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Protein

Synaptonemal complex protein 3

Gene

Sycp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase (PubMed:11311943, PubMed:22761579). Required for centromere pairing during meiosis in male germ cells (PubMed:22761579). Required for normal meiosis during spermatogenesis and male fertility (PubMed:10678170). Plays a lesser role in female fertility (PubMed:10678170, PubMed:12004129). Required for efficient phosphorylation of HORMAD1 and HORMAD2 (PubMed:22346761).5 Publications

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • protein heterodimerization activity Source: MGI

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • cellular response to leukemia inhibitory factor Source: MGI
  • chiasma assembly Source: UniProtKB
  • female meiosis chromosome segregation Source: UniProtKB
  • female meiosis chromosome separation Source: UniProtKB
  • female meiosis sister chromatid cohesion Source: UniProtKB
  • lateral element assembly Source: MGI
  • meiotic cell cycle Source: MGI
  • meiotic DNA repair synthesis Source: MGI
  • mitotic cell cycle Source: MGI
  • spermatid development Source: GO_Central
  • spermatogenesis Source: UniProtKB
  • spermatogenesis, exchange of chromosomal proteins Source: MGI
  • sperm chromatin condensation Source: MGI
  • synapsis Source: MGI
  • synaptonemal complex assembly Source: UniProtKB

Keywordsi

Molecular functionDNA-binding
Biological processCell cycle, Cell division, Meiosis

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptonemal complex protein 3
Short name:
SCP-3
Gene namesi
Name:Sycp3
Synonyms:Scp31 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:109542 Sycp3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

Pathology & Biotechi

Disruption phenotypei

Homozygous males with null mutations have smaller testes and are sterile, due to massive apoptotic cell death of male germ cells during meiotic prophase. Spermatocytes fail to form axial/lateral elements and synaptonemal complexes, and the chromosomes in the mutant spermatocytes do not synapse (PubMed:10678170). In contrast, females are fertile and generate healthy offspring. However, they exhibit a sharp reduction in litter size that increases with advancing maternal age (PubMed:10678170, PubMed:12004129). In contrast to wild-type, a high percentage of the mutant embryos display aneuploidy (PubMed:12004129).2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002230441 – 254Synaptonemal complex protein 3Add BLAST254

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8PhosphoserineCombined sources1
Modified residuei10PhosphoserineCombined sources1
Modified residuei11PhosphoserineCombined sources1
Modified residuei55PhosphoserineCombined sources1
Modified residuei57PhosphoserineBy similarity1
Modified residuei77PhosphoserineCombined sources1
Modified residuei218PhosphothreonineCombined sources1

Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP70281
PRIDEiP70281

PTM databases

iPTMnetiP70281
PhosphoSitePlusiP70281

Expressioni

Tissue specificityi

Detected in oocytes (PubMed:16717126). Detected in spermatocytes and testis (at protein level) (PubMed:10678170, PubMed:16717126, PubMed:22761579).4 Publications

Gene expression databases

CleanExiMM_SYCP3

Interactioni

Subunit structurei

Component of the lateral elements of synaptonemal complexes (PubMed:16717126). Homotetramer; the tetrameric helix bundles assemble end to end into long homopolimeric fibers that exhibit a transversal striation with a periodicity of about 20 nm (in vitro) (By similarity). Interacts with SYCP2 (PubMed:16717126).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203598, 2 interactors
CORUMiP70281
IntActiP70281, 3 interactors
MINTiP70281
STRINGi10090.ENSMUSP00000020252

Structurei

3D structure databases

ProteinModelPortaliP70281
SMRiP70281
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni71 – 76Interaction with DNABy similarity6
Regioni87 – 92Important for oligomerization and fiber formationBy similarity6
Regioni106 – 109Interaction with DNABy similarity4
Regioni249 – 254Important for oligomerization and fiber formationBy similarity6

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili84 – 241Sequence analysisBy similarityAdd BLAST158

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi106 – 109Nuclear localization signalSequence analysis4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi123 – 250Gln-richAdd BLAST128

Domaini

Composed of a long central coiled coil domain. The N-terminal and C-terminal regions interact with DNA.By similarity

Sequence similaritiesi

Belongs to the XLR/SYCP3 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IJ2Y Eukaryota
ENOG4111MZD LUCA
HOGENOMiHOG000236293
HOVERGENiHBG100390
InParanoidiP70281
KOiK19528
PhylomeDBiP70281

Family and domain databases

InterProiView protein in InterPro
IPR006888 XLR/SYCP3/FAM9_dom
PfamiView protein in Pfam
PF04803 Cor1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P70281-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRGCGDSDS SPEPLSKHLK MVPGGRKHSG KSGKPPLVDQ PKKAFDFEKD
60 70 80 90 100
DKDLSGSEED VADEKAPVID KHGKKRSAGI IEDVGGEVQN MLEKFGADIN
110 120 130 140 150
KALLAKRKRI EMYTKASFKA SNQKIEQIWK TQQEEIQKLN NEYSQQFMNV
160 170 180 190 200
LQQWELDIQK FEEQGEKLSN LFRQQQKIFQ QSRIVQSQRM FAMKQIHEQF
210 220 230 240 250
IKSLEDVEKN NDNLFTGTQS ELKKEMAMLQ KKVMMETQQQ EMANVRKSLQ

SMLF
Length:254
Mass (Da):29,347
Last modified:February 1, 1997 - v1
Checksum:iE0121D58A8DCD2EA
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2RSE7A2RSE7_MOUSE
Synaptonemal complex protein 3
Sycp3 mCG_16771
254Annotation score:
M0QWF4M0QWF4_MOUSE
Synaptonemal complex protein 3
Sycp3
248Annotation score:
M0QW86M0QW86_MOUSE
Synaptonemal complex protein 3
Sycp3
108Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti191F → K in BAE20894 (PubMed:16141072).Curated1
Sequence conflicti193M → I in BAE20894 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08485 mRNA Translation: CAA69719.1
Y08486 Genomic DNA Translation: CAA69720.1
AF181478
, AF181473, AF181474, AF181475, AF181476, AF181477 Genomic DNA Translation: AAG17538.1
AK131949 mRNA Translation: BAE20894.1
CCDSiCCDS24111.1
RefSeqiNP_035647.2, NM_011517.2
UniGeneiMm.297977

Genome annotation databases

GeneIDi20962
KEGGimmu:20962

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08485 mRNA Translation: CAA69719.1
Y08486 Genomic DNA Translation: CAA69720.1
AF181478
, AF181473, AF181474, AF181475, AF181476, AF181477 Genomic DNA Translation: AAG17538.1
AK131949 mRNA Translation: BAE20894.1
CCDSiCCDS24111.1
RefSeqiNP_035647.2, NM_011517.2
UniGeneiMm.297977

3D structure databases

ProteinModelPortaliP70281
SMRiP70281
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203598, 2 interactors
CORUMiP70281
IntActiP70281, 3 interactors
MINTiP70281
STRINGi10090.ENSMUSP00000020252

PTM databases

iPTMnetiP70281
PhosphoSitePlusiP70281

Proteomic databases

PaxDbiP70281
PRIDEiP70281

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi20962
KEGGimmu:20962

Organism-specific databases

CTDi50511
MGIiMGI:109542 Sycp3

Phylogenomic databases

eggNOGiENOG410IJ2Y Eukaryota
ENOG4111MZD LUCA
HOGENOMiHOG000236293
HOVERGENiHBG100390
InParanoidiP70281
KOiK19528
PhylomeDBiP70281

Miscellaneous databases

ChiTaRSiSycp3 mouse
PROiPR:P70281
SOURCEiSearch...

Gene expression databases

CleanExiMM_SYCP3

Family and domain databases

InterProiView protein in InterPro
IPR006888 XLR/SYCP3/FAM9_dom
PfamiView protein in Pfam
PF04803 Cor1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSYCP3_MOUSE
AccessioniPrimary (citable) accession number: P70281
Secondary accession number(s): Q3V2A4, Q549A7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: November 7, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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