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Protein

Leucine-rich repeats and immunoglobulin-like domains protein 1

Gene

Lrig1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation.By similarity

GO - Biological processi

  • hair cycle process Source: MGI
  • innervation Source: MGI
  • otolith morphogenesis Source: MGI
  • sensory perception of sound Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-177929 Signaling by EGFR
R-MMU-6807004 Negative regulation of MET activity

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeats and immunoglobulin-like domains protein 1
Short name:
LIG-1
Gene namesi
Name:Lrig1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:107935 Lrig1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini35 – 796ExtracellularSequence analysisAdd BLAST762
Transmembranei797 – 817HelicalSequence analysisAdd BLAST21
Topological domaini818 – 1091CytoplasmicSequence analysisAdd BLAST274

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mutant mice are born at the expected Mendelian rate and initially display no visible phenotype. One to four months after birth, they develop skin abnormalities including alopecia and epidermal hyperplasia that are reminiscent of psoriasis.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_000001482835 – 1091Leucine-rich repeats and immunoglobulin-like domains protein 1Add BLAST1057

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi47 ↔ 56By similarity
Glycosylationi76N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi152N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi248N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi294N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi320N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi385N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi446 ↔ 470By similarity
Disulfide bondi448 ↔ 491By similarity
Disulfide bondi518 ↔ 579PROSITE-ProRule annotation
Disulfide bondi622 ↔ 674PROSITE-ProRule annotation
Glycosylationi686N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi716 ↔ 765PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP70193
PaxDbiP70193
PRIDEiP70193

PTM databases

iPTMnetiP70193
PhosphoSitePlusiP70193

Expressioni

Tissue specificityi

Detected in brain (at protein level) (PubMed:12067728). Predominantly expressed in the brain, restricted to a small subset of glial cells, such as Bergmann glial cells of the cerebellum and glial cells in the nerve fiber layer of the olfactory bulb. Expressed also in the skin. Low expression is detected in the thymus and heart. No expression in the kidney, liver, lung or small intestine.2 Publications

Gene expression databases

BgeeiENSMUSG00000030029
GenevisibleiP70193 MM

Interactioni

Subunit structurei

Interacts (via extracellular LRR and Ig-like domains) with EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 (via extracellular domain). The physiological relevance of the interaction is controversial; LRIG1 may have low affinity for EGFR, and interaction may occur only when high levels of both proteins are present.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032105

Structurei

3D structure databases

ProteinModelPortaliP70193
SMRiP70193
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 70LRRNTAdd BLAST36
Repeati71 – 92LRR 1Add BLAST22
Repeati95 – 116LRR 2Add BLAST22
Repeati118 – 139LRR 3Add BLAST22
Repeati142 – 163LRR 4Add BLAST22
Repeati166 – 187LRR 5Add BLAST22
Repeati191 – 212LRR 6Add BLAST22
Repeati214 – 235LRR 7Add BLAST22
Repeati238 – 259LRR 8Add BLAST22
Repeati262 – 283LRR 9Add BLAST22
Repeati286 – 307LRR 10Add BLAST22
Repeati310 – 331LRR 11Add BLAST22
Repeati334 – 355LRR 12Add BLAST22
Repeati358 – 380LRR 13Add BLAST23
Repeati385 – 406LRR 14Add BLAST22
Repeati409 – 430LRR 15Add BLAST22
Domaini442 – 493LRRCTAdd BLAST52
Domaini497 – 596Ig-like C2-type 1Add BLAST100
Domaini601 – 690Ig-like C2-type 2Add BLAST90
Domaini695 – 781Ig-like C2-type 3Add BLAST87

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi522 – 526Poly-Ser5

Domaini

Contains LRR and Ig-domains that can mediate low-affinity interaction with EGFR. The LRRs and the Ig-domains are each sufficient for EGFR/ERBB1 binding. This interaction is abolished only when both the LRRs and the Ig-domains are deleted.By similarity

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4194 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00920000148954
HOGENOMiHOG000113380
HOVERGENiHBG052353
InParanoidiP70193
OMAiKLQRNNI
OrthoDBiEOG091G04H0
TreeFamiTF325380

Family and domain databases

Gene3Di2.60.40.10, 3 hits
3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
PfamiView protein in Pfam
PF07679 I-set, 2 hits
PF13855 LRR_8, 5 hits
PF01463 LRRCT, 1 hit
PF01462 LRRNT, 1 hit
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SM00369 LRR_TYP, 14 hits
SM00082 LRRCT, 1 hit
SM00013 LRRNT, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS51450 LRR, 14 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P70193-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARPGPGVLG APRLAPRLLL WLLLLLLQWP ESAGAQAGPR APCAAACTCA
60 70 80 90 100
GDSLDCSGRG LATLPRDLPS WTRSLNLSYN RLSEIDSAAF EDLTNLQEVY
110 120 130 140 150
LNSNELTAIP SLGAASIGVV SLFLQHNKIL SVDGSQLKSY LSLEVLDLSS
160 170 180 190 200
NNITEIRSSC FPNGLRIREL NLASNRISIL ESGAFDGLSR SLLTLRLSKN
210 220 230 240 250
RITQLPVKAF KLPRLTQLDL NRNRIRLIEG LTFQGLDSLE VLRLQRNNIS
260 270 280 290 300
RLTDGAFWGL SKMHVLHLEY NSLVEVNSGS LYGLTALHQL HLSNNSISRI
310 320 330 340 350
QRDGWSFCQK LHELILSFNN LTRLDEESLA ELSSLSILRL SHNAISHIAE
360 370 380 390 400
GAFKGLKSLR VLDLDHNEIS GTIEDTSGAF TGLDNLSKLT LFGNKIKSVA
410 420 430 440 450
KRAFSGLESL EHLNLGENAI RSVQFDAFAK MKNLKELYIS SESFLCDCQL
460 470 480 490 500
KWLPPWLMGR MLQAFVTATC AHPESLKGQS IFSVLPDSFV CDDFPKPQII
510 520 530 540 550
TQPETTMAVV GKDIRFTCSA ASSSSSPMTF AWKKDNEVLA NADMENFAHV
560 570 580 590 600
RAQDGEVMEY TTILHLRHVT FGHEGRYQCI ITNHFGSTYS HKARLTVNVL
610 620 630 640 650
PSFTKIPHDI AIRTGTTARL ECAATGHPNP QIAWQKDGGT DFPAARERRM
660 670 680 690 700
HVMPDDDVFF ITDVKIDDMG VYSCTAQNSA GSVSANATLT VLETPSLAVP
710 720 730 740 750
LEDRVVTVGE TVAFQCKATG SPTPRITWLK GGRPLSLTER HHFTPGNQLL
760 770 780 790 800
VVQNVMIDDA GRYTCEMSNP LGTERAHSQL SILPTPGCRK DGTTVGIFTI
810 820 830 840 850
AVVCSIVLTS LVWVCIIYQT RKKSEEYSVT NTDETIVPPD VPSYLSSQGT
860 870 880 890 900
LSDRQETVVR TEGGHQANGH IESNGVCLRD PSLFPEVDIH STTCRQPKLC
910 920 930 940 950
VGYTREPWKV TEKADRTAAP HTTAHSGSAV CSDCSTDTAY HPQPVPRDSG
960 970 980 990 1000
QPGTASSQEL RQHDREYSPH HPYSGTADGS HTLSGGSLYP SNHDRILPSL
1010 1020 1030 1040 1050
KNKAASADGN GDSSWTLAKL HEADCIDLKP SPTLASGSPE LMEDAISTEA
1060 1070 1080 1090
QHLLVSNGHL PKACDSSPES VPLKGQITGK RRGPLLLAPR S
Length:1,091
Mass (Da):119,156
Last modified:July 27, 2011 - v2
Checksum:i938BF3C154520DC0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti38G → R in BAA11416 (PubMed:8798419).Curated1
Sequence conflicti52D → N in BAA11416 (PubMed:8798419).Curated1
Sequence conflicti114A → T in BAA11416 (PubMed:8798419).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78572 mRNA Translation: BAA11416.1
AC122272 Genomic DNA No translation available.
AC155330 Genomic DNA No translation available.
CCDSiCCDS20380.1
PIRiA58532
RefSeqiNP_032403.2, NM_008377.2
UniGeneiMm.245210

Genome annotation databases

EnsembliENSMUST00000032105; ENSMUSP00000032105; ENSMUSG00000030029
ENSMUST00000101126; ENSMUSP00000098686; ENSMUSG00000030029
ENSMUST00000204645; ENSMUSP00000144963; ENSMUSG00000030029
GeneIDi16206
KEGGimmu:16206
UCSCiuc009czu.1 mouse

Similar proteinsi

Entry informationi

Entry nameiLRIG1_MOUSE
AccessioniPrimary (citable) accession number: P70193
Secondary accession number(s): E9QL89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: July 27, 2011
Last modified: June 20, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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