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Protein

Homeobox protein cut-like 2

Gene

Cux2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be a transcription factor involved in neural specification. Binds to DNA in a sequence-specific manner.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi482 – 569CUT 1PROSITE-ProRule annotationAdd BLAST88
DNA bindingi828 – 915CUT 2PROSITE-ProRule annotationAdd BLAST88
DNA bindingi983 – 1070CUT 3PROSITE-ProRule annotationAdd BLAST88
DNA bindingi1113 – 1172HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • DNA binding Source: MGI
  • RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB
  • RNA polymerase II regulatory region sequence-specific DNA binding Source: UniProtKB
  • sequence-specific DNA binding Source: MGI
  • transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB

GO - Biological processi

  • cellular response to organic substance Source: MGI
  • cognition Source: MGI
  • Golgi vesicle transport Source: GO_Central
  • negative regulation of transcription, DNA-templated Source: MGI
  • negative regulation of transcription by RNA polymerase II Source: NTNU_SB
  • positive regulation of dendrite morphogenesis Source: UniProtKB
  • positive regulation of dendritic spine morphogenesis Source: UniProtKB
  • positive regulation of excitatory postsynaptic potential Source: UniProtKB
  • positive regulation of gene expression Source: UniProtKB
  • positive regulation of synapse assembly Source: UniProtKB
  • short-term memory Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein cut-like 2
Alternative name(s):
Homeobox protein Cux-2
Gene namesi
Name:Cux2
Synonyms:Cutl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:107321 Cux2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002023971 – 1426Homeobox protein cut-like 2Add BLAST1426

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei81PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP70298
PaxDbiP70298
PeptideAtlasiP70298
PRIDEiP70298

PTM databases

iPTMnetiP70298
PhosphoSitePlusiP70298

Expressioni

Tissue specificityi

Restricted to neural tissues. Expressed exclusively in the central and peripheral nervous systems.

Gene expression databases

BgeeiENSMUSG00000042589
CleanExiMM_CUX2
ExpressionAtlasiP70298 baseline and differential
GenevisibleiP70298 MM

Interactioni

Protein-protein interaction databases

IntActiP70298, 1 interactor
STRINGi10090.ENSMUSP00000083497

Structurei

3D structure databases

ProteinModelPortaliP70298
SMRiP70298
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili131 – 311Sequence analysisAdd BLAST181
Coiled coili587 – 655Sequence analysisAdd BLAST69

Sequence similaritiesi

Belongs to the CUT homeobox family.Curated

Keywords - Domaini

Coiled coil, Homeobox, Repeat

Phylogenomic databases

eggNOGiKOG0963 Eukaryota
KOG2252 Eukaryota
ENOG410XPKP LUCA
GeneTreeiENSGT00530000063019
HOGENOMiHOG000143386
HOVERGENiHBG051268
InParanoidiP70298
KOiK09313
OMAiACCSPQG
OrthoDBiEOG091G011E
TreeFamiTF318206

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR003350 CUT_dom
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR010982 Lambda_DNA-bd_dom_sf
PfamiView protein in Pfam
PF02376 CUT, 3 hits
PF00046 Homeobox, 1 hit
SMARTiView protein in SMART
SM01109 CUT, 3 hits
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF47413 SSF47413, 3 hits
PROSITEiView protein in PROSITE
PS51042 CUT, 3 hits
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P70298-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAPVLKSFQ AEVVALSKRS REAEAAFLSV YKQLIEAPDP VPSFEVARTL
60 70 80 90 100
DDRLQRPSFD PSGQRLQDVH IAWKRCPEPP SAREQNEGTC PTGHTPANGN
110 120 130 140 150
HLPGPEDTLV TDTLLQKNEA ERQKGLQEVH ITLAARLGEA EEKIKVLHSA
160 170 180 190 200
LKATQTELLE LRRKYDEEAA SKADEVGLIM TNLEKANQRA EAAQREVESL
210 220 230 240 250
REQLASVNSS IRLACCSPQG PSGEKVSFAL CSGPRLEAAL ASKDREILRL
260 270 280 290 300
LKDAQQLRHS LQELEEVSAN QIADLERQLA AKSEAIEKLQ EKLEAQADYE
310 320 330 340 350
EIKTELSILR AMKLASSTCS LPQTLAKPDD PLLVAKDVFF PTQKFLLEKP
360 370 380 390 400
ALLASPEEDP SEDDSIKGSL GTEPPYPPQL PPPPGPEDPL SPSPAQPLLG
410 420 430 440 450
PSLGPDGPRT FSLSPFPSLA PGERLAGDSL LSKHMMGPAA FKGETGNLLA
460 470 480 490 500
FPPTFYGGAK PPSAPAASVP CPEPTGAPEA VDGAGPEEEQ LDTAEIAFQV
510 520 530 540 550
KEQLLKHNIG QRVFGHYVLG LSQGSVSEIL ARPKPWRKLT VKGKEPFIKM
560 570 580 590 600
KQFLSDEQNV LALRTIQVRQ RGSITPRIRT PETGSDDAIK SILEQAKKEI
610 620 630 640 650
ESQKGGESKN SPASVSIPNG TASSSTSEDA IKNILEQARR EMQAQQQALL
660 670 680 690 700
EMESGPRGRS VPPSPPERPS PATASQNGAL TCVKQEDGGG GSGSSSTVQA
710 720 730 740 750
PLAVLSPAAF VQRIIRKVKS EIGDAGYFDH HWASDRGLLS RPYASVSPSL
760 770 780 790 800
SSSSSYSGQP NGRAWPRGDE ATIAPEDEAA MGEDEAPRVG ELKAEAGAPE
810 820 830 840 850
VGGGRLPYYP AYVPRTLKPT VPPLTPEQYE LYMYREVDTL ELTRQVKEKL
860 870 880 890 900
AKNGICQRIF GEKVLGLSQG SVSDMLSRPK PWSKLTQKGR EPFIRMQLWL
910 920 930 940 950
SDQLGQGQGQ APTQQPSASQ ASPTEPTSSP SPPPSPTEPE KTSQEPLGLS
960 970 980 990 1000
LESSKENQQP EGRASSSLGG KPFSSSQAAG GIQEMVAMSP ELDTYSITKR
1010 1020 1030 1040 1050
VKEVLTDNNL GQRLFGESIL GLTQGSVSDL LSRPKPWHKL SLKGREPFVR
1060 1070 1080 1090 1100
MQLWLSDPHN VEKLRDMKKL EKKAYLKRRY GLIGTGSDSE SPAAHSECPS
1110 1120 1130 1140 1150
PCLQPQELSL MQAKKPRVVL APAEKEALRK AYQLEPYPSQ QTIELLSFQL
1160 1170 1180 1190 1200
NLKTNTVINW FHNYRSRMRR EMLVEGTQDD PDFDPSGGPN VLTPGHTHRE
1210 1220 1230 1240 1250
PTPQSPDSET EDQKPPMKSL ELQEPEGPLQ RAAPDRALVK IKQEEGLEVD
1260 1270 1280 1290 1300
GDSQPQDVGD PDRGQDGPKE EHTHPLGNSD LSELAPGPFL SGTPNPDCPS
1310 1320 1330 1340 1350
LHNPQEKGTG EQVHSEPLSF KSTSESSCCS LEGPPNSPSV ISSPDLTTCV
1360 1370 1380 1390 1400
SPAPSSSAPI SPSLPGAPPA KVPSTSPTGD TAAALHPSTK VNPNLQRRHE
1410 1420
KMANLNSIIY RLERAANREE VLEWEF
Length:1,426
Mass (Da):154,664
Last modified:July 27, 2011 - v2
Checksum:i485B87D1C88D2577
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti199S → G in AAC52762 (PubMed:8798433).Curated1
Sequence conflicti209S → N in AAC52762 (PubMed:8798433).Curated1
Sequence conflicti324T → M in AAC52762 (PubMed:8798433).Curated1
Sequence conflicti410T → N in AAC52762 (PubMed:8798433).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U45665 mRNA Translation: AAC52762.1
BC065113 mRNA Translation: AAH65113.1
CCDSiCCDS39251.1
PIRiT30817
RefSeqiNP_001299837.1, NM_001312908.1
NP_031830.2, NM_007804.2
UniGeneiMm.156172
Mm.332661

Genome annotation databases

EnsembliENSMUST00000086317; ENSMUSP00000083497; ENSMUSG00000042589
ENSMUST00000111752; ENSMUSP00000107381; ENSMUSG00000042589
ENSMUST00000168288; ENSMUSP00000130302; ENSMUSG00000042589
GeneIDi13048
KEGGimmu:13048
UCSCiuc008zkm.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCUX2_MOUSE
AccessioniPrimary (citable) accession number: P70298
Secondary accession number(s): Q6P1E6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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