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Protein

Homeobox protein Hox-D13

Gene

Hoxd13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor that binds gene promoters and activates their transcription (PubMed:23995701). Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (By similarity).By similarity1 Publication

Caution

It is uncertain whether Met-1 or Met-9 is the initiator.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi272 – 331HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-D13
Alternative name(s):
Homeobox protein Hox-4.8
Gene namesi
Name:Hoxd13
Synonyms:Hox-4.8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:96205 Hoxd13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi321Q → K: Changes the specificity for binding motifs in promoters. Recognizes the PITX1 consensus DNA-binding sites and triggers the expression of a gene pattern similar to PITX1. 1 Publication1
Mutagenesisi321Q → R: Changes the function in transcription regulation. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002002451 – 339Homeobox protein Hox-D13Add BLAST339

Proteomic databases

MaxQBiP70217
PaxDbiP70217
PRIDEiP70217

PTM databases

PhosphoSitePlusiP70217

Expressioni

Gene expression databases

BgeeiENSMUSG00000001819 Expressed in 87 organ(s), highest expression level in forelimb bud
CleanExiMM_HOXD13
GenevisibleiP70217 MM

Interactioni

Protein-protein interaction databases

BioGridi200395, 7 interactors
IntActiP70217, 1 interactor
STRINGi10090.ENSMUSP00000001872

Structurei

3D structure databases

ProteinModelPortaliP70217
SMRiP70217
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi25 – 29Poly-Ser5
Compositional biasi53 – 67Poly-AlaAdd BLAST15
Compositional biasi81 – 88Poly-Ser8
Compositional biasi105 – 114Poly-Ala10

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0487 Eukaryota
ENOG4111FJP LUCA
GeneTreeiENSGT00910000143984
HOGENOMiHOG000231176
HOVERGENiHBG106958
InParanoidiP70217
KOiK09298
OMAiFAYPGTS
OrthoDBiEOG091G0E5Q
PhylomeDBiP70217
TreeFamiTF330813

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR022067 HoxA13_N
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF12284 HoxA13_N, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P70217-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRSGTWDMD GLRADGGAAG AAPASSSSSV AAPGQCRGFL SAPVFAGTHS
60 70 80 90 100
GRAAAAAAAA AAAAAAASSF AYPGTSERTG SSSSSSSSAV IATRPEAPVA
110 120 130 140 150
KECPAPAAAA TAAAPPGAPA LGYGYHFGNG YYSCRMSHGV GLQQNALKSS
160 170 180 190 200
PHASLGGFPV EKYMDVSGLA SSSVPTNEVP ARAKEVSFYQ GYTSPYQHVP
210 220 230 240 250
GYIDMVSTFG SGEPRHEAYI SMEGYQSWTL ANGWNSQVYC AKDQPQGSHF
260 270 280 290 300
WKSSFPGDVA LNQPDMCVYR RGRKKRVPYT KLQLKELENE YAINKFINKD
310 320 330
KRRRISAATN LSERQVTIWF QNRRVKDKKI VSKLKDTVS
Length:339
Mass (Da):35,889
Last modified:September 5, 2006 - v2
Checksum:iC1BD2FAF6D56E533
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9M → I in BC109143 (PubMed:15489334).Curated1
Sequence conflicti69S → T in CAA67675 (PubMed:8978698).Curated1
Sequence conflicti304R → T in AAB21366 (PubMed:1685889).Curated1
Sequence conflicti307A → R in AAB21366 (PubMed:1685889).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99291 mRNA Translation: CAA67675.1
AL928644 Genomic DNA Translation: CAM20525.1
BC109143 mRNA No translation available.
BC109144 mRNA No translation available.
S80553 Genomic DNA Translation: AAB21366.2
CCDSiCCDS16139.1
PIRiA56563
RefSeqiNP_032301.2, NM_008275.3
UniGeneiMm.57227

Genome annotation databases

EnsembliENSMUST00000001872; ENSMUSP00000001872; ENSMUSG00000001819
GeneIDi15433
KEGGimmu:15433
UCSCiuc008kdu.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99291 mRNA Translation: CAA67675.1
AL928644 Genomic DNA Translation: CAM20525.1
BC109143 mRNA No translation available.
BC109144 mRNA No translation available.
S80553 Genomic DNA Translation: AAB21366.2
CCDSiCCDS16139.1
PIRiA56563
RefSeqiNP_032301.2, NM_008275.3
UniGeneiMm.57227

3D structure databases

ProteinModelPortaliP70217
SMRiP70217
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200395, 7 interactors
IntActiP70217, 1 interactor
STRINGi10090.ENSMUSP00000001872

PTM databases

PhosphoSitePlusiP70217

Proteomic databases

MaxQBiP70217
PaxDbiP70217
PRIDEiP70217

Protocols and materials databases

DNASUi15433
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001872; ENSMUSP00000001872; ENSMUSG00000001819
GeneIDi15433
KEGGimmu:15433
UCSCiuc008kdu.2 mouse

Organism-specific databases

CTDi3239
MGIiMGI:96205 Hoxd13

Phylogenomic databases

eggNOGiKOG0487 Eukaryota
ENOG4111FJP LUCA
GeneTreeiENSGT00910000143984
HOGENOMiHOG000231176
HOVERGENiHBG106958
InParanoidiP70217
KOiK09298
OMAiFAYPGTS
OrthoDBiEOG091G0E5Q
PhylomeDBiP70217
TreeFamiTF330813

Miscellaneous databases

PROiPR:P70217
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001819 Expressed in 87 organ(s), highest expression level in forelimb bud
CleanExiMM_HOXD13
GenevisibleiP70217 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR022067 HoxA13_N
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF12284 HoxA13_N, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHXD13_MOUSE
AccessioniPrimary (citable) accession number: P70217
Secondary accession number(s): A2ASM5
, Q2VPB0, Q2VPB1, Q64177
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 5, 2006
Last modified: November 7, 2018
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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