354, MM |
Interactioni
Subunit structurei
Interacts with CREBBP/CBP, NOTCH1/p300 and HDAC1. Appears to exist in two distinct complexes in the cell, one which includes CREBBP and NOTCH1 and the other which contains HDAC1.
1 PublicationProtein-protein interaction databases
BioGRIDi | 201538, 1 interactor |
STRINGi | 10090.ENSMUSP00000133484 |
Miscellaneous databases
RNActi | P70354, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the Msh homeobox family.Curated
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0492, Eukaryota |
GeneTreei | ENSGT00940000164040 |
HOGENOMi | CLU_072675_3_1_1 |
InParanoidi | P70354 |
OMAi | CGLYYLS |
OrthoDBi | 1197782at2759 |
PhylomeDBi | P70354 |
TreeFami | TF350699 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa IPR000047, HTH_motif |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX PR00031, HTHREPRESSR |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P70354-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MARATFDMNA AGLEARGGGH TEHGPLPFSV ESLLEAERVP GSESGELGVE
60 70 80 90 100
RPLGASKPGA WPPPVAHSCP PRAPSPPPCT LRKHKTNRKP RTPFTTAQLL
110 120 130 140 150
ALERKFHQKQ YLSIAERAEF SSSLSLTETQ VKIWFQNRRA KAKRLQEAEL
160 170 180 190 200
EKLKLAAKPL LPAAFALPFP LGTQLHSSAA TFGGNAVPGI LAGPVAAYGM
YYLS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketG3X9C7 | G3X9C7_MOUSE | Homeobox protein MSX-3 | Msx3 | 146 | Annotation score: |
Sequence cautioni
The sequence AAH51983 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 75 | S → I in CAA65367 (PubMed:8861099).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U62523 mRNA Translation: AAB49935.1 AF060229 Genomic DNA Translation: AAC15459.1 BC051983 mRNA Translation: AAH51983.1 Different initiation. X96518 Genomic DNA Translation: CAA65367.1 M38577 Genomic DNA Translation: AAA37825.1 |
CCDSi | CCDS21961.1 |
PIRi | PS0409 |
RefSeqi | NP_034966.1, NM_010836.3 |
Genome annotation databases
Ensembli | ENSMUST00000172775; ENSMUSP00000133484; ENSMUSG00000025469 |
GeneIDi | 17703 |
KEGGi | mmu:17703 |
UCSCi | uc012fwf.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U62523 mRNA Translation: AAB49935.1 AF060229 Genomic DNA Translation: AAC15459.1 BC051983 mRNA Translation: AAH51983.1 Different initiation. X96518 Genomic DNA Translation: CAA65367.1 M38577 Genomic DNA Translation: AAA37825.1 |
CCDSi | CCDS21961.1 |
PIRi | PS0409 |
RefSeqi | NP_034966.1, NM_010836.3 |
3D structure databases
SMRi | P70354 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 201538, 1 interactor |
STRINGi | 10090.ENSMUSP00000133484 |
Proteomic databases
PaxDbi | P70354 |
PRIDEi | P70354 |
Genome annotation databases
Ensembli | ENSMUST00000172775; ENSMUSP00000133484; ENSMUSG00000025469 |
GeneIDi | 17703 |
KEGGi | mmu:17703 |
UCSCi | uc012fwf.1, mouse |
Organism-specific databases
CTDi | 17703 |
MGIi | MGI:106587, Msx3 |
Phylogenomic databases
eggNOGi | KOG0492, Eukaryota |
GeneTreei | ENSGT00940000164040 |
HOGENOMi | CLU_072675_3_1_1 |
InParanoidi | P70354 |
OMAi | CGLYYLS |
OrthoDBi | 1197782at2759 |
PhylomeDBi | P70354 |
TreeFami | TF350699 |
Miscellaneous databases
BioGRID-ORCSi | 17703, 0 hits in 17 CRISPR screens |
PROi | PR:P70354 |
RNActi | P70354, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000025469, Expressed in neural tube and 70 other tissues |
Genevisiblei | P70354, MM |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa IPR000047, HTH_motif |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX PR00031, HTHREPRESSR |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MSX3_MOUSE | |
Accessioni | P70354Primary (citable) accession number: P70354 Secondary accession number(s): P70246, Q03360, Q80W10 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | February 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 156 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families