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Entry version 161 (29 Sep 2021)
Sequence version 2 (27 Jul 2011)
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Protein

Leucine-rich repeats and immunoglobulin-like domains protein 1

Gene

Lrig1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-177929, Signaling by EGFR
R-MMU-6807004, Negative regulation of MET activity

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leucine-rich repeats and immunoglobulin-like domains protein 1
Short name:
LIG-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Lrig1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:107935, Lrig1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000030029

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini35 – 796ExtracellularSequence analysisAdd BLAST762
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei797 – 817HelicalSequence analysisAdd BLAST21
Topological domaini818 – 1091CytoplasmicSequence analysisAdd BLAST274

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mutant mice are born at the expected Mendelian rate and initially display no visible phenotype. One to four months after birth, they develop skin abnormalities including alopecia and epidermal hyperplasia that are reminiscent of psoriasis.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 34Sequence analysisAdd BLAST34
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001482835 – 1091Leucine-rich repeats and immunoglobulin-like domains protein 1Add BLAST1057

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi47 ↔ 56By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi76N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi152N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi248N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi294N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi320N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi385N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi446 ↔ 470By similarity
Disulfide bondi448 ↔ 491By similarity
Disulfide bondi518 ↔ 579PROSITE-ProRule annotation
Disulfide bondi622 ↔ 674PROSITE-ProRule annotation
Glycosylationi686N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi716 ↔ 765PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P70193

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P70193

PRoteomics IDEntifications database

More...
PRIDEi
P70193

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
292034

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
2474, 1 N-Linked glycan (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
P70193, 7 sites, 1 N-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P70193

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P70193

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in brain (at protein level) (PubMed:12067728). Predominantly expressed in the brain, restricted to a small subset of glial cells, such as Bergmann glial cells of the cerebellum and glial cells in the nerve fiber layer of the olfactory bulb. Expressed also in the skin. Low expression is detected in the thymus and heart. No expression in the kidney, liver, lung or small intestine.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000030029, Expressed in hindbrain and 315 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P70193, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via extracellular LRR and Ig-like domains) with EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 (via extracellular domain). The physiological relevance of the interaction is controversial; LRIG1 may have low affinity for EGFR, and interaction may occur only when high levels of both proteins are present.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
200652, 3 interactors

Protein interaction database and analysis system

More...
IntActi
P70193, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000098686

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P70193, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P70193

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini35 – 70LRRNTAdd BLAST36
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati71 – 92LRR 1Add BLAST22
Repeati95 – 116LRR 2Add BLAST22
Repeati118 – 139LRR 3Add BLAST22
Repeati142 – 163LRR 4Add BLAST22
Repeati166 – 187LRR 5Add BLAST22
Repeati191 – 212LRR 6Add BLAST22
Repeati214 – 235LRR 7Add BLAST22
Repeati238 – 259LRR 8Add BLAST22
Repeati262 – 283LRR 9Add BLAST22
Repeati286 – 307LRR 10Add BLAST22
Repeati310 – 331LRR 11Add BLAST22
Repeati334 – 355LRR 12Add BLAST22
Repeati358 – 380LRR 13Add BLAST23
Repeati385 – 406LRR 14Add BLAST22
Repeati409 – 430LRR 15Add BLAST22
Domaini442 – 493LRRCTAdd BLAST52
Domaini497 – 596Ig-like C2-type 1Add BLAST100
Domaini601 – 690Ig-like C2-type 2Add BLAST90
Domaini695 – 781Ig-like C2-type 3Add BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni912 – 990DisorderedSequence analysisAdd BLAST79
Regioni1059 – 1091DisorderedSequence analysisAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi921 – 939Polar residuesSequence analysisAdd BLAST19
Compositional biasi975 – 989Polar residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains LRR and Ig-domains that can mediate low-affinity interaction with EGFR. The LRRs and the Ig-domains are each sufficient for EGFR/ERBB1 binding. This interaction is abolished only when both the LRRs and the Ig-domains are deleted.By similarity

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4194, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158502

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000288_18_24_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P70193

Identification of Orthologs from Complete Genome Data

More...
OMAi
WLKGDHP

Database of Orthologous Groups

More...
OrthoDBi
161719at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P70193

TreeFam database of animal gene trees

More...
TreeFami
TF325380

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 3 hits
3.80.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000483, Cys-rich_flank_reg_C
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR000372, LRRNT

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07679, I-set, 2 hits
PF13855, LRR_8, 5 hits
PF01463, LRRCT, 1 hit
PF01462, LRRNT, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409, IG, 3 hits
SM00408, IGc2, 3 hits
SM00369, LRR_TYP, 14 hits
SM00082, LRRCT, 1 hit
SM00013, LRRNT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726, SSF48726, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835, IG_LIKE, 3 hits
PS51450, LRR, 14 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P70193-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARPGPGVLG APRLAPRLLL WLLLLLLQWP ESAGAQAGPR APCAAACTCA
60 70 80 90 100
GDSLDCSGRG LATLPRDLPS WTRSLNLSYN RLSEIDSAAF EDLTNLQEVY
110 120 130 140 150
LNSNELTAIP SLGAASIGVV SLFLQHNKIL SVDGSQLKSY LSLEVLDLSS
160 170 180 190 200
NNITEIRSSC FPNGLRIREL NLASNRISIL ESGAFDGLSR SLLTLRLSKN
210 220 230 240 250
RITQLPVKAF KLPRLTQLDL NRNRIRLIEG LTFQGLDSLE VLRLQRNNIS
260 270 280 290 300
RLTDGAFWGL SKMHVLHLEY NSLVEVNSGS LYGLTALHQL HLSNNSISRI
310 320 330 340 350
QRDGWSFCQK LHELILSFNN LTRLDEESLA ELSSLSILRL SHNAISHIAE
360 370 380 390 400
GAFKGLKSLR VLDLDHNEIS GTIEDTSGAF TGLDNLSKLT LFGNKIKSVA
410 420 430 440 450
KRAFSGLESL EHLNLGENAI RSVQFDAFAK MKNLKELYIS SESFLCDCQL
460 470 480 490 500
KWLPPWLMGR MLQAFVTATC AHPESLKGQS IFSVLPDSFV CDDFPKPQII
510 520 530 540 550
TQPETTMAVV GKDIRFTCSA ASSSSSPMTF AWKKDNEVLA NADMENFAHV
560 570 580 590 600
RAQDGEVMEY TTILHLRHVT FGHEGRYQCI ITNHFGSTYS HKARLTVNVL
610 620 630 640 650
PSFTKIPHDI AIRTGTTARL ECAATGHPNP QIAWQKDGGT DFPAARERRM
660 670 680 690 700
HVMPDDDVFF ITDVKIDDMG VYSCTAQNSA GSVSANATLT VLETPSLAVP
710 720 730 740 750
LEDRVVTVGE TVAFQCKATG SPTPRITWLK GGRPLSLTER HHFTPGNQLL
760 770 780 790 800
VVQNVMIDDA GRYTCEMSNP LGTERAHSQL SILPTPGCRK DGTTVGIFTI
810 820 830 840 850
AVVCSIVLTS LVWVCIIYQT RKKSEEYSVT NTDETIVPPD VPSYLSSQGT
860 870 880 890 900
LSDRQETVVR TEGGHQANGH IESNGVCLRD PSLFPEVDIH STTCRQPKLC
910 920 930 940 950
VGYTREPWKV TEKADRTAAP HTTAHSGSAV CSDCSTDTAY HPQPVPRDSG
960 970 980 990 1000
QPGTASSQEL RQHDREYSPH HPYSGTADGS HTLSGGSLYP SNHDRILPSL
1010 1020 1030 1040 1050
KNKAASADGN GDSSWTLAKL HEADCIDLKP SPTLASGSPE LMEDAISTEA
1060 1070 1080 1090
QHLLVSNGHL PKACDSSPES VPLKGQITGK RRGPLLLAPR S
Length:1,091
Mass (Da):119,156
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i938BF3C154520DC0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti38G → R in BAA11416 (PubMed:8798419).Curated1
Sequence conflicti52D → N in BAA11416 (PubMed:8798419).Curated1
Sequence conflicti114A → T in BAA11416 (PubMed:8798419).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D78572 mRNA Translation: BAA11416.1
AC122272 Genomic DNA No translation available.
AC155330 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS20380.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A58532

NCBI Reference Sequences

More...
RefSeqi
NP_032403.2, NM_008377.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000032105; ENSMUSP00000032105; ENSMUSG00000030029
ENSMUST00000101126; ENSMUSP00000098686; ENSMUSG00000030029
ENSMUST00000204645; ENSMUSP00000144963; ENSMUSG00000030029

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
16206

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:16206

UCSC genome browser

More...
UCSCi
uc009czu.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78572 mRNA Translation: BAA11416.1
AC122272 Genomic DNA No translation available.
AC155330 Genomic DNA No translation available.
CCDSiCCDS20380.1
PIRiA58532
RefSeqiNP_032403.2, NM_008377.2

3D structure databases

SMRiP70193
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi200652, 3 interactors
IntActiP70193, 2 interactors
STRINGi10090.ENSMUSP00000098686

PTM databases

GlyConnecti2474, 1 N-Linked glycan (1 site)
GlyGeniP70193, 7 sites, 1 N-linked glycan (1 site)
iPTMnetiP70193
PhosphoSitePlusiP70193

Proteomic databases

MaxQBiP70193
PaxDbiP70193
PRIDEiP70193
ProteomicsDBi292034

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
55087, 231 antibodies

The DNASU plasmid repository

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DNASUi
16206

Genome annotation databases

EnsembliENSMUST00000032105; ENSMUSP00000032105; ENSMUSG00000030029
ENSMUST00000101126; ENSMUSP00000098686; ENSMUSG00000030029
ENSMUST00000204645; ENSMUSP00000144963; ENSMUSG00000030029
GeneIDi16206
KEGGimmu:16206
UCSCiuc009czu.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
26018
MGIiMGI:107935, Lrig1
VEuPathDBiHostDB:ENSMUSG00000030029

Phylogenomic databases

eggNOGiKOG4194, Eukaryota
GeneTreeiENSGT00940000158502
HOGENOMiCLU_000288_18_24_1
InParanoidiP70193
OMAiWLKGDHP
OrthoDBi161719at2759
PhylomeDBiP70193
TreeFamiTF325380

Enzyme and pathway databases

ReactomeiR-MMU-177929, Signaling by EGFR
R-MMU-6807004, Negative regulation of MET activity

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
16206, 4 hits in 63 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Lrig1, mouse

Protein Ontology

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PROi
PR:P70193
RNActiP70193, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000030029, Expressed in hindbrain and 315 other tissues
GenevisibleiP70193, MM

Family and domain databases

Gene3Di2.60.40.10, 3 hits
3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR000483, Cys-rich_flank_reg_C
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR000372, LRRNT
PfamiView protein in Pfam
PF07679, I-set, 2 hits
PF13855, LRR_8, 5 hits
PF01463, LRRCT, 1 hit
PF01462, LRRNT, 1 hit
SMARTiView protein in SMART
SM00409, IG, 3 hits
SM00408, IGc2, 3 hits
SM00369, LRR_TYP, 14 hits
SM00082, LRRCT, 1 hit
SM00013, LRRNT, 1 hit
SUPFAMiSSF48726, SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835, IG_LIKE, 3 hits
PS51450, LRR, 14 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLRIG1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P70193
Secondary accession number(s): E9QL89
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: July 27, 2011
Last modified: September 29, 2021
This is version 161 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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