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Protein

Pituitary adenylate cyclase-activating polypeptide type I receptor

Gene

Adcyap1r1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract.

GO - Molecular functioni

  • adenylate cyclase binding Source: MGI
  • ADP-ribosylation factor binding Source: MGI
  • G-protein coupled receptor activity Source: MGI
  • neuropeptide binding Source: MGI
  • vasoactive intestinal polypeptide receptor activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, G-protein coupled receptor, Receptor, Transducer
Biological processDifferentiation, Spermatogenesis

Enzyme and pathway databases

ReactomeiR-MMU-418555 G alpha (s) signalling events
R-MMU-420092 Glucagon-type ligand receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Pituitary adenylate cyclase-activating polypeptide type I receptor
Short name:
PACAP type I receptor
Short name:
PACAP-R-1
Short name:
PACAP-R1
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:108449 Adcyap1r1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 155ExtracellularSequence analysisAdd BLAST135
Transmembranei156 – 178Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini179 – 186CytoplasmicSequence analysis8
Transmembranei187 – 205Helical; Name=2Sequence analysisAdd BLAST19
Topological domaini206 – 227ExtracellularSequence analysisAdd BLAST22
Transmembranei228 – 253Helical; Name=3Sequence analysisAdd BLAST26
Topological domaini254 – 268CytoplasmicSequence analysisAdd BLAST15
Transmembranei269 – 291Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini292 – 309ExtracellularSequence analysisAdd BLAST18
Transmembranei310 – 332Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini333 – 378CytoplasmicSequence analysisAdd BLAST46
Transmembranei379 – 399Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini400 – 413ExtracellularSequence analysisAdd BLAST14
Transmembranei414 – 433Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini434 – 496CytoplasmicSequence analysisAdd BLAST63

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001284221 – 496Pituitary adenylate cyclase-activating polypeptide type I receptorAdd BLAST476

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 63By similarity
Glycosylationi48N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi54 ↔ 118By similarity
Glycosylationi60N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi77 ↔ 134By similarity
Glycosylationi117N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei462PhosphoserineCombined sources1
Modified residuei475PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP70205
PaxDbiP70205
PRIDEiP70205

PTM databases

iPTMnetiP70205
PhosphoSitePlusiP70205
SwissPalmiP70205

Expressioni

Gene expression databases

BgeeiENSMUSG00000029778
ExpressionAtlasiP70205 baseline and differential
GenevisibleiP70205 MM

Interactioni

Subunit structurei

Interacts (via N-terminal extracellular domain) with ADCYAP1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiP70205, 1 interactor
MINTiP70205
STRINGi10090.ENSMUSP00000063784

Structurei

3D structure databases

ProteinModelPortaliP70205
SMRiP70205
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni125 – 139Important for ligand binding and specificityBy similarityAdd BLAST15

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4564 Eukaryota
ENOG410XRS2 LUCA
GeneTreeiENSGT00760000118800
HOGENOMiHOG000008249
HOVERGENiHBG008318
InParanoidiP70205
KOiK04587
PhylomeDBiP70205
TreeFamiTF315710

Family and domain databases

Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR002285 GPCR_2_PACAP_1_rcpt
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
PANTHERiPTHR12011:SF228 PTHR12011:SF228, 1 hit
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF02793 HRM, 1 hit
PRINTSiPR00249 GPCRSECRETIN
PR01156 PACAPRECEPTR
SMARTiView protein in SMART
SM00008 HormR, 1 hit
SUPFAMiSSF111418 SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS00649 G_PROTEIN_RECEP_F2_1, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P70205-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARTLQLSLT ALLLLPMAIA MHSDCIFKKE QAMCLERIQR ANDLMGLNES
60 70 80 90 100
SPGCPGMWDN ITCWKPAQIG EMVLVSCPEV FRIFNPDQVW MTETIGDSGF
110 120 130 140 150
ADSNSLEITD MGVVGRNCTE DGWSEPFPHY FDACGFDDYE PESGDQDYYY
160 170 180 190 200
LSVKALYTVG YSTSLVTLTT AMVILCRFRK LHCTRNFIHM NLFVSFMLRA
210 220 230 240 250
ISVFIKDWIL YAEQDSSHCF VSTVECKAVM VFFHYCVVSN YFWLFIEGLY
260 270 280 290 300
LFTLLVETFF PERRYFYWYT IIGWGTPTVC VTVWAVLRLY FDDAGCWDMN
310 320 330 340 350
DSTALWWVIK GPVVGSIMVN FVLFIGIIII LVQKLQSPDM GGNESSIYFS
360 370 380 390 400
CVQKCYCKPQ RAQQHSCKMS ELSTITLRLA RSTLLLIPLF GIHYTVFAFS
410 420 430 440 450
PENVSKRERL VFELGLGSFQ GFVVAVLYCF LNGEVQAEIK RKWRSWKVNR
460 470 480 490
YFTMDFKHRH PSLASSGVNG GTQLSILSKS SSQLRMSSLP ADNLAT
Length:496
Mass (Da):56,640
Last modified:February 1, 1997 - v1
Checksum:i47B5D51D4209060A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D82935 mRNA Translation: BAA11639.1
CCDSiCCDS20167.1
RefSeqiNP_031433.3, NM_007407.4
UniGeneiMm.44245

Genome annotation databases

EnsembliENSMUST00000070736; ENSMUSP00000063784; ENSMUSG00000029778
GeneIDi11517
KEGGimmu:11517
UCSCiuc009cat.2 mouse

Similar proteinsi

Entry informationi

Entry nameiPACR_MOUSE
AccessioniPrimary (citable) accession number: P70205
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: June 20, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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