UniProtKB - P70263 (PD2R_MOUSE)
Protein
Prostaglandin D2 receptor
Gene
Ptgdr
Organism
Mus musculus (Mouse)
Status
Functioni
Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity). Involved in PLA2G3-dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (PubMed:23624557).By similarity1 Publication
GO - Molecular functioni
- prostaglandin D receptor activity Source: MGI
- prostaglandin J receptor activity Source: MGI
GO - Biological processi
- adenosine metabolic process Source: MGI
- cellular response to prostaglandin D stimulus Source: MGI
- inflammatory response Source: MGI
- male sex determination Source: MGI
- mast cell degranulation Source: UniProtKB-KW
- positive regulation of cytosolic calcium ion concentration Source: GO_Central
- sleep Source: MGI
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Mast cell degranulation |
Enzyme and pathway databases
Reactomei | R-MMU-391908, Prostanoid ligand receptors R-MMU-418555, G alpha (s) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: Prostaglandin D2 receptorShort name: PGD receptor Short name: PGD2 receptor Alternative name(s): Prostanoid DP receptor |
Gene namesi | Name:Ptgdr |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:102966, Ptgdr |
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Multi-pass membrane protein Curated
Plasma Membrane
- plasma membrane Source: MGI
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 20 | ExtracellularSequence analysisAdd BLAST | 20 | |
Transmembranei | 21 – 41 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 42 – 58 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 59 – 79 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 80 – 106 | ExtracellularSequence analysisAdd BLAST | 27 | |
Transmembranei | 107 – 127 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 128 – 149 | CytoplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 150 – 170 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 171 – 194 | ExtracellularSequence analysisAdd BLAST | 24 | |
Transmembranei | 195 – 215 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 216 – 261 | CytoplasmicSequence analysisAdd BLAST | 46 | |
Transmembranei | 262 – 282 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 283 – 306 | ExtracellularSequence analysisAdd BLAST | 24 | |
Transmembranei | 307 – 327 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 328 – 357 | CytoplasmicSequence analysisAdd BLAST | 30 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Disruption phenotypei
Mutant mice show decreased susceptibility to passive cutaneous anaphylaxis associated with decreased mast cell degranulation.1 Publication
Chemistry databases
ChEMBLi | CHEMBL3933 |
GuidetoPHARMACOLOGYi | 338 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000070048 | 1 – 357 | Prostaglandin D2 receptorAdd BLAST | 357 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 2 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 89 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 104 ↔ 182 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P70263 |
PRIDEi | P70263 |
PTM databases
GlyGeni | P70263, 2 sites |
PhosphoSitePlusi | P70263 |
Expressioni
Tissue specificityi
Most abundantly expressed in the ileum, followed by lung, stomach and uterus.
Gene expression databases
Bgeei | ENSMUSG00000071489, Expressed in granulocyte and 55 other tissues |
Genevisiblei | P70263, MM |
Interactioni
Protein-protein interaction databases
IntActi | P70263, 1 interactor |
STRINGi | 10090.ENSMUSP00000093653 |
Chemistry databases
BindingDBi | P70263 |
Miscellaneous databases
RNActi | P70263, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01000000214569 |
HOGENOMi | CLU_045991_0_2_1 |
InParanoidi | P70263 |
OMAi | FRIFFHK |
OrthoDBi | 972015at2759 |
PhylomeDBi | P70263 |
TreeFami | TF324982 |
Family and domain databases
InterProi | View protein in InterPro IPR017452, GPCR_Rhodpsn_7TM IPR000376, Pglndn_D_rcpt IPR008365, Prostanoid_rcpt |
PANTHERi | PTHR11866, PTHR11866, 1 hit PTHR11866:SF14, PTHR11866:SF14, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR01788, PROSTANOIDR PR00854, PRSTNOIDDPR |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P70263-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNESYRCQTS TWVERGSSAT MGAVLFGAGL LGNLLALVLL ARSGLGSCRP
60 70 80 90 100
GPLHPPPSVF YVLVCGLTVT DLLGKCLISP MVLAAYAQNQ SLKELLPASG
110 120 130 140 150
NQLCETFAFL MSFFGLASTL QLLAMAVECW LSLGHPFFYQ RHVTLRRGVL
160 170 180 190 200
VAPVVAAFCL AFCALPFAGF GKFVQYCPGT WCFIQMIHKE RSFSVIGFSV
210 220 230 240 250
LYSSLMALLV LATVVCNLGA MYNLYDMHRR QRHYPHRCSR DRAQSGSDYR
260 270 280 290 300
HGSLHPLEEL DHFVLLALMT VLFTMCSLPL IYRAYYGAFK LENKAEGDSE
310 320 330 340 350
DLQALRFLSV ISIVDPWIFI IFRTSVFRML FHKVFTRPLI YRNWSSHSQQ
SNVESTL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 75 | K → N in BAC27895 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK032488 mRNA Translation: BAC27895.1 D29765 Genomic DNA Translation: BAA06168.1 BC132297 mRNA Translation: AAI32298.1 |
CCDSi | CCDS26971.1 |
PIRi | I59269 I80042 |
RefSeqi | NP_032988.3, NM_008962.4 |
Genome annotation databases
Ensembli | ENSMUST00000095959; ENSMUSP00000093653; ENSMUSG00000071489 |
GeneIDi | 19214 |
KEGGi | mmu:19214 |
UCSCi | uc007ter.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK032488 mRNA Translation: BAC27895.1 D29765 Genomic DNA Translation: BAA06168.1 BC132297 mRNA Translation: AAI32298.1 |
CCDSi | CCDS26971.1 |
PIRi | I59269 I80042 |
RefSeqi | NP_032988.3, NM_008962.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | P70263, 1 interactor |
STRINGi | 10090.ENSMUSP00000093653 |
Chemistry databases
BindingDBi | P70263 |
ChEMBLi | CHEMBL3933 |
GuidetoPHARMACOLOGYi | 338 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P70263, 2 sites |
PhosphoSitePlusi | P70263 |
Proteomic databases
PaxDbi | P70263 |
PRIDEi | P70263 |
Protocols and materials databases
Antibodypediai | 10764, 214 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000095959; ENSMUSP00000093653; ENSMUSG00000071489 |
GeneIDi | 19214 |
KEGGi | mmu:19214 |
UCSCi | uc007ter.1, mouse |
Organism-specific databases
CTDi | 5729 |
MGIi | MGI:102966, Ptgdr |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01000000214569 |
HOGENOMi | CLU_045991_0_2_1 |
InParanoidi | P70263 |
OMAi | FRIFFHK |
OrthoDBi | 972015at2759 |
PhylomeDBi | P70263 |
TreeFami | TF324982 |
Enzyme and pathway databases
Reactomei | R-MMU-391908, Prostanoid ligand receptors R-MMU-418555, G alpha (s) signalling events |
Miscellaneous databases
BioGRID-ORCSi | 19214, 0 hits in 17 CRISPR screens |
PROi | PR:P70263 |
RNActi | P70263, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000071489, Expressed in granulocyte and 55 other tissues |
Genevisiblei | P70263, MM |
Family and domain databases
InterProi | View protein in InterPro IPR017452, GPCR_Rhodpsn_7TM IPR000376, Pglndn_D_rcpt IPR008365, Prostanoid_rcpt |
PANTHERi | PTHR11866, PTHR11866, 1 hit PTHR11866:SF14, PTHR11866:SF14, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR01788, PROSTANOIDR PR00854, PRSTNOIDDPR |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PD2R_MOUSE | |
Accessioni | P70263Primary (citable) accession number: P70263 Secondary accession number(s): A2RSY4, Q8CCM3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | February 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 149 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries