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Protein

Sodium channel protein

Gene

Scn10a

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates the voltage-dependent sodium ion permeability of excitable membranes.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Sodium channelUniRule annotation, Voltage-gated channelUniRule annotation
Biological processIon transport, Sodium transport, Transport
LigandSodium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium channel proteinUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Scn10aImported
Synonyms:snsImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:108029 Scn10a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei128 – 146HelicalUniRule annotationAdd BLAST19
Transmembranei158 – 177HelicalUniRule annotationAdd BLAST20
Transmembranei189 – 210HelicalUniRule annotationAdd BLAST22
Transmembranei222 – 243HelicalUniRule annotationAdd BLAST22
Transmembranei249 – 268HelicalUniRule annotationAdd BLAST20
Transmembranei372 – 399HelicalUniRule annotationAdd BLAST28
Transmembranei695 – 716HelicalUniRule annotationAdd BLAST22
Transmembranei783 – 803HelicalUniRule annotationAdd BLAST21
Transmembranei863 – 889HelicalUniRule annotationAdd BLAST27
Transmembranei1154 – 1172HelicalUniRule annotationAdd BLAST19
Transmembranei1193 – 1209HelicalUniRule annotationAdd BLAST17
Transmembranei1221 – 1240HelicalUniRule annotationAdd BLAST20
Transmembranei1285 – 1305HelicalUniRule annotationAdd BLAST21
Transmembranei1358 – 1376HelicalUniRule annotationAdd BLAST19
Transmembranei1396 – 1419HelicalUniRule annotationAdd BLAST24
Transmembranei1469 – 1492HelicalUniRule annotationAdd BLAST24
Transmembranei1512 – 1530HelicalUniRule annotationAdd BLAST19
Transmembranei1542 – 1561HelicalUniRule annotationAdd BLAST20
Transmembranei1597 – 1625HelicalUniRule annotationAdd BLAST29
Transmembranei1700 – 1723HelicalUniRule annotationAdd BLAST24

Keywords - Cellular componenti

Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
P70276, 2 interactors

Molecular INTeraction database

More...
MINTi
P70276

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P70276

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini129 – 405Ion_transInterPro annotationAdd BLAST277
Domaini665 – 893Ion_transInterPro annotationAdd BLAST229
Domaini903 – 1148Na_trans_assocInterPro annotationAdd BLAST246
Domaini1152 – 1428Ion_transInterPro annotationAdd BLAST277
Domaini1477 – 1733Ion_transInterPro annotationAdd BLAST257

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili407 – 430Sequence analysisAdd BLAST24
Coiled coili1000 – 1020Sequence analysisAdd BLAST21

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sodium channel (TC 1.A.1.10) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2301 Eukaryota
ENOG410XNP6 LUCA

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG053100

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.350, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005821 Ion_trans_dom
IPR028809 Na_channel_a10su
IPR001696 Na_channel_asu
IPR010526 Na_trans_assoc
IPR027359 Volt_channel_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10037:SF208 PTHR10037:SF208, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00520 Ion_trans, 4 hits
PF06512 Na_trans_assoc, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00170 NACHANNEL

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P70276-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEFPFGSVGT TNFRRFTPES LAEIEKQIAA HRAAKKGRTK QRGQKDKSEK
60 70 80 90 100
PRPQLDLKAC NQLPRFYGEL PAELVGEPLE DLDPFYSTHR TFILLNKSRT
110 120 130 140 150
ISRFSATWAL WLFSPFNLIR RTAIKVSVHS WFSIFITVTI LVNCVCMTRT
160 170 180 190 200
DLPEKLEYVF TVVYTFEALI KILARGFCLN EFTYLRDPWN WLDFSVITLA
210 220 230 240 250
YVGAAVDLRG ISGLRTFRVL RALKTVSVIP GLKVIVGALI HSVRKLADVT
260 270 280 290 300
ILTVFCLSVF ALVGLQLFKG NLKNKCIKNG TDPHKADNLS SEMAEDIFIK
310 320 330 340 350
PGTTDPLLCG NGSDAGHCPN GYVCQKTPDN PDFNYTSFDS FAWAFLSLFR
360 370 380 390 400
LMTQDSWERL YQQTLRASGK MYMVFFVLVI FLGSFYLVNL ILAVVTMAYE
410 420 430 440 450
EQSQATIAEI EAKEKKFQEA LEVLQKEQEV LAALGIDTTS FYSHSGSPLA
460 470 480 490 500
SKNANERRPR VKSRVSEGST DDNRSPQSDP YNQRRMSFLG LSSGRRRASH
510 520 530 540 550
GSVFHFRAPS QDVSFPDGIL DDGVFHGDQE SRRNSILLGR GAGQAGPLPR
560 570 580 590 600
SPLPQSPNPG RKHGKEGQLG MPTGELAAGT PEGPALDAAG QKNFLSAGYL
610 620 630 640 650
NEPFRAQRAM SVVSIMTSVI EELEESKLKC PPCLISFAQK YLIWECCPKW
660 670 680 690 700
RKFKMVLLEL VTDPFAELTI TLCIVVNTVF MAMEHYPMTD AFDAMLQAGN
710 720 730 740 750
IVFTVFFTME MAFKIIAFDP YYYFQKKWNI FDCVIVTVSL LELSASKKGS
760 770 780 790 800
LSVLRSLRLL RVFKLAKSWP TLNMLIKIIG NSVGALGNLT FILAIIVFIF
810 820 830 840 850
ALVGKQLLSE NYGCRRDGVS VWNGEKLRWH MCDFFHSFLV VFRILCGEWI
860 870 880 890 900
ENMWVCMEVS QNYICLTLFL TVMVLGNLVV LNLFIALLLN SFSADNLTAP
910 920 930 940 950
EDDGEVNNLQ LALARIQVLG HRASRAITSY IRSHCRFRWP KVETQLGMKP
960 970 980 990 1000
PLTSCKVENH IATDAVNAAV GNLTKPALSG PKENHGDFIT DPNVWVSVPI
1010 1020 1030 1040 1050
AEGESDLDEL EEDVEQASQS SWQEESPKGQ QELLPQVQKC ENHQAARSPT
1060 1070 1080 1090 1100
SGMSSEDLAP YLGERWKRKD NPQVPAEGVD DTSSSEGSTV DCPDPEEILR
1110 1120 1130 1140 1150
KIPELAEDLD EPDDCFTEGC TRRCPCCKVN TSKSPWATGW QVRKTCYRIV
1160 1170 1180 1190 1200
EHSWFESFII FMILLSSGTL AFEDNYLEEK PRVKSVLEYT DRVFTFIFVF
1210 1220 1230 1240 1250
EMLLKWVAYG FKKYFTNAWC WLDFLIVNIS LTSLIAKILE YSDVASIKAL
1260 1270 1280 1290 1300
RTLRALRPLR ALSRFEGMRV VVDALVGAIP SIMNVLLVCL IFWLIFSIMG
1310 1320 1330 1340 1350
VNLFAGKFSR CVDTRSNPFS VVNSTFVNNK SDCHNQNNTG HFFWVNVKVN
1360 1370 1380 1390 1400
FDNVAMGYLA LLQVATFKGW MDIMYAAVDS RDINSQPNWE ESLYMYLYFV
1410 1420 1430 1440 1450
VFIIFGGFFT LNLFVGVIID NFNQQKKKLG GQDIFMTEEQ KKYYNAMKKL
1460 1470 1480 1490 1500
GSKKPQKPIP RPLNKYQGFV FDIVTRQAFD IIIMVLICLN MITMMVETDN
1510 1520 1530 1540 1550
QSEEKTKVLG RINQFFVAVF TGECVMKVFA LRQYYFTNGW NVFDFIVVIL
1560 1570 1580 1590 1600
SIASLLFSAI LKSLESYFSP TFFRVIRLAR IGRILRLIRA AKGIRTLLFA
1610 1620 1630 1640 1650
LMMSLPALFN IALLLFLVMF IYSIFGMASF ANVIDEAGID DMFNFKTFGN
1660 1670 1680 1690 1700
SMLCLFQITT SAGWDGLLSP ILNTGPPYCD PNRPNSNGSK GNCGSPAVGI
1710 1720 1730 1740 1750
LFFTTYIIIS FLIVVNMYIA VILENFNVAT EESTEPLSED DFDMFYETWE
1760 1770 1780 1790 1800
KFDPEATQFI AFSALSDFAD TLSGPLRIPK PNQNILIQMD LPLVPGDKIH
1810 1820 1830 1840 1850
CLDILFAFTK NVLGESGELD SLKTNMEEKF MATNLSKASY EPIATTLRCK
1860 1870 1880 1890 1900
QEDISATIIQ KAYRNYMLQR SLMLSNTLHV PRAEEDGVSL PKGGYVTFMA
1910 1920 1930 1940 1950
NDNGGLPDKS ETASATSFPP SYESVTRGLS DRANINTSSS MQNEDEVTAK

EGNSPGPQ
Length:1,958
Mass (Da):220,404
Last modified:February 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAE3811C17721EB72
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y09108 mRNA Translation: CAA70325.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.247042
Mm.455125
Mm.489505

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09108 mRNA Translation: CAA70325.1
UniGeneiMm.247042
Mm.455125
Mm.489505

3D structure databases

ProteinModelPortaliP70276
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP70276, 2 interactors
MINTiP70276

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:108029 Scn10a

Phylogenomic databases

eggNOGiKOG2301 Eukaryota
ENOG410XNP6 LUCA
HOVERGENiHBG053100

Miscellaneous databases

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR028809 Na_channel_a10su
IPR001696 Na_channel_asu
IPR010526 Na_trans_assoc
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR10037:SF208 PTHR10037:SF208, 1 hit
PfamiView protein in Pfam
PF00520 Ion_trans, 4 hits
PF06512 Na_trans_assoc, 1 hit
PRINTSiPR00170 NACHANNEL

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiP70276_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P70276
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 1, 1997
Last sequence update: February 1, 1997
Last modified: February 28, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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