Mothers against decapentaplegic homolog 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• co-SMAD binding Source: MGI
• DEAD/H-box RNA helicase binding Source: MGI
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
• DNA-binding transcription factor activity Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis."
    Xiao C., Shim J.-H., Klueppel M., Zhang S.S.-M., Dong C., Flavell R.A., Fu X.-Y., Wrana J.L., Hogan B.L.M., Ghosh S.
    Genes Dev. 17:2933-2949(2003) [PubMed] [Europe PMC] [Abstract]
  • "Isl1Cre reveals a common Bmp pathway in heart and limb development."
    Yang L., Cai C.L., Lin L., Qyang Y., Chung C., Monteiro R.M., Mummery C.L., Fishman G.I., Cogen A., Evans S.
    Development 133:1575-1585(2006) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: MGIInferred from direct assayⁱ
  • "New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance."
    Schwaerzer G.K., Hiepen C., Schrewe H., Nickel J., Ploeger F., Sebald W., Mueller T., Knaus P.
    J. Bone Miner. Res. 27:429-442(2012) [PubMed] [Europe PMC] [Abstract]
• identical protein binding Source: MGI <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Structural basis for the cooperative DNA recognition by Smad4 MH1 dimers."
    Baburajendran N., Jauch R., Tan C.Y., Narasimhan K., Kolatkar P.R.
    Nucleic Acids Res 39:8213-8222(2011) [PubMed] [Europe PMC] [Abstract]
• I-SMAD binding Source: MGI
• metal ion binding Source: UniProtKB-KW
• primary miRNA binding Source: BHF-UCLInferred from direct assayⁱ
  • "Bmp signaling regulates myocardial differentiation from cardiac progenitors through a MicroRNA-mediated mechanism."
    Wang J., Greene S.B., Bonilla-Claudio M., Tao Y., Zhang J., Bai Y., Huang Z., Black B.L., Wang F., Martin J.F.
    Dev Cell 19:903-912(2010) [PubMed] [Europe PMC] [Abstract]
• protein kinase binding Source: MGI
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGIInferred from direct assayⁱ
  • "Smad4-dependent desmoglein-4 expression contributes to hair follicle integrity."
    Owens P., Bazzi H., Engelking E., Han G., Christiano A.M., Wang X.J.
    Dev Biol 322:156-166(2008) [PubMed] [Europe PMC] [Abstract]
• sequence-specific DNA binding Source: UniProtKBInferred from direct assayⁱ
  • "Co-motif discovery identifies an Esrrb-Sox2-DNA ternary complex as a mediator of transcriptional differences between mouse embryonic and epiblast stem cells."
    Hutchins A.P., Choo S.H., Mistri T.K., Rahmani M., Woon C.T., Ng C.K., Jauch R., Robson P.
    Stem Cells 31:269-281(2013) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• anatomical structure morphogenesis Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• BMP signaling pathway Source: MGIInferred from direct assayⁱ
  • "New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance."
    Schwaerzer G.K., Hiepen C., Schrewe H., Nickel J., Ploeger F., Sebald W., Mueller T., Knaus P.
    J. Bone Miner. Res. 27:429-442(2012) [PubMed] [Europe PMC] [Abstract]
  • "C-terminal domain (CTD) small phosphatase-like 2 modulates the canonical bone morphogenetic protein (BMP) signaling and mesenchymal differentiation via Smad dephosphorylation."
    Zhao Y., Xiao M., Sun B., Zhang Z., Shen T., Duan X., Yu P.B., Feng X.H., Lin X.
    J Biol Chem 289:26441-26450(2014) [PubMed] [Europe PMC] [Abstract]
• bone development Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation."
    Retting K.N., Song B., Yoon B.S., Lyons K.M.
    Development 136:1093-1104(2009) [PubMed] [Europe PMC] [Abstract]
• cardiac muscle cell proliferation Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation."
    Prall O.W., Menon M.K., Solloway M.J., Watanabe Y., Zaffran S., Bajolle F., Biben C., McBride J.J., Robertson B.R., Chaulet H., Stennard F.A., Wise N., Schaft D., Wolstein O., Furtado M.B., Shiratori H., Chien K.R., Hamada H.

    , Black B.L., Saga Y., Robertson E.J., Buckingham M.E., Harvey R.P.
    Cell 128:947-959(2007) [PubMed] [Europe PMC] [Abstract]
• cartilage development Source: MGIInferred from genetic interactionⁱ
  • "BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation."
    Retting K.N., Song B., Yoon B.S., Lyons K.M.
    Development 136:1093-1104(2009) [PubMed] [Europe PMC] [Abstract]
• cell differentiation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cellular response to BMP stimulus Source: BHF-UCLInferred from genetic interactionⁱ
  • "The canonical BMP signaling pathway plays a crucial part in stimulation of dentin sialophosphoprotein expression by BMP-2."
    Cho Y.D., Yoon W.J., Woo K.M., Baek J.H., Park J.C., Ryoo H.M.
    J Biol Chem 285:36369-36376(2010) [PubMed] [Europe PMC] [Abstract]
• cellular response to organic cyclic compound Source: MGIInferred from direct assayⁱ
  • "Inhibition of microtubule assembly in osteoblasts stimulates bone morphogenetic protein 2 expression and bone formation through transcription factor Gli2."
    Zhao M., Ko S.Y., Liu J.H., Chen D., Zhang J., Wang B., Harris S.E., Oyajobi B.O., Mundy G.R.
    Mol Cell Biol 29:1291-1305(2009) [PubMed] [Europe PMC] [Abstract]
• embryonic pattern specification Source: UniProtKB
• gamete generation Source: MGIInferred from mutant phenotypeⁱ
  • "In vivo convergence of BMP and MAPK signaling pathways: impact of differential Smad1 phosphorylation on development and homeostasis."
    Aubin J., Davy A., Soriano P.
    Genes Dev 18:1482-1494(2004) [PubMed] [Europe PMC] [Abstract]
• hindbrain development Source: MGIInferred from mutant phenotypeⁱ
  • "Smad1 and Smad8 function similarly in mammalian central nervous system development."
    Hester M., Thompson J.C., Mills J., Liu Y., El-Hodiri H.M., Weinstein M.
    Mol Cell Biol 25:4683-4692(2005) [PubMed] [Europe PMC] [Abstract]
• homeostatic process Source: MGIInferred from mutant phenotypeⁱ
  • "In vivo convergence of BMP and MAPK signaling pathways: impact of differential Smad1 phosphorylation on development and homeostasis."
    Aubin J., Davy A., Soriano P.
    Genes Dev 18:1482-1494(2004) [PubMed] [Europe PMC] [Abstract]
• inflammatory response Source: UniProtKB <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Activation of bone morphogenetic protein/Smad signaling in bronchial epithelial cells during airway inflammation."
    Rosendahl A., Pardali E., Speletas M., Ten Dijke P., Heldin C.H., Sideras P.
    Am J Respir Cell Mol Biol 27:160-169(2002) [PubMed] [Europe PMC] [Abstract]
• MAPK cascade Source: MGIInferred from mutant phenotypeⁱ
  • "In vivo convergence of BMP and MAPK signaling pathways: impact of differential Smad1 phosphorylation on development and homeostasis."
    Aubin J., Davy A., Soriano P.
    Genes Dev 18:1482-1494(2004) [PubMed] [Europe PMC] [Abstract]
• mesodermal cell fate commitment Source: MGIInferred from genetic interactionⁱ
  • Ref.10

    "Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells."
    Suzuki A., Raya A., Kawakami Y., Morita M., Matsui T., Nakashima K., Gage F.H., Rodriguez-Esteban C., Izpisua Belmonte J.C.
    Proc. Natl. Acad. Sci. U.S.A. 103:10294-10299(2006) [PubMed] [Europe PMC] [Abstract]

    Cited for: INTERACTION WITH NANOG.
• midbrain development Source: MGIInferred from mutant phenotypeⁱ
  • "Smad1 and Smad8 function similarly in mammalian central nervous system development."
    Hester M., Thompson J.C., Mills J., Liu Y., El-Hodiri H.M., Weinstein M.
    Mol Cell Biol 25:4683-4692(2005) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell population proliferation Source: MGIInferred from mutant phenotypeⁱ
  • "Smad1 and Smad8 function similarly in mammalian central nervous system development."
    Hester M., Thompson J.C., Mills J., Liu Y., El-Hodiri H.M., Weinstein M.
    Mol Cell Biol 25:4683-4692(2005) [PubMed] [Europe PMC] [Abstract]
• negative regulation of muscle cell differentiation Source: MGIInferred from direct assayⁱ
  • "New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance."
    Schwaerzer G.K., Hiepen C., Schrewe H., Nickel J., Ploeger F., Sebald W., Mueller T., Knaus P.
    J. Bone Miner. Res. 27:429-442(2012) [PubMed] [Europe PMC] [Abstract]
• osteoblast differentiation Source: MGIInferred from direct assayⁱ
  • "Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage."
    Katagiri T., Yamaguchi A., Komaki M., Abe E., Takahashi N., Ikeda T., Rosen V., Wozney J.M., Fujisawa-Sehara A., Suda T.
    J Cell Biol 127:1755-1766(1994) [PubMed] [Europe PMC] [Abstract]
• osteoblast fate commitment Source: MGIInferred from genetic interactionⁱ
  • "Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2."
    Sowa H., Kaji H., Hendy G.N., Canaff L., Komori T., Sugimoto T., Chihara K.
    J Biol Chem 279:40267-40275(2004) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cartilage development Source: MGIInferred from direct assayⁱ
  • "miR-199a, a bone morphogenic protein 2-responsive MicroRNA, regulates chondrogenesis via direct targeting to Smad1."
    Lin E.A., Kong L., Bai X.H., Luan Y., Liu C.J.
    J Biol Chem 284:11326-11335(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell differentiation Source: MGI
• positive regulation of gene expression Source: MGIInferred from mutant phenotypeⁱ
  • "Critical function of Prdm14 for the establishment of the germ cell lineage in mice."
    Yamaji M., Seki Y., Kurimoto K., Yabuta Y., Yuasa M., Shigeta M., Yamanaka K., Ohinata Y., Saitou M.
    Nat. Genet. 40:1016-1022(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of osteoblast differentiation Source: MGIInferred from genetic interactionⁱ
  • "Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2."
    Sowa H., Kaji H., Hendy G.N., Canaff L., Komori T., Sugimoto T., Chihara K.
    J Biol Chem 279:40267-40275(2004) [PubMed] [Europe PMC] [Abstract]
• positive regulation of pri-miRNA transcription by RNA polymerase II Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Bmp signaling regulates myocardial differentiation from cardiac progenitors through a MicroRNA-mediated mechanism."
    Wang J., Greene S.B., Bonilla-Claudio M., Tao Y., Zhang J., Bai Y., Huang Z., Black B.L., Wang F., Martin J.F.
    Dev Cell 19:903-912(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of sprouting angiogenesis Source: MGI
• positive regulation of transcription by RNA polymerase II Source: MGIInferred from direct assayⁱ
  • "The interferon-inducible p204 protein acts as a transcriptional coactivator of Cbfa1 and enhances osteoblast differentiation."
    Liu C.-J., Chang E., Yu J., Carlson C.S., Prazak L., Yu X.-P., Ding B., Lengyel P., Di Cesare P.E.
    J. Biol. Chem. 280:2788-2796(2005) [PubMed] [Europe PMC] [Abstract]
  • "Isl1Cre reveals a common Bmp pathway in heart and limb development."
    Yang L., Cai C.L., Lin L., Qyang Y., Chung C., Monteiro R.M., Mummery C.L., Fishman G.I., Cogen A., Evans S.
    Development 133:1575-1585(2006) [PubMed] [Europe PMC] [Abstract]
  • "Two BMP responsive elements, STAT, and bZIP/HNF4/COUP motifs of the hepcidin promoter are critical for BMP, SMAD1, and HJV responsiveness."
    Truksa J., Lee P., Beutler E.
    Blood 113:688-695(2009) [PubMed] [Europe PMC] [Abstract]
  • "miR-199a, a bone morphogenic protein 2-responsive MicroRNA, regulates chondrogenesis via direct targeting to Smad1."
    Lin E.A., Kong L., Bai X.H., Luan Y., Liu C.J.
    J Biol Chem 284:11326-11335(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus Source: BHF-UCLInferred from genetic interactionⁱ
  • "The canonical BMP signaling pathway plays a crucial part in stimulation of dentin sialophosphoprotein expression by BMP-2."
    Cho Y.D., Yoon W.J., Woo K.M., Baek J.H., Park J.C., Ryoo H.M.
    J Biol Chem 285:36369-36376(2010) [PubMed] [Europe PMC] [Abstract]
• protein phosphorylation Source: MGIInferred from direct assayⁱ
  • "Teashirt 3 is necessary for ureteral smooth muscle differentiation downstream of SHH and BMP4."
    Caubit X., Lye C.M., Martin E., Core N., Long D.A., Vola C., Jenkins D., Garratt A.N., Skaer H., Woolf A.S., Fasano L.
    Development 135:3301-3310(2008) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: MGIInferred from direct assayⁱ
  • "Regulation of Hex gene expression by a Smads-dependent signaling pathway."
    Zhang W., Yatskievych T.A., Cao X., Antin P.B.
    J Biol Chem 277:45435-45441(2002) [PubMed] [Europe PMC] [Abstract]
  • "Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis."
    Xiao C., Shim J.-H., Klueppel M., Zhang S.S.-M., Dong C., Flavell R.A., Fu X.-Y., Wrana J.L., Hogan B.L.M., Ghosh S.
    Genes Dev. 17:2933-2949(2003) [PubMed] [Europe PMC] [Abstract]
• response to drug Source: MGI
• SMAD protein complex assembly Source: MGI
• SMAD protein signal transduction Source: BHF-UCLInferred from genetic interactionⁱ
  • "Lack of the bone morphogenetic protein BMP6 induces massive iron overload."
    Meynard D., Kautz L., Darnaud V., Canonne-Hergaux F., Coppin H., Roth M.P.
    Nat Genet 41:478-481(2009) [PubMed] [Europe PMC] [Abstract]
• transforming growth factor beta receptor signaling pathway Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• ureteric bud development Source: UniProtKBInferred from expression patternⁱ
  • "Smad expression during kidney development."
    Vrljicak P., Myburgh D., Ryan A.K., van Rooijen M.A., Mummery C.L., Gupta I.R.
    Am J Physiol Renal Physiol 286:F625-33(2004) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• co-SMAD binding Source: MGI
• DEAD/H-box RNA helicase binding Source: MGI
• identical protein binding Source: MGIInferred from physical interactionⁱ
  • "Structural basis for the cooperative DNA recognition by Smad4 MH1 dimers."
    Baburajendran N., Jauch R., Tan C.Y., Narasimhan K., Kolatkar P.R.
    Nucleic Acids Res 39:8213-8222(2011) [PubMed] [Europe PMC] [Abstract]
• I-SMAD binding Source: MGI
• protein kinase binding Source: MGI

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MNVTSLFSFT SPAVKRLLGW KQGDEEEKWA EKAVDALVKK LKKKKGAMEE 
        60         70         80         90        100
LEKALSCPGQ PSNCVTIPRS LDGRLQVSHR KGLPHVIYCR VWRWPDLQSH 
       110        120        130        140        150
HELKPLECCE FPFGSKQKEV CINPYHYKRV ESPVLPPVLV PRHSEYNPQH 
       160        170        180        190        200
SLLAQFRNLG QNEPHMPLNA TFPDSFQQPN SHPFPHSPNS SYPNSPGGSS 
       210        220        230        240        250
STYPHSPTSS DPGSPFQMPA DTPPPAYLPP EDPMAQDGSQ PMDTNMMAPP 
       260        270        280        290        300
LPAEISRGDV QAVAYEEPKH WCSIVYYELN NRVGEAFHAS STSVLVDGFT 
       310        320        330        340        350
DPSNNKNRFC LGLLSNVNRN STIENTRRHI GKGVHLYYVG GEVYAECLSD 
       360        370        380        390        400
SSIFVQSRNC NYHHGFHPTT VCKIPSGCSL KIFNNQEFAQ LLAQSVNHGF 
       410        420        430        440        450
ETVYELTKMC TIRMSFVKGW GAEYHRQDVT STPCWIEIHL HGPLQWLDKV 
       460 
LTQMGSPHNP ISSVS                                       

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
2. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
3. SIMILARITY comments
   Index of protein domains and families