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Protein

Nuclear transcription factor Y subunit gamma

Gene

Nfyc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear transcription factor Y subunit gamma
Alternative name(s):
CAAT box DNA-binding protein subunit C
Nuclear transcription factor Y subunit C
Short name:
NF-YC
Gene namesi
Name:Nfyc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:107901 Nfyc

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002182471 – 335Nuclear transcription factor Y subunit gammaAdd BLAST335

Proteomic databases

EPDiP70353
MaxQBiP70353
PaxDbiP70353
PeptideAtlasiP70353
PRIDEiP70353

PTM databases

PhosphoSitePlusiP70353

Expressioni

Gene expression databases

BgeeiENSMUSG00000032897 Expressed in 41 organ(s), highest expression level in thymus
CleanExiMM_NFYC
ExpressionAtlasiP70353 baseline and differential
GenevisibleiP70353 MM

Interactioni

Subunit structurei

Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201762, 23 interactors
ComplexPortaliCPX-89 CCAAT-binding factor complex
IntActiP70353, 22 interactors
STRINGi10090.ENSMUSP00000047441

Structurei

3D structure databases

ProteinModelPortaliP70353
SMRiP70353
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NFYC/HAP5 subunit family.Curated

Phylogenomic databases

eggNOGiKOG1657 Eukaryota
COG5208 LUCA
GeneTreeiENSGT00530000063560
HOGENOMiHOG000231074
HOVERGENiHBG002885
InParanoidiP70353
KOiK08066
OMAiMPAGQDI
OrthoDBiEOG091G0HN1
PhylomeDBiP70353
TreeFamiTF354207

Family and domain databases

Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR003958 CBFA_NFYB_domain
IPR009072 Histone-fold
IPR027170 NFYC/HAP5_su
PANTHERiPTHR10252:SF8 PTHR10252:SF8, 1 hit
PfamiView protein in Pfam
PF00808 CBFD_NFYB_HMF, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P70353-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTEGGFGGT SSSDAQQSLQ SFWPRVMEEI RNLTVKDFRV QELPLARIKK
60 70 80 90 100
IMKLDEDVKM ISAEAPVLFA KAAQIFITEL TLRAWIHTED NKRRTLQRND
110 120 130 140 150
IAMAITKFDQ FDFLIDIVPR DELKPPKRQE EVRQSVTPAE PVQYYFTLAQ
160 170 180 190 200
QPTAVQVQGQ QQGQQTTSST TTIQPGQIII AQPQQGQTTP VTMQVGEGQQ
210 220 230 240 250
VQIVQAQPQG QAQQTQSGTG QTMQVMQQII TNTGEIQQIP VQLNAGQLQY
260 270 280 290 300
IRLAQPVSGT QVVQGQIQTL ATNAQQITQT EVQQGQQQFS QFTDGQQLYQ
310 320 330
IQQVTMPAGQ DLAQPMFIQS ANQPSDGQTP QVTGD
Length:335
Mass (Da):37,254
Last modified:November 8, 2005 - v2
Checksum:iD14620C1773C31E5
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A763A2A763_MOUSE
Nuclear transcription factor Y subu...
Nfyc
98Annotation score:
A2A762A2A762_MOUSE
Nuclear transcription factor Y subu...
Nfyc
163Annotation score:
A2A764A2A764_MOUSE
Nuclear transcription factor Y subu...
Nfyc
53Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti72A → G in AAC52892 (PubMed:8910521).Curated1
Sequence conflicti87H → R in AAC52892 (PubMed:8910521).Curated1
Sequence conflicti95T → P in AAC52892 (PubMed:8910521).Curated1
Sequence conflicti163G → P in AAC52892 (PubMed:8910521).Curated1
Sequence conflicti236I → T in AAC52892 (PubMed:8910521).Curated1
Sequence conflicti246G → A in AAC52892 (PubMed:8910521).Curated1
Sequence conflicti287Q → E in AAC52892 (PubMed:8910521).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62297 mRNA Translation: AAC52892.1
AB006181 mRNA Translation: BAA22216.1
BC020117 mRNA Translation: AAH20117.1
BC085261 mRNA Translation: AAH85261.1
CCDSiCCDS18594.1
RefSeqiNP_001041633.1, NM_001048168.2
NP_001264024.1, NM_001277095.1
NP_032718.2, NM_008692.4
XP_006502909.1, XM_006502846.1
XP_017175513.1, XM_017320024.1
XP_017175514.1, XM_017320025.1
UniGeneiMm.318389
Mm.435590
Mm.450444
Mm.477613

Genome annotation databases

EnsembliENSMUST00000043429; ENSMUSP00000047441; ENSMUSG00000032897
ENSMUST00000097906; ENSMUSP00000095516; ENSMUSG00000032897
ENSMUST00000118902; ENSMUSP00000112610; ENSMUSG00000032897
ENSMUST00000120779; ENSMUSP00000112810; ENSMUSG00000032897
GeneIDi18046
KEGGimmu:18046
UCSCiuc008unn.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62297 mRNA Translation: AAC52892.1
AB006181 mRNA Translation: BAA22216.1
BC020117 mRNA Translation: AAH20117.1
BC085261 mRNA Translation: AAH85261.1
CCDSiCCDS18594.1
RefSeqiNP_001041633.1, NM_001048168.2
NP_001264024.1, NM_001277095.1
NP_032718.2, NM_008692.4
XP_006502909.1, XM_006502846.1
XP_017175513.1, XM_017320024.1
XP_017175514.1, XM_017320025.1
UniGeneiMm.318389
Mm.435590
Mm.450444
Mm.477613

3D structure databases

ProteinModelPortaliP70353
SMRiP70353
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201762, 23 interactors
ComplexPortaliCPX-89 CCAAT-binding factor complex
IntActiP70353, 22 interactors
STRINGi10090.ENSMUSP00000047441

PTM databases

PhosphoSitePlusiP70353

Proteomic databases

EPDiP70353
MaxQBiP70353
PaxDbiP70353
PeptideAtlasiP70353
PRIDEiP70353

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043429; ENSMUSP00000047441; ENSMUSG00000032897
ENSMUST00000097906; ENSMUSP00000095516; ENSMUSG00000032897
ENSMUST00000118902; ENSMUSP00000112610; ENSMUSG00000032897
ENSMUST00000120779; ENSMUSP00000112810; ENSMUSG00000032897
GeneIDi18046
KEGGimmu:18046
UCSCiuc008unn.2 mouse

Organism-specific databases

CTDi4802
MGIiMGI:107901 Nfyc

Phylogenomic databases

eggNOGiKOG1657 Eukaryota
COG5208 LUCA
GeneTreeiENSGT00530000063560
HOGENOMiHOG000231074
HOVERGENiHBG002885
InParanoidiP70353
KOiK08066
OMAiMPAGQDI
OrthoDBiEOG091G0HN1
PhylomeDBiP70353
TreeFamiTF354207

Miscellaneous databases

ChiTaRSiNfyc mouse
PROiPR:P70353
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032897 Expressed in 41 organ(s), highest expression level in thymus
CleanExiMM_NFYC
ExpressionAtlasiP70353 baseline and differential
GenevisibleiP70353 MM

Family and domain databases

Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR003958 CBFA_NFYB_domain
IPR009072 Histone-fold
IPR027170 NFYC/HAP5_su
PANTHERiPTHR10252:SF8 PTHR10252:SF8, 1 hit
PfamiView protein in Pfam
PF00808 CBFD_NFYB_HMF, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNFYC_MOUSE
AccessioniPrimary (citable) accession number: P70353
Secondary accession number(s): O35088, Q6GU21
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 8, 2005
Last modified: November 7, 2018
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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