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Protein

Homeobox protein Hox-B13

Gene

Hoxb13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds preferentially to methylated DNA (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi218 – 277HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B13
Gene namesi
Name:Hoxb13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:107730 Hoxb13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002001611 – 286Homeobox protein Hox-B13Add BLAST286

Proteomic databases

PaxDbiP70321
PRIDEiP70321

PTM databases

PhosphoSitePlusiP70321

Expressioni

Tissue specificityi

Exhibits both spatial and temporal colinearity within the main body axis. At E12.5, is detected in hindgut, urogenital tract, spinal chord and tailbud. Not detected in secondary axes such as the limb and the genital tubercule.

Gene expression databases

BgeeiENSMUSG00000049604 Expressed in 51 organ(s), highest expression level in prostate gland ventral lobe
CleanExiMM_HOXB13
GenevisibleiP70321 MM

Interactioni

Subunit structurei

Heterodimer with MEIS1 and MEIS2.By similarity

Protein-protein interaction databases

BioGridi200376, 4 interactors
IntActiP70321, 1 interactor
STRINGi10090.ENSMUSP00000056315

Structurei

3D structure databases

ProteinModelPortaliP70321
SMRiP70321
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni219 – 248Interaction with DNABy similarityAdd BLAST30
Regioni260 – 275Interaction with 5-mCpG DNABy similarityAdd BLAST16
Regioni272 – 275Interaction with DNABy similarity4

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0487 Eukaryota
ENOG4111FJP LUCA
GeneTreeiENSGT00910000143984
HOGENOMiHOG000231176
HOVERGENiHBG106958
InParanoidiP70321
OMAiGCAFRRG
OrthoDBiEOG091G0E5Q
PhylomeDBiP70321
TreeFamiTF330813

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR022067 HoxA13_N
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF12284 HoxA13_N, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P70321-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPGNYATLD GAKDIEGLLG AGGGRNLVSH SSPLASHPAA PTLMPTVNYA
60 70 80 90 100
PLDLPGSAEP PKQCHPCPGV PQGASPAPVP YGYFGGGYYS CRVSRSSLKP
110 120 130 140 150
CAQTAALATY PSETPAPGEE YPSRPTEFAF YPGYPGPYQP MASYLDVSVV
160 170 180 190 200
QTLGAPGEPR HDSLLPVDSY QPWALAGGWN SQMCCQGEQN PPGPFWKAAF
210 220 230 240 250
AEPSVQHPPP DGCAFRRGRK KRIPYSKGQL RELEREYAAN KFITKDKRRK
260 270 280
ISAATSLSER QITIWFQNRR VKEKKVLAKV KTSTTP
Length:286
Mass (Da):30,963
Last modified:February 1, 1997 - v1
Checksum:i1A6BFB4C4720E25F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57051 mRNA Translation: AAC52769.1
BC013639 mRNA Translation: AAH13639.1
BC051087 mRNA Translation: AAH51087.2
BC058813 mRNA Translation: AAH58813.1
CCDSiCCDS25291.1
RefSeqiNP_032293.1, NM_008267.3
UniGeneiMm.57221

Genome annotation databases

EnsembliENSMUST00000062709; ENSMUSP00000056315; ENSMUSG00000049604
GeneIDi15408
KEGGimmu:15408
UCSCiuc007lbk.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57051 mRNA Translation: AAC52769.1
BC013639 mRNA Translation: AAH13639.1
BC051087 mRNA Translation: AAH51087.2
BC058813 mRNA Translation: AAH58813.1
CCDSiCCDS25291.1
RefSeqiNP_032293.1, NM_008267.3
UniGeneiMm.57221

3D structure databases

ProteinModelPortaliP70321
SMRiP70321
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200376, 4 interactors
IntActiP70321, 1 interactor
STRINGi10090.ENSMUSP00000056315

PTM databases

PhosphoSitePlusiP70321

Proteomic databases

PaxDbiP70321
PRIDEiP70321

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000062709; ENSMUSP00000056315; ENSMUSG00000049604
GeneIDi15408
KEGGimmu:15408
UCSCiuc007lbk.1 mouse

Organism-specific databases

CTDi10481
MGIiMGI:107730 Hoxb13

Phylogenomic databases

eggNOGiKOG0487 Eukaryota
ENOG4111FJP LUCA
GeneTreeiENSGT00910000143984
HOGENOMiHOG000231176
HOVERGENiHBG106958
InParanoidiP70321
OMAiGCAFRRG
OrthoDBiEOG091G0E5Q
PhylomeDBiP70321
TreeFamiTF330813

Miscellaneous databases

PROiPR:P70321
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000049604 Expressed in 51 organ(s), highest expression level in prostate gland ventral lobe
CleanExiMM_HOXB13
GenevisibleiP70321 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR022067 HoxA13_N
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF12284 HoxA13_N, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHXB13_MOUSE
AccessioniPrimary (citable) accession number: P70321
Secondary accession number(s): Q80Y12
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 7, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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