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Protein

Netrin receptor DCC

Gene

Dcc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Receptor
Biological processApoptosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-373752 Netrin-1 signaling
R-MMU-418885 DCC mediated attractive signaling
R-MMU-418889 Caspase activation via Dependence Receptors in the absence of ligand

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Netrin receptor DCC
Alternative name(s):
Tumor suppressor protein DCC
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dcc
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:94869 Dcc

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini26 – 1097ExtracellularSequence analysisAdd BLAST1072
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1098 – 1122HelicalSequence analysisAdd BLAST25
Topological domaini1123 – 1447CytoplasmicSequence analysisAdd BLAST325

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001474526 – 1447Netrin receptor DCCAdd BLAST1422

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi60N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi61 ↔ 117PROSITE-ProRule annotation
Glycosylationi94N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi161 ↔ 212PROSITE-ProRule annotation
Disulfide bondi261 ↔ 310PROSITE-ProRule annotation
Glycosylationi299N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi318N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi352 ↔ 400PROSITE-ProRule annotation
Glycosylationi478N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi628N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi702N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1178Phosphoserine; by MAPK1By similarity1
Modified residuei1187Phosphothreonine; by MAPK1By similarity1
Modified residuei1267Phosphoserine; by MAPK1By similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P70211

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P70211

PeptideAtlas

More...
PeptideAtlasi
P70211

PRoteomics IDEntifications database

More...
PRIDEi
P70211

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P70211

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P70211

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In the embryo, expressed at high levels in the developing brain and neural tube. In the embryo, expressed in developing neurons of the telencephalic cortical plate and in developing brainstem nuclei (PubMed:28250456). In adult, highly expressed in brain with very low levels found in testis, heart and thymus. Isoform C is expressed only in the embryo.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Low levels in early gestation. Highest levels expressed during mid gestation. Levels decrease in late gestation and remain at this level in the adult.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000060534 Expressed in 151 organ(s), highest expression level in rest of cerebellum marginal layer (mouse)

CleanEx database of gene expression profiles

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CleanExi
MM_DCC

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P70211 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the cytoplasmic part of UNC5A, UNC5B, UNC5C and probably UNC5D. Interacts with MAPK1. Interacts with NTN1 (By similarity). Interacts with DSCAM. Interacts with PTK2/FAK1. Interacts with MYO10. Interacts with CBLN4; this interaction can be competed by NTN1.By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
199064, 6 interactors

Database of interacting proteins

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DIPi
DIP-46587N

Protein interaction database and analysis system

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IntActi
P70211, 12 interactors

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000110593

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11447
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P70211

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P70211

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini36 – 135Ig-like C2-type 1Add BLAST100
Domaini139 – 229Ig-like C2-type 2Add BLAST91
Domaini234 – 326Ig-like C2-type 3Add BLAST93
Domaini331 – 416Ig-like C2-type 4Add BLAST86
Domaini431 – 524Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST94
Domaini530 – 620Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST91
Domaini625 – 718Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST94
Domaini728 – 821Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST94
Domaini846 – 942Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST97
Domaini947 – 1044Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST98

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the immunoglobulin superfamily. DCC family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4221 Eukaryota
ENOG410Z913 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158867

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000230686

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG005455

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P70211

KEGG Orthology (KO)

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KOi
K06765

Identification of Orthologs from Complete Genome Data

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OMAi
KMMIPMD

Database of Orthologous Groups

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OrthoDBi
EOG091G098C

TreeFam database of animal gene trees

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TreeFami
TF321506

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 6 hits

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.10, 10 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR033012 DCC
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR010560 Neogenin_C

The PANTHER Classification System

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PANTHERi
PTHR44146:SF3 PTHR44146:SF3, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00041 fn3, 6 hits
PF07679 I-set, 3 hits
PF13895 Ig_2, 1 hit
PF06583 Neogenin_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 6 hits
SM00409 IG, 5 hits
SM00408 IGc2, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 4 hits
SSF49265 SSF49265, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 6 hits
PS50835 IG_LIKE, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket
Isoform A (identifier: P70211-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MENSLGCVWV PKLAFVLFGA SLLSAHLQVT GFQIKPFTSL HFVSEPSDAV
60 70 80 90 100
TMRGGNVLLN CSAESDRGVP VIKWKKDGLI LALGMDDRKQ QLPNGSLLIQ
110 120 130 140 150
NILHSRHHKP DEGLYQCEAS LADSGSIISR TAKVTVAGPL RFLSQTESIT
160 170 180 190 200
AFMGDTVLLK CEVIGEPMPT IHWQKNQQDL NPLPGDSRVV VLPSGALQIS
210 220 230 240 250
RLQPGDSGVY RCSARNPASI RTGNEAEVRI LSDPGLHRQL YFLQRPSNVI
260 270 280 290 300
AIEGKDAVLE CCVSGYPPPS FTWLRGEEVI QLRSKKYSLL GGSNLLISNV
310 320 330 340 350
TDDDSGTYTC VVTYKNENIS ASAELTVLVP PWFLNHPSNL YAYESMDIEF
360 370 380 390 400
ECAVSGKPVP TVNWMKNGDV VIPSDYFQIV GGSNLRILGV VKSDEGFYQC
410 420 430 440 450
VAENEAGNAQ SSAQLIVPKP AIPSSSILPS APRDVLPVLV SSRFVRLSWR
460 470 480 490 500
PPAEAKGNIQ TFTVFFSREG DNRERALNTT QPGSLQLTVG NLKPEAMYTF
510 520 530 540 550
RVVAYNEWGP GESSQPIKVA TQPELQVPGP VENLHAVSTS PTSILITWEP
560 570 580 590 600
PAYANGPVQG YRLFCTEVST GKEQNIEVDG LSYKLEGLKK FTEYTLRFLA
610 620 630 640 650
YNRYGPGVST DDITVVTLSD VPSAPPQNIS LEVVNSRSIK VSWLPPPSGT
660 670 680 690 700
QNGFITGYKI RHRKTTRRGE METLEPNNLW YLFTGLEKGS QYSFQVSAMT
710 720 730 740 750
VNGTGPPSNW YTAETPENDL DESQVPDQPS SLHVRPQTNC IIMSWTPPLN
760 770 780 790 800
PNIVVRGYII GYGVGSPYAE TVRVDSKQRY YSIERLESSS HYVISLKAFN
810 820 830 840 850
NAGEGVPLYE SATTRSITDP TDPVDYYPLL DDFPTSGPDV STPMLPPVGV
860 870 880 890 900
QAVALTHEAV RVSWADNSVP KNQKTSDVRL YTVRWRTSFS ASAKYKSEDT
910 920 930 940 950
TSLSYTATGL KPNTMYEFSV MVTKNRRSST WSMTAHATTY EAAPTSAPKD
960 970 980 990 1000
LTVITREGKP RAVIVSWQPP LEANGKITAY ILFYTLDKNI PIDDWIMETI
1010 1020 1030 1040 1050
SGDRLTHQIM DLSLDTMYYF RIQARNVKGV GPLSDPILFR TLKVEHPDKM
1060 1070 1080 1090 1100
ANDQGRHGDG GYWPVDTNLI DRSTLNEPPI GQMHPPHGSV TPQKNSNLLV
1110 1120 1130 1140 1150
ITVVTVGVLT VLVVVIVAVI CTRRSSAQQR KKRATHSVSK RKGSQKDLRP
1160 1170 1180 1190 1200
PDLWIHHEEM EMKNIEKPTG TDPAGRDSPI QSCQDLTPVS HSQSETQMGS
1210 1220 1230 1240 1250
KSASHSGQDT EDAGSSMSTL ERSLAARRAT RAKLMIPMEA QSSNPAVVSA
1260 1270 1280 1290 1300
IPVPTLESAQ YPGILPSPTC GYPHPQFTLR PVPFPTLSVD RGFGAGRTQS
1310 1320 1330 1340 1350
VSEGPTTQQQ PMLPPAQPEH PSSEEAPSRT IPTACVRPTH PLRSFANPLL
1360 1370 1380 1390 1400
PPPMSAIEPK VPYTPLLSQP GPTLPKTHVK TASLGLAGKA RSPLLPVSVP
1410 1420 1430 1440
TAPEVSEESH KPTEDPASVY EQDDLSEQMA SLEGLMKQLN AITGSAF
Length:1,447
Mass (Da):158,341
Last modified:October 3, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF905BE27C991EA42
GO
Isoform C (identifier: P70211-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     819-838: Missing.

Show »
Length:1,427
Mass (Da):156,135
Checksum:iCEF2CE39FE115F9B
GO
Isoform B (identifier: P70211-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-84: Missing.

Note: Produced by alternative initiation at Met-85 of isoform A.
Show »
Length:1,363
Mass (Da):149,345
Checksum:i0B1075107D6A1DBC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1138V → G in CAA59786 (PubMed:8570174).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0188071 – 84Missing in isoform B. 1 PublicationAdd BLAST84
Alternative sequenceiVSP_002501819 – 838Missing in isoform C. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X85788 mRNA Translation: CAA59786.1
AC105957 Genomic DNA No translation available.
AC107230 Genomic DNA No translation available.
AC109179 Genomic DNA No translation available.
AC109499 Genomic DNA No translation available.
AC121523 Genomic DNA No translation available.
AC136637 Genomic DNA No translation available.
AC161177 Genomic DNA No translation available.
AC163492 Genomic DNA No translation available.
AC167547 Genomic DNA No translation available.
AC167548 Genomic DNA No translation available.
AC167549 Genomic DNA No translation available.
CH466528 Genomic DNA Translation: EDL09563.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS29336.1 [P70211-1]

NCBI Reference Sequences

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RefSeqi
NP_031857.2, NM_007831.3 [P70211-1]
XP_006525651.1, XM_006525588.3 [P70211-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.167882

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000073379; ENSMUSP00000073094; ENSMUSG00000060534 [P70211-2]
ENSMUST00000114943; ENSMUSP00000110593; ENSMUSG00000060534 [P70211-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
13176

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:13176

UCSC genome browser

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UCSCi
uc008fop.1 mouse [P70211-1]
uc008foq.1 mouse [P70211-2]

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85788 mRNA Translation: CAA59786.1
AC105957 Genomic DNA No translation available.
AC107230 Genomic DNA No translation available.
AC109179 Genomic DNA No translation available.
AC109499 Genomic DNA No translation available.
AC121523 Genomic DNA No translation available.
AC136637 Genomic DNA No translation available.
AC161177 Genomic DNA No translation available.
AC163492 Genomic DNA No translation available.
AC167547 Genomic DNA No translation available.
AC167548 Genomic DNA No translation available.
AC167549 Genomic DNA No translation available.
CH466528 Genomic DNA Translation: EDL09563.1
CCDSiCCDS29336.1 [P70211-1]
RefSeqiNP_031857.2, NM_007831.3 [P70211-1]
XP_006525651.1, XM_006525588.3 [P70211-2]
UniGeneiMm.167882

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3PZDX-ray2.50B1410-1445[»]
4PLOX-ray2.90B721-942[»]
ProteinModelPortaliP70211
SMRiP70211
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199064, 6 interactors
DIPiDIP-46587N
IntActiP70211, 12 interactors
STRINGi10090.ENSMUSP00000110593

PTM databases

iPTMnetiP70211
PhosphoSitePlusiP70211

Proteomic databases

MaxQBiP70211
PaxDbiP70211
PeptideAtlasiP70211
PRIDEiP70211

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000073379; ENSMUSP00000073094; ENSMUSG00000060534 [P70211-2]
ENSMUST00000114943; ENSMUSP00000110593; ENSMUSG00000060534 [P70211-1]
GeneIDi13176
KEGGimmu:13176
UCSCiuc008fop.1 mouse [P70211-1]
uc008foq.1 mouse [P70211-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1630
MGIiMGI:94869 Dcc

Phylogenomic databases

eggNOGiKOG4221 Eukaryota
ENOG410Z913 LUCA
GeneTreeiENSGT00940000158867
HOGENOMiHOG000230686
HOVERGENiHBG005455
InParanoidiP70211
KOiK06765
OMAiKMMIPMD
OrthoDBiEOG091G098C
TreeFamiTF321506

Enzyme and pathway databases

ReactomeiR-MMU-373752 Netrin-1 signaling
R-MMU-418885 DCC mediated attractive signaling
R-MMU-418889 Caspase activation via Dependence Receptors in the absence of ligand

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Dcc mouse

Protein Ontology

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PROi
PR:P70211

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000060534 Expressed in 151 organ(s), highest expression level in rest of cerebellum marginal layer (mouse)
CleanExiMM_DCC
GenevisibleiP70211 MM

Family and domain databases

CDDicd00063 FN3, 6 hits
Gene3Di2.60.40.10, 10 hits
InterProiView protein in InterPro
IPR033012 DCC
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR010560 Neogenin_C
PANTHERiPTHR44146:SF3 PTHR44146:SF3, 1 hit
PfamiView protein in Pfam
PF00041 fn3, 6 hits
PF07679 I-set, 3 hits
PF13895 Ig_2, 1 hit
PF06583 Neogenin_C, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 6 hits
SM00409 IG, 5 hits
SM00408 IGc2, 4 hits
SUPFAMiSSF48726 SSF48726, 4 hits
SSF49265 SSF49265, 4 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 6 hits
PS50835 IG_LIKE, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDCC_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P70211
Secondary accession number(s): G3X9X6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 3, 2012
Last modified: December 5, 2018
This is version 173 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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