Smad1

Functionⁱ

Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD) (By similarity). May play a role in the initiation and maintenance of spermatogenesis. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1 (By similarity). May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343).By similarity1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	64	Zinc	1
Metal bindingⁱ	109	Zinc	1
Metal bindingⁱ	121	Zinc	1
Metal bindingⁱ	126	Zinc	1

GO - Molecular functionⁱ

co-SMAD binding Source: MGI
DEAD/H-box RNA helicase binding Source: MGI
DNA-binding transcription factor activity
Source: MGI
Inferred from direct assayⁱ
- 14633973
- 16556916
identical protein binding Source: MGI
I-SMAD binding Source: MGI
metal ion binding Source: UniProtKB-KW
primary miRNA binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 21145505
protein heterodimerization activity
Source: MGI
Inferred from direct assayⁱ
- 21724602
protein homodimerization activity
Source: MGI
Inferred from direct assayⁱ
- 21724602
protein kinase binding Source: MGI
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: MGI
Inferred from direct assayⁱ
- 18692037
sequence-specific DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 23169531

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

BMP signaling pathway
Source: MGI
Inferred from direct assayⁱ
- 25100727
bone development
Source: MGI
Inferred from genetic interactionⁱ
- 19224984
cardiac muscle cell proliferation
Source: MGI
Inferred from mutant phenotypeⁱ
- 17350578
cartilage development
Source: MGI
Inferred from genetic interactionⁱ
- 19224984
cellular response to BMP stimulus
Source: BHF-UCL
Inferred from genetic interactionⁱ
- 20843790
cellular response to organic cyclic compound
Source: MGI
Inferred from direct assayⁱ
- 19103752
embryonic pattern specification Source: UniProtKB
gamete generation
Source: MGI
Inferred from mutant phenotypeⁱ
- 15198985
hindbrain development
Source: MGI
Inferred from mutant phenotypeⁱ
- 15899870
homeostatic process
Source: MGI
Inferred from mutant phenotypeⁱ
- 15198985
inflammatory response
Source: UniProtKB
Inferred from expression patternⁱ
- 12151307
MAPK cascade
Source: MGI
Inferred from mutant phenotypeⁱ
- 15198985
mesodermal cell fate commitment
Source: MGI
Inferred from genetic interactionⁱ
- 16801560
midbrain development
Source: MGI
Inferred from mutant phenotypeⁱ
- 15899870
negative regulation of cell proliferation
Source: MGI
Inferred from mutant phenotypeⁱ
- 15899870
osteoblast fate commitment
Source: MGI
Inferred from genetic interactionⁱ
- 15150273
positive regulation of cartilage development
Source: MGI
Inferred from direct assayⁱ
- 19251704
positive regulation of cell differentiation Source: MGI
positive regulation of gene expression
Source: MGI
Inferred from mutant phenotypeⁱ
- 18622394
positive regulation of osteoblast differentiation
Source: MGI
Inferred from genetic interactionⁱ
- 15150273
positive regulation of pri-miRNA transcription by RNA polymerase II
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 21145505
positive regulation of sprouting angiogenesis Source: MGI
positive regulation of transcription by RNA polymerase II
Source: MGI
Inferred from direct assayⁱ
positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
Source: BHF-UCL
Inferred from genetic interactionⁱ
- 20843790
protein phosphorylation
Source: MGI
Inferred from direct assayⁱ
- 18776146
regulation of transcription by RNA polymerase II
Source: MGI
Inferred from direct assayⁱ
- 12270938
- 14633973
response to drug Source: MGI
SMAD protein complex assembly Source: MGI
SMAD protein signal transduction
Source: BHF-UCL
Inferred from genetic interactionⁱ
- 19252488
transforming growth factor beta receptor signaling pathway Source: InterPro
ureteric bud development
Source: UniProtKB
Inferred from expression patternⁱ
- 14656760

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-MMU-201451 Signaling by BMP R-MMU-5689880 Ub-specific processing proteases R-MMU-8941326 RUNX2 regulates bone development

Reactomeⁱ

R-MMU-201451 Signaling by BMP
R-MMU-5689880 Ub-specific processing proteases
R-MMU-8941326 RUNX2 regulates bone development

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Mothers against decapentaplegic homolog 1 Short name: MAD homolog 1 Short name: Mothers against DPP homolog 1 Alternative name(s): Dwarfin-A Short name: Dwf-A Mothers-against-DPP-related 1 Short name: Mad-related protein 1 Short name: mMad1 SMAD family member 1 Short name: SMAD 1 Short name: Smad1
Gene namesⁱ	Name:Smad1 Synonyms:Madh1, Madr1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 8

Organism-specific databases

MGIⁱ	MGI:109452 Smad1

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Chemistry databases

ChEMBLⁱ	CHEMBL3883282

ChEMBLⁱ

CHEMBL3883282

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000090848	1 – 465	Mothers against decapentaplegic homolog 1Add BLAST		465

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineBy similarity	1
Modified residueⁱ	322	Phosphothreonine; by MINK1, TNIK and MAP4K4By similarity	1
Modified residueⁱ	463	PhosphoserinePROSITE-ProRule annotationBy similarity	1
Modified residueⁱ	465	PhosphoserinePROSITE-ProRule annotationBy similarity	1

Post-translational modificationⁱ

Phosphorylation of the C-terminal SVS motif by BMP type 1 receptor kinase activates SMAD1 by promoting dissociation from the receptor and trimerization with SMAD4 (By similarity). Dephosphorylation, probably by PPM1A, induces its export from the nucleus to the cytoplasm (PubMed:25755279).By similarity1 Publication

Ubiquitinated by SMAD-specific E3 ubiquitin ligase SMURF1, leading to its degradation. Monoubiquitinated, leading to prevent DNA-binding. Deubiquitination by USP15 alleviates inhibition and promotes activation of TGF-beta target genes (By similarity).By similarity

Keywords - PTMⁱ

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P70340
PaxDbⁱ	P70340
PeptideAtlas More...PeptideAtlasⁱ	P70340
PRIDEⁱ	P70340

PTM databases

iPTMnetⁱ	P70340
PhosphoSitePlusⁱ	P70340

Expressionⁱ

Tissue specificityⁱ

Ubiquitous.

Developmental stageⁱ

Ubiquitously expressed during embryogenesis. Expression starts in some seminiferous tubules at 2 weeks of age. After mid-puberty a stage-specific expression is established. During the cycling of the seminiferous epithelium, expression initiates in the pachytene spermatocytes of stage V seminiferous tubules, peaks at stage X, then decreases as pachytene spermatocytes differentiate into secondary spermatocytes and then round spermatids.

Gene expression databases

Bgeeⁱ	ENSMUSG00000031681 Expressed in 328 organ(s), highest expression level in pineal body
CleanExⁱ	MM_SMAD1
ExpressionAtlasⁱ	P70340 baseline and differential
Genevisibleⁱ	P70340 MM

Interactionⁱ

Subunit structureⁱ

Upon C-terminus phosphorylation: forms trimers with another SMAD1 and the co-SMAD SMAD4. Interacts with PEBP2-alpha subunit, CREB-binding protein (CBP), p300, SMURF1, SMURF2, USP15 and HOXC8. Associates with ZNF423 or ZNF521 in response to BMP2 leading to activate transcription of BMP target genes. Interacts with SKOR1. Interacts (via MH2 domain) with LEMD3. Binding to LEMD3 results in at least a partial reduction of receptor-mediated phosphorylation (By similarity). Also interacts with HGS, NANOG and ZCCHC12. Forms a ternary complex with PSMB4 and OAZ1 before PSMB4 is incorporated into the 20S proteasome (By similarity). Found in a complex with SMAD4 and YY1. Interacts (via MH2 domain) with FAM83G (via MH2 domain); in a SMAD4-independent manner. Interacts with ZC3H3 (PubMed:16115198). Interacts with TMEM119 (PubMed:21239498). Interacts (via MH1 and MH2 domains) with ZNF8 (PubMed:12370310). Interacts with RANBP3L; the interaction increases when SMAD1 is not phosphorylated and mediates SMAD1 nuclear export (PubMed:25755279).By similarity9 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Map3k7	Q62073	3	EBI-6992047,EBI-1775345

With

Entry

#Exp.

IntAct

Notes

Map3k7

Q62073

3

EBI-6992047,EBI-1775345

GO - Molecular functionⁱ

co-SMAD binding Source: MGI
DEAD/H-box RNA helicase binding Source: MGI
identical protein binding Source: MGI
I-SMAD binding Source: MGI
protein heterodimerization activity
Source: MGI
Inferred from direct assayⁱ
- 21724602
protein homodimerization activity
Source: MGI
Inferred from direct assayⁱ
- 21724602
protein kinase binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	201274, 34 interactors
ComplexPortalⁱ	CPX-145 SMAD1 homotrimer CPX-146 SMAD1-SMAD4 complex
CORUMⁱ	P70340
IntActⁱ	P70340, 7 interactors
Molecular INTeraction database More...MINTⁱ	P70340
STRINGⁱ	10090.ENSMUSP00000071035

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	12 – 19	Combined sources	8
Helixⁱ	25 – 41	Combined sources	17
Helixⁱ	47 – 56	Combined sources	10
Beta strandⁱ	66 – 68	Combined sources	3
Beta strandⁱ	71 – 73	Combined sources	3
Beta strandⁱ	75 – 77	Combined sources	3
Beta strandⁱ	80 – 82	Combined sources	3
Helixⁱ	84 – 92	Combined sources	9
Helixⁱ	100 – 102	Combined sources	3
Beta strandⁱ	103 – 105	Combined sources	3
Helixⁱ	113 – 115	Combined sources	3
Beta strandⁱ	118 – 121	Combined sources	4
Helixⁱ	124 – 126	Combined sources	3
Beta strandⁱ	127 – 129	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	P70340
SMRⁱ	P70340
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P70340

EvolutionaryTraceⁱ

P70340

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	12 – 136	MH1PROSITE-ProRule annotationAdd BLAST		125
Domainⁱ	271 – 465	MH2PROSITE-ProRule annotationAdd BLAST		195

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	418 – 428	L3 loopBy similarityAdd BLAST		11

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	39 – 45	Poly-Lys		7

Domainⁱ

The MH2 domain mediates phosphorylation-dependent trimerization through L3 loop binding of phosphoserines in the adjacent subunit.By similarity

Sequence similaritiesⁱ

Belongs to the dwarfin/SMAD family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3701 Eukaryota ENOG410XQKU LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119091
HOGENOMⁱ	HOG000286018
HOVERGENⁱ	HBG053353
InParanoidⁱ	P70340
KEGG Orthology (KO) More...KOⁱ	K04676
OMAⁱ	GTPSKCV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G082C
TreeFamⁱ	TF314923

Family and domain databases

Gene3Dⁱ	2.60.200.10, 1 hit 3.90.520.10, 1 hit
InterProⁱ	View protein in InterPro IPR013790 Dwarfin IPR003619 MAD_homology1_Dwarfin-type IPR013019 MAD_homology_MH1 IPR017855 SMAD-like_dom_sf IPR001132 SMAD_dom_Dwarfin-type IPR008984 SMAD_FHA_dom_sf IPR036578 SMAD_MH1_sf
PANTHERⁱ	PTHR13703 PTHR13703, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03165 MH1, 1 hit PF03166 MH2, 1 hit
SMARTⁱ	View protein in SMART SM00523 DWA, 1 hit SM00524 DWB, 1 hit
SUPFAMⁱ	SSF49879 SSF49879, 1 hit SSF56366 SSF56366, 1 hit
PROSITEⁱ	View protein in PROSITE PS51075 MH1, 1 hit PS51076 MH2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P70340-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNVTSLFSFT SPAVKRLLGW KQGDEEEKWA EKAVDALVKK LKKKKGAMEE 
        60         70         80         90        100
LEKALSCPGQ PSNCVTIPRS LDGRLQVSHR KGLPHVIYCR VWRWPDLQSH 
       110        120        130        140        150
HELKPLECCE FPFGSKQKEV CINPYHYKRV ESPVLPPVLV PRHSEYNPQH 
       160        170        180        190        200
SLLAQFRNLG QNEPHMPLNA TFPDSFQQPN SHPFPHSPNS SYPNSPGGSS 
       210        220        230        240        250
STYPHSPTSS DPGSPFQMPA DTPPPAYLPP EDPMAQDGSQ PMDTNMMAPP 
       260        270        280        290        300
LPAEISRGDV QAVAYEEPKH WCSIVYYELN NRVGEAFHAS STSVLVDGFT 
       310        320        330        340        350
DPSNNKNRFC LGLLSNVNRN STIENTRRHI GKGVHLYYVG GEVYAECLSD 
       360        370        380        390        400
SSIFVQSRNC NYHHGFHPTT VCKIPSGCSL KIFNNQEFAQ LLAQSVNHGF 
       410        420        430        440        450
ETVYELTKMC TIRMSFVKGW GAEYHRQDVT STPCWIEIHL HGPLQWLDKV 
       460 
LTQMGSPHNP ISSVS

Length:465

Mass (Da):52,157

Last modified:July 27, 2011 - v2

Checksum:ⁱ07A56FBEE79A1C2A

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	Q8C3Y6	Q8C3Y6_MOUSE		Mothers against decapentaplegic hom... Mothers against decapentaplegic homolog, MAD homolog, Mothers against DPP homolog (SMAD family member)	Smad1	428	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	95	P → S in AAC52785 (PubMed:8799132).Curated	1
Sequence conflictⁱ	95	P → S in AAG41407 (PubMed:11111041).Curated	1
Sequence conflictⁱ	142	R → K in AAC52785 (PubMed:8799132).Curated	1
Sequence conflictⁱ	142	R → K in AAG41407 (PubMed:11111041).Curated	1
Sequence conflictⁱ	199 – 200	SS → QG in AAB18256 (PubMed:9076678).Curated	2
Sequence conflictⁱ	393	A → E in AAB18256 (PubMed:9076678).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U58992 mRNA Translation: AAC52785.1 U74359 mRNA Translation: AAB18256.1 AF295768 AF295767 Genomic DNA Translation: AAG41407.1 AK017583 mRNA Translation: BAB30820.1 AK054104 mRNA Translation: BAC35658.1 BC058693 mRNA Translation: AAH58693.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS22437.1
NCBI Reference Sequences More...RefSeqⁱ	NP_032565.2, NM_008539.3 XP_006530809.1, XM_006530746.3
UniGeneⁱ	Mm.223717

Genome annotation databases

Ensemblⁱ	ENSMUST00000066091; ENSMUSP00000071035; ENSMUSG00000031681
GeneIDⁱ	17125
KEGGⁱ	mmu:17125
UCSC genome browser More...UCSCⁱ	uc009mip.2 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P70340	Mothers against decapentaplegic homolog 1	)	HUMAN		465	UniRef90_Q15797
Mothers against decapentaplegic homolog 1		DANRE		472
Mothers against decapentaplegic homolog 1		BOVIN		465
Mothers against decapentaplegic homolog		MACMU		465
Mothers against decapentaplegic homolog		Cebus capucinus imitator		465
+135

Protein	Similar proteins		Species	Score	Length	Source
P70340	Mothers against decapentaplegic homolog 1	)	HUMAN		465	UniRef50_Q15797
Mothers against decapentaplegic homolog 1		DANRE		472
Mothers against decapentaplegic homolog 1		BOVIN		465
Mothers against decapentaplegic homolog 5		PONAB		465
Mothers against decapentaplegic homolog 5		CHICK		465
+896

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U58992 mRNA Translation: AAC52785.1 U74359 mRNA Translation: AAB18256.1 AF295768 AF295767 Genomic DNA Translation: AAG41407.1 AK017583 mRNA Translation: BAB30820.1 AK054104 mRNA Translation: BAC35658.1 BC058693 mRNA Translation: AAH58693.1
CCDSⁱ	CCDS22437.1
RefSeqⁱ	NP_032565.2, NM_008539.3 XP_006530809.1, XM_006530746.3
UniGeneⁱ	Mm.223717

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3KMP	X-ray	2.70	A/B	9-132	[»]
ProteinModelPortalⁱ	P70340
SMRⁱ	P70340
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	201274, 34 interactors
ComplexPortalⁱ	CPX-145 SMAD1 homotrimer CPX-146 SMAD1-SMAD4 complex
CORUMⁱ	P70340
IntActⁱ	P70340, 7 interactors
MINTⁱ	P70340
STRINGⁱ	10090.ENSMUSP00000071035

Chemistry databases

ChEMBLⁱ	CHEMBL3883282

ChEMBLⁱ

CHEMBL3883282

PTM databases

iPTMnetⁱ	P70340
PhosphoSitePlusⁱ	P70340

Proteomic databases

MaxQBⁱ	P70340
PaxDbⁱ	P70340
PeptideAtlasⁱ	P70340
PRIDEⁱ	P70340

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000066091; ENSMUSP00000071035; ENSMUSG00000031681
GeneIDⁱ	17125
KEGGⁱ	mmu:17125
UCSCⁱ	uc009mip.2 mouse

Organism-specific databases

CTDⁱ	4086
MGIⁱ	MGI:109452 Smad1

Phylogenomic databases

eggNOGⁱ	KOG3701 Eukaryota ENOG410XQKU LUCA
GeneTreeⁱ	ENSGT00760000119091
HOGENOMⁱ	HOG000286018
HOVERGENⁱ	HBG053353
InParanoidⁱ	P70340
KOⁱ	K04676
OMAⁱ	GTPSKCV
OrthoDBⁱ	EOG091G082C
TreeFamⁱ	TF314923

Enzyme and pathway databases

Reactomeⁱ	R-MMU-201451 Signaling by BMP R-MMU-5689880 Ub-specific processing proteases R-MMU-8941326 RUNX2 regulates bone development

Reactomeⁱ

R-MMU-201451 Signaling by BMP
R-MMU-5689880 Ub-specific processing proteases
R-MMU-8941326 RUNX2 regulates bone development

Miscellaneous databases

ChiTaRSⁱ	Smad1 mouse
EvolutionaryTraceⁱ	P70340
Protein Ontology More...PROⁱ	PR:P70340
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000031681 Expressed in 328 organ(s), highest expression level in pineal body
CleanExⁱ	MM_SMAD1
ExpressionAtlasⁱ	P70340 baseline and differential
Genevisibleⁱ	P70340 MM

Family and domain databases

Gene3Dⁱ	2.60.200.10, 1 hit 3.90.520.10, 1 hit
InterProⁱ	View protein in InterPro IPR013790 Dwarfin IPR003619 MAD_homology1_Dwarfin-type IPR013019 MAD_homology_MH1 IPR017855 SMAD-like_dom_sf IPR001132 SMAD_dom_Dwarfin-type IPR008984 SMAD_FHA_dom_sf IPR036578 SMAD_MH1_sf
PANTHERⁱ	PTHR13703 PTHR13703, 1 hit
Pfamⁱ	View protein in Pfam PF03165 MH1, 1 hit PF03166 MH2, 1 hit
SMARTⁱ	View protein in SMART SM00523 DWA, 1 hit SM00524 DWB, 1 hit
SUPFAMⁱ	SSF49879 SSF49879, 1 hit SSF56366 SSF56366, 1 hit
PROSITEⁱ	View protein in PROSITE PS51075 MH1, 1 hit PS51076 MH2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SMAD1_MOUSE
Accessionⁱ	P70340Primary (citable) accession number: P70340 Secondary accession number(s): P70442, Q6GT95, Q9CYK6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
	Last sequence update:	July 27, 2011
	Last modified:	November 7, 2018
	This is version 184 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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Help

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UniProtKB - P70340 (SMAD1_MOUSE)

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Mothers against decapentaplegic homolog 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ