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UniProtKB - P70208 (PLXA3_MOUSE)

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Protein

Plexin-A3

Gene

Plxna3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.6 Publications

GO - Molecular functioni

  • semaphorin receptor activity Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

  • axon guidance Source: MGI
  • branchiomotor neuron axon guidance Source: ParkinsonsUK-UCL
  • facial nerve structural organization Source: ParkinsonsUK-UCL
  • hippocampus development Source: MGI
  • negative chemotaxis Source: MGI
  • negative regulation of axon extension involved in axon guidance Source: MGI
  • neuron projection extension Source: MGI
  • neuron projection guidance Source: MGI
  • positive regulation of cytoskeleton organization Source: UniProtKB
  • pyramidal neuron development Source: MGI
  • semaphorin-plexin signaling pathway involved in axon guidance Source: ParkinsonsUK-UCL
  • trigeminal nerve structural organization Source: ParkinsonsUK-UCL
View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-MMU-399954 Sema3A PAK dependent Axon repulsion
R-MMU-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
R-MMU-399956 CRMPs in Sema3A signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Plexin-A3
Gene namesi
Name:Plxna3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:107683 Plxna3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 1220ExtracellularSequence analysisAdd BLAST1201
Transmembranei1221 – 1241HelicalSequence analysisAdd BLAST21
Topological domaini1242 – 1872CytoplasmicSequence analysisAdd BLAST631

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

No visible phenotype, but causes subtle changes in the central nervous system. Mice exhibit altered apical dendrite spine morphology in pyramidal neurons. Mice exhibit defasciculation of the facial branchiomotor nerve and of the ophthalmic branch of the trigeminus, with variable severity. The number of neurons in the dorsal root ganglion is higher than normal, probably due to reduced neuronal apoptosis. In mice lacking both Plxna3 and Plxna4, migrating neurons do not show the normal response to Sema3A and Sema3F and do not migrate away from these semaphorins (in vitro).5 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi1279L → R: Strongly reduced response to semaphorin. 1 Publication1
Mutagenesisi1300Y → A: Almost abolishes response to semaphorin. 1 Publication1
Mutagenesisi1309F → A: Almost abolishes response to semaphorin. 1 Publication1
Mutagenesisi1407 – 1408RR → AA: Abolishes response to semaphorin. 1 Publication2
Mutagenesisi1453I → R: Abolishes response to semaphorin. 1 Publication1
Mutagenesisi1464L → G: Almost abolishes response to semaphorin. 1 Publication1
Mutagenesisi1506Q → A: Abolishes response to semaphorin. 1 Publication1
Mutagenesisi1631 – 1632HL → AA: Abolishes response to semaphorin. 1 Publication2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000041110420 – 1872Plexin-A3Add BLAST1853

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi60N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi78 ↔ 87PROSITE-ProRule annotation
Disulfide bondi113 ↔ 121PROSITE-ProRule annotation
Disulfide bondi267 ↔ 388PROSITE-ProRule annotation
Disulfide bondi283 ↔ 339PROSITE-ProRule annotation
Disulfide bondi357 ↔ 376PROSITE-ProRule annotation
Disulfide bondi492 ↔ 509PROSITE-ProRule annotation
Disulfide bondi498 ↔ 540PROSITE-ProRule annotation
Disulfide bondi501 ↔ 518PROSITE-ProRule annotation
Disulfide bondi512 ↔ 524PROSITE-ProRule annotation
Glycosylationi549N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi575 ↔ 595PROSITE-ProRule annotation
Glycosylationi1163N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1597PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP70208
PaxDbiP70208
PeptideAtlasiP70208
PRIDEiP70208

PTM databases

iPTMnetiP70208
PhosphoSitePlusiP70208

Expressioni

Tissue specificityi

Detected in embryonic hindbrain, spinal cord, dorsal root ganglion, trigeminal ganglion and superior cervical ganglion. In newborns, detected throughout all layers of the hippocampus.3 Publications

Gene expression databases

BgeeiENSMUSG00000031398
ExpressionAtlasiP70208 baseline and differential
GenevisibleiP70208 MM

Interactioni

Protein-protein interaction databases

DIPiDIP-48959N
STRINGi10090.ENSMUSP00000004326

Structurei

Secondary structure

11872
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi1248 – 1286Combined sources39
Helixi1300 – 1308Combined sources9
Helixi1316 – 1318Combined sources3
Helixi1325 – 1337Combined sources13
Helixi1341 – 1352Combined sources12
Helixi1359 – 1372Combined sources14
Helixi1374 – 1376Combined sources3
Helixi1377 – 1397Combined sources21
Turni1403 – 1407Combined sources5
Helixi1412 – 1424Combined sources13
Helixi1426 – 1431Combined sources6
Helixi1434 – 1448Combined sources15
Turni1455 – 1457Combined sources3
Helixi1466 – 1468Combined sources3
Beta strandi1478 – 1484Combined sources7
Turni1486 – 1488Combined sources3
Beta strandi1493 – 1499Combined sources7
Helixi1504 – 1515Combined sources12
Turni1516 – 1518Combined sources3
Helixi1521 – 1523Combined sources3
Helixi1527 – 1529Combined sources3
Beta strandi1530 – 1536Combined sources7
Beta strandi1541 – 1544Combined sources4
Beta strandi1546 – 1548Combined sources3
Beta strandi1557 – 1559Combined sources3
Turni1563 – 1567Combined sources5
Beta strandi1573 – 1578Combined sources6
Beta strandi1628 – 1632Combined sources5
Helixi1653 – 1677Combined sources25
Helixi1682 – 1684Combined sources3
Helixi1689 – 1703Combined sources15
Turni1704 – 1706Combined sources3
Helixi1710 – 1720Combined sources11
Turni1721 – 1724Combined sources4
Helixi1725 – 1731Combined sources7
Helixi1733 – 1735Combined sources3
Helixi1743 – 1759Combined sources17
Helixi1773 – 1777Combined sources5
Turni1778 – 1781Combined sources4
Helixi1782 – 1798Combined sources17
Helixi1804 – 1817Combined sources14
Turni1818 – 1820Combined sources3
Helixi1824 – 1837Combined sources14
Helixi1839 – 1848Combined sources10
Helixi1850 – 1854Combined sources5
Helixi1857 – 1869Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3IG3X-ray1.99A1247-1872[»]
ProteinModelPortaliP70208
SMRiP70208
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP70208

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 489SemaPROSITE-ProRule annotationAdd BLAST470
Domaini841 – 934IPT/TIG 1Add BLAST94
Domaini936 – 1021IPT/TIG 2Add BLAST86
Domaini1024 – 1123IPT/TIG 3Add BLAST100
Domaini1126 – 1212IPT/TIG 4Add BLAST87

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1240 – 1294Sequence analysisAdd BLAST55

Sequence similaritiesi

Belongs to the plexin family.Curated

Keywords - Domaini

Coiled coil, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3610 Eukaryota
ENOG410XR88 LUCA
GeneTreeiENSGT00760000119048
HOGENOMiHOG000231377
HOVERGENiHBG105711
InParanoidiP70208
KOiK06820
OMAiNELTNHM
OrthoDBiEOG091G00EK
TreeFamiTF312962

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR031148 Plexin
IPR013548 Plexin_cytoplasmic_RasGAP_dom
IPR002165 Plexin_repeat
IPR016201 PSI
IPR008936 Rho_GTPase_activation_prot
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR22625 PTHR22625, 1 hit
PfamiView protein in Pfam
PF08337 Plexin_cytopl, 1 hit
PF01437 PSI, 2 hits
PF01403 Sema, 1 hit
PF01833 TIG, 4 hits
SMARTiView protein in SMART
SM00429 IPT, 4 hits
SM00423 PSI, 3 hits
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
SSF48350 SSF48350, 2 hits
SSF81296 SSF81296, 4 hits
PROSITEiView protein in PROSITE
PS51004 SEMA, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P70208-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPTVCLLPLL FFTIGGCLGS SRPFRTFVVT DTTLTHLAVH RVTGEVFVGA 
        60         70         80         90        100
VNRVFKLAPN LTELRAHVTG PIEDNARCYP PPSMRVCSHR LVPVDNVNKL 
       110        120        130        140        150
LLIDYAARRL VACGSIWQGI CQFLRLDDLF KLGEPHHRKE HYLSGAQEPD 
       160        170        180        190        200
SMAGVIVEQV QGPSKLFVGT AVDGKSEYFP TLSSRKLIDD EDSGDMFSLV 
       210        220        230        240        250
YQDEFVSSQI KIPSDTLSLY PAFDIYYIYG FVSASFVYFL TLQLDTQQTL 
       260        270        280        290        300
LDTAGEKFFT SKIVRMCAGD SEFYSYVEFP IGCSWRGVEY RLVQSAHLAK 
       310        320        330        340        350
PGLLLAQALG VPADEDVLFT IFSQGQKNRA NPPRQTILCL FTLSSINAHI 
       360        370        380        390        400
RRRIQSCYRG EGTLALPWLL NKELPCINTP LQINGNFCGL VLNQPLGGLH 
       410        420        430        440        450
VIEGLPLLAD STDGMASVAA YTYHQHSVVF IGTRSGNLKK VRVDGSQDAQ 
       460        470        480        490        500
LYETVSVVQG SPILRDLLFS PDHRHIYLLS EKQVSQLPVE TCEQYLSCAA 
       510        520        530        540        550
CLGSGDPHCG WCVLQHRCCR EGACPGASAP HGFAEELSKC IQVRVRPNNV 
       560        570        580        590        600
SVTSSGVQLT VAMRNVPDLS VGVSCSFEEV TESEAILLPS GELRCPSPSL 
       610        620        630        640        650
QELQTLTRGH GATHTVRLQL LSMETGVRFA GVDFVFYNCS ALQSCMSCVG 
       660        670        680        690        700
SPYPCHWCKY RHVCTSHPHE CSFQEGRVHS PEGCPEILPQ GDLLIPVGVM 
       710        720        730        740        750
QPLTLRAKNL PQPQSGQKNY ECVVRVQGRQ HRVPAVRFNS SSVQCQNASY 
       760        770        780        790        800
FYEGDEFGDT ELDFSVVWDG DFPIDKPPSF RALLYKCWAQ RPSCGLCLKA 
       810        820        830        840        850
DPRFNCGWCI SEHRCQLRAH CPAPKSNWMH PSQKGARCSH PRITQIHPLT 
       860        870        880        890        900
GPKEGGTRVT IVGENLGLTS REVGLRVAGV RCNSIPTEYV SAERIVCEME 
       910        920        930        940        950
ESLVPSPPPG PAELCVGDCS ADFRTQSQQL YSFVTPTFDR VSPSRGPASG 
       960        970        980        990       1000
GTRLTISGIS LDAGSRVTVI IRDGECQFVR RDAEAIVCIS PVSTLGPSQS 
      1010       1020       1030       1040       1050
PITLAIDHAN ISNTGVIYTY TQDPTVTHLE PTWSIINGST SITVSGTHLL 
      1060       1070       1080       1090       1100
TVQEPRVRAK YRGIETTNTC QVINDTAMLC KAPGIFLGHP QPRAQGEHPD 
      1110       1120       1130       1140       1150
EFGFLLDHVQ AARSLNRSSF TYYPDPSFEP LGPSGVLDVK PGSHVVLKGK 
      1160       1170       1180       1190       1200
NLIPAAAGSS RLNYTVLIGG QPCALTVSDT QLLCDSPSQT GRQPVMVLVG 
      1210       1220       1230       1240       1250
GLEFWLGTLH ITADRALTLP AMVGLAAGGG LLLLAITVVL VAYKRKTQDA 
      1260       1270       1280       1290       1300
DRTLKRLQLQ MDNLESRVAL ECKEAFAELQ TDINELTNHM DGVQIPFLDY 
      1310       1320       1330       1340       1350
RTYAVRVLFP GIEAHPVLKE LDTPPNVEKA LRLFGQLLHS RAFLLTFIHT 
      1360       1370       1380       1390       1400
LEAQSSFSMR DRGTVASLTM VALQSRLDYA TGLLKQLLAD LIEKNLESKN 
      1410       1420       1430       1440       1450
HPKLLLRRTE SVAEKMLTNW FTFLLHKFLK ECAGEPLFLL YCAIKQQMEK 
      1460       1470       1480       1490       1500
GPIDAITGEA RYSLSEDKLI RQQIDYKTLT LHCVCPESEG SAQVPVKVLN 
      1510       1520       1530       1540       1550
CDSITQAKDK LLDTVYKGIP YSQRPKAEDM DLEWRQGRMA RIILQDEDIT 
      1560       1570       1580       1590       1600
TKIECDWKRV NSLAHYQVTD GSLVALVPKQ VSAYNMANSF TFTRSLSRYE 
      1610       1620       1630       1640       1650
SLLRAASSPD SLRSRAPMLT PDQEAGTKLW HLVRNHDHTD HREGDRGSKM 
      1660       1670       1680       1690       1700
VSEIYLTRLL ATKGTLQKFV DDLFETVFST AHRGSALPLA IKYMFDFLDE 
      1710       1720       1730       1740       1750
QADQRQISDP DVRHTWKSNC LPLRFWVNVI KNPQFVFDIH KNSITDACLS 
      1760       1770       1780       1790       1800
VVAQTFMDSC STSEHRLGKD SPSNKLLYAK DIPNYKSWVE RYYRDIAKMA 
      1810       1820       1830       1840       1850
SISDQDMDAY LVEQSRLHAN DFNVLSALSE LYFYVTKYRQ EILTSLDRDA 
      1860       1870 
SCRKHKLRQK LEQIITLVSS SS
Length:1,872
Mass (Da):207,958
Last modified:July 27, 2011 - v2
Checksum:i39D57886A0C4830A
GO
Isoform 2 (identifier: P70208-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1072-1148: Missing.

Show »
Length:1,795
Mass (Da):199,604
Checksum:i2E590AF8E22FEBA5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1627T → A in BAC33681 (PubMed:16141072).Curated1
Sequence conflicti1861L → P in BAA13190 (PubMed:8806646).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0416091072 – 1148Missing in isoform 2. 1 PublicationAdd BLAST77

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86950 mRNA Translation: BAA13190.1
BC093482 mRNA Translation: AAH93482.1
AJ748653 mRNA Translation: CAG38687.1
AK049319 mRNA Translation: BAC33681.1
CCDSiCCDS30228.1 [P70208-1]
PIRiJC4976
RefSeqiNP_032909.2, NM_008883.2 [P70208-1]
XP_006527963.1, XM_006527900.2
UniGeneiMm.1685

Genome annotation databases

EnsembliENSMUST00000004326; ENSMUSP00000004326; ENSMUSG00000031398 [P70208-1]
GeneIDi18846
KEGGimmu:18846
UCSCiuc009too.1 mouse [P70208-1]
uc012hku.1 mouse [P70208-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPLXA3_MOUSE
AccessioniPrimary (citable) accession number: P70208
Secondary accession number(s): A5D6Q5, Q684J0, Q8BWZ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 27, 2011
Last modified: April 25, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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