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Protein

Cathepsin E

Gene

Ctse

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain.2 Publications

Catalytic activityi

Similar to cathepsin D, but slightly broader specificity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei97PROSITE-ProRule annotation1
Active sitei282PROSITE-ProRule annotation1

GO - Molecular functioni

  • aspartic-type endopeptidase activity Source: UniProtKB
  • protein homodimerization activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionAspartyl protease, Hydrolase, Protease

Enzyme and pathway databases

BRENDAi3.4.23.34 3474
ReactomeiR-MMU-2132295 MHC class II antigen presentation

Protein family/group databases

MEROPSiA01.010

Names & Taxonomyi

Protein namesi
Recommended name:
Cathepsin E (EC:3.4.23.34)
Gene namesi
Name:Ctse
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:107361 Ctse

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1681627

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20By similarityAdd BLAST20
PropeptideiPRO_000002597621 – 59Activation peptideBy similarityAdd BLAST39
ChainiPRO_000002597760 – 397Cathepsin EAdd BLAST338

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi61InterchainCurated
Glycosylationi91N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi110 ↔ 115By similarity
Disulfide bondi273 ↔ 277By similarity
Glycosylationi323N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Glycosylated. The nature of the carbohydrate chain varies between cell types. In fibroblasts, the proenzyme contains a high mannose-type oligosaccharide, while the mature enzyme contains a complex-type oligosaccharide.1 Publication

Keywords - PTMi

Autocatalytic cleavage, Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

MaxQBiP70269
PaxDbiP70269
PRIDEiP70269

PTM databases

PhosphoSitePlusiP70269
SwissPalmiP70269

Miscellaneous databases

PMAP-CutDBiP70269

Expressioni

Tissue specificityi

Expressed abundantly in the stomach, Clara cells and alveolar macrophages of the lung, brain microglia, spleen and activated B-lymphocytes. Not expressed in resting B-lymphocytes.2 Publications

Gene expression databases

BgeeiENSMUSG00000004552
CleanExiMM_CTSE
ExpressionAtlasiP70269 baseline and differential
GenevisibleiP70269 MM

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

GO - Molecular functioni

  • protein homodimerization activity Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000073072

Chemistry databases

BindingDBiP70269

Structurei

3D structure databases

ProteinModelPortaliP70269
SMRiP70269
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini79 – 393Peptidase A1PROSITE-ProRule annotationAdd BLAST315

Sequence similaritiesi

Belongs to the peptidase A1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1339 Eukaryota
ENOG410XNV7 LUCA
GeneTreeiENSGT00760000118929
HOGENOMiHOG000197681
HOVERGENiHBG000482
InParanoidiP70269
KOiK01382
OMAiKEPGQTF
OrthoDBiEOG091G0JP7
TreeFamiTF314990

Family and domain databases

Gene3Di2.40.70.10, 2 hits
InterProiView protein in InterPro
IPR001461 Aspartic_peptidase_A1
IPR001969 Aspartic_peptidase_AS
IPR012848 Aspartic_peptidase_N
IPR033145 Cathepsin_E
IPR033121 PEPTIDASE_A1
IPR021109 Peptidase_aspartic_dom_sf
PANTHERiPTHR13683 PTHR13683, 1 hit
PTHR13683:SF81 PTHR13683:SF81, 1 hit
PfamiView protein in Pfam
PF07966 A1_Propeptide, 1 hit
PF00026 Asp, 1 hit
PRINTSiPR00792 PEPSIN
SUPFAMiSSF50630 SSF50630, 1 hit
PROSITEiView protein in PROSITE
PS00141 ASP_PROTEASE, 2 hits
PS51767 PEPTIDASE_A1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P70269-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPLLVLLLL LLLDLAQAQG ALHRVPLRRH QSLRKKLRAQ GQLSEFWRSH
60 70 80 90 100
NLDMTRLSES CNVYSSVNEP LINYLDMEYF GTISIGTPPQ NFTVIFDTGS
110 120 130 140 150
SNLWVPSVYC TSPACKAHPV FHPSQSDTYT EVGNHFSIQY GTGSLTGIIG
160 170 180 190 200
ADQVSVEGLT VDGQQFGESV KEPGQTFVNA EFDGILGLGY PSLAAGGVTP
210 220 230 240 250
VFDNMMAQNL VALPMFSVYL SSDPQGGSGS ELTFGGYDPS HFSGSLNWIP
260 270 280 290 300
VTKQAYWQIA LDGIQVGDTV MFCSEGCQAI VDTGTSLITG PPDKIKQLQE
310 320 330 340 350
AIGATPIDGE YAVDCATLDT MPNVTFLINE VSYTLNPTDY ILPDLVEGMQ
360 370 380 390
FCGSGFQGLD IPPPAGPLWI LGDVFIRQFY SVFDRGNNQV GLAPAVP
Length:397
Mass (Da):42,938
Last modified:July 27, 2011 - v2
Checksum:iDF6AEFD5F78B3747
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti297Q → H in CAA66056 (PubMed:9180269).Curated1
Sequence conflicti297Q → H in CAJ18460 (Ref. 5) Curated1
Sequence conflicti297Q → H in AAH05432 (PubMed:15489334).Curated1
Sequence conflicti347E → D in CAA66056 (PubMed:9180269).Curated1
Sequence conflicti347E → D in CAA71859 (PubMed:9602058).Curated1
Sequence conflicti347E → D in CAJ18460 (Ref. 5) Curated1
Sequence conflicti347E → D in AAH05432 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97399 mRNA Translation: CAA66056.1
Y10928 Genomic DNA Translation: CAA71859.1
AJ009840
, AJ009841, AJ009842, AJ009843, AJ009844, AJ009845, AJ009846, AJ009847, AJ009848 Genomic DNA Translation: CAA08880.2
AK143581 mRNA Translation: BAE25449.1
AK145875 mRNA Translation: BAE26716.1
AK157907 mRNA Translation: BAE34257.1
AK165271 mRNA Translation: BAE38113.1
CT010252 mRNA Translation: CAJ18460.1
CH466520 Genomic DNA Translation: EDL39705.1
BC005432 mRNA Translation: AAH05432.1
CCDSiCCDS15271.1
RefSeqiNP_031825.2, NM_007799.3
UniGeneiMm.230249

Genome annotation databases

EnsembliENSMUST00000073350; ENSMUSP00000073072; ENSMUSG00000004552
GeneIDi13034
KEGGimmu:13034
UCSCiuc007cnn.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCATE_MOUSE
AccessioniPrimary (citable) accession number: P70269
Secondary accession number(s): O35647, Q3UKT5, Q4FK00
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: June 20, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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