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Protein

Plexin-A2

Gene

Plxna2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.3 Publications

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • semaphorin receptor activity Source: UniProtKB

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-399954 Sema3A PAK dependent Axon repulsion
R-MMU-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
R-MMU-399956 CRMPs in Sema3A signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Plexin-A2
Short name:
Plex 2
Short name:
Plexin-2
Gene namesi
Name:Plxna2
Synonyms:Kiaa0463
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:107684 Plxna2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini35 – 1237ExtracellularSequence analysisAdd BLAST1203
Transmembranei1238 – 1258HelicalSequence analysisAdd BLAST21
Topological domaini1259 – 1894CytoplasmicSequence analysisAdd BLAST636

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi193D → K: Abolishes interaction with SEMA6A. 1 Publication1
Mutagenesisi221F → A or R: Abolishes interaction with SEMA6A. 2 Publications1
Mutagenesisi396A → E: Abolishes interaction with SEMA6A. 2 Publications1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_000023274835 – 1894Plexin-A2Add BLAST1860

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi15N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi76N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi94 ↔ 103
Disulfide bondi129 ↔ 137
Glycosylationi163N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi284 ↔ 405
Disulfide bondi300 ↔ 356
Glycosylationi327N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi374 ↔ 393
Disulfide bondi511 ↔ 528
Disulfide bondi517 ↔ 559
Disulfide bondi520 ↔ 537
Disulfide bondi531 ↔ 543
Disulfide bondi594 ↔ 613
Glycosylationi598N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi696N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi756N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1180N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1205N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1612PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP70207
PaxDbiP70207
PeptideAtlasiP70207
PRIDEiP70207

PTM databases

iPTMnetiP70207
PhosphoSitePlusiP70207

Expressioni

Gene expression databases

BgeeiENSMUSG00000026640 Expressed in 301 organ(s), highest expression level in ganglionic eminence
CleanExiMM_PLXNA2
ExpressionAtlasiP70207 baseline and differential
GenevisibleiP70207 MM

Interactioni

Subunit structurei

Homodimer. Interacts with RND1 (By similarity). Interacts directly with NRP1 and NRP2. The PLXNA2 homodimer interacts with a SEMA6A homodimer, giving rise to a heterotetramer.By similarity4 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202262, 1 interactor
DIPiDIP-32252N
IntActiP70207, 3 interactors
STRINGi10090.ENSMUSP00000027952

Structurei

Secondary structure

11894
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP70207
SMRiP70207
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP70207

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 508SemaPROSITE-ProRule annotationAdd BLAST474
Domaini858 – 951IPT/TIG 1Add BLAST94
Domaini954 – 1037IPT/TIG 2Add BLAST84
Domaini1041 – 1139IPT/TIG 3Add BLAST99
Domaini1143 – 1228IPT/TIG 4Add BLAST86

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1261 – 1310Sequence analysisAdd BLAST50

Sequence similaritiesi

Belongs to the plexin family.Curated

Keywords - Domaini

Coiled coil, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IN3A Eukaryota
ENOG410ZA1D LUCA
GeneTreeiENSGT00760000119048
HOGENOMiHOG000231377
HOVERGENiHBG105711
InParanoidiP70207
KOiK06820
OMAiINISEDC
OrthoDBiEOG091G00EK
PhylomeDBiP70207
TreeFamiTF312962

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 6 hits
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR031148 Plexin
IPR013548 Plexin_cytoplasmic_RasGAP_dom
IPR002165 Plexin_repeat
IPR016201 PSI
IPR008936 Rho_GTPase_activation_prot
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR22625 PTHR22625, 1 hit
PfamiView protein in Pfam
PF08337 Plexin_cytopl, 1 hit
PF01437 PSI, 1 hit
PF01403 Sema, 1 hit
PF01833 TIG, 4 hits
SMARTiView protein in SMART
SM00429 IPT, 4 hits
SM00423 PSI, 3 hits
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
SSF48350 SSF48350, 1 hit
SSF81296 SSF81296, 4 hits
PROSITEiView protein in PROSITE
PS51004 SEMA, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P70207-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEQRRFYLRA MQADNLSVVL LSVAWLLLAR GTTGMPQYST FHSENRDWTF
60 70 80 90 100
NHLTVHRRTG AVYVGAINRV YKLTGNLTIQ VAHKTGPEED NKACYPPLIV
110 120 130 140 150
QPCSEVLTLT NNVNKLLIID YSENRLLACG SLYQGVCKLL RLDDLFILVE
160 170 180 190 200
PSHKKEHYLS SVNKTGTMYG VIVRSEGEDG KLFIGTAVDG KQDYFPTLSS
210 220 230 240 250
RKLPRDPESS AMLDYELHSD FVSSLIKIPS DTLALVSHFD IFYIYGFASG
260 270 280 290 300
GFVYFLTVQP ETPDGMAINS AGDLFYTSRI VRLCKDDPKF HSYVSLPFGC
310 320 330 340 350
TRAGVEYRLL QAAYLAKPGE ALAQAFNISS DEDVLFAIFS KGQKQYHHPP
360 370 380 390 400
DDSALCAFPI RAINLQIKER LQSCYHGEGN LELNWLLGKD VQCTKAPVPI
410 420 430 440 450
DDNFCGLDIN QPLGGSTPVE GLTLYTTSRD RLTSVASYVY NGYSVVFVGT
460 470 480 490 500
KSGKLKKIRA DGPPHGGVQY EMVSVFKDGS PILRDMAFSI NQLYLYVMSE
510 520 530 540 550
RQVTRVPVES CEQYTTCGEC LSSGDPHCGW CALHNMCSRR DKCQRAWEAN
560 570 580 590 600
RFAASISQCM SLEVHPNSIS VSDHSRLLSL VVNDAPNLSE GIACAFGNLT
610 620 630 640 650
EVEGQVSGSQ VICISPGPKD VPVIPLDQDW FGLELQLRSK ETGKIFVSTE
660 670 680 690 700
FKFYNCSAHQ LCLSCVNSAF RCHWCKYRNL CTHDPTTCSF QEGRINVSED
710 720 730 740 750
CPQLVPTEEI LIPVGEVKPI TLKARNLPQP QSGQRGYECV LSIQGAVHRV
760 770 780 790 800
PALRFNSSSV QCQNSSYQYD GMDISNLAVD FAVVWNGNFI IDNPQDLKVH
810 820 830 840 850
LYKCAAQRES CGLCLKADHK FECGWCSGER RCTLHQHCPS TSSPWLDWSS
860 870 880 890 900
HNVKCSNPQI TEILTVSGPP EGGTRVTIHG VNLGLDFSEI AHHVQVAGVP
910 920 930 940 950
CTPIPGEYII AEQIVCEMGH AVIGTTSGPV RLCIGECKPE FMTKSHQQYT
960 970 980 990 1000
FVNPSVLSLS PIRGPESGGT MVTITGHYLG AGSSVAVYLG NQTCEFYGRS
1010 1020 1030 1040 1050
MNEIVCVSPP SSNGLGPVPV SVSVDRARVD SSLQFEYIDD PRVQRIEPEW
1060 1070 1080 1090 1100
SITSGHTPLT ITGFNLDVIQ EPRVRVKFNG KESVNVCTVV NTTTLTCLAP
1110 1120 1130 1140 1150
SLTSDYRPGL DTVERPDEFG FLFNNVQSLL IYNDTKFIYY PNPTFELLSP
1160 1170 1180 1190 1200
TGILDQKPGS PIILKGKNLC PPASGGAKLN YTVMIGETPC TVTVSETQLL
1210 1220 1230 1240 1250
CEPPNLTGQH KVMVHVGGMV FSPGSVSVIS DSLLTLPAII SIAAGGSLLL
1260 1270 1280 1290 1300
IIVIIVLIAY KRKSRENDLT LKRLQMQMDN LESRVALECK EAFAELQTDI
1310 1320 1330 1340 1350
NELTSDLDRS GIPYLDYRTY AMRVLFPGIE DHPVLRELEV QGNGQQHVEK
1360 1370 1380 1390 1400
ALKLFAQLIN NKVFLLTFIR TLELQRSFSM RDRGNVASLI MTGLQGRLEY
1410 1420 1430 1440 1450
ATDVLKQLLS DLIDKNLENK NHPKLLLRRT ESVAEKMLTN WFAFLLHKFL
1460 1470 1480 1490 1500
KECAGEPLFM LYCAIKQQME KGPIDAITGE ARYSLSEDKL IRQQIEYKTL
1510 1520 1530 1540 1550
ILNCVNPDNE NSPEIPVKVL NCDTITQVKE KILDAVYKNV PYSQRPRAVD
1560 1570 1580 1590 1600
MDLEWRQGRI ARVVLQDEDI TTKIEGDWKR LNTLMHYQVS DRSVVALVPK
1610 1620 1630 1640 1650
QTSSYNIPAS ASISRTSISR YDSSFRYTGS PDSLRSRVPM ITPDLESGVK
1660 1670 1680 1690 1700
VWHLVKNHDH GDQKEGDRGS KMVSEIYLTR LLATKGTLQK FVDDLFETLF
1710 1720 1730 1740 1750
STVHRGSALP LAIKYMFDFL DEQADRHSIH DTDVRHTWKS NCLPLRFWVN
1760 1770 1780 1790 1800
VIKNPQFVFD IHKGSITDAC LSVVAQTFMD SCSTSEHRLG KDSPSNKLLY
1810 1820 1830 1840 1850
AKDIPSYKNW VERYYADIAK LPAISDQDMN AYLAEQSRLH ATEFNMLSAL
1860 1870 1880 1890
NEIYSYVSKY SEELIGALEQ DEQARRQRLA YKVEHLINAM SIES
Length:1,894
Mass (Da):211,535
Last modified:July 7, 2009 - v2
Checksum:i9F6C34F48BC29CEE
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6VSI0F6VSI0_MOUSE
Plexin-A2
Plxna2
83Annotation score:

Sequence cautioni

The sequence AAH68155 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA13189 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti211A → P in AAH68155 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86949 mRNA Translation: BAA13189.1 Different initiation.
BC024509 mRNA Translation: AAH24509.1
BC056475 mRNA Translation: AAH56475.1
BC068155 mRNA Translation: AAH68155.1 Different initiation.
AK122289 mRNA Translation: BAC65571.1
CCDSiCCDS35827.1
PIRiJC4975
RefSeqiNP_032908.2, NM_008882.2
UniGeneiMm.2251

Genome annotation databases

EnsembliENSMUST00000027952; ENSMUSP00000027952; ENSMUSG00000026640
GeneIDi18845
KEGGimmu:18845
UCSCiuc007een.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86949 mRNA Translation: BAA13189.1 Different initiation.
BC024509 mRNA Translation: AAH24509.1
BC056475 mRNA Translation: AAH56475.1
BC068155 mRNA Translation: AAH68155.1 Different initiation.
AK122289 mRNA Translation: BAC65571.1
CCDSiCCDS35827.1
PIRiJC4975
RefSeqiNP_032908.2, NM_008882.2
UniGeneiMm.2251

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3AL8X-ray3.60B31-561[»]
3AL9X-ray2.10A/B31-561[»]
3OKTX-ray2.30A35-703[»]
3OKYX-ray2.20A35-703[»]
4GZAX-ray7.00A/B/C/D/E/F33-703[»]
5L5GX-ray10.00A/B/C/D33-1231[»]
5L74X-ray1.36A655-803[»]
ProteinModelPortaliP70207
SMRiP70207
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202262, 1 interactor
DIPiDIP-32252N
IntActiP70207, 3 interactors
STRINGi10090.ENSMUSP00000027952

PTM databases

iPTMnetiP70207
PhosphoSitePlusiP70207

Proteomic databases

MaxQBiP70207
PaxDbiP70207
PeptideAtlasiP70207
PRIDEiP70207

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027952; ENSMUSP00000027952; ENSMUSG00000026640
GeneIDi18845
KEGGimmu:18845
UCSCiuc007een.1 mouse

Organism-specific databases

CTDi5362
MGIiMGI:107684 Plxna2
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IN3A Eukaryota
ENOG410ZA1D LUCA
GeneTreeiENSGT00760000119048
HOGENOMiHOG000231377
HOVERGENiHBG105711
InParanoidiP70207
KOiK06820
OMAiINISEDC
OrthoDBiEOG091G00EK
PhylomeDBiP70207
TreeFamiTF312962

Enzyme and pathway databases

ReactomeiR-MMU-399954 Sema3A PAK dependent Axon repulsion
R-MMU-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
R-MMU-399956 CRMPs in Sema3A signaling

Miscellaneous databases

ChiTaRSiPlxna2 mouse
EvolutionaryTraceiP70207
PROiPR:P70207
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026640 Expressed in 301 organ(s), highest expression level in ganglionic eminence
CleanExiMM_PLXNA2
ExpressionAtlasiP70207 baseline and differential
GenevisibleiP70207 MM

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 6 hits
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR031148 Plexin
IPR013548 Plexin_cytoplasmic_RasGAP_dom
IPR002165 Plexin_repeat
IPR016201 PSI
IPR008936 Rho_GTPase_activation_prot
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR22625 PTHR22625, 1 hit
PfamiView protein in Pfam
PF08337 Plexin_cytopl, 1 hit
PF01437 PSI, 1 hit
PF01403 Sema, 1 hit
PF01833 TIG, 4 hits
SMARTiView protein in SMART
SM00429 IPT, 4 hits
SM00423 PSI, 3 hits
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
SSF48350 SSF48350, 1 hit
SSF81296 SSF81296, 4 hits
PROSITEiView protein in PROSITE
PS51004 SEMA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPLXA2_MOUSE
AccessioniPrimary (citable) accession number: P70207
Secondary accession number(s): Q6NVE6
, Q6PHN4, Q80TZ7, Q8R1I4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: July 7, 2009
Last modified: November 7, 2018
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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