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Protein

Chorion-specific transcription factor GCMa

Gene

Gcm1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor that is necessary for placental development (PubMed:8962155). Involved in the control of expression of placental growth factor (PGF) and other placenta-specific genes. Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer. Binds to the SYDE1 promoter. Has a central role in mediating the differentiation of trophoblast cells along both the villous and extravillous pathways in placental development (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi76Zinc 11
Metal bindingi82Zinc 21
Metal bindingi86Zinc 21
Metal bindingi113Zinc 21
Metal bindingi116Zinc 21
Metal bindingi125Zinc 11
Metal bindingi152Zinc 11
Metal bindingi154Zinc 11

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi14 – 169GCMPROSITE-ProRule annotationAdd BLAST156

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Chorion-specific transcription factor GCMa
Alternative name(s):
GCM motif protein 1
Short name:
mGCM1
Short name:
mGCMa
Glial cells missing homolog 1
Gene namesi
Name:Gcm1
Synonyms:Gcma
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:108045 Gcm1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi63N → A: No effect on DNA binding. 1 Publication1
Mutagenesisi63N → Q: Slight decrease of DNA binding. 1 Publication1
Mutagenesisi65N → A: Strong decrease of DNA binding. 1 Publication1
Mutagenesisi65N → D: Loss of DNA binding. 1 Publication1
Mutagenesisi74K → A, L or M: Loss of DNA binding. 1 Publication1
Mutagenesisi76C → A: Loss of transcription activation. 1 Publication1
Mutagenesisi82C → A: Loss of transcription activation. 1 Publication1
Mutagenesisi113C → A: Loss of transcription activation. 1 Publication1
Mutagenesisi125C → A: Loss of transcription activation. 1 Publication1
Mutagenesisi152H → A: Loss of transcription activation. 1 Publication1
Mutagenesisi154H → A: Loss of transcription activation. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001266481 – 436Chorion-specific transcription factor GCMaAdd BLAST436

Post-translational modificationi

Polyubiquitinated in the presence of UBE2D2 and FBXW2 (in vitro).By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiP70348
PRIDEiP70348

PTM databases

iPTMnetiP70348
PhosphoSitePlusiP70348

Expressioni

Tissue specificityi

Placenta specific.1 Publication

Gene expression databases

BgeeiENSMUSG00000023333 Expressed in 13 organ(s), highest expression level in labyrinthine zone (mouse)
CleanExiMM_GCM1
ExpressionAtlasiP70348 baseline and differential
GenevisibleiP70348 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024104

Structurei

Secondary structure

1436
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP70348
SMRiP70348
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP70348

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IKM6 Eukaryota
ENOG4110IIJ LUCA
GeneTreeiENSGT00390000006777
HOGENOMiHOG000112700
HOVERGENiHBG039460
InParanoidiP70348
KOiK21598
OMAiWDFDEEM
OrthoDBiEOG091G06SW
PhylomeDBiP70348
TreeFamiTF324146

Family and domain databases

InterProiView protein in InterPro
IPR039791 GCM
IPR036115 GCM_dom_sf
IPR003902 Tscrpt_reg_GCM
PANTHERiPTHR12414 PTHR12414, 1 hit
PfamiView protein in Pfam
PF03615 GCM, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD014393 GCM_motif, 1 hit
SUPFAMiSSF90073 SSF90073, 1 hit
PROSITEiView protein in PROSITE
PS50807 GCM, 1 hit

Sequencei

Sequence statusi: Complete.

P70348-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELDDFDPED KEILSWDIND VKLPQNVKTT DWFQEWPDSY VKHIYSSDDR
60 70 80 90 100
NAQRHLSSWA MRNTNNHNSR ILKKSCLGVV VCSRDCSTEE GRKIYLRPAI
110 120 130 140 150
CDKARQKQQR KSCPNCNGPL KLIPCRGHGG FPVTNFWRHD GRFIFFQSKG
160 170 180 190 200
EHDHPRPETK LEAEARRAMK KVHMASASNS LRMKGRPAAK ALPAEIPSQG
210 220 230 240 250
SLPLTWSFQE GVQLPGTYST PLIANAPQQN SLNDCLSFPK SYDLGGSTEL
260 270 280 290 300
EDPTSTLDSM KFYERCKFSS SRIYGSEEQF QPPVPGTYGD YEDLQTWNKN
310 320 330 340 350
VALGRNPSDD IYYPAYPLPV ASWPYDYFPS QNSLEHLPQQ VPSEPPAAQP
360 370 380 390 400
GCHPLWSNPG GEPYEEKVSV DLSSYVPSLT YHPPQQDPFL LTYGSPTQQQ
410 420 430
HALPGKSNRW DFDEEMACMG LDHFNNEMLL NFCSLR
Length:436
Mass (Da):49,589
Last modified:February 1, 1997 - v1
Checksum:i99F4E441800582DB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti211G → S in BAA13650 (PubMed:8962155).Curated1
Sequence conflicti230N → K in BAA13650 (PubMed:8962155).Curated1
Sequence conflicti241S → N in BAA13650 (PubMed:8962155).Curated1
Sequence conflicti413D → E in BAA13650 (PubMed:8962155).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59876 mRNA Translation: AAC52822.1
D88612 mRNA Translation: BAA13650.1
BC066866 mRNA Translation: AAH66866.1
CCDSiCCDS23356.1
PIRiS74257
RefSeqiNP_032129.2, NM_008103.3
UniGeneiMm.1400

Genome annotation databases

EnsembliENSMUST00000024104; ENSMUSP00000024104; ENSMUSG00000023333
GeneIDi14531
KEGGimmu:14531
UCSCiuc009qto.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59876 mRNA Translation: AAC52822.1
D88612 mRNA Translation: BAA13650.1
BC066866 mRNA Translation: AAH66866.1
CCDSiCCDS23356.1
PIRiS74257
RefSeqiNP_032129.2, NM_008103.3
UniGeneiMm.1400

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ODHX-ray2.85A1-174[»]
ProteinModelPortaliP70348
SMRiP70348
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024104

PTM databases

iPTMnetiP70348
PhosphoSitePlusiP70348

Proteomic databases

PaxDbiP70348
PRIDEiP70348

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024104; ENSMUSP00000024104; ENSMUSG00000023333
GeneIDi14531
KEGGimmu:14531
UCSCiuc009qto.1 mouse

Organism-specific databases

CTDi8521
MGIiMGI:108045 Gcm1

Phylogenomic databases

eggNOGiENOG410IKM6 Eukaryota
ENOG4110IIJ LUCA
GeneTreeiENSGT00390000006777
HOGENOMiHOG000112700
HOVERGENiHBG039460
InParanoidiP70348
KOiK21598
OMAiWDFDEEM
OrthoDBiEOG091G06SW
PhylomeDBiP70348
TreeFamiTF324146

Miscellaneous databases

EvolutionaryTraceiP70348
PROiPR:P70348
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023333 Expressed in 13 organ(s), highest expression level in labyrinthine zone (mouse)
CleanExiMM_GCM1
ExpressionAtlasiP70348 baseline and differential
GenevisibleiP70348 MM

Family and domain databases

InterProiView protein in InterPro
IPR039791 GCM
IPR036115 GCM_dom_sf
IPR003902 Tscrpt_reg_GCM
PANTHERiPTHR12414 PTHR12414, 1 hit
PfamiView protein in Pfam
PF03615 GCM, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD014393 GCM_motif, 1 hit
SUPFAMiSSF90073 SSF90073, 1 hit
PROSITEiView protein in PROSITE
PS50807 GCM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGCM1_MOUSE
AccessioniPrimary (citable) accession number: P70348
Secondary accession number(s): O09103
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: February 1, 1997
Last modified: November 7, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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