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Protein

T-box transcription factor TBX3

Gene

Tbx3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi107 – 220T-box; first partPROSITE-ProRule annotationAdd BLAST114
DNA bindingi241 – 305T-box; second partPROSITE-ProRule annotationAdd BLAST65

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
T-box transcription factor TBX3
Short name:
T-box protein 3
Gene namesi
Name:Tbx3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:98495 Tbx3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001844291 – 741T-box transcription factor TBX3Add BLAST741

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei369PhosphoserineBy similarity1
Modified residuei432PhosphoserineBy similarity1
Modified residuei438PhosphoserineBy similarity1
Modified residuei456PhosphoserineBy similarity1
Modified residuei705PhosphoserineCombined sources1
Modified residuei736PhosphoserineBy similarity1
Modified residuei738PhosphoserineBy similarity1
Modified residuei740PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP70324
PaxDbiP70324
PeptideAtlasiP70324
PRIDEiP70324

PTM databases

iPTMnetiP70324
PhosphoSitePlusiP70324

Expressioni

Tissue specificityi

In adults, highest levels in lung. Also found in brain, heart, kidney, liver and ovary.

Developmental stagei

First expressed in the blastocyst at day 3.5. At day 7.5, expressed in the extraembryonic endoderm and in the mesoderm of the chorion and amnion. At day 9.5, in the facial region, forelimb, pharyngeal epithelium, mesenchyme of the pharyngeal arches and the lateral body wall and, at day 12.5, in the trigeminal ganglia, developing central nervous system and in the mammary buds.1 Publication

Gene expression databases

BgeeiENSMUSG00000018604 Expressed in 293 organ(s), highest expression level in blastocyst
CleanExiMM_TBX3
ExpressionAtlasiP70324 baseline and differential
GenevisibleiP70324 MM

Interactioni

Subunit structurei

Interacts with PML.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203988, 2 interactors
IntActiP70324, 2 interactors
STRINGi10090.ENSMUSP00000018748

Structurei

3D structure databases

ProteinModelPortaliP70324
SMRiP70324
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG3585 Eukaryota
ENOG410XSTS LUCA
GeneTreeiENSGT00760000118897
HOGENOMiHOG000038046
HOVERGENiHBG000412
InParanoidiP70324
KOiK10177
OMAiRHPFLNA
OrthoDBiEOG091G0I8R
TreeFamiTF106341

Family and domain databases

CDDicd00182 TBOX, 1 hit
Gene3Di2.60.40.820, 1 hit
InterProiView protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR036960 T-box_sf
IPR022582 TBX
IPR001699 TF_T-box
IPR018186 TF_T-box_CS
PANTHERiPTHR11267 PTHR11267, 1 hit
PfamiView protein in Pfam
PF00907 T-box, 1 hit
PF12598 TBX, 1 hit
PRINTSiPR00937 TBOX
SMARTiView protein in SMART
SM00425 TBOX, 1 hit
SUPFAMiSSF49417 SSF49417, 1 hit
PROSITEiView protein in PROSITE
PS01283 TBOX_1, 1 hit
PS01264 TBOX_2, 1 hit
PS50252 TBOX_3, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P70324-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLSMRDPVI PGTSMAYHPF LPHRAPDFAM SAVLGHQPPF FPALTLPPNG
60 70 80 90 100
AAALSLPGAL AKPIMDQLVG AAETGIPFSS LGPQAHLRPL KTMEPEEDVE
110 120 130 140 150
DDPKVHLEAK ELWDQFHKRG TEMVITKSGR RMFPPFKVRC SGLDKKAKYI
160 170 180 190 200
LLMDIIAADD CRYKFHNSRW MVAGKADPEM PKRMYIHPDS PATGEQWMSK
210 220 230 240 250
VVTFHKLKLT NNISDKHGFT LAFPSDHATW QGNYSFGTQT ILNSMHKYQP
260 270 280 290 300
RFHIVRANDI LKLPYSTFRT YLFPETEFIA VTAYQNDKIT QLKIDNNPFA
310 320 330 340 350
KGFRDTGNGR REKRKQLTLQ SMRVFEERHK KETSDESSSE QAAFNCFAQA
360 370 380 390 400
SSPAVSIVGT SNLKDLCPSE AESDAEAESK EEHGPEACDA AKISTTTAEE
410 420 430 440 450
PGRDKGSPAT RAQLFPAEPS RARDTARLDK ASPDSRHSPA TISSSTRVPG
460 470 480 490 500
ADERRSPGRE GPVATKVDEA RAIPAKDAFA PLSVQTDATA HLAQGPLPGL
510 520 530 540 550
GFAPGLAGQQ FFNGHPLFLH PGQFAMGGAF SSMAAGMGPL LATVSGASTG
560 570 580 590 600
VSGLESTAMA SAAAAQGLSG ASAATLPFHL QQHVLASQGL AMSPFGSLFP
610 620 630 640 650
YPYTYMAAAA AASTAAASSS VHRHPFLNLN SMRPRLRYSP YSIPVPVPDS
660 670 680 690 700
SSLLATALPS MASAAGPLDG KAAALAASPA SVAVDSGSEL NSRSSTLSSG
710 720 730 740
SVSLSPKLCS EKEAATSELQ SIQRLVSGLE AKPDRSCSGS P
Length:741
Mass (Da):79,160
Last modified:July 27, 2011 - v3
Checksum:iB502FE817EFF124D
GO
Isoform 2 (identifier: P70324-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     221-240: Missing.

Show »
Length:721
Mass (Da):76,949
Checksum:iF086EA71843D4D2B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti154 – 155DI → T in AAC53107 (PubMed:8878690).Curated2
Sequence conflicti184M → R in AAC53107 (PubMed:8878690).Curated1
Sequence conflicti306 – 309TGNG → IGHC in AAC53107 (PubMed:8878690).Curated4
Sequence conflicti569S → Y in BAC34999 (PubMed:16141072).Curated1
Sequence conflicti717S → N in BAC34999 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_013377221 – 240Missing in isoform 2. 2 PublicationsAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052453 mRNA Translation: BAC34999.1
AC140675 Genomic DNA No translation available.
U57328 mRNA Translation: AAC53107.1
U15567 mRNA Translation: AAC52698.1
CCDSiCCDS19613.1 [P70324-1]
CCDS19614.1 [P70324-2]
RefSeqiNP_035665.2, NM_011535.3 [P70324-1]
XP_006530339.1, XM_006530276.3 [P70324-1]
UniGeneiMm.219139

Genome annotation databases

EnsembliENSMUST00000018748; ENSMUSP00000018748; ENSMUSG00000018604 [P70324-1]
ENSMUST00000079719; ENSMUSP00000078657; ENSMUSG00000018604 [P70324-2]
ENSMUST00000121021; ENSMUSP00000112519; ENSMUSG00000018604 [P70324-2]
GeneIDi21386
KEGGimmu:21386
UCSCiuc008zgu.2 mouse [P70324-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052453 mRNA Translation: BAC34999.1
AC140675 Genomic DNA No translation available.
U57328 mRNA Translation: AAC53107.1
U15567 mRNA Translation: AAC52698.1
CCDSiCCDS19613.1 [P70324-1]
CCDS19614.1 [P70324-2]
RefSeqiNP_035665.2, NM_011535.3 [P70324-1]
XP_006530339.1, XM_006530276.3 [P70324-1]
UniGeneiMm.219139

3D structure databases

ProteinModelPortaliP70324
SMRiP70324
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203988, 2 interactors
IntActiP70324, 2 interactors
STRINGi10090.ENSMUSP00000018748

PTM databases

iPTMnetiP70324
PhosphoSitePlusiP70324

Proteomic databases

MaxQBiP70324
PaxDbiP70324
PeptideAtlasiP70324
PRIDEiP70324

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000018748; ENSMUSP00000018748; ENSMUSG00000018604 [P70324-1]
ENSMUST00000079719; ENSMUSP00000078657; ENSMUSG00000018604 [P70324-2]
ENSMUST00000121021; ENSMUSP00000112519; ENSMUSG00000018604 [P70324-2]
GeneIDi21386
KEGGimmu:21386
UCSCiuc008zgu.2 mouse [P70324-1]

Organism-specific databases

CTDi6926
MGIiMGI:98495 Tbx3

Phylogenomic databases

eggNOGiKOG3585 Eukaryota
ENOG410XSTS LUCA
GeneTreeiENSGT00760000118897
HOGENOMiHOG000038046
HOVERGENiHBG000412
InParanoidiP70324
KOiK10177
OMAiRHPFLNA
OrthoDBiEOG091G0I8R
TreeFamiTF106341

Miscellaneous databases

PROiPR:P70324
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000018604 Expressed in 293 organ(s), highest expression level in blastocyst
CleanExiMM_TBX3
ExpressionAtlasiP70324 baseline and differential
GenevisibleiP70324 MM

Family and domain databases

CDDicd00182 TBOX, 1 hit
Gene3Di2.60.40.820, 1 hit
InterProiView protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR036960 T-box_sf
IPR022582 TBX
IPR001699 TF_T-box
IPR018186 TF_T-box_CS
PANTHERiPTHR11267 PTHR11267, 1 hit
PfamiView protein in Pfam
PF00907 T-box, 1 hit
PF12598 TBX, 1 hit
PRINTSiPR00937 TBOX
SMARTiView protein in SMART
SM00425 TBOX, 1 hit
SUPFAMiSSF49417 SSF49417, 1 hit
PROSITEiView protein in PROSITE
PS01283 TBOX_1, 1 hit
PS01264 TBOX_2, 1 hit
PS50252 TBOX_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTBX3_MOUSE
AccessioniPrimary (citable) accession number: P70324
Secondary accession number(s): E9QM97, Q60708, Q8BWH7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 153 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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