Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
The new UniProt website is here! Take me to UniProt BETA

UniProtKB - P70298 (CUX2_MOUSE)

Entry version 170 (25 May 2022)
Sequence version 2 (27 Jul 2011)
Previous versions | rss
Add a publicationFeedback
Protein

Homeobox protein cut-like 2

Gene

Cux2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor involved in the control of neuronal proliferation and differentiation in the brain (PubMed:18033766, PubMed:20510857).

Regulates dendrite development and branching, dendritic spine formation, and synaptogenesis in cortical layers II-III (PubMed:20510857).

Binds to DNA in a sequence-specific manner.

2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi482 – 569CUT 1PROSITE-ProRule annotationAdd BLAST88
DNA bindingi828 – 915CUT 2PROSITE-ProRule annotationAdd BLAST88
DNA bindingi983 – 1070CUT 3PROSITE-ProRule annotationAdd BLAST88
DNA bindingi1113 – 1172HomeoboxPROSITE-ProRule annotationAdd BLAST60

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Homeobox protein cut-like 2
Alternative name(s):
Homeobox protein Cux-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cux2
Synonyms:Cutl2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:107321, Cux2

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000042589

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Knockout mice show moderately but consistently bigger brains than wild-type animals. Cell density and thickness of upper cortical layers (II-IV) are increased, while there are no differences in neuronal density in layers V and VI (PubMed:18033766). Neurons in layer II-III show simpler morphologies, with a significant decrease in the dendritic length and the number of branches, as well as a severe reduction of dendritic spines density associated with synaptic defects. The working memory is impaired (PubMed:20510857).2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002023971 – 1426Homeobox protein cut-like 2Add BLAST1426

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei81PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		P70298

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P70298

PeptideAtlas

More...PeptideAtlasi		P70298

PRoteomics IDEntifications database

More...PRIDEi		P70298

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		284068

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P70298

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P70298

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Restricted to neural tissues. Expressed exclusively in the central and peripheral nervous systems.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000042589, Expressed in brain and 283 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P70298, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		P70298, 1 interactor

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000107381

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P70298, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P70298

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P70298

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni77 – 104DisorderedSequence analysisAdd BLAST28
Regioni351 – 419DisorderedSequence analysisAdd BLAST69
Regioni460 – 488DisorderedSequence analysisAdd BLAST29
Regioni599 – 628DisorderedSequence analysisAdd BLAST30
Regioni653 – 676DisorderedSequence analysisAdd BLAST24
Regioni743 – 769DisorderedSequence analysisAdd BLAST27
Regioni904 – 977DisorderedSequence analysisAdd BLAST74
Regioni1177 – 1392DisorderedSequence analysisAdd BLAST216

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili131 – 311Sequence analysisAdd BLAST181
Coiled coili587 – 655Sequence analysisAdd BLAST69

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi374 – 401Pro residuesSequence analysisAdd BLAST28
Compositional biasi606 – 628Polar residuesSequence analysisAdd BLAST23
Compositional biasi744 – 761Polar residuesSequence analysisAdd BLAST18
Compositional biasi904 – 925Polar residuesSequence analysisAdd BLAST22
Compositional biasi926 – 940Pro residuesSequence analysisAdd BLAST15
Compositional biasi941 – 977Polar residuesSequence analysisAdd BLAST37
Compositional biasi1202 – 1219Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi1256 – 1277Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi1296 – 1357Polar residuesSequence analysisAdd BLAST62
Compositional biasi1358 – 1372Pro residuesSequence analysisAdd BLAST15
Compositional biasi1374 – 1392Polar residuesSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CUT homeobox family.Curated

Keywords - Domaini

Coiled coil, Homeobox, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0963, Eukaryota
KOG2252, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160241

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_005104_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P70298

Identification of Orthologs from Complete Genome Data

More...OMAi		QVDTAEI

Database of Orthologous Groups

More...OrthoDBi		181575at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P70298

TreeFam database of animal gene trees

More...TreeFami		TF318206

Family and domain databases

Conserved Domains Database

More...CDDi		cd00086, homeodomain, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.260.40, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003350, CUT_dom
IPR009057, Homeobox-like_sf
IPR017970, Homeobox_CS
IPR001356, Homeobox_dom
IPR010982, Lambda_DNA-bd_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02376, CUT, 3 hits
PF00046, Homeodomain, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01109, CUT, 3 hits
SM00389, HOX, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46689, SSF46689, 1 hit
SSF47413, SSF47413, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51042, CUT, 3 hits
PS00027, HOMEOBOX_1, 1 hit
PS50071, HOMEOBOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P70298-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVAPVLKSFQ AEVVALSKRS REAEAAFLSV YKQLIEAPDP VPSFEVARTL 
        60         70         80         90        100
DDRLQRPSFD PSGQRLQDVH IAWKRCPEPP SAREQNEGTC PTGHTPANGN 
       110        120        130        140        150
HLPGPEDTLV TDTLLQKNEA ERQKGLQEVH ITLAARLGEA EEKIKVLHSA 
       160        170        180        190        200
LKATQTELLE LRRKYDEEAA SKADEVGLIM TNLEKANQRA EAAQREVESL 
       210        220        230        240        250
REQLASVNSS IRLACCSPQG PSGEKVSFAL CSGPRLEAAL ASKDREILRL 
       260        270        280        290        300
LKDAQQLRHS LQELEEVSAN QIADLERQLA AKSEAIEKLQ EKLEAQADYE 
       310        320        330        340        350
EIKTELSILR AMKLASSTCS LPQTLAKPDD PLLVAKDVFF PTQKFLLEKP 
       360        370        380        390        400
ALLASPEEDP SEDDSIKGSL GTEPPYPPQL PPPPGPEDPL SPSPAQPLLG 
       410        420        430        440        450
PSLGPDGPRT FSLSPFPSLA PGERLAGDSL LSKHMMGPAA FKGETGNLLA 
       460        470        480        490        500
FPPTFYGGAK PPSAPAASVP CPEPTGAPEA VDGAGPEEEQ LDTAEIAFQV 
       510        520        530        540        550
KEQLLKHNIG QRVFGHYVLG LSQGSVSEIL ARPKPWRKLT VKGKEPFIKM 
       560        570        580        590        600
KQFLSDEQNV LALRTIQVRQ RGSITPRIRT PETGSDDAIK SILEQAKKEI 
       610        620        630        640        650
ESQKGGESKN SPASVSIPNG TASSSTSEDA IKNILEQARR EMQAQQQALL 
       660        670        680        690        700
EMESGPRGRS VPPSPPERPS PATASQNGAL TCVKQEDGGG GSGSSSTVQA 
       710        720        730        740        750
PLAVLSPAAF VQRIIRKVKS EIGDAGYFDH HWASDRGLLS RPYASVSPSL 
       760        770        780        790        800
SSSSSYSGQP NGRAWPRGDE ATIAPEDEAA MGEDEAPRVG ELKAEAGAPE 
       810        820        830        840        850
VGGGRLPYYP AYVPRTLKPT VPPLTPEQYE LYMYREVDTL ELTRQVKEKL 
       860        870        880        890        900
AKNGICQRIF GEKVLGLSQG SVSDMLSRPK PWSKLTQKGR EPFIRMQLWL 
       910        920        930        940        950
SDQLGQGQGQ APTQQPSASQ ASPTEPTSSP SPPPSPTEPE KTSQEPLGLS 
       960        970        980        990       1000
LESSKENQQP EGRASSSLGG KPFSSSQAAG GIQEMVAMSP ELDTYSITKR 
      1010       1020       1030       1040       1050
VKEVLTDNNL GQRLFGESIL GLTQGSVSDL LSRPKPWHKL SLKGREPFVR 
      1060       1070       1080       1090       1100
MQLWLSDPHN VEKLRDMKKL EKKAYLKRRY GLIGTGSDSE SPAAHSECPS 
      1110       1120       1130       1140       1150
PCLQPQELSL MQAKKPRVVL APAEKEALRK AYQLEPYPSQ QTIELLSFQL 
      1160       1170       1180       1190       1200
NLKTNTVINW FHNYRSRMRR EMLVEGTQDD PDFDPSGGPN VLTPGHTHRE 
      1210       1220       1230       1240       1250
PTPQSPDSET EDQKPPMKSL ELQEPEGPLQ RAAPDRALVK IKQEEGLEVD 
      1260       1270       1280       1290       1300
GDSQPQDVGD PDRGQDGPKE EHTHPLGNSD LSELAPGPFL SGTPNPDCPS 
      1310       1320       1330       1340       1350
LHNPQEKGTG EQVHSEPLSF KSTSESSCCS LEGPPNSPSV ISSPDLTTCV 
      1360       1370       1380       1390       1400
SPAPSSSAPI SPSLPGAPPA KVPSTSPTGD TAAALHPSTK VNPNLQRRHE 
      1410       1420 
KMANLNSIIY RLERAANREE VLEWEF
Length:1,426
Mass (Da):154,664
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i485B87D1C88D2577
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6YIR2F6YIR2_MOUSE
Homeobox protein cut-like 2
Cux2
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YUK2D3YUK2_MOUSE
Homeobox protein cut-like 2
Cux2
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti199S → G in AAC52762 (PubMed:8798433).Curated1
Sequence conflicti209S → N in AAC52762 (PubMed:8798433).Curated1
Sequence conflicti324T → M in AAC52762 (PubMed:8798433).Curated1
Sequence conflicti410T → N in AAC52762 (PubMed:8798433).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U45665 mRNA Translation: AAC52762.1
BC065113 mRNA Translation: AAH65113.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS39251.1

Protein sequence database of the Protein Information Resource

More...PIRi		T30817

NCBI Reference Sequences

More...RefSeqi		NP_001299837.1, NM_001312908.1
NP_031830.2, NM_007804.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000086317; ENSMUSP00000083497; ENSMUSG00000042589
ENSMUST00000111752; ENSMUSP00000107381; ENSMUSG00000042589
ENSMUST00000168288; ENSMUSP00000130302; ENSMUSG00000042589

Database of genes from NCBI RefSeq genomes

More...GeneIDi		13048

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:13048

UCSC genome browser

More...UCSCi		uc008zkm.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U45665 mRNA Translation: AAC52762.1
BC065113 mRNA Translation: AAH65113.1
CCDSiCCDS39251.1
PIRiT30817
RefSeqiNP_001299837.1, NM_001312908.1
NP_031830.2, NM_007804.2

3D structure databases

AlphaFoldDBiP70298
SMRiP70298
ModBaseiSearch...

Protein-protein interaction databases

IntActiP70298, 1 interactor
STRINGi10090.ENSMUSP00000107381

PTM databases

iPTMnetiP70298
PhosphoSitePlusiP70298

Proteomic databases

MaxQBiP70298
PaxDbiP70298
PeptideAtlasiP70298
PRIDEiP70298
ProteomicsDBi284068

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		31073, 82 antibodies from 21 providers

The DNASU plasmid repository

More...DNASUi		13048

Genome annotation databases

EnsembliENSMUST00000086317; ENSMUSP00000083497; ENSMUSG00000042589
ENSMUST00000111752; ENSMUSP00000107381; ENSMUSG00000042589
ENSMUST00000168288; ENSMUSP00000130302; ENSMUSG00000042589
GeneIDi13048
KEGGimmu:13048
UCSCiuc008zkm.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23316
MGIiMGI:107321, Cux2
VEuPathDBiHostDB:ENSMUSG00000042589

Phylogenomic databases

eggNOGiKOG0963, Eukaryota
KOG2252, Eukaryota
GeneTreeiENSGT00940000160241
HOGENOMiCLU_005104_1_0_1
InParanoidiP70298
OMAiQVDTAEI
OrthoDBi181575at2759
PhylomeDBiP70298
TreeFamiTF318206

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		13048, 2 hits in 71 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Cux2, mouse

Protein Ontology

More...PROi		PR:P70298
RNActiP70298, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000042589, Expressed in brain and 283 other tissues
GenevisibleiP70298, MM

Family and domain databases

CDDicd00086, homeodomain, 1 hit
Gene3Di1.10.260.40, 3 hits
InterProiView protein in InterPro
IPR003350, CUT_dom
IPR009057, Homeobox-like_sf
IPR017970, Homeobox_CS
IPR001356, Homeobox_dom
IPR010982, Lambda_DNA-bd_dom_sf
PfamiView protein in Pfam
PF02376, CUT, 3 hits
PF00046, Homeodomain, 1 hit
SMARTiView protein in SMART
SM01109, CUT, 3 hits
SM00389, HOX, 1 hit
SUPFAMiSSF46689, SSF46689, 1 hit
SSF47413, SSF47413, 3 hits
PROSITEiView protein in PROSITE
PS51042, CUT, 3 hits
PS00027, HOMEOBOX_1, 1 hit
PS50071, HOMEOBOX_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCUX2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P70298
Secondary accession number(s): Q6P1E6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 27, 2011
Last modified: May 25, 2022
This is version 170 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again