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Protein

Proto-oncogene FRAT1

Gene

Frat1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. May play a role in tumor progression and collaborate with PIM1 and MYC in lymphomagenesis.1 Publication

GO - Biological processi

Keywordsi

Biological processWnt signaling pathway

Enzyme and pathway databases

ReactomeiR-MMU-196299 Beta-catenin phosphorylation cascade
R-MMU-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane

Names & Taxonomyi

Protein namesi
Recommended name:
Proto-oncogene FRAT1
Alternative name(s):
Frequently rearranged in advanced T-cell lymphomas 1
Short name:
FRAT-1
Gene namesi
Name:Frat1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:109450 Frat1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

Activation contributes to progression of mouse T-cell lymphomas (PubMed:9034327).1 Publication

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000873331 – 274Proto-oncogene FRAT1Add BLAST274

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei243PhosphoserineCombined sources1
Modified residuei246PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP70339

PTM databases

iPTMnetiP70339
PhosphoSitePlusiP70339

Expressioni

Tissue specificityi

Highly expressed in testis. Lower level of expression in spleen, thymus and brain.

Developmental stagei

Expressed at low levels during embryonic development.

Gene expression databases

ExpressionAtlasiP70339 baseline and differential

Interactioni

Subunit structurei

Binds DVL1. Binds GSK-3 and prevent GSK-3-dependent phosphorylation.

Protein-protein interaction databases

ComplexPortaliCPX-108 Nuclear export complex Frat1-Gsk3b
CORUMiP70339

Structurei

3D structure databases

SMRiP70339
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni191 – 214Involved in GSK-3 bindingBy similarityAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi6 – 22Glu-rich (highly acidic)Add BLAST17
Compositional biasi6 – 10Poly-Glu5
Compositional biasi66 – 71Poly-Pro6
Compositional biasi189 – 192Poly-Asp4

Sequence similaritiesi

Belongs to the GSK-3-binding protein family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000007081
HOVERGENiHBG051660
InParanoidiP70339
KOiK03069
OMAiWYLAANT
PhylomeDBiP70339

Family and domain databases

InterProiView protein in InterPro
IPR008014 GSK3-bd
PANTHERiPTHR35154 PTHR35154, 1 hit
PfamiView protein in Pfam
PF05350 GSK-3_bind, 1 hit

Sequencei

Sequence statusi: Complete.

P70339-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPCRREEEEE AGDEAEGEED DDSFLLLQQS VTLGGSTDVD QLIVQIGETL
60 70 80 90 100
QLDAAHDRPA SPCAAPGPPP PQVLAALPAD KTGTPARRLL RPTGSAETGN
110 120 130 140 150
PAPPGAVRCV LGERGRVRGR SAPYCVAEIS PGASALPQQP GLDGPPGTGK
160 170 180 190 200
LSTPQPLSGP CRRGWLRNAA ASRRLQQRRG SQPETRTGDD DDPHRLLQQL
210 220 230 240 250
VLSGNLIKEA VRRLHSRQLQ LHAKLPAHPF LGPLSAPVHE PPSPGSPRAA
260 270
CSDPGAFMGR AQLRTGDDLL VPGS
Length:274
Mass (Da):28,875
Last modified:May 24, 2004 - v2
Checksum:i1C0482997EA95323
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58974 mRNA Translation: AAB72010.2
CCDSiCCDS84438.1
RefSeqiNP_032069.2, NM_008043.3
UniGeneiMm.4573

Genome annotation databases

EnsembliENSMUST00000087155; ENSMUSP00000147726; ENSMUSG00000067199
GeneIDi14296
KEGGimmu:14296
UCSCiuc008hmi.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58974 mRNA Translation: AAB72010.2
CCDSiCCDS84438.1
RefSeqiNP_032069.2, NM_008043.3
UniGeneiMm.4573

3D structure databases

SMRiP70339
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-108 Nuclear export complex Frat1-Gsk3b
CORUMiP70339

PTM databases

iPTMnetiP70339
PhosphoSitePlusiP70339

Proteomic databases

PRIDEiP70339

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000087155; ENSMUSP00000147726; ENSMUSG00000067199
GeneIDi14296
KEGGimmu:14296
UCSCiuc008hmi.2 mouse

Organism-specific databases

CTDi10023
MGIiMGI:109450 Frat1

Phylogenomic databases

GeneTreeiENSGT00390000007081
HOVERGENiHBG051660
InParanoidiP70339
KOiK03069
OMAiWYLAANT
PhylomeDBiP70339

Enzyme and pathway databases

ReactomeiR-MMU-196299 Beta-catenin phosphorylation cascade
R-MMU-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane

Miscellaneous databases

PROiPR:P70339
SOURCEiSearch...

Gene expression databases

ExpressionAtlasiP70339 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR008014 GSK3-bd
PANTHERiPTHR35154 PTHR35154, 1 hit
PfamiView protein in Pfam
PF05350 GSK-3_bind, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFRAT1_MOUSE
AccessioniPrimary (citable) accession number: P70339
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 24, 2004
Last modified: July 18, 2018
This is version 99 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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