UniProtKB - P70335 (ROCK1_MOUSE)
Rho-associated protein kinase 1
Rock1
Functioni
Protein kinase which is a key regulator of the actin cytoskeleton and cell polarity (PubMed:19036714, PubMed:19181962).
Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (PubMed:19036714, PubMed:19181962).
Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (By similarity).
Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability (PubMed:20008297).
Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis (By similarity).
Plays a role in terminal erythroid differentiation (By similarity).
Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (PubMed:30115939).
Promotes keratinocyte terminal differentiation (By similarity).
Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (PubMed:21768292).
May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles (PubMed:15753128).
By similarity6 PublicationsCatalytic activityi
- EC:2.7.11.1By similarityThis reaction proceeds in the forwardBy similarity direction.
- EC:2.7.11.1By similarityThis reaction proceeds in the forwardBy similarity direction.
Cofactori
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 105 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 198 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 82 – 90 | ATPPROSITE-ProRule annotation | 9 | |
Zinc fingeri | 1228 – 1283 | Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST | 56 |
GO - Molecular functioni
- aspartic-type endopeptidase inhibitor activity Source: MGI
- ATP binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: UniProtKB
- protein serine kinase activity Source: RHEA
- Rho-dependent protein serine/threonine kinase activity Source: MGI
- small GTPase binding Source: MGI
GO - Biological processi
- actin cytoskeleton organization Source: BHF-UCL
- actomyosin structure organization Source: GO_Central
- apical constriction Source: MGI
- apoptotic process Source: UniProtKB-KW
- bleb assembly Source: MGI
- blood vessel diameter maintenance Source: ARUK-UCL
- cortical actin cytoskeleton organization Source: MGI
- cytoskeleton organization Source: MGI
- embryonic morphogenesis Source: GO_Central
- epithelial to mesenchymal transition Source: BHF-UCL
- glomerular visceral epithelial cell migration Source: UniProtKB
- I-kappaB kinase/NF-kappaB signaling Source: MGI
- leukocyte cell-cell adhesion Source: MGI
- leukocyte migration Source: MGI
- leukocyte tethering or rolling Source: MGI
- membrane to membrane docking Source: MGI
- mitotic cytokinesis Source: GO_Central
- mRNA destabilization Source: ARUK-UCL
- myoblast migration Source: UniProtKB
- negative regulation of amyloid-beta formation Source: MGI
- negative regulation of amyloid precursor protein catabolic process Source: MGI
- negative regulation of angiogenesis Source: MGI
- negative regulation of bicellular tight junction assembly Source: MGI
- negative regulation of myosin-light-chain-phosphatase activity Source: MGI
- negative regulation of neuron apoptotic process Source: MGI
- negative regulation of phosphorylation Source: UniProtKB
- negative regulation of protein binding Source: MGI
- neuron projection arborization Source: MGI
- neuron projection development Source: MGI
- peptidyl-serine phosphorylation Source: MGI
- peptidyl-threonine phosphorylation Source: GO_Central
- positive regulation of amyloid-beta clearance Source: MGI
- positive regulation of autophagy Source: MGI
- positive regulation of cardiac muscle hypertrophy Source: MGI
- positive regulation of connective tissue replacement Source: MGI
- positive regulation of dephosphorylation Source: MGI
- positive regulation of focal adhesion assembly Source: UniProtKB
- positive regulation of gene expression Source: MGI
- positive regulation of MAPK cascade Source: MGI
- positive regulation of phosphatase activity Source: MGI
- protein localization to plasma membrane Source: MGI
- protein phosphorylation Source: UniProtKB
- regulation of actin cytoskeleton organization Source: UniProtKB
- regulation of actin filament-based process Source: MGI
- regulation of angiotensin-activated signaling pathway Source: MGI
- regulation of cell junction assembly Source: GO_Central
- regulation of cell migration Source: UniProtKB
- regulation of establishment of endothelial barrier Source: MGI
- regulation of keratinocyte differentiation Source: MGI
- regulation of microtubule cytoskeleton organization Source: UniProtKB
- regulation of neuron differentiation Source: MGI
- regulation of synaptic vesicle endocytosis Source: MGI
- response to angiotensin Source: ARUK-UCL
- response to transforming growth factor beta Source: ARUK-UCL
- Rho protein signal transduction Source: MGI
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Apoptosis |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-111465, Apoptotic cleavage of cellular proteins R-MMU-3928662, EPHB-mediated forward signaling R-MMU-416482, G alpha (12/13) signalling events R-MMU-416572, Sema4D induced cell migration and growth-cone collapse R-MMU-4420097, VEGFA-VEGFR2 Pathway R-MMU-5627117, RHO GTPases Activate ROCKs R-MMU-6798695, Neutrophil degranulation R-MMU-8980692, RHOA GTPase cycle R-MMU-9013026, RHOB GTPase cycle R-MMU-9013106, RHOC GTPase cycle R-MMU-9013407, RHOH GTPase cycle R-MMU-9013422, RHOBTB1 GTPase cycle R-MMU-9696264, RND3 GTPase cycle |
Names & Taxonomyi
Protein namesi | Recommended name: Rho-associated protein kinase 1 (EC:2.7.11.1)Alternative name(s): Rho-associated, coiled-coil-containing protein kinase 1 Rho-associated, coiled-coil-containing protein kinase I Short name: ROCK-I p160 ROCK-1 Short name: p160ROCK |
Gene namesi | Name:Rock1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:107927, Rock1 |
VEuPathDBi | HostDB:ENSMUSG00000024290 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Golgi apparatus
- Golgi apparatus membrane By similarity; Peripheral membrane protein By similarity
Cytoskeleton
- centriole 1 Publication
- cytoskeleton 1 Publication
Other locations
- bleb By similarity
- lamellipodium 1 Publication
- ruffle 1 Publication
Note: A small proportion is associated with Golgi membranes (By similarity). Associated with the mother centriole and an intercentriolar linker (PubMed:16741948). Colocalizes with ITGB1BP1 and ITGB1 at the cell membrane predominantly in lamellipodia and membrane ruffles, but also in retraction fibers (PubMed:16741948). Localizes at the cell membrane in an ITGB1BP1-dependent manner (PubMed:16741948).By similarity1 Publication
Cytoskeleton
- centriole Source: UniProtKB-SubCell
- cytoskeleton Source: UniProtKB
Golgi apparatus
- Golgi membrane Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- amyloid-beta complex Source: Ensembl
- bleb Source: UniProtKB-SubCell
- cytoplasm Source: GO_Central
- cytoplasmic stress granule Source: ARUK-UCL
- lamellipodium Source: UniProtKB
- ruffle Source: UniProtKB
Keywords - Cellular componenti
Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Golgi apparatus, MembranePathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000086620 | 2 – 1354 | Rho-associated protein kinase 1Add BLAST | 1353 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineBy similarity | 1 | |
Modified residuei | 1105 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1108 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1328 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 1113 – 1114 | Cleavage; by caspase-3By similarity | 2 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | P70335 |
jPOSTi | P70335 |
MaxQBi | P70335 |
PaxDbi | P70335 |
PeptideAtlasi | P70335 |
PRIDEi | P70335 |
ProteomicsDBi | 300565 [P70335-1] 300566 [P70335-2] |
PTM databases
iPTMneti | P70335 |
PhosphoSitePlusi | P70335 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000024290, Expressed in aorta and 315 other tissues |
ExpressionAtlasi | P70335, baseline and differential |
Genevisiblei | P70335, MM |
Interactioni
Subunit structurei
Homodimer (By similarity).
Interacts with RHOA (activated by GTP), RHOB, RHOC, GEM, MYLC2B, RHOE, PPP1R12A, LIMK1, LIMK2, TSG101, CHORDC1, DAPK3, PFN1 and JIP3 (By similarity).
Interacts with FHOD1 in a Src-dependent manner (By similarity).
Interacts with PTEN.
Interacts with ITGB1BP1 (via N-terminus and PTB domain).
Interacts with SHROOM3 (PubMed:22493320).
By similarity4 PublicationsBinary interactionsi
P70335
With | #Exp. | IntAct |
---|---|---|
Rnd3 [P61588] | 7 | EBI-989293,EBI-6930266 |
GO - Molecular functioni
- small GTPase binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 202950, 43 interactors |
DIPi | DIP-35521N |
IntActi | P70335, 29 interactors |
MINTi | P70335 |
STRINGi | 10090.ENSMUSP00000069549 |
Miscellaneous databases
RNActi | P70335, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 76 – 338 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 263 | |
Domaini | 341 – 409 | AGC-kinase C-terminalPROSITE-ProRule annotationAdd BLAST | 69 | |
Domaini | 479 – 556 | REM-1PROSITE-ProRule annotationAdd BLAST | 78 | |
Domaini | 949 – 1015 | RhoBDPROSITE-ProRule annotationAdd BLAST | 67 | |
Domaini | 1118 – 1317 | PHPROSITE-ProRule annotationAdd BLAST | 200 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 368 – 727 | Interaction with FHOD1By similarityAdd BLAST | 360 | |
Regioni | 707 – 946 | SHROOM3 binding1 PublicationAdd BLAST | 240 | |
Regioni | 998 – 1010 | RHOA bindingBy similarityAdd BLAST | 13 | |
Regioni | 1115 – 1354 | Auto-inhibitoryBy similarityAdd BLAST | 240 | |
Regioni | 1333 – 1354 | DisorderedSequence analysisAdd BLAST | 22 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 422 – 692 | Sequence analysisAdd BLAST | 271 | |
Coiled coili | 1011 – 1102 | Sequence analysisAdd BLAST | 92 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1228 – 1283 | Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST | 56 |
Keywords - Domaini
Coiled coil, Zinc-fingerPhylogenomic databases
eggNOGi | KOG0612, Eukaryota |
GeneTreei | ENSGT01030000234517 |
HOGENOMi | CLU_000288_140_0_1 |
InParanoidi | P70335 |
OMAi | XETLATQ |
PhylomeDBi | P70335 |
TreeFami | TF313551 |
Family and domain databases
CDDi | cd00029, C1, 1 hit cd11639, HR1_ROCK1, 1 hit |
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR000961, AGC-kinase_C IPR046349, C1-like_sf IPR011072, HR1_rho-bd IPR011009, Kinase-like_dom_sf IPR002219, PE/DAG-bd IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR020684, ROCK1/ROCK2 IPR037310, ROCK1_HR1 IPR015008, ROCK_Rho-bd_dom IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit PF08912, Rho_Binding, 1 hit |
PIRSFi | PIRSF037568, Rho_kinase, 1 hit |
SMARTi | View protein in SMART SM00109, C1, 1 hit SM00233, PH, 1 hit SM00133, S_TK_X, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit SSF57889, SSF57889, 1 hit |
PROSITEi | View protein in PROSITE PS51285, AGC_KINASE_CTER, 1 hit PS50003, PH_DOMAIN, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit PS51860, REM_1, 1 hit PS51859, RHO_BD, 1 hit PS50081, ZF_DAG_PE_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSTGDSFETR FEKIDNLLRD PKSEVNSDCL LDGLDALVYD LDFPALRKNK
60 70 80 90 100
NIDNFLSRYK DTINKIRDLR MKAEDYEVVK VIGRGAFGEV QLVRHKSTRK
110 120 130 140 150
VYAMKLLSKF EMIKRSDSAF FWEERDIMAF ANSPWVVQLF YAFQDDRYLY
160 170 180 190 200
MVMEYMPGGD LVNLMSNYDV PEKWARFYTA EVVLALDAIH SMGFIHRDVK
210 220 230 240 250
PDNMLLDKSG HLKLADFGTC MKMNKEGMVR CDTAVGTPDY ISPEVLKSQG
260 270 280 290 300
GDGYYGRECD WWSVGVFLYE MLVGDTPFYA DSLVGTYSKI MNHKNSLTFP
310 320 330 340 350
DDNDISKEAK NLICAFLTDR EVRLGRNGVE EIKRHLFFKN DQWAWETLRD
360 370 380 390 400
TVAPVVPDLS SDIDTSNFDD LEEDKGDEET FPIPKAFVGN QLPFVGFTYY
410 420 430 440 450
SNRRYLPSAN ASENRSSSNV DKSLQESLQK TIYKLEEQLH NEMQLKDEME
460 470 480 490 500
QKCRTSNLKL DKIMKELDEE GNQRRNLESA VSQIEKEKML LQHRINEYQR
510 520 530 540 550
KVEQENEKRR NIENEVSTLK DQLEDLRKAS QTSQLANEKL TQLQKQLEEA
560 570 580 590 600
NDLLRTESDT AVRLRKSHTE MSKSISQLES LNRELQERNR ILENSKSQAD
610 620 630 640 650
KDYYQLQAVL EAERRDRGHD SEMIGDLQAR ITSLQEEVKH LKHNLERVEG
660 670 680 690 700
ERKEAQDMLN HSEKEKNNLE IDLNYKLKSI QQRLEQEVNE HKVTKARLTD
710 720 730 740 750
KHQSIEEAKS VAMCEMEKKL KEEREAREKA ENRVVETEKQ CSMLDVDLKQ
760 770 780 790 800
SQQKLEHLTE NKERMEDEVK NLALQLEQES NKRLLLQNEL KTQAFEADNL
810 820 830 840 850
KGLEKQMKQE INTLLEAKRL LEFELAQLTK QYRGNEGQMR ELQDQLEAEQ
860 870 880 890 900
YFSTLYKTQV KELKEEIEEK NRENLRKIQE LQSEKETLST QLDLAETKAE
910 920 930 940 950
SEQLARGILE EQYFELTQES KKAASRNRQE ITDKDHTVSR LEETNSVLTK
960 970 980 990 1000
DIEMLRKENE ELNERMRTAE EEYKLKKEEE INNLKAAFEK NISTERTLKT
1010 1020 1030 1040 1050
QAVNKLAEIM NRKDFKIDRK KANTQDLRKK EKENRKLQLE LNQEREKFNQ
1060 1070 1080 1090 1100
MVVKHQKELN DMQAQLVEEC THRNELQMQL ASKESDIEQL RAKLLDLSDS
1110 1120 1130 1140 1150
TSVASFPSAD ETDGNLPESR IEGWLSVPNR GNIKRYGWKK QYVVVSSKKI
1160 1170 1180 1190 1200
LFYNDEQDKE QSSPSMVLDI DKLFHVRPVT QGDVYRAETE EIPKIFQILY
1210 1220 1230 1240 1250
ANEGECRKDI EVEPVQQGEK TNFQNHKGHE FIPTLYHFPA NCEACAKPLW
1260 1270 1280 1290 1300
HVFKPPPALE CRRCHVKCHR DHLDKKEDLI SPCKVSYDVT SARDMLLLAC
1310 1320 1330 1340 1350
SQDEQKKWVT HLVKKIPKNP PSGFVRASPR TLSTRSTANQ SFRKVVKNTS
GKTS
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q4EGR2 | A0A3Q4EGR2_MOUSE | Non-specific serine/threonine prote... | Rock1 | 1,089 | Annotation score: | ||
A0A3Q4L2X0 | A0A3Q4L2X0_MOUSE | Rho-associated protein kinase 1 | Rock1 | 504 | Annotation score: |
Sequence cautioni
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_010448 | 425 | Missing in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U58512 mRNA Translation: AAC53132.1 AK050269 mRNA Translation: BAC34154.1 Different initiation. AK085974 mRNA Translation: BAC39581.1 BC057154 mRNA Translation: AAH57154.1 Sequence problems. |
CCDSi | CCDS29053.2 [P70335-1] |
PIRi | S74244 |
RefSeqi | NP_033097.1, NM_009071.2 [P70335-1] XP_006525788.1, XM_006525725.1 [P70335-2] |
Genome annotation databases
Ensembli | ENSMUST00000067947; ENSMUSP00000069549; ENSMUSG00000024290 [P70335-1] |
GeneIDi | 19877 |
KEGGi | mmu:19877 |
UCSCi | uc008eaq.1, mouse [P70335-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U58512 mRNA Translation: AAC53132.1 AK050269 mRNA Translation: BAC34154.1 Different initiation. AK085974 mRNA Translation: BAC39581.1 BC057154 mRNA Translation: AAH57154.1 Sequence problems. |
CCDSi | CCDS29053.2 [P70335-1] |
PIRi | S74244 |
RefSeqi | NP_033097.1, NM_009071.2 [P70335-1] XP_006525788.1, XM_006525725.1 [P70335-2] |
3D structure databases
AlphaFoldDBi | P70335 |
SMRi | P70335 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 202950, 43 interactors |
DIPi | DIP-35521N |
IntActi | P70335, 29 interactors |
MINTi | P70335 |
STRINGi | 10090.ENSMUSP00000069549 |
PTM databases
iPTMneti | P70335 |
PhosphoSitePlusi | P70335 |
Proteomic databases
EPDi | P70335 |
jPOSTi | P70335 |
MaxQBi | P70335 |
PaxDbi | P70335 |
PeptideAtlasi | P70335 |
PRIDEi | P70335 |
ProteomicsDBi | 300565 [P70335-1] 300566 [P70335-2] |
Protocols and materials databases
Antibodypediai | 1128, 690 antibodies from 46 providers |
DNASUi | 19877 |
Genome annotation databases
Ensembli | ENSMUST00000067947; ENSMUSP00000069549; ENSMUSG00000024290 [P70335-1] |
GeneIDi | 19877 |
KEGGi | mmu:19877 |
UCSCi | uc008eaq.1, mouse [P70335-1] |
Organism-specific databases
CTDi | 6093 |
MGIi | MGI:107927, Rock1 |
VEuPathDBi | HostDB:ENSMUSG00000024290 |
Phylogenomic databases
eggNOGi | KOG0612, Eukaryota |
GeneTreei | ENSGT01030000234517 |
HOGENOMi | CLU_000288_140_0_1 |
InParanoidi | P70335 |
OMAi | XETLATQ |
PhylomeDBi | P70335 |
TreeFami | TF313551 |
Enzyme and pathway databases
Reactomei | R-MMU-111465, Apoptotic cleavage of cellular proteins R-MMU-3928662, EPHB-mediated forward signaling R-MMU-416482, G alpha (12/13) signalling events R-MMU-416572, Sema4D induced cell migration and growth-cone collapse R-MMU-4420097, VEGFA-VEGFR2 Pathway R-MMU-5627117, RHO GTPases Activate ROCKs R-MMU-6798695, Neutrophil degranulation R-MMU-8980692, RHOA GTPase cycle R-MMU-9013026, RHOB GTPase cycle R-MMU-9013106, RHOC GTPase cycle R-MMU-9013407, RHOH GTPase cycle R-MMU-9013422, RHOBTB1 GTPase cycle R-MMU-9696264, RND3 GTPase cycle |
Miscellaneous databases
BioGRID-ORCSi | 19877, 6 hits in 73 CRISPR screens |
ChiTaRSi | Rock1, mouse |
PROi | PR:P70335 |
RNActi | P70335, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000024290, Expressed in aorta and 315 other tissues |
ExpressionAtlasi | P70335, baseline and differential |
Genevisiblei | P70335, MM |
Family and domain databases
CDDi | cd00029, C1, 1 hit cd11639, HR1_ROCK1, 1 hit |
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR000961, AGC-kinase_C IPR046349, C1-like_sf IPR011072, HR1_rho-bd IPR011009, Kinase-like_dom_sf IPR002219, PE/DAG-bd IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR020684, ROCK1/ROCK2 IPR037310, ROCK1_HR1 IPR015008, ROCK_Rho-bd_dom IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit PF08912, Rho_Binding, 1 hit |
PIRSFi | PIRSF037568, Rho_kinase, 1 hit |
SMARTi | View protein in SMART SM00109, C1, 1 hit SM00233, PH, 1 hit SM00133, S_TK_X, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit SSF57889, SSF57889, 1 hit |
PROSITEi | View protein in PROSITE PS51285, AGC_KINASE_CTER, 1 hit PS50003, PH_DOMAIN, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit PS51860, REM_1, 1 hit PS51859, RHO_BD, 1 hit PS50081, ZF_DAG_PE_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ROCK1_MOUSE | |
Accessioni | P70335Primary (citable) accession number: P70335 Secondary accession number(s): Q8C3G4, Q8C7H0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 24, 2004 |
Last sequence update: | February 1, 1997 | |
Last modified: | May 25, 2022 | |
This is version 205 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families