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UniProtKB - P70351 (EZH1_MOUSE)

Entry version 161 (02 Dec 2020)
Sequence version 1 (01 Feb 1997)
Previous versions | rss
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Protein

Histone-lysine N-methyltransferase EZH1

Gene

Ezh1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Methyltransferase, Repressor, Transferase
Biological processTranscription, Transcription regulation
LigandS-adenosyl-L-methionine

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone-lysine N-methyltransferase EZH1 (EC:2.1.1.3561 Publication)
Alternative name(s):
ENX-2
Enhancer of zeste homolog 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ezh1
Synonyms:Enx2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1097695, Ezh1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002139911 – 747Histone-lysine N-methyltransferase EZH1Add BLAST747

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki327Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P70351

MaxQB - The MaxQuant DataBase

More...MaxQBi		P70351

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P70351

PeptideAtlas

More...PeptideAtlasi		P70351

PRoteomics IDEntifications database

More...PRIDEi		P70351

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P70351

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P70351

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at high levels in kidney, adrenal gland, testis and brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000006920, Expressed in adult mammalian kidney and 293 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P70351, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P70351, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the PRC2/EED-EZH1 complex, which includes EED, EZH1, SUZ12, RBBP4 and AEBP2. The PRC2/EED-EZH1 is less abundant than the PRC2/EED-EZH2 complex, has weak methyltransferase activity and compacts chromatin in the absence of the methyltransferase cofactor S-adenosyl-L-methionine (SAM).

Interacts with EZHIP; the interaction blocks EZH1 methyltransferase activity (PubMed:31451685).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		199563, 19 interactors

Database of interacting proteins

More...DIPi		DIP-56992N

Protein interaction database and analysis system

More...IntActi		P70351, 8 interactors

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000102906

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P70351, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini504 – 606CXCPROSITE-ProRule annotationAdd BLAST103
Domaini613 – 728SETPROSITE-ProRule annotationAdd BLAST116

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi491 – 496Nuclear localization signalSequence analysis6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi524 – 606Cys-richAdd BLAST83

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. EZ subfamily.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1079, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156604

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_011342_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P70351

Database of Orthologous Groups

More...OrthoDBi		875190at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P70351

TreeFam database of animal gene trees

More...TreeFami		TF314509

Family and domain databases

Conserved Domains Database

More...CDDi		cd00167, SANT, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026489, CXC_dom
IPR032926, EZH1
IPR021654, EZH1/EZH2
IPR041343, PRC2_HTH_1
IPR041355, Pre-SET_CXC
IPR001005, SANT/Myb
IPR001214, SET_dom
IPR033467, Tesmin/TSO1-like_CXC

The PANTHER Classification System

More...PANTHERi		PTHR45747:SF1, PTHR45747:SF1, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF11616, EZH2_WD-Binding, 1 hit
PF18118, PRC2_HTH_1, 1 hit
PF18264, preSET_CXC, 1 hit
PF00856, SET, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01114, CXC, 1 hit
SM00717, SANT, 2 hits
SM00317, SET, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51633, CXC, 1 hit
PS50280, SET, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P70351-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDIASPPTSK CITYWKRKVK SEYMRLRQLK RLQANMGAKA LYVANFAKVQ 
        60         70         80         90        100
EKTQILNEEW KKLRVQPVQP MKPVSGHPFL KKCTIESIFP GFDSQDMLMR 
       110        120        130        140        150
SLNTVALVPI MYSWSPLQQN FMVEDETVLC NIPYMGDEVK EEDETFIEEL 
       160        170        180        190        200
INNYDGKVHG EEEMIPGSVL ISDAVFLELV DALNQYSDEE EDGHNDPSDG 
       210        220        230        240        250
KQDDSKEDLP VTRKRKRHAI EGNKKSSKKQ FPNDMIFSAI ASMFPENGVP 
       260        270        280        290        300
DDMKERYREL TEMSDPNALP PQCTPNIDGP NAKSVQREQS LHSFHTLFCR 
       310        320        330        340        350
RCFKYDCFLH PFHATPNVYK RKNKEIKIEP EPCGTDCFLL LEGAKEYAML 
       360        370        380        390        400
HNPRSKCSGR RRRRHPVVSA SCSNASASAM AETKEGDSDR DTGNDWASSS 
       410        420        430        440        450
SEANSRCQTP TKQKASPAPA QLCVVEAPSE PVEWTGAEES LFRVFHGTYF 
       460        470        480        490        500
NNFCSIARLL GTKTCKQVFQ FAVKESLILK LPTDELMNPA QKKKRKHRLW 
       510        520        530        540        550
AAHCRKIQLK KDNNSTQVYN YQPCDHPDRP CDSTCPCIMT QNFCEKFCQC 
       560        570        580        590        600
SPDCQNRFPG CRCKTQCNTK QCPCYLAVRE CDPDLCLTCG ASEHWDCKVV 
       610        620        630        640        650
SCKNCSIQRG LKKHLLLAPS DVAGWGTFIK ESVQKNEFIS EYCGELISQD 
       660        670        680        690        700
EADRRGKVYD KYMSSFLFNL NNDFVVDATR KGNKIRFANH SVNPNCYAKV 
       710        720        730        740 
VMVNGDHRIG IFAKRAIQAG EELFFDYRYS QADALKYVGI ERETDVF
Length:747
Mass (Da):85,188
Last modified:February 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i43CECFBDF3E49192
GO
Isoform 2 (identifier: P70351-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     555-747: QNRFPGCRCK...VGIERETDVF → KSTLLSPSSTQVVGLGVPRLFSPAP

Show »
Length:579
Mass (Da):65,730
Checksum:iB42CCD4108D013EA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J1C0A0A0R4J1C0_MOUSE
[Histone H3]-lysine(27) N-trimethyl...
Ezh1
750Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH07135 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAL90764 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAL90765 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA25018 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE23827 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE24446 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE32680 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE37674 differs from that shown. Reason: Erroneous initiation.Curated
The sequence EDL03899 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti84T → A in BAE32680 (PubMed:16141072).Curated1
Sequence conflicti446H → Y in AAD54021 (PubMed:9473645).Curated1
Sequence conflicti452N → Y in AAD54021 (PubMed:9473645).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_036388555 – 747QNRFP…ETDVF → KSTLLSPSSTQVVGLGVPRL FSPAP in isoform 2. 1 PublicationAdd BLAST193

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U60453 mRNA Translation: AAC53279.1
AB004817 mRNA Translation: BAA25018.1 Different initiation.
AF104360 Genomic DNA Translation: AAD54021.1
AF483490 mRNA Translation: AAL90764.1 Different initiation.
AF483491 mRNA Translation: AAL90765.1 Different initiation.
AK045374 mRNA Translation: BAC32334.1
AK138942 mRNA Translation: BAE23827.1 Different initiation.
AK140694 mRNA Translation: BAE24446.1 Different initiation.
AK154565 mRNA Translation: BAE32680.1 Different initiation.
AK164192 mRNA Translation: BAE37674.1 Different initiation.
AL590969 Genomic DNA No translation available.
CH466677 Genomic DNA Translation: EDL03899.1 Different initiation.
BC007135 mRNA Translation: AAH07135.1 Different initiation.

NCBI Reference Sequences

More...RefSeqi		NP_031996.1, NM_007970.3
XP_006532241.1, XM_006532178.3 [P70351-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000100417; ENSMUSP00000097984; ENSMUSG00000006920 [P70351-2]
ENSMUST00000107284; ENSMUSP00000102905; ENSMUSG00000006920 [P70351-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		14055

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:14055

UCSC genome browser

More...UCSCi		uc007lnw.3, mouse [P70351-2]
uc011yfk.2, mouse [P70351-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60453 mRNA Translation: AAC53279.1
AB004817 mRNA Translation: BAA25018.1 Different initiation.
AF104360 Genomic DNA Translation: AAD54021.1
AF483490 mRNA Translation: AAL90764.1 Different initiation.
AF483491 mRNA Translation: AAL90765.1 Different initiation.
AK045374 mRNA Translation: BAC32334.1
AK138942 mRNA Translation: BAE23827.1 Different initiation.
AK140694 mRNA Translation: BAE24446.1 Different initiation.
AK154565 mRNA Translation: BAE32680.1 Different initiation.
AK164192 mRNA Translation: BAE37674.1 Different initiation.
AL590969 Genomic DNA No translation available.
CH466677 Genomic DNA Translation: EDL03899.1 Different initiation.
BC007135 mRNA Translation: AAH07135.1 Different initiation.
RefSeqiNP_031996.1, NM_007970.3
XP_006532241.1, XM_006532178.3 [P70351-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi199563, 19 interactors
DIPiDIP-56992N
IntActiP70351, 8 interactors
STRINGi10090.ENSMUSP00000102906

PTM databases

iPTMnetiP70351
PhosphoSitePlusiP70351

Proteomic databases

EPDiP70351
MaxQBiP70351
PaxDbiP70351
PeptideAtlasiP70351
PRIDEiP70351

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1432, 389 antibodies

Genome annotation databases

EnsembliENSMUST00000100417; ENSMUSP00000097984; ENSMUSG00000006920 [P70351-2]
ENSMUST00000107284; ENSMUSP00000102905; ENSMUSG00000006920 [P70351-1]
GeneIDi14055
KEGGimmu:14055
UCSCiuc007lnw.3, mouse [P70351-2]
uc011yfk.2, mouse [P70351-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2145
MGIiMGI:1097695, Ezh1

Phylogenomic databases

eggNOGiKOG1079, Eukaryota
GeneTreeiENSGT00940000156604
HOGENOMiCLU_011342_0_0_1
InParanoidiP70351
OrthoDBi875190at2759
PhylomeDBiP70351
TreeFamiTF314509

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		14055, 1 hit in 19 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Ezh1, mouse

Protein Ontology

More...PROi		PR:P70351
RNActiP70351, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000006920, Expressed in adult mammalian kidney and 293 other tissues
ExpressionAtlasiP70351, baseline and differential
GenevisibleiP70351, MM

Family and domain databases

CDDicd00167, SANT, 1 hit
InterProiView protein in InterPro
IPR026489, CXC_dom
IPR032926, EZH1
IPR021654, EZH1/EZH2
IPR041343, PRC2_HTH_1
IPR041355, Pre-SET_CXC
IPR001005, SANT/Myb
IPR001214, SET_dom
IPR033467, Tesmin/TSO1-like_CXC
PANTHERiPTHR45747:SF1, PTHR45747:SF1, 1 hit
PfamiView protein in Pfam
PF11616, EZH2_WD-Binding, 1 hit
PF18118, PRC2_HTH_1, 1 hit
PF18264, preSET_CXC, 1 hit
PF00856, SET, 1 hit
SMARTiView protein in SMART
SM01114, CXC, 1 hit
SM00717, SANT, 2 hits
SM00317, SET, 1 hit
PROSITEiView protein in PROSITE
PS51633, CXC, 1 hit
PS50280, SET, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEZH1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P70351
Secondary accession number(s): A2A4K5
, Q3TPR1, Q3U3V5, Q3UU02, Q8BR85, Q922L1, Q9R089
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: December 2, 2020
This is version 161 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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