Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ancient ubiquitous protein 1

Gene

Aup1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome.By similarity

GO - Molecular functioni

  • ubiquitin binding Source: GO_Central
  • ubiquitin-protein transferase activator activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ancient ubiquitous protein 1
Gene namesi
Name:Aup1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:107789 Aup1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20LumenalSequence analysisAdd BLAST20
Transmembranei21 – 41Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST21
Topological domaini42 – 410CytoplasmicSequence analysisAdd BLAST369

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000207661 – 410Ancient ubiquitous protein 1Add BLAST410

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei292PhosphoserineBy similarity1
Modified residuei363PhosphoserineBy similarity1
Modified residuei367PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP70295
MaxQBiP70295
PaxDbiP70295
PRIDEiP70295

PTM databases

iPTMnetiP70295
PhosphoSitePlusiP70295
SwissPalmiP70295

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

CleanExiMM_AUP1

Interactioni

Subunit structurei

Identified in a complex that contains SEL1L, OS9, FAF2/UBXD8, UBE2J1/UBC6E and AUP1. Interacts with the cytoplasmic tail of ITGA2B, ITGA1, ITGA2, ITGA5, ITGAV and ITGAM (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiP70295, 2 interactors
MINTiP70295
STRINGi10090.ENSMUSP00000090281

Structurei

3D structure databases

ProteinModelPortaliP70295
SMRiP70295
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini296 – 338CUEPROSITE-ProRule annotationAdd BLAST43

Sequence similaritiesi

Belongs to the AUP1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2898 Eukaryota
ENOG410Y6KF LUCA
HOVERGENiHBG004321
InParanoidiP70295

Family and domain databases

InterProiView protein in InterPro
IPR003892 CUE
PfamiView protein in Pfam
PF02845 CUE, 1 hit
SMARTiView protein in SMART
SM00546 CUE, 1 hit
PROSITEiView protein in PROSITE
PS51140 CUE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P70295-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPPPAPGPE RLFDSHRLPS DGFLLLALLL YAPVGLCLLV LRLFLGLHVF
60 70 80 90 100
LVSCALPDSV LRRFVVRTMC AVLGLVARQE DSGLRDHRVR VLISNHVTPF
110 120 130 140 150
DHNIVNLLTT CSTPLLNSPP SFVCWSRGFM EMDRRVELVE SLKKFCASTR
160 170 180 190 200
LPPTPLLLFP EEEATNGREG LLRFSSWPFS IQDVVQPLTL QVQRPLVSVT
210 220 230 240 250
VSDASWVSEL LWSLFVPFTV YQVRWLHPIR RQLGEESEEF ALRVQQLVAK
260 270 280 290 300
ELGQIGTRLT PADKAEHMKR QRHPRLRPQS VQSSFPSPPS PSSDVQLTTL
310 320 330 340 350
AHRVKEVLPH VPLNVIQRDL ARTGCVDLTI TNLLEGAVAF MPEDVTEGSQ
360 370 380 390 400
SPPAPSAPKF PSSGLATPQP TALTFAKSSW ARQESLQERK QALYEYARRR
410
FRERQAQEAE
Length:410
Mass (Da):46,121
Last modified:February 1, 1997 - v1
Checksum:iE7D070CEB296BD5B
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3U3K9Q3U3K9_MOUSE
Ancient ubiquitous protein 1
Aup1
439Annotation score:
A0A0N4SVA6A0A0N4SVA6_MOUSE
Ancient ubiquitous protein 1
Aup1
391Annotation score:
A0A0N4SW18A0A0N4SW18_MOUSE
Ancient ubiquitous protein 1
Aup1
160Annotation score:
A0A0N4SW79A0A0N4SW79_MOUSE
Ancient ubiquitous protein 1
Aup1
104Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41736 mRNA Translation: AAC52839.1
BC016485 mRNA Translation: AAH16485.1
UniGeneiMm.386752

Genome annotation databases

UCSCiuc009clz.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41736 mRNA Translation: AAC52839.1
BC016485 mRNA Translation: AAH16485.1
UniGeneiMm.386752

3D structure databases

ProteinModelPortaliP70295
SMRiP70295
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP70295, 2 interactors
MINTiP70295
STRINGi10090.ENSMUSP00000090281

PTM databases

iPTMnetiP70295
PhosphoSitePlusiP70295
SwissPalmiP70295

Proteomic databases

EPDiP70295
MaxQBiP70295
PaxDbiP70295
PRIDEiP70295

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc009clz.2 mouse

Organism-specific databases

MGIiMGI:107789 Aup1

Phylogenomic databases

eggNOGiKOG2898 Eukaryota
ENOG410Y6KF LUCA
HOVERGENiHBG004321
InParanoidiP70295

Miscellaneous databases

PROiPR:P70295
SOURCEiSearch...

Gene expression databases

CleanExiMM_AUP1

Family and domain databases

InterProiView protein in InterPro
IPR003892 CUE
PfamiView protein in Pfam
PF02845 CUE, 1 hit
SMARTiView protein in SMART
SM00546 CUE, 1 hit
PROSITEiView protein in PROSITE
PS51140 CUE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAUP1_MOUSE
AccessioniPrimary (citable) accession number: P70295
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: February 1, 1997
Last modified: November 7, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again