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Protein

Surfeit locus protein 6

Gene

Surf6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly.1 Publication

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • RNA binding Source: UniProtKB

GO - Biological processi

  • ribosomal large subunit biogenesis Source: GO_Central
  • ribosomal small subunit biogenesis Source: GO_Central
  • ribosome assembly Source: UniProtKB
  • ribosome biogenesis Source: MGI

Keywordsi

Molecular functionDNA-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Surfeit locus protein 6
Gene namesi
Name:Surf6
Synonyms:Surf-6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:98447 Surf6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002209701 – 355Surfeit locus protein 6Add BLAST355

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei106Citrulline1 Publication1
Modified residuei136PhosphoserineBy similarity1
Modified residuei223PhosphothreonineBy similarity1

Post-translational modificationi

Citrullinated by PADI4.1 Publication

Keywords - PTMi

Citrullination, Phosphoprotein

Proteomic databases

EPDiP70279
PaxDbiP70279
PeptideAtlasiP70279
PRIDEiP70279

PTM databases

iPTMnetiP70279
PhosphoSitePlusiP70279

Expressioni

Tissue specificityi

Expressed in all tissues tested, including heart, brain, spleen, lung, liver, muscle, kidney and testis.

Gene expression databases

BgeeiENSMUSG00000036160 Expressed in 282 organ(s), highest expression level in embryo
CleanExiMM_SURF6
ExpressionAtlasiP70279 baseline and differential
GenevisibleiP70279 MM

Interactioni

Protein-protein interaction databases

BioGridi203584, 2 interactors
STRINGi10090.ENSMUSP00000048457

Structurei

3D structure databases

ProteinModelPortaliP70279
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi45 – 49Nuclear localization signalSequence analysis5
Motifi152 – 156Nuclear localization signalSequence analysis5

Sequence similaritiesi

Belongs to the SURF6 family.Curated

Phylogenomic databases

eggNOGiKOG2885 Eukaryota
ENOG4111G0Y LUCA
GeneTreeiENSGT00390000006980
HOGENOMiHOG000133097
HOVERGENiHBG054998
InParanoidiP70279
OMAiDEDRPWY
OrthoDBiEOG091G0O75
PhylomeDBiP70279
TreeFamiTF321608

Family and domain databases

InterProiView protein in InterPro
IPR029190 Rrp14/SURF6_C
IPR007019 SURF6
PANTHERiPTHR14369 PTHR14369, 1 hit
PfamiView protein in Pfam
PF04935 SURF6, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P70279-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASLLAKDTY LQDLAKKICA QPGPERQRST WGVRTKGSEA AGAPKKKRKK
60 70 80 90 100
TQKKSPEQEQ KAMDHKTKAL GKKPPTSSRP KNPMVSKQEK GLSSLGSPKD
110 120 130 140 150
SQGTARESVF ALDFLRQRLH EKIQLARGQG STKELSAATL EKRQRRKQER
160 170 180 190 200
ERKKRKRKER QAKQQVAEAE KKEEPVEVTP KMACKELQES GLIFNKVEVT
210 220 230 240 250
EEEPASKAQR KKEKRQKVKG NLTPLTGRNY RQLLDRLQAR QGRLDELRDQ
260 270 280 290 300
DAAKAQELEA KMKWTNLLYK AEGVKIRDDE RLLQEALKRK EKRRAQRQRK
310 320 330 340 350
WEKRSEHVVE KMQQRQDKRR QNLRKKKAAR AERRLQKAHK KGRVLPQDLE

RAGLS
Length:355
Mass (Da):41,235
Last modified:February 1, 1997 - v1
Checksum:i8C55841EDD8259B8
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2ALA0A2ALA0_MOUSE
Surfeit locus protein 6
Surf6
208Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92842 mRNA Translation: CAA63428.1
BC026514 mRNA Translation: AAH26514.1
BC037634 mRNA Translation: AAH37634.1
AK043984 mRNA Translation: BAC31725.1
AK075636 mRNA Translation: BAC35872.1
CCDSiCCDS15812.1
RefSeqiNP_033324.1, NM_009298.4
UniGeneiMm.245577
Mm.487749

Genome annotation databases

EnsembliENSMUST00000047632; ENSMUSP00000048457; ENSMUSG00000036160
GeneIDi20935
KEGGimmu:20935
UCSCiuc008iwc.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92842 mRNA Translation: CAA63428.1
BC026514 mRNA Translation: AAH26514.1
BC037634 mRNA Translation: AAH37634.1
AK043984 mRNA Translation: BAC31725.1
AK075636 mRNA Translation: BAC35872.1
CCDSiCCDS15812.1
RefSeqiNP_033324.1, NM_009298.4
UniGeneiMm.245577
Mm.487749

3D structure databases

ProteinModelPortaliP70279
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203584, 2 interactors
STRINGi10090.ENSMUSP00000048457

PTM databases

iPTMnetiP70279
PhosphoSitePlusiP70279

Proteomic databases

EPDiP70279
PaxDbiP70279
PeptideAtlasiP70279
PRIDEiP70279

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047632; ENSMUSP00000048457; ENSMUSG00000036160
GeneIDi20935
KEGGimmu:20935
UCSCiuc008iwc.1 mouse

Organism-specific databases

CTDi6838
MGIiMGI:98447 Surf6

Phylogenomic databases

eggNOGiKOG2885 Eukaryota
ENOG4111G0Y LUCA
GeneTreeiENSGT00390000006980
HOGENOMiHOG000133097
HOVERGENiHBG054998
InParanoidiP70279
OMAiDEDRPWY
OrthoDBiEOG091G0O75
PhylomeDBiP70279
TreeFamiTF321608

Miscellaneous databases

ChiTaRSiSurf6 mouse
PROiPR:P70279
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036160 Expressed in 282 organ(s), highest expression level in embryo
CleanExiMM_SURF6
ExpressionAtlasiP70279 baseline and differential
GenevisibleiP70279 MM

Family and domain databases

InterProiView protein in InterPro
IPR029190 Rrp14/SURF6_C
IPR007019 SURF6
PANTHERiPTHR14369 PTHR14369, 1 hit
PfamiView protein in Pfam
PF04935 SURF6, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSURF6_MOUSE
AccessioniPrimary (citable) accession number: P70279
Secondary accession number(s): Q8BPI4, Q8BRL7, Q8R0Q7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: February 1, 1997
Last modified: September 12, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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