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Protein

Prostaglandin D2 receptor

Gene

Ptgdr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity).By similarity

GO - Molecular functioni

  • prostaglandin D receptor activity Source: MGI
  • prostaglandin E receptor activity Source: GO_Central
  • prostaglandin J receptor activity Source: MGI

GO - Biological processi

  • adenosine metabolic process Source: MGI
  • cellular response to prostaglandin D stimulus Source: MGI
  • cellular response to prostaglandin E stimulus Source: GO_Central
  • inflammatory response Source: MGI
  • male sex determination Source: MGI
  • positive regulation of blood vessel diameter Source: GO_Central
  • sleep Source: MGI

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-391908 Prostanoid ligand receptors
R-MMU-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin D2 receptor
Short name:
PGD receptor
Short name:
PGD2 receptor
Alternative name(s):
Prostanoid DP receptor
Gene namesi
Name:Ptgdr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:102966 Ptgdr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20ExtracellularSequence analysisAdd BLAST20
Transmembranei21 – 41Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini42 – 58CytoplasmicSequence analysisAdd BLAST17
Transmembranei59 – 79Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini80 – 106ExtracellularSequence analysisAdd BLAST27
Transmembranei107 – 127Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini128 – 149CytoplasmicSequence analysisAdd BLAST22
Transmembranei150 – 170Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini171 – 194ExtracellularSequence analysisAdd BLAST24
Transmembranei195 – 215Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini216 – 261CytoplasmicSequence analysisAdd BLAST46
Transmembranei262 – 282Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini283 – 306ExtracellularSequence analysisAdd BLAST24
Transmembranei307 – 327Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini328 – 357CytoplasmicSequence analysisAdd BLAST30

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3933
GuidetoPHARMACOLOGYi338

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700481 – 357Prostaglandin D2 receptorAdd BLAST357

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi2N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi89N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi104 ↔ 182PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP70263
PRIDEiP70263

PTM databases

PhosphoSitePlusiP70263

Expressioni

Tissue specificityi

Most abundantly expressed in the ileum, followed by lung, stomach and uterus.

Gene expression databases

BgeeiENSMUSG00000071489
CleanExiMM_PTGDR
GenevisibleiP70263 MM

Interactioni

Protein-protein interaction databases

IntActiP70263, 1 interactor
STRINGi10090.ENSMUSP00000093653

Chemistry databases

BindingDBiP70263

Structurei

3D structure databases

ProteinModelPortaliP70263
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000119188
HOGENOMiHOG000115475
HOVERGENiHBG003074
InParanoidiP70263
KOiK04332
OMAiSLCQAFA
OrthoDBiEOG091G0F07
PhylomeDBiP70263
TreeFamiTF324982

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000376 Pglndn_D_rcpt
IPR008365 Prostanoid_rcpt
PANTHERiPTHR11866 PTHR11866, 1 hit
PTHR11866:SF14 PTHR11866:SF14, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01788 PROSTANOIDR
PR00854 PRSTNOIDDPR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P70263-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNESYRCQTS TWVERGSSAT MGAVLFGAGL LGNLLALVLL ARSGLGSCRP
60 70 80 90 100
GPLHPPPSVF YVLVCGLTVT DLLGKCLISP MVLAAYAQNQ SLKELLPASG
110 120 130 140 150
NQLCETFAFL MSFFGLASTL QLLAMAVECW LSLGHPFFYQ RHVTLRRGVL
160 170 180 190 200
VAPVVAAFCL AFCALPFAGF GKFVQYCPGT WCFIQMIHKE RSFSVIGFSV
210 220 230 240 250
LYSSLMALLV LATVVCNLGA MYNLYDMHRR QRHYPHRCSR DRAQSGSDYR
260 270 280 290 300
HGSLHPLEEL DHFVLLALMT VLFTMCSLPL IYRAYYGAFK LENKAEGDSE
310 320 330 340 350
DLQALRFLSV ISIVDPWIFI IFRTSVFRML FHKVFTRPLI YRNWSSHSQQ

SNVESTL
Length:357
Mass (Da):40,005
Last modified:February 1, 1997 - v1
Checksum:i91CBFF7A5936EB05
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti75K → N in BAC27895 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032488 mRNA Translation: BAC27895.1
D29765 Genomic DNA Translation: BAA06168.1
BC132297 mRNA Translation: AAI32298.1
CCDSiCCDS26971.1
PIRiI59269
I80042
RefSeqiNP_032988.3, NM_008962.4
UniGeneiMm.5105

Genome annotation databases

EnsembliENSMUST00000095959; ENSMUSP00000093653; ENSMUSG00000071489
GeneIDi19214
KEGGimmu:19214
UCSCiuc007ter.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPD2R_MOUSE
AccessioniPrimary (citable) accession number: P70263
Secondary accession number(s): A2RSY4, Q8CCM3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: June 20, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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