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UniProtKB - P70298 (CUX2_MOUSE)
Protein
Homeobox protein cut-like 2
Gene
Cux2
Organism
Mus musculus (Mouse)
Status
Functioni
Transcription factor involved in the control of neuronal proliferation and differentiation in the brain (PubMed:18033766, PubMed:20510857).
Regulates dendrite development and branching, dendritic spine formation, and synaptogenesis in cortical layers II-III (PubMed:20510857).
Binds to DNA in a sequence-specific manner.
2 PublicationsRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 482 – 569 | CUT 1PROSITE-ProRule annotationAdd BLAST | 88 | |
DNA bindingi | 828 – 915 | CUT 2PROSITE-ProRule annotationAdd BLAST | 88 | |
DNA bindingi | 983 – 1070 | CUT 3PROSITE-ProRule annotationAdd BLAST | 88 | |
DNA bindingi | 1113 – 1172 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA binding Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: NTNU_SB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: UniProtKB
- sequence-specific DNA binding Source: MGI
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- cellular response to organic substance Source: MGI
- cognition Source: MGI
- negative regulation of transcription, DNA-templated Source: MGI
- negative regulation of transcription by RNA polymerase II Source: NTNU_SB
- positive regulation of dendrite morphogenesis Source: UniProtKB
- positive regulation of dendritic spine morphogenesis Source: UniProtKB
- positive regulation of excitatory postsynaptic potential Source: UniProtKB
- positive regulation of gene expression Source: UniProtKB
- positive regulation of synapse assembly Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
- short-term memory Source: UniProtKB
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Homeobox protein cut-like 2Alternative name(s): Homeobox protein Cux-2 |
Gene namesi | Name:Cux2 Synonyms:Cutl2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:107321, Cux2 |
VEuPathDBi | HostDB:ENSMUSG00000042589 |
Pathology & Biotechi
Disruption phenotypei
Knockout mice show moderately but consistently bigger brains than wild-type animals. Cell density and thickness of upper cortical layers (II-IV) are increased, while there are no differences in neuronal density in layers V and VI (PubMed:18033766). Neurons in layer II-III show simpler morphologies, with a significant decrease in the dendritic length and the number of branches, as well as a severe reduction of dendritic spines density associated with synaptic defects. The working memory is impaired (PubMed:20510857).2 Publications
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000202397 | 1 – 1426 | Homeobox protein cut-like 2Add BLAST | 1426 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 81 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P70298 |
PaxDbi | P70298 |
PeptideAtlasi | P70298 |
PRIDEi | P70298 |
ProteomicsDBi | 284068 |
PTM databases
iPTMneti | P70298 |
PhosphoSitePlusi | P70298 |
Expressioni
Tissue specificityi
Restricted to neural tissues. Expressed exclusively in the central and peripheral nervous systems.
Gene expression databases
Bgeei | ENSMUSG00000042589, Expressed in brain and 283 other tissues |
Genevisiblei | P70298, MM |
Interactioni
Protein-protein interaction databases
IntActi | P70298, 1 interactor |
STRINGi | 10090.ENSMUSP00000107381 |
Miscellaneous databases
RNActi | P70298, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 77 – 104 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 351 – 419 | DisorderedSequence analysisAdd BLAST | 69 | |
Regioni | 460 – 488 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 599 – 628 | DisorderedSequence analysisAdd BLAST | 30 | |
Regioni | 653 – 676 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 743 – 769 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 904 – 977 | DisorderedSequence analysisAdd BLAST | 74 | |
Regioni | 1177 – 1392 | DisorderedSequence analysisAdd BLAST | 216 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 131 – 311 | Sequence analysisAdd BLAST | 181 | |
Coiled coili | 587 – 655 | Sequence analysisAdd BLAST | 69 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 374 – 401 | Pro residuesSequence analysisAdd BLAST | 28 | |
Compositional biasi | 606 – 628 | Polar residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 744 – 761 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 904 – 925 | Polar residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 926 – 940 | Pro residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 941 – 977 | Polar residuesSequence analysisAdd BLAST | 37 | |
Compositional biasi | 1202 – 1219 | Basic and acidic residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 1256 – 1277 | Basic and acidic residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 1296 – 1357 | Polar residuesSequence analysisAdd BLAST | 62 | |
Compositional biasi | 1358 – 1372 | Pro residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1374 – 1392 | Polar residuesSequence analysisAdd BLAST | 19 |
Sequence similaritiesi
Belongs to the CUT homeobox family.Curated
Keywords - Domaini
Coiled coil, Homeobox, RepeatPhylogenomic databases
eggNOGi | KOG0963, Eukaryota KOG2252, Eukaryota |
GeneTreei | ENSGT00940000160241 |
HOGENOMi | CLU_005104_1_0_1 |
InParanoidi | P70298 |
OMAi | QVDTAEI |
OrthoDBi | 181575at2759 |
PhylomeDBi | P70298 |
TreeFami | TF318206 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
Gene3Di | 1.10.260.40, 3 hits |
InterProi | View protein in InterPro IPR003350, CUT_dom IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR010982, Lambda_DNA-bd_dom_sf |
Pfami | View protein in Pfam PF02376, CUT, 3 hits PF00046, Homeodomain, 1 hit |
SMARTi | View protein in SMART SM01109, CUT, 3 hits SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit SSF47413, SSF47413, 3 hits |
PROSITEi | View protein in PROSITE PS51042, CUT, 3 hits PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
P70298-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVAPVLKSFQ AEVVALSKRS REAEAAFLSV YKQLIEAPDP VPSFEVARTL
60 70 80 90 100
DDRLQRPSFD PSGQRLQDVH IAWKRCPEPP SAREQNEGTC PTGHTPANGN
110 120 130 140 150
HLPGPEDTLV TDTLLQKNEA ERQKGLQEVH ITLAARLGEA EEKIKVLHSA
160 170 180 190 200
LKATQTELLE LRRKYDEEAA SKADEVGLIM TNLEKANQRA EAAQREVESL
210 220 230 240 250
REQLASVNSS IRLACCSPQG PSGEKVSFAL CSGPRLEAAL ASKDREILRL
260 270 280 290 300
LKDAQQLRHS LQELEEVSAN QIADLERQLA AKSEAIEKLQ EKLEAQADYE
310 320 330 340 350
EIKTELSILR AMKLASSTCS LPQTLAKPDD PLLVAKDVFF PTQKFLLEKP
360 370 380 390 400
ALLASPEEDP SEDDSIKGSL GTEPPYPPQL PPPPGPEDPL SPSPAQPLLG
410 420 430 440 450
PSLGPDGPRT FSLSPFPSLA PGERLAGDSL LSKHMMGPAA FKGETGNLLA
460 470 480 490 500
FPPTFYGGAK PPSAPAASVP CPEPTGAPEA VDGAGPEEEQ LDTAEIAFQV
510 520 530 540 550
KEQLLKHNIG QRVFGHYVLG LSQGSVSEIL ARPKPWRKLT VKGKEPFIKM
560 570 580 590 600
KQFLSDEQNV LALRTIQVRQ RGSITPRIRT PETGSDDAIK SILEQAKKEI
610 620 630 640 650
ESQKGGESKN SPASVSIPNG TASSSTSEDA IKNILEQARR EMQAQQQALL
660 670 680 690 700
EMESGPRGRS VPPSPPERPS PATASQNGAL TCVKQEDGGG GSGSSSTVQA
710 720 730 740 750
PLAVLSPAAF VQRIIRKVKS EIGDAGYFDH HWASDRGLLS RPYASVSPSL
760 770 780 790 800
SSSSSYSGQP NGRAWPRGDE ATIAPEDEAA MGEDEAPRVG ELKAEAGAPE
810 820 830 840 850
VGGGRLPYYP AYVPRTLKPT VPPLTPEQYE LYMYREVDTL ELTRQVKEKL
860 870 880 890 900
AKNGICQRIF GEKVLGLSQG SVSDMLSRPK PWSKLTQKGR EPFIRMQLWL
910 920 930 940 950
SDQLGQGQGQ APTQQPSASQ ASPTEPTSSP SPPPSPTEPE KTSQEPLGLS
960 970 980 990 1000
LESSKENQQP EGRASSSLGG KPFSSSQAAG GIQEMVAMSP ELDTYSITKR
1010 1020 1030 1040 1050
VKEVLTDNNL GQRLFGESIL GLTQGSVSDL LSRPKPWHKL SLKGREPFVR
1060 1070 1080 1090 1100
MQLWLSDPHN VEKLRDMKKL EKKAYLKRRY GLIGTGSDSE SPAAHSECPS
1110 1120 1130 1140 1150
PCLQPQELSL MQAKKPRVVL APAEKEALRK AYQLEPYPSQ QTIELLSFQL
1160 1170 1180 1190 1200
NLKTNTVINW FHNYRSRMRR EMLVEGTQDD PDFDPSGGPN VLTPGHTHRE
1210 1220 1230 1240 1250
PTPQSPDSET EDQKPPMKSL ELQEPEGPLQ RAAPDRALVK IKQEEGLEVD
1260 1270 1280 1290 1300
GDSQPQDVGD PDRGQDGPKE EHTHPLGNSD LSELAPGPFL SGTPNPDCPS
1310 1320 1330 1340 1350
LHNPQEKGTG EQVHSEPLSF KSTSESSCCS LEGPPNSPSV ISSPDLTTCV
1360 1370 1380 1390 1400
SPAPSSSAPI SPSLPGAPPA KVPSTSPTGD TAAALHPSTK VNPNLQRRHE
1410 1420
KMANLNSIIY RLERAANREE VLEWEF
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF6YIR2 | F6YIR2_MOUSE | Homeobox protein cut-like 2 | Cux2 | 147 | Annotation score: | ||
D3YUK2 | D3YUK2_MOUSE | Homeobox protein cut-like 2 | Cux2 | 61 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 199 | S → G in AAC52762 (PubMed:8798433).Curated | 1 | |
Sequence conflicti | 209 | S → N in AAC52762 (PubMed:8798433).Curated | 1 | |
Sequence conflicti | 324 | T → M in AAC52762 (PubMed:8798433).Curated | 1 | |
Sequence conflicti | 410 | T → N in AAC52762 (PubMed:8798433).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U45665 mRNA Translation: AAC52762.1 BC065113 mRNA Translation: AAH65113.1 |
CCDSi | CCDS39251.1 |
PIRi | T30817 |
RefSeqi | NP_001299837.1, NM_001312908.1 NP_031830.2, NM_007804.2 |
Genome annotation databases
Ensembli | ENSMUST00000086317; ENSMUSP00000083497; ENSMUSG00000042589 ENSMUST00000111752; ENSMUSP00000107381; ENSMUSG00000042589 ENSMUST00000168288; ENSMUSP00000130302; ENSMUSG00000042589 |
GeneIDi | 13048 |
KEGGi | mmu:13048 |
UCSCi | uc008zkm.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U45665 mRNA Translation: AAC52762.1 BC065113 mRNA Translation: AAH65113.1 |
CCDSi | CCDS39251.1 |
PIRi | T30817 |
RefSeqi | NP_001299837.1, NM_001312908.1 NP_031830.2, NM_007804.2 |
3D structure databases
AlphaFoldDBi | P70298 |
SMRi | P70298 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | P70298, 1 interactor |
STRINGi | 10090.ENSMUSP00000107381 |
PTM databases
iPTMneti | P70298 |
PhosphoSitePlusi | P70298 |
Proteomic databases
MaxQBi | P70298 |
PaxDbi | P70298 |
PeptideAtlasi | P70298 |
PRIDEi | P70298 |
ProteomicsDBi | 284068 |
Protocols and materials databases
Antibodypediai | 31073, 82 antibodies from 21 providers |
DNASUi | 13048 |
Genome annotation databases
Ensembli | ENSMUST00000086317; ENSMUSP00000083497; ENSMUSG00000042589 ENSMUST00000111752; ENSMUSP00000107381; ENSMUSG00000042589 ENSMUST00000168288; ENSMUSP00000130302; ENSMUSG00000042589 |
GeneIDi | 13048 |
KEGGi | mmu:13048 |
UCSCi | uc008zkm.1, mouse |
Organism-specific databases
CTDi | 23316 |
MGIi | MGI:107321, Cux2 |
VEuPathDBi | HostDB:ENSMUSG00000042589 |
Phylogenomic databases
eggNOGi | KOG0963, Eukaryota KOG2252, Eukaryota |
GeneTreei | ENSGT00940000160241 |
HOGENOMi | CLU_005104_1_0_1 |
InParanoidi | P70298 |
OMAi | QVDTAEI |
OrthoDBi | 181575at2759 |
PhylomeDBi | P70298 |
TreeFami | TF318206 |
Miscellaneous databases
BioGRID-ORCSi | 13048, 2 hits in 71 CRISPR screens |
ChiTaRSi | Cux2, mouse |
PROi | PR:P70298 |
RNActi | P70298, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000042589, Expressed in brain and 283 other tissues |
Genevisiblei | P70298, MM |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
Gene3Di | 1.10.260.40, 3 hits |
InterProi | View protein in InterPro IPR003350, CUT_dom IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR010982, Lambda_DNA-bd_dom_sf |
Pfami | View protein in Pfam PF02376, CUT, 3 hits PF00046, Homeodomain, 1 hit |
SMARTi | View protein in SMART SM01109, CUT, 3 hits SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit SSF47413, SSF47413, 3 hits |
PROSITEi | View protein in PROSITE PS51042, CUT, 3 hits PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CUX2_MOUSE | |
Accessioni | P70298Primary (citable) accession number: P70298 Secondary accession number(s): Q6P1E6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 27, 2001 |
Last sequence update: | July 27, 2011 | |
Last modified: | May 25, 2022 | |
This is version 170 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families