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Protein

Nucleolysin TIAR

Gene

Tial1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis (By similarity).By similarity

GO - Molecular functioni

  • AU-rich element binding Source: MGI
  • DNA binding Source: InterPro

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • germ cell development Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • stem cell division Source: MGI

Keywordsi

Molecular functionRNA-binding
Biological processApoptosis

Enzyme and pathway databases

ReactomeiR-MMU-6803529 FGFR2 alternative splicing

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolysin TIAR
Alternative name(s):
TIA-1-related protein
Gene namesi
Name:Tial1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:107913 Tial1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000819791 – 392Nucleolysin TIARAdd BLAST392

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei139N6-acetyllysineBy similarity1
Modified residuei218PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated by MAPK14 following DNA damage, releasing TIAR from GADD45A mRNA.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP70318
PaxDbiP70318
PeptideAtlasiP70318
PRIDEiP70318

PTM databases

iPTMnetiP70318
PhosphoSitePlusiP70318

Expressioni

Tissue specificityi

Expressed both in primordial germ cells (PGCs) and in neighboring somatic cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000030846
ExpressionAtlasiP70318 baseline and differential
GenevisibleiP70318 MM

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi204192, 3 interactors
IntActiP70318, 28 interactors
MINTiP70318
STRINGi10090.ENSMUSP00000101833

Structurei

3D structure databases

ProteinModelPortaliP70318
SMRiP70318
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 102RRM 1PROSITE-ProRule annotationAdd BLAST94
Domaini114 – 192RRM 2PROSITE-ProRule annotationAdd BLAST79
Domaini222 – 294RRM 3PROSITE-ProRule annotationAdd BLAST73

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0148 Eukaryota
ENOG410XQ8U LUCA
GeneTreeiENSGT00910000144106
HOGENOMiHOG000206748
HOVERGENiHBG105006
InParanoidiP70318
KOiK13201
OMAiSWGKDKT
OrthoDBiEOG091G0FH8
PhylomeDBiP70318
TreeFamiTF312915

Family and domain databases

CDDicd12616 RRM1_TIAR, 1 hit
cd12617 RRM2_TIAR, 1 hit
cd12620 RRM3_TIAR, 1 hit
Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR003954 RRM_dom_euk
IPR034492 TIAR_RRM1
IPR034494 TIAR_RRM2
IPR034496 TIAR_RRM3
PfamiView protein in Pfam
PF00076 RRM_1, 3 hits
SMARTiView protein in SMART
SM00360 RRM, 3 hits
SM00361 RRM_1, 3 hits
SUPFAMiSSF54928 SSF54928, 3 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 3 hits

Sequencei

Sequence statusi: Complete.

P70318-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMEDDGQPRT LYVGNLSRDV TEVLILQLFS QIGPCKSCKM ITEQPDSRRV
60 70 80 90 100
NSSVGFSVLQ HTSNDPYCFV EFYEHRDAAA ALAAMNGRKI LGKEVKVNWA
110 120 130 140 150
TTPSSQKKDT SNHFHVFVGD LSPEITTEDI KSAFAPFGKI SDARVVKDMA
160 170 180 190 200
TGKSKGYGFV SFYNKLDAEN AIVHMGGQWL GGRQIRTNWA TRKPPAPKST
210 220 230 240 250
QETNTKQLRF EDVVNQSSPK NCTVYCGGIA SGLTDQLMRQ TFSPFGQIME
260 270 280 290 300
IRVFPEKGYS FVRFSTHESA AHAIVSVNGT TIEGHVVKCY WGKESPDMTK
310 320 330 340 350
NFQQVDYSQW GQWSQVYGNP QQYGQYMANG WQVPPYGVYG QPWNQQGFGV
360 370 380 390
DQSPSAAWMG GFGAQPPQGQ APPPVIPPPN QAGYGMASFP TQ
Length:392
Mass (Da):43,389
Last modified:February 1, 1997 - v1
Checksum:i66E6AF14B9EBE77A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U55861 mRNA Translation: AAC52870.1
CCDSiCCDS21897.1
PIRiS72436
RefSeqiNP_033409.1, NM_009383.2
UniGeneiMm.242072

Genome annotation databases

EnsembliENSMUST00000106226; ENSMUSP00000101833; ENSMUSG00000030846
GeneIDi21843
KEGGimmu:21843
UCSCiuc009jyy.1 mouse

Similar proteinsi

Entry informationi

Entry nameiTIAR_MOUSE
AccessioniPrimary (citable) accession number: P70318
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: July 18, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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