Rho-associated protein kinase 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. the chemical reaction it catalyzes. This information usually correlates with the presence of an EC (Enzyme Commission) number in the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityⁱ

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactorⁱ

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationⁱ

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ATP binding Source: UniProtKB-KW
• GTP-Rho binding Source: MGI
• metal ion binding Source: UniProtKB-KW
• protein serine/threonine kinase activity Source: MGI

GO - Biological processⁱ

• actin cytoskeleton organization Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • 16249236
• apical constriction Source: MGIInferred from genetic interactionⁱ
  • 21685893
• apoptotic process Source: UniProtKB-KW
• bleb assembly Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 17135244
• cortical actin cytoskeleton organization Source: MGI
• cytoskeleton organization Source: MGI
• I-kappaB kinase/NF-kappaB signaling Source: MGI
• leukocyte cell-cell adhesion Source: MGI
• leukocyte migration Source: MGI
• leukocyte tethering or rolling Source: MGI
• membrane to membrane docking Source: MGI
• myoblast migration Source: UniProtKBInferred from mutant phenotypeⁱ
  • 17654484
• negative regulation of amyloid-beta formation Source: MGI
• negative regulation of amyloid precursor protein catabolic process Source: MGI
• negative regulation of angiogenesis Source: MGI
• negative regulation of bicellular tight junction assembly Source: MGI
• negative regulation of myosin-light-chain-phosphatase activity Source: MGI
• negative regulation of neuron apoptotic process Source: MGIInferred from mutant phenotypeⁱ
  • 15071095
• negative regulation of protein binding Source: MGI
• neuron projection arborization Source: MGI
• neuron projection development Source: MGI
• positive regulation of amyloid-beta clearance Source: MGI
• positive regulation of autophagy Source: MGI
• positive regulation of cardiac muscle hypertrophy Source: MGI
• positive regulation of connective tissue replacement Source: MGI
• positive regulation of focal adhesion assembly Source: UniProtKBInferred from mutant phenotypeⁱ
  • 17654484
• positive regulation of gene expression Source: MGI
• positive regulation of MAPK cascade Source: MGI
• protein localization to plasma membrane Source: MGI
• regulation of actin cytoskeleton organization Source: MGI
• regulation of actin filament-based process Source: MGIInferred from genetic interactionⁱ
  • 21685893
• regulation of angiotensin-activated signaling pathway Source: MGI
• regulation of establishment of cell polarity Source: InterPro
• regulation of establishment of endothelial barrier Source: MGI
• regulation of keratinocyte differentiation Source: MGI
• regulation of neuron differentiation Source: MGI
• regulation of stress fiber assembly Source: InterPro
• regulation of synaptic vesicle endocytosis Source: MGI
• response to angiotensin Source: ARUK-UCLInferred from genetic interactionⁱ
  • 28679962
• response to transforming growth factor beta Source: ARUK-UCLInferred from genetic interactionⁱ
  • 28679962
• Rho protein signal transduction Source: MGIInferred from sequence orthologyⁱ
  • 18332105

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypeⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Sites

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• GTP-Rho binding Source: MGI

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Coiled coil

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

        10         20         30         40         50
MSTGDSFETR FEKIDNLLRD PKSEVNSDCL LDGLDALVYD LDFPALRKNK 
        60         70         80         90        100
NIDNFLSRYK DTINKIRDLR MKAEDYEVVK VIGRGAFGEV QLVRHKSTRK 
       110        120        130        140        150
VYAMKLLSKF EMIKRSDSAF FWEERDIMAF ANSPWVVQLF YAFQDDRYLY 
       160        170        180        190        200
MVMEYMPGGD LVNLMSNYDV PEKWARFYTA EVVLALDAIH SMGFIHRDVK 
       210        220        230        240        250
PDNMLLDKSG HLKLADFGTC MKMNKEGMVR CDTAVGTPDY ISPEVLKSQG 
       260        270        280        290        300
GDGYYGRECD WWSVGVFLYE MLVGDTPFYA DSLVGTYSKI MNHKNSLTFP 
       310        320        330        340        350
DDNDISKEAK NLICAFLTDR EVRLGRNGVE EIKRHLFFKN DQWAWETLRD 
       360        370        380        390        400
TVAPVVPDLS SDIDTSNFDD LEEDKGDEET FPIPKAFVGN QLPFVGFTYY 
       410        420        430        440        450
SNRRYLPSAN ASENRSSSNV DKSLQESLQK TIYKLEEQLH NEMQLKDEME 
       460        470        480        490        500
QKCRTSNLKL DKIMKELDEE GNQRRNLESA VSQIEKEKML LQHRINEYQR 
       510        520        530        540        550
KVEQENEKRR NIENEVSTLK DQLEDLRKAS QTSQLANEKL TQLQKQLEEA 
       560        570        580        590        600
NDLLRTESDT AVRLRKSHTE MSKSISQLES LNRELQERNR ILENSKSQAD 
       610        620        630        640        650
KDYYQLQAVL EAERRDRGHD SEMIGDLQAR ITSLQEEVKH LKHNLERVEG 
       660        670        680        690        700
ERKEAQDMLN HSEKEKNNLE IDLNYKLKSI QQRLEQEVNE HKVTKARLTD 
       710        720        730        740        750
KHQSIEEAKS VAMCEMEKKL KEEREAREKA ENRVVETEKQ CSMLDVDLKQ 
       760        770        780        790        800
SQQKLEHLTE NKERMEDEVK NLALQLEQES NKRLLLQNEL KTQAFEADNL 
       810        820        830        840        850
KGLEKQMKQE INTLLEAKRL LEFELAQLTK QYRGNEGQMR ELQDQLEAEQ 
       860        870        880        890        900
YFSTLYKTQV KELKEEIEEK NRENLRKIQE LQSEKETLST QLDLAETKAE 
       910        920        930        940        950
SEQLARGILE EQYFELTQES KKAASRNRQE ITDKDHTVSR LEETNSVLTK 
       960        970        980        990       1000
DIEMLRKENE ELNERMRTAE EEYKLKKEEE INNLKAAFEK NISTERTLKT 
      1010       1020       1030       1040       1050
QAVNKLAEIM NRKDFKIDRK KANTQDLRKK EKENRKLQLE LNQEREKFNQ 
      1060       1070       1080       1090       1100
MVVKHQKELN DMQAQLVEEC THRNELQMQL ASKESDIEQL RAKLLDLSDS 
      1110       1120       1130       1140       1150
TSVASFPSAD ETDGNLPESR IEGWLSVPNR GNIKRYGWKK QYVVVSSKKI 
      1160       1170       1180       1190       1200
LFYNDEQDKE QSSPSMVLDI DKLFHVRPVT QGDVYRAETE EIPKIFQILY 
      1210       1220       1230       1240       1250
ANEGECRKDI EVEPVQQGEK TNFQNHKGHE FIPTLYHFPA NCEACAKPLW 
      1260       1270       1280       1290       1300
HVFKPPPALE CRRCHVKCHR DHLDKKEDLI SPCKVSYDVT SARDMLLLAC 
      1310       1320       1330       1340       1350
SQDEQKKWVT HLVKKIPKNP PSGFVRASPR TLSTRSTANQ SFRKVVKNTS 

GKTS                                                   

        10         20         30         40         50
MSTGDSFETR FEKIDNLLRD PKSEVNSDCL LDGLDALVYD LDFPALRKNK 
        60         70         80         90        100
NIDNFLSRYK DTINKIRDLR MKAEDYEVVK VIGRGAFGEV QLVRHKSTRK 
       110        120        130        140        150
VYAMKLLSKF EMIKRSDSAF FWEERDIMAF ANSPWVVQLF YAFQDDRYLY 
       160        170        180        190        200
MVMEYMPGGD LVNLMSNYDV PEKWARFYTA EVVLALDAIH SMGFIHRDVK 
       210        220        230        240        250
PDNMLLDKSG HLKLADFGTC MKMNKEGMVR CDTAVGTPDY ISPEVLKSQG 
       260        270        280        290        300
GDGYYGRECD WWSVGVFLYE MLVGDTPFYA DSLVGTYSKI MNHKNSLTFP 
       310        320        330        340        350
DDNDISKEAK NLICAFLTDR EVRLGRNGVE EIKRHLFFKN DQWAWETLRD 
       360        370        380        390        400
TVAPVVPDLS SDIDTSNFDD LEEDKGDEET FPIPKAFVGN QLPFVGFTYY 
       410        420        430        440        450
SNRRYLPSAN ASENRSSSNV DKSLESLQKT IYKLEEQLHN EMQLKDEMEQ 
       460        470        480        490        500
KCRTSNLKLD KIMKELDEEG NQRRNLESAV SQIEKEKMLL QHRINEYQRK 
       510        520        530        540        550
VEQENEKRRN IENEVSTLKD QLEDLRKASQ TSQLANEKLT QLQKQLEEAN 
       560        570        580        590        600
DLLRTESDTA VRLRKSHTEM SKSISQLESL NRELQERNRI LENSKSQADK 
       610        620        630        640        650
DYYQLQAVLE AERRDRGHDS EMIGDLQARI TSLQEEVKHL KHNLERVEGE 
       660        670        680        690        700
RKEAQDMLNH SEKEKNNLEI DLNYKLKSIQ QRLEQEVNEH KVTKARLTDK 
       710        720        730        740        750
HQSIEEAKSV AMCEMEKKLK EEREAREKAE NRVVETEKQC SMLDVDLKQS 
       760        770        780        790        800
QQKLEHLTEN KERMEDEVKN LALQLEQESN KRLLLQNELK TQAFEADNLK 
       810        820        830        840        850
GLEKQMKQEI NTLLEAKRLL EFELAQLTKQ YRGNEGQMRE LQDQLEAEQY 
       860        870        880        890        900
FSTLYKTQVK ELKEEIEEKN RENLRKIQEL QSEKETLSTQ LDLAETKAES 
       910        920        930        940        950
EQLARGILEE QYFELTQESK KAASRNRQEI TDKDHTVSRL EETNSVLTKD 
       960        970        980        990       1000
IEMLRKENEE LNERMRTAEE EYKLKKEEEI NNLKAAFEKN ISTERTLKTQ 
      1010       1020       1030       1040       1050
AVNKLAEIMN RKDFKIDRKK ANTQDLRKKE KENRKLQLEL NQEREKFNQM 
      1060       1070       1080       1090       1100
VVKHQKELND MQAQLVEECT HRNELQMQLA SKESDIEQLR AKLLDLSDST 
      1110       1120       1130       1140       1150
SVASFPSADE TDGNLPESRI EGWLSVPNRG NIKRYGWKKQ YVVVSSKKIL 
      1160       1170       1180       1190       1200
FYNDEQDKEQ SSPSMVLDID KLFHVRPVTQ GDVYRAETEE IPKIFQILYA 
      1210       1220       1230       1240       1250
NEGECRKDIE VEPVQQGEKT NFQNHKGHEF IPTLYHFPAN CEACAKPLWH 
      1260       1270       1280       1290       1300
VFKPPPALEC RRCHVKCHRD HLDKKEDLIS PCKVSYDVTS ARDMLLLACS 
      1310       1320       1330       1340       1350
QDEQKKWVTH LVKKIPKNPP SGFVRASPRT LSTRSTANQS FRKVVKNTSG 

KTS                                                    

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ