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UniProtKB - P70208 (PLXA3_MOUSE)

Entry version 150 (25 May 2022)
Sequence version 2 (27 Jul 2011)
Previous versions | rss
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Protein

Plexin-A3

Gene

Plxna3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.

6 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • semaphorin receptor activity Source: UniProtKB
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-399954, Sema3A PAK dependent Axon repulsion
R-MMU-399955, SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
R-MMU-399956, CRMPs in Sema3A signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Plexin-A3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Plxna3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:107683, Plxna3

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000031398

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini20 – 1220ExtracellularSequence analysisAdd BLAST1201
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1221 – 1241HelicalSequence analysisAdd BLAST21
Topological domaini1242 – 1872CytoplasmicSequence analysisAdd BLAST631

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

No visible phenotype, but causes subtle changes in the central nervous system. Mice exhibit altered apical dendrite spine morphology in pyramidal neurons. Mice exhibit defasciculation of the facial branchiomotor nerve and of the ophthalmic branch of the trigeminus, with variable severity. The number of neurons in the dorsal root ganglion is higher than normal, probably due to reduced neuronal apoptosis. In mice lacking both Plxna3 and Plxna4, migrating neurons do not show the normal response to Sema3A and Sema3F and do not migrate away from these semaphorins (in vitro).5 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1279L → R: Strongly reduced response to semaphorin. 1 Publication1
Mutagenesisi1300Y → A: Almost abolishes response to semaphorin. 1 Publication1
Mutagenesisi1309F → A: Almost abolishes response to semaphorin. 1 Publication1
Mutagenesisi1407 – 1408RR → AA: Abolishes response to semaphorin. 1 Publication2
Mutagenesisi1453I → R: Abolishes response to semaphorin. 1 Publication1
Mutagenesisi1464L → G: Almost abolishes response to semaphorin. 1 Publication1
Mutagenesisi1506Q → A: Abolishes response to semaphorin. 1 Publication1
Mutagenesisi1631 – 1632HL → AA: Abolishes response to semaphorin. 1 Publication2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000041110420 – 1872Plexin-A3Add BLAST1853

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi60N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi78 ↔ 87PROSITE-ProRule annotation
Disulfide bondi113 ↔ 121PROSITE-ProRule annotation
Disulfide bondi267 ↔ 388PROSITE-ProRule annotation
Disulfide bondi283 ↔ 339PROSITE-ProRule annotation
Disulfide bondi357 ↔ 376PROSITE-ProRule annotation
Disulfide bondi492 ↔ 509PROSITE-ProRule annotation
Disulfide bondi498 ↔ 540PROSITE-ProRule annotation
Disulfide bondi501 ↔ 518PROSITE-ProRule annotation
Disulfide bondi512 ↔ 524PROSITE-ProRule annotation
Glycosylationi549N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi575 ↔ 595PROSITE-ProRule annotation
Glycosylationi1163N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1597PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		P70208

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P70208

PeptideAtlas

More...PeptideAtlasi		P70208

PRoteomics IDEntifications database

More...PRIDEi		P70208

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		289630 [P70208-1]
289631 [P70208-2]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		2591, 1 N-Linked glycan (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P70208, 4 sites, 1 N-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P70208

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P70208

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in embryonic hindbrain, spinal cord, dorsal root ganglion, trigeminal ganglion and superior cervical ganglion. In newborns, detected throughout all layers of the hippocampus.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000031398, Expressed in cerebral cortex and 287 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P70208, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P70208, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		202263, 4 interactors

Database of interacting proteins

More...DIPi		DIP-48959N

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000004326

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P70208, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11872
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P70208

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P70208

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P70208

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini20 – 489SemaPROSITE-ProRule annotationAdd BLAST470
Domaini841 – 934IPT/TIG 1Add BLAST94
Domaini936 – 1021IPT/TIG 2Add BLAST86
Domaini1024 – 1123IPT/TIG 3Add BLAST100
Domaini1126 – 1212IPT/TIG 4Add BLAST87

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1240 – 1294Sequence analysisAdd BLAST55

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the plexin family.Curated

Keywords - Domaini

Coiled coil, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3610, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01020000230473

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001436_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P70208

Identification of Orthologs from Complete Genome Data

More...OMAi		VYYNCSV

Database for complete collections of gene phylogenies

More...PhylomeDBi		P70208

TreeFam database of animal gene trees

More...TreeFami		TF312962

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.506.10, 1 hit
2.130.10.10, 1 hit
2.60.40.10, 5 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR002909, IPT_dom
IPR031148, Plexin
IPR013548, Plexin_cytoplasmic_RasGAP_dom
IPR002165, Plexin_repeat
IPR016201, PSI
IPR008936, Rho_GTPase_activation_prot
IPR001627, Semap_dom
IPR036352, Semap_dom_sf
IPR041019, TIG1_plexin
IPR041362, TIG2_plexin
IPR015943, WD40/YVTN_repeat-like_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR22625, PTHR22625, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08337, Plexin_cytopl, 1 hit
PF01437, PSI, 2 hits
PF01403, Sema, 1 hit
PF01833, TIG, 4 hits
PF18020, TIG_2, 1 hit
PF17960, TIG_plexin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00429, IPT, 4 hits
SM00423, PSI, 3 hits
SM00630, Sema, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF101912, SSF101912, 1 hit
SSF48350, SSF48350, 1 hit
SSF81296, SSF81296, 4 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51004, SEMA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P70208-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPTVCLLPLL FFTIGGCLGS SRPFRTFVVT DTTLTHLAVH RVTGEVFVGA 
        60         70         80         90        100
VNRVFKLAPN LTELRAHVTG PIEDNARCYP PPSMRVCSHR LVPVDNVNKL 
       110        120        130        140        150
LLIDYAARRL VACGSIWQGI CQFLRLDDLF KLGEPHHRKE HYLSGAQEPD 
       160        170        180        190        200
SMAGVIVEQV QGPSKLFVGT AVDGKSEYFP TLSSRKLIDD EDSGDMFSLV 
       210        220        230        240        250
YQDEFVSSQI KIPSDTLSLY PAFDIYYIYG FVSASFVYFL TLQLDTQQTL 
       260        270        280        290        300
LDTAGEKFFT SKIVRMCAGD SEFYSYVEFP IGCSWRGVEY RLVQSAHLAK 
       310        320        330        340        350
PGLLLAQALG VPADEDVLFT IFSQGQKNRA NPPRQTILCL FTLSSINAHI 
       360        370        380        390        400
RRRIQSCYRG EGTLALPWLL NKELPCINTP LQINGNFCGL VLNQPLGGLH 
       410        420        430        440        450
VIEGLPLLAD STDGMASVAA YTYHQHSVVF IGTRSGNLKK VRVDGSQDAQ 
       460        470        480        490        500
LYETVSVVQG SPILRDLLFS PDHRHIYLLS EKQVSQLPVE TCEQYLSCAA 
       510        520        530        540        550
CLGSGDPHCG WCVLQHRCCR EGACPGASAP HGFAEELSKC IQVRVRPNNV 
       560        570        580        590        600
SVTSSGVQLT VAMRNVPDLS VGVSCSFEEV TESEAILLPS GELRCPSPSL 
       610        620        630        640        650
QELQTLTRGH GATHTVRLQL LSMETGVRFA GVDFVFYNCS ALQSCMSCVG 
       660        670        680        690        700
SPYPCHWCKY RHVCTSHPHE CSFQEGRVHS PEGCPEILPQ GDLLIPVGVM 
       710        720        730        740        750
QPLTLRAKNL PQPQSGQKNY ECVVRVQGRQ HRVPAVRFNS SSVQCQNASY 
       760        770        780        790        800
FYEGDEFGDT ELDFSVVWDG DFPIDKPPSF RALLYKCWAQ RPSCGLCLKA 
       810        820        830        840        850
DPRFNCGWCI SEHRCQLRAH CPAPKSNWMH PSQKGARCSH PRITQIHPLT 
       860        870        880        890        900
GPKEGGTRVT IVGENLGLTS REVGLRVAGV RCNSIPTEYV SAERIVCEME 
       910        920        930        940        950
ESLVPSPPPG PAELCVGDCS ADFRTQSQQL YSFVTPTFDR VSPSRGPASG 
       960        970        980        990       1000
GTRLTISGIS LDAGSRVTVI IRDGECQFVR RDAEAIVCIS PVSTLGPSQS 
      1010       1020       1030       1040       1050
PITLAIDHAN ISNTGVIYTY TQDPTVTHLE PTWSIINGST SITVSGTHLL 
      1060       1070       1080       1090       1100
TVQEPRVRAK YRGIETTNTC QVINDTAMLC KAPGIFLGHP QPRAQGEHPD 
      1110       1120       1130       1140       1150
EFGFLLDHVQ AARSLNRSSF TYYPDPSFEP LGPSGVLDVK PGSHVVLKGK 
      1160       1170       1180       1190       1200
NLIPAAAGSS RLNYTVLIGG QPCALTVSDT QLLCDSPSQT GRQPVMVLVG 
      1210       1220       1230       1240       1250
GLEFWLGTLH ITADRALTLP AMVGLAAGGG LLLLAITVVL VAYKRKTQDA 
      1260       1270       1280       1290       1300
DRTLKRLQLQ MDNLESRVAL ECKEAFAELQ TDINELTNHM DGVQIPFLDY 
      1310       1320       1330       1340       1350
RTYAVRVLFP GIEAHPVLKE LDTPPNVEKA LRLFGQLLHS RAFLLTFIHT 
      1360       1370       1380       1390       1400
LEAQSSFSMR DRGTVASLTM VALQSRLDYA TGLLKQLLAD LIEKNLESKN 
      1410       1420       1430       1440       1450
HPKLLLRRTE SVAEKMLTNW FTFLLHKFLK ECAGEPLFLL YCAIKQQMEK 
      1460       1470       1480       1490       1500
GPIDAITGEA RYSLSEDKLI RQQIDYKTLT LHCVCPESEG SAQVPVKVLN 
      1510       1520       1530       1540       1550
CDSITQAKDK LLDTVYKGIP YSQRPKAEDM DLEWRQGRMA RIILQDEDIT 
      1560       1570       1580       1590       1600
TKIECDWKRV NSLAHYQVTD GSLVALVPKQ VSAYNMANSF TFTRSLSRYE 
      1610       1620       1630       1640       1650
SLLRAASSPD SLRSRAPMLT PDQEAGTKLW HLVRNHDHTD HREGDRGSKM 
      1660       1670       1680       1690       1700
VSEIYLTRLL ATKGTLQKFV DDLFETVFST AHRGSALPLA IKYMFDFLDE 
      1710       1720       1730       1740       1750
QADQRQISDP DVRHTWKSNC LPLRFWVNVI KNPQFVFDIH KNSITDACLS 
      1760       1770       1780       1790       1800
VVAQTFMDSC STSEHRLGKD SPSNKLLYAK DIPNYKSWVE RYYRDIAKMA 
      1810       1820       1830       1840       1850
SISDQDMDAY LVEQSRLHAN DFNVLSALSE LYFYVTKYRQ EILTSLDRDA 
      1860       1870 
SCRKHKLRQK LEQIITLVSS SS
Length:1,872
Mass (Da):207,958
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i39D57886A0C4830A
GO
Isoform 2 (identifier: P70208-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1072-1148: Missing.

Show »
Length:1,795
Mass (Da):199,604
Checksum:i2E590AF8E22FEBA5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1627T → A in BAC33681 (PubMed:16141072).Curated1
Sequence conflicti1861L → P in BAA13190 (PubMed:8806646).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0416091072 – 1148Missing in isoform 2. 1 PublicationAdd BLAST77

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
D86950 mRNA Translation: BAA13190.1
BC093482 mRNA Translation: AAH93482.1
AJ748653 mRNA Translation: CAG38687.1
AK049319 mRNA Translation: BAC33681.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS30228.1 [P70208-1]

Protein sequence database of the Protein Information Resource

More...PIRi		JC4976

NCBI Reference Sequences

More...RefSeqi		NP_032909.2, NM_008883.2 [P70208-1]
XP_006527963.1, XM_006527900.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000004326; ENSMUSP00000004326; ENSMUSG00000031398 [P70208-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		18846

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:18846

UCSC genome browser

More...UCSCi		uc009too.1, mouse [P70208-1]
uc012hku.1, mouse [P70208-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86950 mRNA Translation: BAA13190.1
BC093482 mRNA Translation: AAH93482.1
AJ748653 mRNA Translation: CAG38687.1
AK049319 mRNA Translation: BAC33681.1
CCDSiCCDS30228.1 [P70208-1]
PIRiJC4976
RefSeqiNP_032909.2, NM_008883.2 [P70208-1]
XP_006527963.1, XM_006527900.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3IG3X-ray1.99A1247-1872[»]
AlphaFoldDBiP70208
SMRiP70208
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi202263, 4 interactors
DIPiDIP-48959N
STRINGi10090.ENSMUSP00000004326

PTM databases

GlyConnecti2591, 1 N-Linked glycan (1 site)
GlyGeniP70208, 4 sites, 1 N-linked glycan (1 site)
iPTMnetiP70208
PhosphoSitePlusiP70208

Proteomic databases

MaxQBiP70208
PaxDbiP70208
PeptideAtlasiP70208
PRIDEiP70208
ProteomicsDBi289630 [P70208-1]
289631 [P70208-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		31267, 57 antibodies from 18 providers

The DNASU plasmid repository

More...DNASUi		18846

Genome annotation databases

EnsembliENSMUST00000004326; ENSMUSP00000004326; ENSMUSG00000031398 [P70208-1]
GeneIDi18846
KEGGimmu:18846
UCSCiuc009too.1, mouse [P70208-1]
uc012hku.1, mouse [P70208-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55558
MGIiMGI:107683, Plxna3
VEuPathDBiHostDB:ENSMUSG00000031398

Phylogenomic databases

eggNOGiKOG3610, Eukaryota
GeneTreeiENSGT01020000230473
HOGENOMiCLU_001436_2_0_1
InParanoidiP70208
OMAiVYYNCSV
PhylomeDBiP70208
TreeFamiTF312962

Enzyme and pathway databases

ReactomeiR-MMU-399954, Sema3A PAK dependent Axon repulsion
R-MMU-399955, SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
R-MMU-399956, CRMPs in Sema3A signaling

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		18846, 1 hit in 72 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Plxna3, mouse
EvolutionaryTraceiP70208

Protein Ontology

More...PROi		PR:P70208
RNActiP70208, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000031398, Expressed in cerebral cortex and 287 other tissues
ExpressionAtlasiP70208, baseline and differential
GenevisibleiP70208, MM

Family and domain databases

Gene3Di1.10.506.10, 1 hit
2.130.10.10, 1 hit
2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR002909, IPT_dom
IPR031148, Plexin
IPR013548, Plexin_cytoplasmic_RasGAP_dom
IPR002165, Plexin_repeat
IPR016201, PSI
IPR008936, Rho_GTPase_activation_prot
IPR001627, Semap_dom
IPR036352, Semap_dom_sf
IPR041019, TIG1_plexin
IPR041362, TIG2_plexin
IPR015943, WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR22625, PTHR22625, 1 hit
PfamiView protein in Pfam
PF08337, Plexin_cytopl, 1 hit
PF01437, PSI, 2 hits
PF01403, Sema, 1 hit
PF01833, TIG, 4 hits
PF18020, TIG_2, 1 hit
PF17960, TIG_plexin, 1 hit
SMARTiView protein in SMART
SM00429, IPT, 4 hits
SM00423, PSI, 3 hits
SM00630, Sema, 1 hit
SUPFAMiSSF101912, SSF101912, 1 hit
SSF48350, SSF48350, 1 hit
SSF81296, SSF81296, 4 hits
PROSITEiView protein in PROSITE
PS51004, SEMA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLXA3_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P70208
Secondary accession number(s): A5D6Q5, Q684J0, Q8BWZ5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 27, 2011
Last modified: May 25, 2022
This is version 150 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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