UniProtKB - P70333 (HNRH2_MOUSE)
Protein
Heterogeneous nuclear ribonucleoprotein H2
Gene
Hnrnph2
Organism
Mus musculus (Mouse)
Status
Functioni
This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG) (By similarity).By similarity
GO - Molecular functioni
- RNA binding Source: GO_Central
GO - Biological processi
- regulation of RNA splicing Source: GO_Central
Keywordsi
Molecular function | Ribonucleoprotein, RNA-binding |
Enzyme and pathway databases
Reactomei | R-MMU-72163, mRNA Splicing - Major Pathway R-MMU-72203, Processing of Capped Intron-Containing Pre-mRNA |
Names & Taxonomyi
Protein namesi | Recommended name: Heterogeneous nuclear ribonucleoprotein H2Short name: hnRNP H2 Alternative name(s): Heterogeneous nuclear ribonucleoprotein H' Short name: hnRNP H' Cleaved into the following chain: |
Gene namesi | Name:Hnrnph2 Synonyms:Hnrph2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1201779, Hnrnph2 |
Subcellular locationi
Nucleus
- nucleoplasm By similarity
Cytosol
- cytosol Source: MGI
Nucleus
- nucleoplasm Source: MGI
Other locations
- postsynaptic density Source: Ensembl
- ribonucleoprotein complex Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000434386 | 1 – 449 | Heterogeneous nuclear ribonucleoprotein H2Add BLAST | 449 | |
Initiator methioninei | Removed; alternateBy similarity | |||
ChainiPRO_0000081860 | 2 – 449 | Heterogeneous nuclear ribonucleoprotein H2, N-terminally processedAdd BLAST | 448 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Modified residuei | 2 | N-acetylmethionine; in Heterogeneous nuclear ribonucleoprotein H2, N-terminally processedBy similarity | 1 | |
Modified residuei | 23 | PhosphoserineBy similarity | 1 | |
Cross-linki | 35 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 54 | PhosphoserineBy similarity | 1 | |
Modified residuei | 63 | PhosphoserineBy similarity | 1 | |
Cross-linki | 87 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 90 | PhosphoserineCombined sources | 1 | |
Cross-linki | 98 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 233 | Dimethylated arginine; alternateBy similarity | 1 | |
Modified residuei | 233 | Omega-N-methylarginine; alternateCombined sources | 1 | |
Modified residuei | 246 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 310 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P70333 |
jPOSTi | P70333 |
MaxQBi | P70333 |
PaxDbi | P70333 |
PeptideAtlasi | P70333 |
PRIDEi | P70333 |
PTM databases
iPTMneti | P70333 |
PhosphoSitePlusi | P70333 |
SwissPalmi | P70333 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000045427, Expressed in ventricular zone and 78 other tissues |
Genevisiblei | P70333, MM |
Interactioni
Subunit structurei
Interacts with TXNL4/DIM1.
By similarityProtein-protein interaction databases
BioGRIDi | 207865, 22 interactors |
IntActi | P70333, 5 interactors |
MINTi | P70333 |
STRINGi | 10090.ENSMUSP00000108828 |
Miscellaneous databases
RNActi | P70333, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 11 – 90 | RRM 1PROSITE-ProRule annotationAdd BLAST | 80 | |
Domaini | 111 – 188 | RRM 2PROSITE-ProRule annotationAdd BLAST | 78 | |
Repeati | 234 – 249 | 1-1Add BLAST | 16 | |
Domaini | 289 – 364 | RRM 3PROSITE-ProRule annotationAdd BLAST | 76 | |
Repeati | 354 – 372 | 2-1Add BLAST | 19 | |
Repeati | 374 – 392 | 2-2Add BLAST | 19 | |
Repeati | 418 – 433 | 1-2Add BLAST | 16 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 234 – 433 | 2 X 16 AA Gly-rich approximate repeatsAdd BLAST | 200 | |
Regioni | 354 – 392 | 2 X 19 AA perfect repeatsAdd BLAST | 39 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG4211, Eukaryota |
GeneTreei | ENSGT00940000153503 |
HOGENOMi | CLU_032003_1_0_1 |
InParanoidi | P70333 |
OMAi | DEDQFDG |
OrthoDBi | 603679at2759 |
PhylomeDBi | P70333 |
TreeFami | TF316157 |
Family and domain databases
Gene3Di | 3.30.70.330, 3 hits |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom IPR012996, Znf_CHHC |
Pfami | View protein in Pfam PF00076, RRM_1, 3 hits PF08080, zf-RNPHF, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 3 hits |
SUPFAMi | SSF54928, SSF54928, 3 hits |
PROSITEi | View protein in PROSITE PS50102, RRM, 3 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P70333-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMLSTEGREG FVVKVRGLPW SCSAEEVMRF FSDCKIQNGT SGVRFIYTRE
60 70 80 90 100
GRPSGEAFVE LESEDEVKLA LKKDRETMGH RYVEVFKSNS VEMDWVLKHT
110 120 130 140 150
GPNSPDTAND GFVRLRGLPF GCSKEEIVQF FSGLEIVPNG MTLPVDFQGR
160 170 180 190 200
STGEAFVQFA SQEIAEKALK KHKERIGHRY IEIFKSSRAE VRTHYDPPRK
210 220 230 240 250
LMTMQRPGPY DRPGAGRGYN SIGRGAGFER MRRGAYGGGY GGYDDYGGYN
260 270 280 290 300
DGYGFGSDRF GRDLNYCFSG MSDHRYGDGG SSFQSTTGHC VHMRGLPYRA
310 320 330 340 350
TENDIYNFFS PLNPMRVHIE IGPDGRVTGE ADVEFATHED AVAAMAKDKA
360 370 380 390 400
NMQHRYVELF LNSTAGTSGG AYDHSYVELF LNSTAGASGG AYGSQMMGGM
410 420 430 440
GLSNQSSYGG PASQQLSGGY GGGYGGQSSM SGYDQVLQEN SSDYQSNLA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U58105 Genomic DNA Translation: AAB47243.1 AK077716 mRNA Translation: BAC36976.1 AK164115 mRNA Translation: BAE37634.1 AK168116 mRNA Translation: BAE40087.1 AK169104 mRNA Translation: BAE40886.1 BC005461 mRNA Translation: AAH05461.1 |
CCDSi | CCDS30397.1 |
RefSeqi | NP_001300645.1, NM_001313716.1 NP_001300646.1, NM_001313717.1 NP_063921.1, NM_019868.4 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U58105 Genomic DNA Translation: AAB47243.1 AK077716 mRNA Translation: BAC36976.1 AK164115 mRNA Translation: BAE37634.1 AK168116 mRNA Translation: BAE40087.1 AK169104 mRNA Translation: BAE40886.1 BC005461 mRNA Translation: AAH05461.1 |
CCDSi | CCDS30397.1 |
RefSeqi | NP_001300645.1, NM_001313716.1 NP_001300646.1, NM_001313717.1 NP_063921.1, NM_019868.4 |
3D structure databases
SMRi | P70333 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 207865, 22 interactors |
IntActi | P70333, 5 interactors |
MINTi | P70333 |
STRINGi | 10090.ENSMUSP00000108828 |
PTM databases
iPTMneti | P70333 |
PhosphoSitePlusi | P70333 |
SwissPalmi | P70333 |
Proteomic databases
EPDi | P70333 |
jPOSTi | P70333 |
MaxQBi | P70333 |
PaxDbi | P70333 |
PeptideAtlasi | P70333 |
PRIDEi | P70333 |
Protocols and materials databases
Antibodypediai | 343, 135 antibodies |
DNASUi | 56258 |
Genome annotation databases
Organism-specific databases
CTDi | 3188 |
MGIi | MGI:1201779, Hnrnph2 |
Phylogenomic databases
eggNOGi | KOG4211, Eukaryota |
GeneTreei | ENSGT00940000153503 |
HOGENOMi | CLU_032003_1_0_1 |
InParanoidi | P70333 |
OMAi | DEDQFDG |
OrthoDBi | 603679at2759 |
PhylomeDBi | P70333 |
TreeFami | TF316157 |
Enzyme and pathway databases
Reactomei | R-MMU-72163, mRNA Splicing - Major Pathway R-MMU-72203, Processing of Capped Intron-Containing Pre-mRNA |
Miscellaneous databases
BioGRID-ORCSi | 56258, 2 hits in 17 CRISPR screens |
ChiTaRSi | Hnrnph2, mouse |
PROi | PR:P70333 |
RNActi | P70333, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000045427, Expressed in ventricular zone and 78 other tissues |
Genevisiblei | P70333, MM |
Family and domain databases
Gene3Di | 3.30.70.330, 3 hits |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom IPR012996, Znf_CHHC |
Pfami | View protein in Pfam PF00076, RRM_1, 3 hits PF08080, zf-RNPHF, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 3 hits |
SUPFAMi | SSF54928, SSF54928, 3 hits |
PROSITEi | View protein in PROSITE PS50102, RRM, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HNRH2_MOUSE | |
Accessioni | P70333Primary (citable) accession number: P70333 Secondary accession number(s): Q3THV9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 26, 2004 |
Last sequence update: | February 1, 1997 | |
Last modified: | February 10, 2021 | |
This is version 167 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot