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Protein

Sodium channel protein

Gene

Scn10a

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mediates the voltage-dependent sodium ion permeability of excitable membranes.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Sodium channelUniRule annotation, Voltage-gated channelUniRule annotation
Biological processIon transport, Sodium transport, Transport
LigandSodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel proteinUniRule annotation
Gene namesi
Name:Scn10aImported
Synonyms:snsImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:108029 Scn10a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei128 – 146HelicalUniRule annotationAdd BLAST19
Transmembranei158 – 177HelicalUniRule annotationAdd BLAST20
Transmembranei189 – 210HelicalUniRule annotationAdd BLAST22
Transmembranei222 – 243HelicalUniRule annotationAdd BLAST22
Transmembranei249 – 268HelicalUniRule annotationAdd BLAST20
Transmembranei372 – 399HelicalUniRule annotationAdd BLAST28
Transmembranei695 – 716HelicalUniRule annotationAdd BLAST22
Transmembranei783 – 803HelicalUniRule annotationAdd BLAST21
Transmembranei863 – 889HelicalUniRule annotationAdd BLAST27
Transmembranei1154 – 1172HelicalUniRule annotationAdd BLAST19
Transmembranei1193 – 1209HelicalUniRule annotationAdd BLAST17
Transmembranei1221 – 1240HelicalUniRule annotationAdd BLAST20
Transmembranei1285 – 1305HelicalUniRule annotationAdd BLAST21
Transmembranei1358 – 1376HelicalUniRule annotationAdd BLAST19
Transmembranei1396 – 1419HelicalUniRule annotationAdd BLAST24
Transmembranei1469 – 1492HelicalUniRule annotationAdd BLAST24
Transmembranei1512 – 1530HelicalUniRule annotationAdd BLAST19
Transmembranei1542 – 1561HelicalUniRule annotationAdd BLAST20
Transmembranei1597 – 1625HelicalUniRule annotationAdd BLAST29
Transmembranei1700 – 1723HelicalUniRule annotationAdd BLAST24

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

IntActiP70276, 2 interactors
MINTiP70276

Structurei

3D structure databases

ProteinModelPortaliP70276
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini129 – 405Ion_transInterPro annotationAdd BLAST277
Domaini665 – 893Ion_transInterPro annotationAdd BLAST229
Domaini903 – 1148Na_trans_assocInterPro annotationAdd BLAST246
Domaini1152 – 1428Ion_transInterPro annotationAdd BLAST277
Domaini1477 – 1733Ion_transInterPro annotationAdd BLAST257

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili407 – 430Sequence analysisAdd BLAST24
Coiled coili1000 – 1020Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the sodium channel (TC 1.A.1.10) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG2301 Eukaryota
ENOG410XNP6 LUCA
HOVERGENiHBG053100

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR028809 Na_channel_a10su
IPR001696 Na_channel_asu
IPR010526 Na_trans_assoc
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR10037:SF208 PTHR10037:SF208, 1 hit
PfamiView protein in Pfam
PF00520 Ion_trans, 4 hits
PF06512 Na_trans_assoc, 1 hit
PRINTSiPR00170 NACHANNEL

Sequencei

Sequence statusi: Complete.

P70276-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFPFGSVGT TNFRRFTPES LAEIEKQIAA HRAAKKGRTK QRGQKDKSEK
60 70 80 90 100
PRPQLDLKAC NQLPRFYGEL PAELVGEPLE DLDPFYSTHR TFILLNKSRT
110 120 130 140 150
ISRFSATWAL WLFSPFNLIR RTAIKVSVHS WFSIFITVTI LVNCVCMTRT
160 170 180 190 200
DLPEKLEYVF TVVYTFEALI KILARGFCLN EFTYLRDPWN WLDFSVITLA
210 220 230 240 250
YVGAAVDLRG ISGLRTFRVL RALKTVSVIP GLKVIVGALI HSVRKLADVT
260 270 280 290 300
ILTVFCLSVF ALVGLQLFKG NLKNKCIKNG TDPHKADNLS SEMAEDIFIK
310 320 330 340 350
PGTTDPLLCG NGSDAGHCPN GYVCQKTPDN PDFNYTSFDS FAWAFLSLFR
360 370 380 390 400
LMTQDSWERL YQQTLRASGK MYMVFFVLVI FLGSFYLVNL ILAVVTMAYE
410 420 430 440 450
EQSQATIAEI EAKEKKFQEA LEVLQKEQEV LAALGIDTTS FYSHSGSPLA
460 470 480 490 500
SKNANERRPR VKSRVSEGST DDNRSPQSDP YNQRRMSFLG LSSGRRRASH
510 520 530 540 550
GSVFHFRAPS QDVSFPDGIL DDGVFHGDQE SRRNSILLGR GAGQAGPLPR
560 570 580 590 600
SPLPQSPNPG RKHGKEGQLG MPTGELAAGT PEGPALDAAG QKNFLSAGYL
610 620 630 640 650
NEPFRAQRAM SVVSIMTSVI EELEESKLKC PPCLISFAQK YLIWECCPKW
660 670 680 690 700
RKFKMVLLEL VTDPFAELTI TLCIVVNTVF MAMEHYPMTD AFDAMLQAGN
710 720 730 740 750
IVFTVFFTME MAFKIIAFDP YYYFQKKWNI FDCVIVTVSL LELSASKKGS
760 770 780 790 800
LSVLRSLRLL RVFKLAKSWP TLNMLIKIIG NSVGALGNLT FILAIIVFIF
810 820 830 840 850
ALVGKQLLSE NYGCRRDGVS VWNGEKLRWH MCDFFHSFLV VFRILCGEWI
860 870 880 890 900
ENMWVCMEVS QNYICLTLFL TVMVLGNLVV LNLFIALLLN SFSADNLTAP
910 920 930 940 950
EDDGEVNNLQ LALARIQVLG HRASRAITSY IRSHCRFRWP KVETQLGMKP
960 970 980 990 1000
PLTSCKVENH IATDAVNAAV GNLTKPALSG PKENHGDFIT DPNVWVSVPI
1010 1020 1030 1040 1050
AEGESDLDEL EEDVEQASQS SWQEESPKGQ QELLPQVQKC ENHQAARSPT
1060 1070 1080 1090 1100
SGMSSEDLAP YLGERWKRKD NPQVPAEGVD DTSSSEGSTV DCPDPEEILR
1110 1120 1130 1140 1150
KIPELAEDLD EPDDCFTEGC TRRCPCCKVN TSKSPWATGW QVRKTCYRIV
1160 1170 1180 1190 1200
EHSWFESFII FMILLSSGTL AFEDNYLEEK PRVKSVLEYT DRVFTFIFVF
1210 1220 1230 1240 1250
EMLLKWVAYG FKKYFTNAWC WLDFLIVNIS LTSLIAKILE YSDVASIKAL
1260 1270 1280 1290 1300
RTLRALRPLR ALSRFEGMRV VVDALVGAIP SIMNVLLVCL IFWLIFSIMG
1310 1320 1330 1340 1350
VNLFAGKFSR CVDTRSNPFS VVNSTFVNNK SDCHNQNNTG HFFWVNVKVN
1360 1370 1380 1390 1400
FDNVAMGYLA LLQVATFKGW MDIMYAAVDS RDINSQPNWE ESLYMYLYFV
1410 1420 1430 1440 1450
VFIIFGGFFT LNLFVGVIID NFNQQKKKLG GQDIFMTEEQ KKYYNAMKKL
1460 1470 1480 1490 1500
GSKKPQKPIP RPLNKYQGFV FDIVTRQAFD IIIMVLICLN MITMMVETDN
1510 1520 1530 1540 1550
QSEEKTKVLG RINQFFVAVF TGECVMKVFA LRQYYFTNGW NVFDFIVVIL
1560 1570 1580 1590 1600
SIASLLFSAI LKSLESYFSP TFFRVIRLAR IGRILRLIRA AKGIRTLLFA
1610 1620 1630 1640 1650
LMMSLPALFN IALLLFLVMF IYSIFGMASF ANVIDEAGID DMFNFKTFGN
1660 1670 1680 1690 1700
SMLCLFQITT SAGWDGLLSP ILNTGPPYCD PNRPNSNGSK GNCGSPAVGI
1710 1720 1730 1740 1750
LFFTTYIIIS FLIVVNMYIA VILENFNVAT EESTEPLSED DFDMFYETWE
1760 1770 1780 1790 1800
KFDPEATQFI AFSALSDFAD TLSGPLRIPK PNQNILIQMD LPLVPGDKIH
1810 1820 1830 1840 1850
CLDILFAFTK NVLGESGELD SLKTNMEEKF MATNLSKASY EPIATTLRCK
1860 1870 1880 1890 1900
QEDISATIIQ KAYRNYMLQR SLMLSNTLHV PRAEEDGVSL PKGGYVTFMA
1910 1920 1930 1940 1950
NDNGGLPDKS ETASATSFPP SYESVTRGLS DRANINTSSS MQNEDEVTAK

EGNSPGPQ
Length:1,958
Mass (Da):220,404
Last modified:February 1, 1997 - v1
Checksum:iAE3811C17721EB72
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09108 mRNA Translation: CAA70325.1
UniGeneiMm.247042
Mm.455125
Mm.489505

Similar proteinsi

Entry informationi

Entry nameiP70276_MOUSE
AccessioniPrimary (citable) accession number: P70276
Entry historyiIntegrated into UniProtKB/TrEMBL: February 1, 1997
Last sequence update: February 1, 1997
Last modified: February 28, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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