Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Inositol 1,4,5-trisphosphate receptor type 3

Gene

Itpr3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channel, Ion channel, Ligand-gated ion channel, Receptor
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-114508 Effects of PIP2 hydrolysis
R-MMU-139853 Elevation of cytosolic Ca2+ levels
R-MMU-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-MMU-5578775 Ion homeostasis
R-MMU-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inositol 1,4,5-trisphosphate receptor type 3
Alternative name(s):
IP3 receptor isoform 3
Short name:
IP3R 3
Short name:
InsP3R3
Type 3 inositol 1,4,5-trisphosphate receptor
Short name:
Type 3 InsP3 receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Itpr3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:96624 Itpr3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 2233CytoplasmicSequence analysisAdd BLAST2233
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2234 – 2254HelicalSequence analysisAdd BLAST21
Topological domaini2255 – 2262ExtracellularSequence analysis8
Transmembranei2263 – 2283HelicalSequence analysisAdd BLAST21
Topological domaini2284 – 2292CytoplasmicSequence analysis9
Transmembranei2293 – 2310HelicalSequence analysisAdd BLAST18
Topological domaini2311 – 2324ExtracellularSequence analysisAdd BLAST14
Transmembranei2325 – 2345HelicalSequence analysisAdd BLAST21
Topological domaini2346 – 2367CytoplasmicSequence analysisAdd BLAST22
Transmembranei2368 – 2388HelicalSequence analysisAdd BLAST21
Topological domaini2389 – 2495ExtracellularSequence analysisAdd BLAST107
Transmembranei2496 – 2516HelicalSequence analysisAdd BLAST21
Topological domaini2517 – 2670CytoplasmicSequence analysisAdd BLAST154

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi168W → A: Loss of calcium flux. 1 Publication1
Mutagenesisi507K → A: Loss of binding activity. 1 Publication1
Mutagenesisi510R → A: Loss of binding activity. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001539291 – 2670Inositol 1,4,5-trisphosphate receptor type 3Add BLAST2670

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei916PhosphoserineCombined sources1
Modified residuei934PhosphoserineCombined sources1
Modified residuei1813PhosphoserineBy similarity1
Modified residuei1832PhosphoserineCombined sources1
Modified residuei1834PhosphoserineBy similarity1
Modified residuei2608PhosphoserineBy similarity1
Modified residuei2669PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on tyrosine residues (By similarity). Phosphorylated by AKT1 on serine and/or threonine residues.By similarity1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P70227

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P70227

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P70227

PeptideAtlas

More...
PeptideAtlasi
P70227

PRoteomics IDEntifications database

More...
PRIDEi
P70227

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P70227

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P70227

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000042644 Expressed in 210 organ(s), highest expression level in zone of skin

CleanEx database of gene expression profiles

More...
CleanExi
MM_ITPR3

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P70227 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer. Interacts with TRPC1, TRPC3, TRPC4. Interacts with TRPV4 (By similarity). Interacts with SIGMAR1 (PubMed:11149946). Interacts with AKT1 and PML (PubMed:21030605). Interacts with LRMP (via coiled-coil domain) (PubMed:20071408). Interacts with CABP1 (By similarity). Interacts with TMBIM4/LFG4 (By similarity). Interacts with CEMIP (By similarity). Interacts with TESPA1 (PubMed:23650607). Interacts with TMEM203 (By similarity). Interacts with BOK; regulates ITPR3 expression (By similarity).By similarity4 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
200849, 5 interactors

Protein interaction database and analysis system

More...
IntActi
P70227, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000038150

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12670
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P70227

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P70227

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P70227

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini113 – 173MIR 1PROSITE-ProRule annotationAdd BLAST61
Domaini174 – 224MIR 2PROSITE-ProRule annotationAdd BLAST51
Domaini232 – 288MIR 3PROSITE-ProRule annotationAdd BLAST57
Domaini295 – 372MIR 4PROSITE-ProRule annotationAdd BLAST78
Domaini378 – 434MIR 5PROSITE-ProRule annotationAdd BLAST57

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni266 – 270Inositol 1,4,5-trisphosphate binding5
Regioni507 – 510Inositol 1,4,5-trisphosphate binding4
Regioni567 – 569Inositol 1,4,5-trisphosphate binding3

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the InsP3 receptor family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3533 Eukaryota
ENOG410XR97 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157078

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007660

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052158

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P70227

KEGG Orthology (KO)

More...
KOi
K04960

Identification of Orthologs from Complete Genome Data

More...
OMAi
SFYNLMT

Database of Orthologous Groups

More...
OrthoDBi
EOG091G00T2

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P70227

TreeFam database of animal gene trees

More...
TreeFami
TF312815

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014821 Ins145_P3_rcpt
IPR000493 InsP3_rcpt
IPR005821 Ion_trans_dom
IPR036300 MIR_dom_sf
IPR016093 MIR_motif
IPR013662 RIH_assoc-dom
IPR000699 RIH_dom
IPR015925 Ryanodine_recept-rel
IPR035910 RyR/IP3R_RIH_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR13715 PTHR13715, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08709 Ins145_P3_rec, 1 hit
PF00520 Ion_trans, 1 hit
PF02815 MIR, 1 hit
PF08454 RIH_assoc, 1 hit
PF01365 RYDR_ITPR, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00779 INSP3RECEPTR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00472 MIR, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100909 SSF100909, 2 hits
SSF82109 SSF82109, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50919 MIR, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P70227-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNEMSSFLHI GDIVSLYAEG SVNGFISTLG LVDDRCVVEP AAGDLDNPPK
60 70 80 90 100
KFRDCLFKVC PMNRYSAQKQ YWKAKQTKQD KEKIADVVLL QKLQHAAQME
110 120 130 140 150
QKQNDTENKK VHGDVVKYGS VIQLLHMKSN KYLTVNKRLP ALLEKNAMRV
160 170 180 190 200
TLDATGNEGS WLFIQPFWKL RSNGDNVVVG DKVILNPVNA GQPLHASNYE
210 220 230 240 250
LSDNAGCKEV NSVNCNTSWK INLFMQFRDH LEEVLKGGDV VRLFHAEQEK
260 270 280 290 300
FLTCDEYRGK LQVFLRTTLR QSATSATSSN ALWEVEVVHH DPCRGGAGHW
310 320 330 340 350
NGLYRFKHLA TGNYLAAEEN PSYKGDVSDP KAAGLGAQGR TGRRNAGEKI
360 370 380 390 400
KYRLVAVPHG NDIASLFELD PTTLQKTDSF VPRNSYVRLR HLCTNTWIQS
410 420 430 440 450
TNAPIDVEEE RPIRLMLGTC PTKEDKEAFA IVSVPVSEIR DLDFANDASS
460 470 480 490 500
MLASAVEKLN EGFISQNDRR FVIQLLEDLV FFVSDVPNNG QNVLDIMVTK
510 520 530 540 550
PNRERQKLMR EQNILKQIFG ILKAPFRDKG GEGPLVRLEE LSDQKNAPYQ
560 570 580 590 600
YMFRLCYRVL RHSQEDYRKN QEHIAKQFGM MQSQIGYDIL AEDTITALLH
610 620 630 640 650
NNRKLLEKHI TKTEVETFVS LVRKNREPRF LDYLSDLCVS NRIAIPVTQE
660 670 680 690 700
LICKCVLDPK NSDILIQTEL RPVKEMAQSH EYLSIEYSEE EVWLTWTDRN
710 720 730 740 750
NEHHEKSVRQ LAQEARAGNA HDENVLSYYR YQLKLFARMC LDRQYLAIDE
760 770 780 790 800
ISKQLGVELL FLCMADEMLP FDLRASFCHL MLHVHVDRDP QELVTPVKFA
810 820 830 840 850
RLWTEIPTAI TIKDYDSNLN ASRDDKKNKF ASTMEFVEDY LNNVVSEAVP
860 870 880 890 900
FANDEKNILT FEVVSLAHNL IYFGFYSFSE LLRLTRTLLG IIDCIQAPAA
910 920 930 940 950
MLQAYEEPGG KNVRRSIQGV GHMMSTMVLS RKQSVFGASS LPAGVGVPEQ
960 970 980 990 1000
LDRSKFEDNE HTVVMETKLK ILEILQFILN VRLDYRISYL LSVFKKEFVE
1010 1020 1030 1040 1050
VFPMQDSGAD GTAPAFDSST ATMNLDRIGE QAEAMFGVGK TSSMLEVDDE
1060 1070 1080 1090 1100
GGRMFLRVLL HLTMHDYPSL VSGALQLLFK HFSQRQEAMH TFKQVQLLIS
1110 1120 1130 1140 1150
AQDVENYKVI KSELDRLRTM VEKSELWVDK KGSVKGEEVE AGATKDKKER
1160 1170 1180 1190 1200
PSDEEGFLQP HGEKSSENYQ IVKGILERLN KMCGVGEQMR KKQQRLLKNM
1210 1220 1230 1240 1250
DAHKVMLDLL QIPYDKSDNK MLEILRYTHQ FLQKFCAGNP GNQALLHKHL
1260 1270 1280 1290 1300
QLFLTPGLLE AETMQHIFLN NYQLCSEISE PVLQHFVHLL ATHGRHVQYL
1310 1320 1330 1340 1350
DFLHTVIKAE GKYVKKCQDM IMTELTNAGD DVVVFYNDKA SLAHLLDMMK
1360 1370 1380 1390 1400
AARDGVEDHS PLMYHISLVD LLAACAEGKN VYTEIKCTSL LPLEDVVTVV
1410 1420 1430 1440 1450
THEDCITEVK MAYVNFVNHC YVDTEVEMKE IYTSNHIWTL FENFTLDMAL
1460 1470 1480 1490 1500
VCNKREKRLS DPTLEKYVLT VVLDTISAFF SSPFSENSTS LQTHQTIVVQ
1510 1520 1530 1540 1550
LLQSTTRLLE CPWLQQQHKG SVEACVRTLA MVAKSRAILL PMDLDAHMSA
1560 1570 1580 1590 1600
LLSSGGSCSA AAQRSAANYK TATRTFPRVI PTANQWDYKN IIEKLQDIIM
1610 1620 1630 1640 1650
ALEERLKPLV QAELSVLVDM LHWPELLFPE GSEAYQRCES GGFLSKLIRH
1660 1670 1680 1690 1700
TKGLMESEEK LCVKVLRTLQ QMLLKKSKFG DRGNQLRKML LQNYLQNRKS
1710 1720 1730 1740 1750
GARGELTDPT GSGLDQDWSA IAATQCRLDK EGATKLVCDL ITSTKNEKIF
1760 1770 1780 1790 1800
QESIGLAIRL LDGGNTEIQK SFYNLMTSDK KSERFFKVLH DRMKRAQQET
1810 1820 1830 1840 1850
KSTVAVNMSD LGSQPREDRE PADPATKGRV SSFSMPSSSR YLLGLGLHRG
1860 1870 1880 1890 1900
HDMSERAQNN EMGTSVLIMR PILRFLQLLC ENHNRDLQNF LRCQNNKTNY
1910 1920 1930 1940 1950
NLVCETLQFL DIMCGSTTGG LGLLGLYINE DNVGLVIQTL ETLTEYCQGP
1960 1970 1980 1990 2000
CHENQTCIVT HESNGIDIIT ALILNDISPL CKYRMDLVLQ LKDNASKLLL
2010 2020 2030 2040 2050
ALMESRHDSE NAERILISLR PQELVDVIKK AYLQEEEREN SEVSPREVGH
2060 2070 2080 2090 2100
NIYILALQLS RHNKQLQHLL KPVRRIQEEE AEGISSMLSL NNKQLSQMLK
2110 2120 2130 2140 2150
SSAPAQEEEE DPLAYYENHT SQIEIVRQDR SMEQIVFPVP AICQFLTEET
2160 2170 2180 2190 2200
KHRLFTTTEQ DEQGSKVSDF FDQSSFLHNE MEWQRRLRSM PLIYWFSRRM
2210 2220 2230 2240 2250
TLWGSISFNL AVFINIIIAF FYPYVEGAST GVLGSPLISL LFWILICFSI
2260 2270 2280 2290 2300
AALFTKRYSV RPLIVALILR SIYYLGIGPT LNILGALNLT NKIVFVVSFV
2310 2320 2330 2340 2350
GNRGTFIRGY KAMVMDMEFL YHVGYILTSV LGLFAHELFY SILLFDLIYR
2360 2370 2380 2390 2400
EETLFNVIKS VTRNGRSILL TALLALILVY LFSIVGFLFL KDDFILEVDR
2410 2420 2430 2440 2450
LPGNHSRASP LGMPHGAATF MGTCSGDKMD CVSEVSVPEI LEEDEEPDST
2460 2470 2480 2490 2500
ERACDTLLMC IVTVMNHGLR NGGGVGDILR KPSKDESLFP ARVVYDLLFF
2510 2520 2530 2540 2550
FIVIIIVLNL IFGVIIDTFA DLRSEKQKKE EILKTTCFIC GLERDKFDNK
2560 2570 2580 2590 2600
TVSFEEHIKL EHNMWNYLYF IVLVRVKNKT DYTGPESYVA QMIKNKNLDW
2610 2620 2630 2640 2650
FPRMRAMSLV SGEGEGEQNE IRILQEKLGS TMKLVSHLTS QLNELKEQMT
2660 2670
EQRKRRQRLG FVDVQNCMSR
Length:2,670
Mass (Da):304,275
Last modified:October 25, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9B5BA808B195C58F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2406 – 2413SRASPLGM → FPPSRARR (PubMed:1374893).Curated8
Sequence conflicti2430D → E in M90088 (PubMed:1374893).Curated1
Sequence conflicti2447P → L in M90088 (PubMed:1374893).Curated1
Sequence conflicti2605 – 2609RAMSL → LGSTS in M90088 (PubMed:1374893).Curated5

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB182289 mRNA Translation: BAD90683.1
AK028491 mRNA Translation: BAC25977.1
BC010323 mRNA Translation: AAH10323.1
M90088 mRNA No translation available.
Z71174 mRNA Translation: CAA94862.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS28560.1

NCBI Reference Sequences

More...
RefSeqi
NP_542120.2, NM_080553.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.458106

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000049308; ENSMUSP00000038150; ENSMUSG00000042644

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
16440

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:16440

UCSC genome browser

More...
UCSCi
uc008bfi.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB182289 mRNA Translation: BAD90683.1
AK028491 mRNA Translation: BAC25977.1
BC010323 mRNA Translation: AAH10323.1
M90088 mRNA No translation available.
Z71174 mRNA Translation: CAA94862.1
CCDSiCCDS28560.1
RefSeqiNP_542120.2, NM_080553.3
UniGeneiMm.458106

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3JRRX-ray1.90A/B1-224[»]
ProteinModelPortaliP70227
SMRiP70227
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200849, 5 interactors
IntActiP70227, 2 interactors
STRINGi10090.ENSMUSP00000038150

PTM databases

iPTMnetiP70227
PhosphoSitePlusiP70227

Proteomic databases

EPDiP70227
MaxQBiP70227
PaxDbiP70227
PeptideAtlasiP70227
PRIDEiP70227

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049308; ENSMUSP00000038150; ENSMUSG00000042644
GeneIDi16440
KEGGimmu:16440
UCSCiuc008bfi.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3710
MGIiMGI:96624 Itpr3

Phylogenomic databases

eggNOGiKOG3533 Eukaryota
ENOG410XR97 LUCA
GeneTreeiENSGT00940000157078
HOGENOMiHOG000007660
HOVERGENiHBG052158
InParanoidiP70227
KOiK04960
OMAiSFYNLMT
OrthoDBiEOG091G00T2
PhylomeDBiP70227
TreeFamiTF312815

Enzyme and pathway databases

ReactomeiR-MMU-114508 Effects of PIP2 hydrolysis
R-MMU-139853 Elevation of cytosolic Ca2+ levels
R-MMU-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-MMU-5578775 Ion homeostasis
R-MMU-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Itpr3 mouse
EvolutionaryTraceiP70227

Protein Ontology

More...
PROi
PR:P70227

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000042644 Expressed in 210 organ(s), highest expression level in zone of skin
CleanExiMM_ITPR3
GenevisibleiP70227 MM

Family and domain databases

InterProiView protein in InterPro
IPR014821 Ins145_P3_rcpt
IPR000493 InsP3_rcpt
IPR005821 Ion_trans_dom
IPR036300 MIR_dom_sf
IPR016093 MIR_motif
IPR013662 RIH_assoc-dom
IPR000699 RIH_dom
IPR015925 Ryanodine_recept-rel
IPR035910 RyR/IP3R_RIH_dom_sf
PANTHERiPTHR13715 PTHR13715, 1 hit
PfamiView protein in Pfam
PF08709 Ins145_P3_rec, 1 hit
PF00520 Ion_trans, 1 hit
PF02815 MIR, 1 hit
PF08454 RIH_assoc, 1 hit
PF01365 RYDR_ITPR, 2 hits
PRINTSiPR00779 INSP3RECEPTR
SMARTiView protein in SMART
SM00472 MIR, 4 hits
SUPFAMiSSF100909 SSF100909, 2 hits
SSF82109 SSF82109, 2 hits
PROSITEiView protein in PROSITE
PS50919 MIR, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiITPR3_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P70227
Secondary accession number(s): Q5DWM4, Q8CED5, Q91Z08
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: October 25, 2005
Last modified: December 5, 2018
This is version 160 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again